PDBe 1zjd

X-ray diffraction
2.6Å resolution

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor XIa light chain Chain: A
Molecule details ›
Chain: A
Length: 237 amino acids
Theoretical weight: 26.71 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P03951 (Residues: 388-624; Coverage: 39%)
Gene name: F11
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Soluble APP-beta Chain: B
Molecule details ›
Chain: B
Length: 57 amino acids
Theoretical weight: 6.28 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05067 (Residues: 289-345; Coverage: 8%)
  • Best match: P05067-7 (Residues: 289-345)
Gene names: A4, AD1, APP
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Factor Xa Inhibitor

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P3221
Unit cell:
a: 92.791Å b: 92.791Å c: 107.014Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.216 0.255
Expression system: Komagataella pastoris