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Literature for peptidase A01.030: yapsin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Li,H., Gui,P., Li,X., Lin,Y., Ma,Z., Yu,H. and Ma,F.<br>CRISPR/Cas9-Mediated Construction of a YPS Gene-Deficient Komagataella phaffii Strain for Enhanced Expression of BIAP ƒ.­<br>Yeast (2025) 42, 195-205. PubMed  Europe PubMed DOI
    2. 2024
  2. Bednarek,A., Kabut,A., Rapala-Kozik,M. and Satala,D.<br>Exploring the effects of culture conditions on Yapsin (YPS) gene expression in Nakaseomyces glabratus<br>Open Life Sci (2024) 19, 20220995-20220995. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2021
  3. Battu,A., Purushotham,R., Dey,P., Vamshi,S.S. and Kaur,R.<br>An aspartyl protease-mediated cleavage regulates structure and function of a flavodoxin-like protein and aids oxidative stress survival<br>PLoS Pathog (2021) 17, e1009355-e1009355. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2015
  4. Adhikari,H., Vadaie,N., Chow,J., Caccamise,L.M., Chavel,C.A., Li,B., Bowitch,A., Stefan,C.J. and Cullen,P.J.<br>Role of the unfolded protein response in regulating the mucin-dependent filamentous-growth mitogen-activated protein kinase pathway<br>Mol Cell Biol (2015) 35, 1414-1432. PubMed  Europe PubMed DOI
  5. Dube,A.K., Belanger,M., Gagnon-Arsenault,I. and Bourbonnais,Y.<br>N-terminal entrance loop of yeast Yps1 and O-glycosylation of substrates are determinant factors controlling the shedding activity of this GPI-anchored endopeptidase<br>BMC Microbiol (2015) 15, 50-50. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2014
  6. Bairwa,G., Rasheed,M., Taigwal,R., Sahoo,R. and Kaur,R.<br>GPI (glycosylphosphatidylinositol)-linked aspartyl proteases regulate vacuole homoeostasis in Candida glabrata<br>Biochem J (2014) 458, 323-334. PubMed  Europe PubMed DOI
    7. 2013
  7. Sazonova,E.A., Zobnina,A.E. and Padkina,M.V.<br>[Effect of disruption of Pichia pastoris YPS1 gene on viability and production of recombinant proteins]<br>Genetika (2013) 49, 696-702. PubMed  Europe PubMed DOI  K
    8. 2012
  8. Cawley,N.X. and Loh,Y.P.<br>Yapsin 1<br>[ISSN:978-0-12-407744-7] (2012) 3, 176-180. DOI
  9. Sohn,M.J., Oh,D.B., Kim,E.J., Cheon,S.A., Kwon,O., Kim,J.Y., Lee,S.Y. and Kang,H.A.<br>HpYPS1 and HpYPS7 encode functional aspartyl proteases localized at the cell surface in the thermotolerant methylotrophic yeast Hansenula polymorpha<br>Yeast (2012) 29, 1-16. PubMed  Europe PubMed DOI
    10. 2011
  10. Bairwa,G. and Kaur,R.<br>A novel role for a glycosylphosphatidylinositol-anchored aspartyl protease, CgYps1, in the regulation of pH homeostasis in Candida glabrata<br>Mol Microbiol (2011) 79, 900-913. PubMed  Europe PubMed DOI
  11. Miyazaki,T., Izumikawa,K., Yamauchi,S., Inamine,T., Nagayoshi,Y., Saijo,T., Seki,M., Kakeya,H., Yamamoto,Y., Yanagihara,K., Miyazaki,Y., Yasuoka,A. and Kohno,S.<br>The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata<br>FEMS Yeast Res (2011) 11, 449-456. PubMed  Europe PubMed DOI
    12. 2010
  12. Cho,E.Y., Cheon,S.A., Kim,H., Choo,J., Lee,D.J., Ryu,H.M., Rhee,S.K., Chung,B.H., Kim,J.Y. and Kang,H.A.<br>Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae<br>J Biotechnol (2010) 149, 1-7. PubMed  Europe PubMed DOI
  13. Miller,K.A., Didone,L. and Krysan,D.J.<br>Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae<br>Eukaryot Cell (2010) 9, 1669-1679. PubMed  Europe PubMed DOI
    14. 2008
