PDBe 5amb

X-ray diffraction
1.55Å resolution

Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 35-42

Released:

Function and Biology Details

Reaction catalysed:
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
P3(40) Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 8 amino acids
Theoretical weight: 745 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 706-713; Coverage: 1%)
Gene names: A4, AD1, APP
Angiotensin-converting enzyme, soluble form Chains: A, B
Molecule details ›
Chains: A, B
Length: 629 amino acids
Theoretical weight: 72.61 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P12821 (Residues: 30-658; Coverage: 49%)
Gene names: ACE, DCP, DCP1
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 72.979Å b: 76.95Å c: 83.219Å
α: 88.63° β: 64.14° γ: 75.22°
R-values:
R R work R free
0.159 0.158 0.181
Expression systems:
  • Not provided
  • Cricetulus griseus