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Literature for peptidase A01.030: yapsin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Bednarek,A., Kabut,A., Rapala-Kozik,M. and Satala,D.
    Exploring the effects of culture conditions on Yapsin (YPS) gene expression in Nakaseomyces glabratus
    Open Life Sci19, 20220995-20220995. PubMed  Europe PubMed DOI
    2. 2021
  2. Battu,A., Purushotham,R., Dey,P., Vamshi,S.S. and Kaur,R.
    An aspartyl protease-mediated cleavage regulates structure and function of a flavodoxin-like protein and aids oxidative stress survival
    PLoS Pathog17, e1009355-e1009355. PubMed  Europe PubMed DOI
    3. 2015
  3. Adhikari,H., Vadaie,N., Chow,J., Caccamise,L.M., Chavel,C.A., Li,B., Bowitch,A., Stefan,C.J. and Cullen,P.J.
    Role of the unfolded protein response in regulating the mucin-dependent filamentous-growth mitogen-activated protein kinase pathway
    Mol Cell Biol35, 1414-1432. PubMed  Europe PubMed DOI
  4. Dube,A.K., Belanger,M., Gagnon-Arsenault,I. and Bourbonnais,Y.
    N-terminal entrance loop of yeast Yps1 and O-glycosylation of substrates are determinant factors controlling the shedding activity of this GPI-anchored endopeptidase
    BMC Microbiol15, 50-50. PubMed  Europe PubMed DOI
    5. 2014
  5. Bairwa,G., Rasheed,M., Taigwal,R., Sahoo,R. and Kaur,R.
    GPI (glycosylphosphatidylinositol)-linked aspartyl proteases regulate vacuole homoeostasis in Candida glabrata
    Biochem J458, 323-334. PubMed  Europe PubMed DOI
    6. 2013
  6. Sazonova,E.A., Zobnina,A.E. and Padkina,M.V.
    [Effect of disruption of Pichia pastoris YPS1 gene on viability and production of recombinant proteins]
    Genetika49, 696-702. PubMed  Europe PubMed DOI  K
    7. 2012
  7. Cawley,N.X. and Loh,Y.P.
    Yapsin 1
    [ISSN:978-0-12-407744-7]3, 176-180. DOI
  8. Sohn,M.J., Oh,D.B., Kim,E.J., Cheon,S.A., Kwon,O., Kim,J.Y., Lee,S.Y. and Kang,H.A.
    HpYPS1 and HpYPS7 encode functional aspartyl proteases localized at the cell surface in the thermotolerant methylotrophic yeast Hansenula polymorpha
    Yeast29, 1-16. PubMed  Europe PubMed DOI
    9. 2011
  9. Bairwa,G. and Kaur,R.
    A novel role for a glycosylphosphatidylinositol-anchored aspartyl protease, CgYps1, in the regulation of pH homeostasis in Candida glabrata
    Mol Microbiol79, 900-913. PubMed  Europe PubMed DOI
  10. Miyazaki,T., Izumikawa,K., Yamauchi,S., Inamine,T., Nagayoshi,Y., Saijo,T., Seki,M., Kakeya,H., Yamamoto,Y., Yanagihara,K., Miyazaki,Y., Yasuoka,A. and Kohno,S.
    The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata
    FEMS Yeast Res11, 449-456. PubMed  Europe PubMed DOI
    11. 2010
  11. Cho,E.Y., Cheon,S.A., Kim,H., Choo,J., Lee,D.J., Ryu,H.M., Rhee,S.K., Chung,B.H., Kim,J.Y. and Kang,H.A.
    Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae
    J Biotechnol149, 1-7. PubMed  Europe PubMed DOI
  12. Miller,K.A., Didone,L. and Krysan,D.J.
    Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae
    Eukaryot Cell9, 1669-1679. PubMed  Europe PubMed DOI
    13. 2008
  13. Gagnon-Arsenault,I., Parise,L., Tremblay,J. and Bourbonnais,Y.
    Activation mechanism, functional role and shedding of glycosylphosphatidylinositol-anchored Yps1p at the Saccharomyces cerevisiae cell surface