  14. Gagnon-Arsenault,I., Parise,L., Tremblay,J. and Bourbonnais,Y.<br>Activation mechanism, functional role and shedding of glycosylphosphatidylinositol-anchored Yps1p at the Saccharomyces cerevisiae cell surface<br>Mol Microbiol (2008) 69, 982-993. PubMed  Europe PubMed DOI
  15. Vadaie,N., Dionne,H., Akajagbor,D.S., Nickerson,S.R., Krysan,D.J. and Cullen,P.J.<br>Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast<br>J Cell Biol (2008) 181, 1073-1081. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2006
  16. Gagnon-Arsenault,I., Tremblay,J. and Bourbonnais,Y.<br>Fungal yapsins and cell wall: a unique family of aspartic peptidases for a distinctive cellular function<br>FEMS Yeast Res (2006) 6, 966-978. PubMed  Europe PubMed DOI  V
    17. 2005
  17. Krysan,D.J., Ting,E.L., Abeijon,C., Kroos,L. and Fuller,R.S.<br>Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae<br>Eukaryot Cell (2005) 4, 1364-1374. PubMed  Europe PubMed DOI  PMC  EPMC  K
    18. 2004
  18. Cawley,N.X. and Loh,Y.P.<br>Yapsin 1<br>[ISSN:0-12-079610-4] (2004) 2, 128-131.  V
    19. 2003
  19. [YEAR:21-2-2003]Cawley,N.X., Chino,M., Maldonado,A., Rodriguez,Y.M., Loh,Y.P. and Ellman,J.A.<br>Synthesis and characterization of the first potent inhibitor of yapsin 1. Implications for the study of yapsin-like enzymes<br>J Biol Chem (21-2-2003) 278, 5523-5530. PubMed  Europe PubMed DOI  I
    20. 2001
  20. Sievi,E., Suntio,T. and Makarow,M.<br>Proteolytic function of GPI-anchored plasma membrane protease Yps1p in the yeast vacuole and Golgi<br>Traffic (2001) 2, 896-907. PubMed  Europe PubMed DOI
    21. 2000
  21. Bourbonnais,Y., Larouche,C. and Tremblay,G.M.<br>Production of full-length human pre-elafin, an elastase specific inhibitor, from yeast requires the absence of a functional yapsin 1 (Yps1p) endoprotease<br>Protein Expr Purif (2000) 20, 485-491. PubMed  Europe PubMed DOI  E
  22. [YEAR:15-3-2000]Olsen,V. and Loh,Y.P.<br>In vivo processing of nonanchored yapsin 1 (Yap3p)<br>Arch Biochem Biophys (15-3-2000) 375, 315-321. PubMed  Europe PubMed DOI
  23. Song,G.Y. and Chung,B.H.<br>Overproduction of human parathyroid hormone by fed-batch culture of a Saccharomyces cerevisiae mutant lacking yeast aspartic protease 3<br>Process Biochem (2000) 35, 503-508. DOI
    24. 1998
  24. [YEAR:15-3-1998]Copley,K.S., Alm,S.M., Schooley,D.A. and Courchesne,W.E.<br>Expression, processing and secretion of a proteolytically-sensitive insect diuretic hormone by Saccharomyces cerevisiae requires the use of a yeast strain lacking genes encoding the Yap3 and Mkc7 endoproteases found in the secretory pathway<br>Biochem J (15-3-1998) 330, 1333-1340. PubMed  Europe PubMed  PMC  EPMC  E
  25. Kang,H.A., Kim,S.J., Choi,E.S., Rhee,S.K. and Chung,B.H.<br>Efficient production of intact human parathyroid hormone in a Saccharomyces cerevisiae mutant deficient in yeast aspartic protease 3 (YAP3)<br>Appl Microbiol Biotechnol (1998) 50, 187-192. PubMed  Europe PubMed DOI
  26. [YEAR:30-1-1998]Kerry-Williams,S.M., Gilbert,S.C., Evans,L.R. and Ballance,D.J.<br>Disruption of the Saccharomyces cerevisiae YAP3 gene reduces the proteolytic degradation of secreted recombinant human albumin<br>Yeast (30-1-1998) 14, 161-169. PubMed  Europe PubMed DOI
  27. Olsen,V., Cawley,N.X. and Loh,Y.P.<br>Yapsin1. Structure, biosynthesis, and specificity<br>Adv Exp Med Biol (1998) 436, 315-319. PubMed  Europe PubMed  V
  28. [YEAR:3-3-1998]Olsen,V., Guruprasad,K., Cawley,N.X., Chen,H.C., Blundell,T.L. and Loh,Y.P.<br>Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: Correlation with electronegative active-site pockets predicted by molecular modeling<br>Biochemistry (3-3-1998) 37, 2768-2777. PubMed  Europe PubMed DOI
