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Literature for peptidase A01.030: yapsin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Li,H., Gui,P., Li,X., Lin,Y., Ma,Z., Yu,H. and Ma,F.
    CRISPR/Cas9-Mediated Construction of a YPS Gene-Deficient Komagataella phaffii Strain for Enhanced Expression of BIAP ƒ.­
    Yeast (2025) 42, 195-205. PubMed  Europe PubMed DOI
    2. 2024
  2. Bednarek,A., Kabut,A., Rapala-Kozik,M. and Satala,D.
    Exploring the effects of culture conditions on Yapsin (YPS) gene expression in Nakaseomyces glabratus
    Open Life Sci (2024) 19, 20220995-20220995. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2021
  3. Battu,A., Purushotham,R., Dey,P., Vamshi,S.S. and Kaur,R.
    An aspartyl protease-mediated cleavage regulates structure and function of a flavodoxin-like protein and aids oxidative stress survival
    PLoS Pathog (2021) 17, e1009355-e1009355. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2015
  4. Adhikari,H., Vadaie,N., Chow,J., Caccamise,L.M., Chavel,C.A., Li,B., Bowitch,A., Stefan,C.J. and Cullen,P.J.
    Role of the unfolded protein response in regulating the mucin-dependent filamentous-growth mitogen-activated protein kinase pathway
    Mol Cell Biol (2015) 35, 1414-1432. PubMed  Europe PubMed DOI
  5. Dube,A.K., Belanger,M., Gagnon-Arsenault,I. and Bourbonnais,Y.
    N-terminal entrance loop of yeast Yps1 and O-glycosylation of substrates are determinant factors controlling the shedding activity of this GPI-anchored endopeptidase
    BMC Microbiol (2015) 15, 50-50. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2014
  6. Bairwa,G., Rasheed,M., Taigwal,R., Sahoo,R. and Kaur,R.
    GPI (glycosylphosphatidylinositol)-linked aspartyl proteases regulate vacuole homoeostasis in Candida glabrata
    Biochem J (2014) 458, 323-334. PubMed  Europe PubMed DOI
    7. 2013
  7. Sazonova,E.A., Zobnina,A.E. and Padkina,M.V.
    [Effect of disruption of Pichia pastoris YPS1 gene on viability and production of recombinant proteins]
    Genetika (2013) 49, 696-702. PubMed  Europe PubMed DOI  K
    8. 2012
  8. Cawley,N.X. and Loh,Y.P.
    Yapsin 1
    [ISSN:978-0-12-407744-7] (2012) 3, 176-180. DOI
  9. Sohn,M.J., Oh,D.B., Kim,E.J., Cheon,S.A., Kwon,O., Kim,J.Y., Lee,S.Y. and Kang,H.A.
    HpYPS1 and HpYPS7 encode functional aspartyl proteases localized at the cell surface in the thermotolerant methylotrophic yeast Hansenula polymorpha
    Yeast (2012) 29, 1-16. PubMed  Europe PubMed DOI
    10. 2011
  10. Bairwa,G. and Kaur,R.
    A novel role for a glycosylphosphatidylinositol-anchored aspartyl protease, CgYps1, in the regulation of pH homeostasis in Candida glabrata
    Mol Microbiol (2011) 79, 900-913. PubMed  Europe PubMed DOI
  11. Miyazaki,T., Izumikawa,K., Yamauchi,S., Inamine,T., Nagayoshi,Y., Saijo,T., Seki,M., Kakeya,H., Yamamoto,Y., Yanagihara,K., Miyazaki,Y., Yasuoka,A. and Kohno,S.