    Mol Microbiol69, 982-993. PubMed  Europe PubMed DOI
  14. Vadaie,N., Dionne,H., Akajagbor,D.S., Nickerson,S.R., Krysan,D.J. and Cullen,P.J.
    Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast
    J Cell Biol181, 1073-1081. PubMed  Europe PubMed DOI
    15. 2006
  15. Gagnon-Arsenault,I., Tremblay,J. and Bourbonnais,Y.
    Fungal yapsins and cell wall: a unique family of aspartic peptidases for a distinctive cellular function
    FEMS Yeast Res6, 966-978. PubMed  Europe PubMed DOI  V
    16. 2005
  16. Krysan,D.J., Ting,E.L., Abeijon,C., Kroos,L. and Fuller,R.S.
    Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae
    Eukaryot Cell4, 1364-1374. PubMed  Europe PubMed DOI  K
    17. 2004
  17. Cawley,N.X. and Loh,Y.P.
    Yapsin 1
    [ISSN:0-12-079610-4]2, 128-131.  V
    18. 2003
  18. [YEAR:21-2-2003]Cawley,N.X., Chino,M., Maldonado,A., Rodriguez,Y.M., Loh,Y.P. and Ellman,J.A.
    Synthesis and characterization of the first potent inhibitor of yapsin 1. Implications for the study of yapsin-like enzymes
    J Biol Chem278, 5523-5530. PubMed  Europe PubMed DOI  I
    19. 2001
  19. Sievi,E., Suntio,T. and Makarow,M.
    Proteolytic function of GPI-anchored plasma membrane protease Yps1p in the yeast vacuole and Golgi
    Traffic2, 896-907. PubMed  Europe PubMed DOI
    20. 2000
  20. Bourbonnais,Y., Larouche,C. and Tremblay,G.M.
    Production of full-length human pre-elafin, an elastase specific inhibitor, from yeast requires the absence of a functional yapsin 1 (Yps1p) endoprotease
    Protein Expr Purif20, 485-491. PubMed  Europe PubMed DOI  E
  21. [YEAR:15-3-2000]Olsen,V. and Loh,Y.P.
    In vivo processing of nonanchored yapsin 1 (Yap3p)
    Arch Biochem Biophys375, 315-321. PubMed  Europe PubMed DOI
  22. Song,G.Y. and Chung,B.H.
    Overproduction of human parathyroid hormone by fed-batch culture of a Saccharomyces cerevisiae mutant lacking yeast aspartic protease 3
    Process Biochem35, 503-508. DOI
    23. 1998
  23. [YEAR:15-3-1998]Copley,K.S., Alm,S.M., Schooley,D.A. and Courchesne,W.E.
    Expression, processing and secretion of a proteolytically-sensitive insect diuretic hormone by Saccharomyces cerevisiae requires the use of a yeast strain lacking genes encoding the Yap3 and Mkc7 endoproteases found in the secretory pathway
    Biochem J330, 1333-1340. PubMed  Europe PubMed  E
  24. Kang,H.A., Kim,S.J., Choi,E.S., Rhee,S.K. and Chung,B.H.
    Efficient production of intact human parathyroid hormone in a Saccharomyces cerevisiae mutant deficient in yeast aspartic protease 3 (YAP3)
    Appl Microbiol Biotechnol50, 187-192. PubMed  Europe PubMed DOI
  25. [YEAR:30-1-1998]Kerry-Williams,S.M., Gilbert,S.C., Evans,L.R. and Ballance,D.J.
    Disruption of the Saccharomyces cerevisiae YAP3 gene reduces the proteolytic degradation of secreted recombinant human albumin
    Yeast14, 161-169. PubMed  Europe PubMed DOI
  26. Olsen,V., Cawley,N.X. and Loh,Y.P.
    Yapsin1. Structure, biosynthesis, and specificity
    Adv Exp Med Biol436, 315-319. PubMed  Europe PubMed  V
  27. [YEAR:3-3-1998]Olsen,V., Guruprasad,K., Cawley,N.X., Chen,H.C., Blundell,T.L. and Loh,Y.P.
    Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: Correlation with electronegative active-site pockets predicted by molecular modeling
    Biochemistry37, 2768-2777. PubMed  Europe PubMed DOI
    28. 1996
  28. Cawley,N.X., Chen,H.C., Beinfeld,M.C. and Loh,Y.P.
    Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3
    J Biol Chem271, 4168-4176. PubMed  Europe PubMed DOI
  29. Cool,D.R., Louie,D.Y. and Loh,Y.P.
    Yeast aspartic protease 3 is sorted to secretory granules and activated to process proopiomelanocortin in PC12 cells
    Endocrinology137, 5441-5446. PubMed  Europe PubMed DOI
  30. Ledgerwood,E.C., Brennan,S.O., Cawley,N.X., Loh,Y.P. and George,P.M.
    Yeast aspartic protease 3 (Yap3) prefers substrates with basic residues in the P2, P1 and P2' positions
    FEBS Lett383, 67-71. PubMed  Europe PubMed  P
    31. 1995
  31. Ash,J., Dominguez,M., Bergeron,J.J., Thomas,D.Y. and Bourbonnais,Y.
    The yeast proprotein convertase encoded by YAP3 is a glycophosphatidylinositol-anchored protein that localizes to the plasma membrane
    J Biol Chem270, 20847-20854. PubMed  Europe PubMed DOI
  32. Azaryan,A.V., Friedman,T.C., Cawley,N.X. and Loh,Y.P.
    Characteristics of YAP3, a new prohormone processing aspartic protease from S. cerevisiae
    Adv Exp Med Biol362, 569-572. PubMed  Europe PubMed
  33. Cawley,N.X., Wong,M., Pu,L.P., Tam,W. and Loh,Y.P.
    Secretion of yeast aspartic protease 3 is regulated by its carboxy-terminal tail: Characterization of secreted YAP3p
    Biochemistry34, 7430-7437. PubMed  Europe PubMed DOI
  34. Chaudhuri,B. and Stephan,C.
    A C-terminal domain, which prevents secretion of the neuroendocrine protein 7B2 in Saccharomyces cerevisiae, inhibits Kex2 yet is processed by the Yap3 protease
    FEBS Lett364, 91-97. PubMed  Europe PubMed DOI
  35. Loh,Y.P. and Cawley,N.X.
    Processing enzymes of pepsin family: yeast aspartic protease 3 and pro-opiomelanocortin converting enzyme
    Methods Enzymol248, 136-146. PubMed  Europe PubMed DOI  V
  36. Loh,Y.P., Cawley,N.X., Friedman,T.C. and Pu,L.P.
    Yeast and mammalian basic residue-specific aspartic proteases in prohormone conversion
    Adv Exp Med Biol362, 519-527. PubMed  Europe PubMed
    37. 1994
  37. Bourbonnais,Y., Germain,D., Ash,J. and Thomas,D.Y.
    Cleavage of prosomatostatins by the yeast Yap3 and Kex2 endoprotease
    Biochimie76, 226-233. PubMed  Europe PubMed
    38. 1993
  38. [YEAR:5-6-1993]Azaryan,A.V., Wong,M., Friedman,T.C., Cawley,N.X., Estivariz,F.E., Chen,H.C. and Loh,Y.P.
    Purification and characterization of a paired basic residue-specific yeast aspartic protease encoded by the YAP3 gene. Similarity to the mammalian pro-opiomelanocortin-converting enzyme
    J Biol Chem268, 11968-11975. PubMed  Europe PubMed
  39. Bourbonnais,Y., Ash,J., Daigle,M. and Thomas,D.Y.
    Isolation and characterization of S. cerevisiae mutants defective in somatostatin expression: cloning and functional role of a yeast gene encoding an aspartyl protease in precursor processing at monobasic cleavage sites
    EMBO J12, 285-294. PubMed  Europe PubMed
  40. [YEAR:18-10-1993]Cawley,N.X., Noe,B.D. and Loh,Y.P.
    Purified yeast aspartic protease 3 cleaves anglerfish pro-somatostatin I and II at di- and monobasic sites to generate somatostatin-14 and -28
    FEBS Lett332, 273-276. PubMed  Europe PubMed DOI
    41. 1990
  41. Egel-Mitani,M., Flygenring,H.P. and Hansen,M.T.
    A novel aspartyl protease allowing KEX2-independent MFalpha propheromone processing in yeast
    Yeast6, 127-137. PubMed  Europe PubMed DOI

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