    29. 1996
  29. Cawley,N.X., Chen,H.C., Beinfeld,M.C. and Loh,Y.P.<br>Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3<br>J Biol Chem (1996) 271, 4168-4176. PubMed  Europe PubMed DOI
  30. Cool,D.R., Louie,D.Y. and Loh,Y.P.<br>Yeast aspartic protease 3 is sorted to secretory granules and activated to process proopiomelanocortin in PC12 cells<br>Endocrinology (1996) 137, 5441-5446. PubMed  Europe PubMed DOI
  31. Ledgerwood,E.C., Brennan,S.O., Cawley,N.X., Loh,Y.P. and George,P.M.<br>Yeast aspartic protease 3 (Yap3) prefers substrates with basic residues in the P2, P1 and P2' positions<br>FEBS Lett (1996) 383, 67-71. PubMed  Europe PubMed  P
    32. 1995
  32. Ash,J., Dominguez,M., Bergeron,J.J., Thomas,D.Y. and Bourbonnais,Y.<br>The yeast proprotein convertase encoded by YAP3 is a glycophosphatidylinositol-anchored protein that localizes to the plasma membrane<br>J Biol Chem (1995) 270, 20847-20854. PubMed  Europe PubMed DOI
  33. Azaryan,A.V., Friedman,T.C., Cawley,N.X. and Loh,Y.P.<br>Characteristics of YAP3, a new prohormone processing aspartic protease from S. cerevisiae<br>Adv Exp Med Biol (1995) 362, 569-572. PubMed  Europe PubMed
  34. Cawley,N.X., Wong,M., Pu,L.P., Tam,W. and Loh,Y.P.<br>Secretion of yeast aspartic protease 3 is regulated by its carboxy-terminal tail: Characterization of secreted YAP3p<br>Biochemistry (1995) 34, 7430-7437. PubMed  Europe PubMed DOI
  35. Chaudhuri,B. and Stephan,C.<br>A C-terminal domain, which prevents secretion of the neuroendocrine protein 7B2 in Saccharomyces cerevisiae, inhibits Kex2 yet is processed by the Yap3 protease<br>FEBS Lett (1995) 364, 91-97. PubMed  Europe PubMed DOI
  36. Loh,Y.P., Cawley,N.X., Friedman,T.C. and Pu,L.P.<br>Yeast and mammalian basic residue-specific aspartic proteases in prohormone conversion<br>Adv Exp Med Biol (1995) 362, 519-527. PubMed  Europe PubMed
  37. Loh,Y.P. and Cawley,N.X.<br>Processing enzymes of pepsin family: yeast aspartic protease 3 and pro-opiomelanocortin converting enzyme<br>Methods Enzymol (1995) 248, 136-146. PubMed  Europe PubMed DOI  V
    38. 1994
  38. Bourbonnais,Y., Germain,D., Ash,J. and Thomas,D.Y.<br>Cleavage of prosomatostatins by the yeast Yap3 and Kex2 endoprotease<br>Biochimie (1994) 76, 226-233. PubMed  Europe PubMed
    39. 1993
  39. [YEAR:5-6-1993]Azaryan,A.V., Wong,M., Friedman,T.C., Cawley,N.X., Estivariz,F.E., Chen,H.C. and Loh,Y.P.<br>Purification and characterization of a paired basic residue-specific yeast aspartic protease encoded by the YAP3 gene. Similarity to the mammalian pro-opiomelanocortin-converting enzyme<br>J Biol Chem (5-6-1993) 268, 11968-11975. PubMed  Europe PubMed
  40. Bourbonnais,Y., Ash,J., Daigle,M. and Thomas,D.Y.<br>Isolation and characterization of S. cerevisiae mutants defective in somatostatin expression: cloning and functional role of a yeast gene encoding an aspartyl protease in precursor processing at monobasic cleavage sites<br>EMBO J (1993) 12, 285-294. PubMed  Europe PubMed  PMC  EPMC
  41. [YEAR:18-10-1993]Cawley,N.X., Noe,B.D. and Loh,Y.P.<br>Purified yeast aspartic protease 3 cleaves anglerfish pro-somatostatin I and II at di- and monobasic sites to generate somatostatin-14 and -28<br>FEBS Lett (18-10-1993) 332, 273-276. PubMed  Europe PubMed DOI
    42. 1990
  42. Egel-Mitani,M., Flygenring,H.P. and Hansen,M.T.<br>A novel aspartyl protease allowing KEX2-independent MFalpha propheromone processing in yeast<br>Yeast (1990) 6, 127-137. PubMed  Europe PubMed DOI

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