Structure for inhibitor I02.015: protease nexin-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

PDB	Organism	Resolution	Comment
1AAP	Homo sapiens	1.50 Å	inhibitor domain
The reactive site residue Arg15 is shown in blue ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
inhibitor domain	1.50 Å	1AAP	1AAP	1AAP	1AAP	1AAP	1AAP	Hynes et al., 1990
NMR structure of residues 1-28	0.00 Å	1AMB	1AMB	1AMB	1AMB	1AMB	1AMB	Talafous et al., 1994
NMR structure of residues 1-28	0.00 Å	1AMC	1AMC	1AMC	1AMC	1AMC	1AMC	Talafous et al., 1994
NMR structure of residues 1-40	0.00 Å	1AML	1AML	1AML	1AML	1AML	1AML	Sticht et al., 1995
NMR structure of residues 1-40	0.00 Å	1BA4	1BA4	1BA4	1BA4	1BA4	1BA4	Coles et al., 1998
NMR structure of residues 1-40	0.00 Å	1BA6	1BA6	1BA6	1BA6	1BA6	1BA6	Watson et al., 1998
NMR structure of residues 1-28	0.00 Å	1BJB	1BJB	1BJB	1BJB	1BJB	1BJB	Poulsen et al., 2000
NMR structure of residues 1-28	0.00 Å	1BJC	1BJC	1BJC	1BJC	1BJC	1BJC	Poulsen et al., 2000
complex with rat trypsin variant	2.10 Å	1BRC	1BRC	1BRC	1BRC	1BRC	1BRC	Perona et al., 1993
Complex with bovine chymotrypsin	0.00 Å	1CA0	1CA0	1CA0	1CA0	1CA0	1CA0	Scheidig et al., 1997
NMR structure of residues 10-35	0.00 Å	1HZ3	1HZ3	1HZ3	1HZ3	1HZ3	1HZ3	Zhang et al., 2000
N-terminal domain	1.80 Å	1MWP	1MWP	1MWP	1MWP	1MWP	1MWP	Rossjohn et al., 1999
NMR structure of residues 25-35	0.00 Å	1QCM	1QCM	1QCM	1QCM	1QCM	1QCM	Kohno et al., 1996
complex with cattle cationic trypsin	1.80 Å	1TAW	1TAW	1TAW	1TAW	1TAW	1TAW	Scheidig et al., 1997
complex with coagulation factor XI catalytic domain	2.60 Å	1ZJD	1ZJD	1ZJD	1ZJD	1ZJD	1ZJD	Navaneetham et al., 2005
complex with human mesotrypsin	2.48 Å	3L33	3L33	3L33	3L33	3L33	3L33
complex with human presequence protease	2.70 Å	4NGE	4NGE	4NGE	4NGE	4NGE	4NGE
amyloid-beta 4-10; complex with angiotensin-1 converting enzyme N- domain	1.90 Å	5AM8	5AM8	5AM8	5AM8	5AM8	5AM8
amyloid-beta 35-42; complex with angiotensin-1 converting enzyme N- domain	1.55 Å	5AMB	5AMB	5AMB	5AMB	5AMB	5AMB
human mesotrypsin in complex with amyloid precursor protein inhibitor variant appi-m17g/i18f/f34v	1.83 Å	5C67	5C67	5C67	5C67	5C67	5C67
combinatorial engineering of proteolytically resistant appi variants that selectively inhibit human kallikrein 6 for cancer therapy	1.85 Å	5NX1	5NX1	5NX1	5NX1	5NX1	5NX1
combinatorial engineering of proteolytically resistant appi variants that selectively inhibit human kallikrein 6 for cancer therapy	2.30 Å	5NX3	5NX3	5NX3	5NX3	5NX3	5NX3
appi variant Thr11Val/Met17Arg/Ile18Phe/Phe34Val; complex with human mesotrypsin	2.30 Å	6GFI	6GFI	6GFI	6GFI	6GFI	6GFI
recognition of the amyloid precursor protein by human gamma-secretase	2.60 Å	6IYC	6IYC	6IYC	6IYC	6IYC	6IYC
Mus musculus
NMR structure	0.00 Å	2ROZ	2ROZ	2ROZ	2ROZ	2ROZ	2ROZ	Li et al., 2008
NMR structure	0.00 Å	2YSZ	2YSZ	2YSZ	2YSZ	2YSZ	2YSZ	Li et al., 2008
NMR structure	0.00 Å	2YT0	2YT0	2YT0	2YT0	2YT0	2YT0	Li et al., 2008
NMR structure	0.00 Å	2YT1	2YT1	2YT1	2YT1	2YT1	2YT1	Li et al., 2008
complex with DR6 CRD domain	2.20 Å	4YN0	4YN0	4YN0	4YN0	4YN0	4YN0	Xu et al., 2015
Rattus norvegicus
NGYENPTYK peptide; complex with PTB domain of mouse Disabled homolog 1	2.45 Å	1M7E	1M7E	1M7E	1M7E	1M7E	1M7E	Yun et al., 2003
NMR structure; amyloid beta-peptide 28mer	0.00 Å	1NMJ	1NMJ	1NMJ	1NMJ	1NMJ	1NMJ	Huang et al., 2004
9mer peptide; complex with PTB domain of mouse Disabled homolog 1	2.30 Å	1OQN	1OQN	1OQN	1OQN	1OQN	1OQN	Yun et al., 2003
NMR structure	0.00 Å	2LI9	2LI9	2LI9	2LI9	2LI9	2LI9	Istrate et al., 2012