    The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata
    FEMS Yeast Res (2011) 11, 449-456. PubMed  Europe PubMed DOI
    12. 2010
  12. Cho,E.Y., Cheon,S.A., Kim,H., Choo,J., Lee,D.J., Ryu,H.M., Rhee,S.K., Chung,B.H., Kim,J.Y. and Kang,H.A.
    Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae
    J Biotechnol (2010) 149, 1-7. PubMed  Europe PubMed DOI
  13. Miller,K.A., Didone,L. and Krysan,D.J.
    Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae
    Eukaryot Cell (2010) 9, 1669-1679. PubMed  Europe PubMed DOI
    14. 2008
  14. Gagnon-Arsenault,I., Parise,L., Tremblay,J. and Bourbonnais,Y.
    Activation mechanism, functional role and shedding of glycosylphosphatidylinositol-anchored Yps1p at the Saccharomyces cerevisiae cell surface
    Mol Microbiol (2008) 69, 982-993. PubMed  Europe PubMed DOI
  15. Vadaie,N., Dionne,H., Akajagbor,D.S., Nickerson,S.R., Krysan,D.J. and Cullen,P.J.
    Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast
    J Cell Biol (2008) 181, 1073-1081. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2006
  16. Gagnon-Arsenault,I., Tremblay,J. and Bourbonnais,Y.
    Fungal yapsins and cell wall: a unique family of aspartic peptidases for a distinctive cellular function
    FEMS Yeast Res (2006) 6, 966-978. PubMed  Europe PubMed DOI  V
    17. 2005
  17. Krysan,D.J., Ting,E.L., Abeijon,C., Kroos,L. and Fuller,R.S.
    Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae
    Eukaryot Cell (2005) 4, 1364-1374. PubMed  Europe PubMed DOI  PMC  EPMC  K
    18. 2004
  18. Cawley,N.X. and Loh,Y.P.
    Yapsin 1
    [ISSN:0-12-079610-4] (2004) 2, 128-131.  V
    19. 2003
  19. [YEAR:21-2-2003]Cawley,N.X., Chino,M., Maldonado,A., Rodriguez,Y.M., Loh,Y.P. and Ellman,J.A.
    Synthesis and characterization of the first potent inhibitor of yapsin 1. Implications for the study of yapsin-like enzymes
    J Biol Chem (21-2-2003) 278, 5523-5530. PubMed  Europe PubMed DOI  I
    20. 2001
  20. Sievi,E., Suntio,T. and Makarow,M.
    Proteolytic function of GPI-anchored plasma membrane protease Yps1p in the yeast vacuole and Golgi
    Traffic (2001) 2, 896-907. PubMed  Europe PubMed DOI
    21. 2000
  21. Bourbonnais,Y., Larouche,C. and Tremblay,G.M.
    Production of full-length human pre-elafin, an elastase specific inhibitor, from yeast requires the absence of a functional yapsin 1 (Yps1p) endoprotease
    Protein Expr Purif (2000) 20, 485-491. PubMed  Europe PubMed DOI  E
  22. [YEAR:15-3-2000]Olsen,V. and Loh,Y.P.
    In vivo processing of nonanchored yapsin 1 (Yap3p)
    Arch Biochem Biophys (15-3-2000) 375, 315-321. PubMed  Europe PubMed DOI
  23. Song,G.Y. and Chung,B.H.
    Overproduction of human parathyroid hormone by fed-batch culture of a Saccharomyces cerevisiae mutant lacking yeast aspartic protease 3
    Process Biochem (2000) 35, 503-508. DOI
    24. 1998
  24. [YEAR:15-3-1998]Copley,K.S., Alm,S.M., Schooley,D.A. and Courchesne,W.E.
    Expression, processing and secretion of a proteolytically-sensitive insect diuretic hormone by Saccharomyces cerevisiae requires the use of a yeast strain lacking genes encoding the Yap3 and Mkc7 endoproteases found in the secretory pathway
    Biochem J (15-3-1998) 330, 1333-1340. PubMed  Europe PubMed  PMC  EPMC  E
  25. Kang,H.A., Kim,S.J., Choi,E.S., Rhee,S.K. and Chung,B.H.
    Efficient production of intact human parathyroid hormone in a Saccharomyces cerevisiae mutant deficient in yeast aspartic protease 3 (YAP3)
    Appl Microbiol Biotechnol (1998) 50, 187-192. PubMed  Europe PubMed DOI
  26. [YEAR:30-1-1998]Kerry-Williams,S.M., Gilbert,S.C., Evans,L.R. and Ballance,D.J.
    Disruption of the Saccharomyces cerevisiae YAP3 gene reduces the proteolytic degradation of secreted recombinant human albumin
    Yeast (30-1-1998) 14, 161-169. PubMed  Europe PubMed DOI
  27. Olsen,V., Cawley,N.X. and Loh,Y.P.
    Yapsin1. Structure, biosynthesis, and specificity
    Adv Exp Med Biol (1998) 436, 315-319. PubMed  Europe PubMed  V
  28. [YEAR:3-3-1998]Olsen,V., Guruprasad,K., Cawley,N.X., Chen,H.C., Blundell,T.L. and Loh,Y.P.
    Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: Correlation with electronegative active-site pockets predicted by molecular modeling
    Biochemistry (3-3-1998) 37, 2768-2777. PubMed  Europe PubMed DOI
    29. 1996
  29. Cawley,N.X., Chen,H.C., Beinfeld,M.C. and Loh,Y.P.
    Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3
    J Biol Chem (1996) 271, 4168-4176. PubMed  Europe PubMed DOI
  30. Cool,D.R., Louie,D.Y. and Loh,Y.P.
    Yeast aspartic protease 3 is sorted to secretory granules and activated to process proopiomelanocortin in PC12 cells
    Endocrinology (1996) 137, 5441-5446. PubMed  Europe PubMed DOI
  31. Ledgerwood,E.C., Brennan,S.O., Cawley,N.X., Loh,Y.P. and George,P.M.
    Yeast aspartic protease 3 (Yap3) prefers substrates with basic residues in the P2, P1 and P2' positions
    FEBS Lett (1996) 383, 67-71. PubMed  Europe PubMed  P
    32. 1995
  32. Ash,J., Dominguez,M., Bergeron,J.J., Thomas,D.Y. and Bourbonnais,Y.
    The yeast proprotein convertase encoded by YAP3 is a glycophosphatidylinositol-anchored protein that localizes to the plasma membrane
    J Biol Chem (1995) 270, 20847-20854. PubMed  Europe PubMed DOI
  33. Azaryan,A.V., Friedman,T.C., Cawley,N.X. and Loh,Y.P.
    Characteristics of YAP3, a new prohormone processing aspartic protease from S. cerevisiae
    Adv Exp Med Biol (1995) 362, 569-572. PubMed  Europe PubMed
  34. Cawley,N.X., Wong,M., Pu,L.P., Tam,W. and Loh,Y.P.
    Secretion of yeast aspartic protease 3 is regulated by its carboxy-terminal tail: Characterization of secreted YAP3p
    Biochemistry (1995) 34, 7430-7437. PubMed  Europe PubMed DOI
  35. Chaudhuri,B. and Stephan,C.
    A C-terminal domain, which prevents secretion of the neuroendocrine protein 7B2 in Saccharomyces cerevisiae, inhibits Kex2 yet is processed by the Yap3 protease
    FEBS Lett (1995) 364, 91-97. PubMed  Europe PubMed DOI
  36. Loh,Y.P., Cawley,N.X., Friedman,T.C. and Pu,L.P.
    Yeast and mammalian basic residue-specific aspartic proteases in prohormone conversion
    Adv Exp Med Biol (1995) 362, 519-527. PubMed  Europe PubMed
  37. Loh,Y.P. and Cawley,N.X.
    Processing enzymes of pepsin family: yeast aspartic protease 3 and pro-opiomelanocortin converting enzyme
    Methods Enzymol (1995) 248, 136-146. PubMed  Europe PubMed DOI  V
    38. 1994
  38. Bourbonnais,Y., Germain,D., Ash,J. and Thomas,D.Y.
    Cleavage of prosomatostatins by the yeast Yap3 and Kex2 endoprotease
    Biochimie (1994) 76, 226-233. PubMed  Europe PubMed
    39. 1993
  39. [YEAR:5-6-1993]Azaryan,A.V., Wong,M., Friedman,T.C., Cawley,N.X., Estivariz,F.E., Chen,H.C. and Loh,Y.P.
    Purification and characterization of a paired basic residue-specific yeast aspartic protease encoded by the YAP3 gene. Similarity to the mammalian pro-opiomelanocortin-converting enzyme
    J Biol Chem (5-6-1993) 268, 11968-11975. PubMed  Europe PubMed
  40. Bourbonnais,Y., Ash,J., Daigle,M. and Thomas,D.Y.
    Isolation and characterization of S. cerevisiae mutants defective in somatostatin expression: cloning and functional role of a yeast gene encoding an aspartyl protease in precursor processing at monobasic cleavage sites
    EMBO J (1993) 12, 285-294. PubMed  Europe PubMed  PMC  EPMC
  41. [YEAR:18-10-1993]Cawley,N.X., Noe,B.D. and Loh,Y.P.
    Purified yeast aspartic protease 3 cleaves anglerfish pro-somatostatin I and II at di- and monobasic sites to generate somatostatin-14 and -28
    FEBS Lett (18-10-1993) 332, 273-276. PubMed  Europe PubMed DOI
    42. 1990
  42. Egel-Mitani,M., Flygenring,H.P. and Hansen,M.T.
    A novel aspartyl protease allowing KEX2-independent MFalpha propheromone processing in yeast
    Yeast (1990) 6, 127-137. PubMed  Europe PubMed DOI

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