Literature for inhibitor I02.015: protease nexin-2

(Topics flags: S Structure, M Mutation, P Specificity, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2023
1. Sananes,A., Cohen,I., Allon,I., Ben-David,O., Abu Shareb,R., Yegodayev,K.M., Stepensky,D., Elkabets,M. and Papo,N.
   Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers
   Mol Oncol17, 2337-2355. PubMed  Europe PubMed DOI
2022
2. Hitschler,L. and Lang,T.
   The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10
   J Biol Chem298, 101911-101911. PubMed  Europe PubMed DOI
3. Januario,Y.C., Eden,J., de Oliveira,L.S., De Pace,R., Tavares,L.A., da Silva-Januario,M.E., Apolloni,V.B., Wilby,E.L., Altmeyer,R., Burgos,P.V., Correa,S.A.L., Gershlick,D.C. and daSilva,L.L.P.
   Clathrin adaptor AP-1-mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments
   J Biol Chem298, 102172-102172. PubMed  Europe PubMed DOI
2020
4. Boix,C.P., Lopez-Font,I., Cuchillo-Ibanez,I. and Saez-Valero,J.
   Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer's disease
   Alzheimers Res Ther12, 96-96. PubMed  Europe PubMed DOI
5. Escamilla-Ayala,A.A., Sannerud,R., Mondin,M., Poersch,K., Vermeire,W., Paparelli,L., Berlage,C., Koenig,M., Chavez-Gutierrez,L., Ulbrich,M.H., Munck,S., Mizuno,H. and Annaert,W.
   Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/gamma-secretase at the cell surface
   elife9, PubMed  Europe PubMed DOI
6. Lauer,A.A., Mett,J., Janitschke,D., Thiel,A., Stahlmann,C.P., Bachmann,C.M., Ritzmann,F., Schrul,B., Muller,U.C., Stein,R., Riemenschneider,M., Grimm,H.S., Hartmann,T. and Grimm,M.O.W.
   Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease
   Aging Celle13264-e13264. PubMed  Europe PubMed DOI
7. Trambauer,J., Fukumori,A. and Steiner,H.
   Pathogenic Abeta generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications
   Curr Opin Neurobiol61, 73-81. PubMed  Europe PubMed DOI
2019
8. Cohen,I., Coban,M., Shahar,A., Sankaran,B., Hockla,A., Lacham,S., Caulfield,T.R., Radisky,E.S. and Papo,N.
   Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin
   J Biol Chem294, 5105-5120. PubMed  Europe PubMed DOI  S
9. Menon,P.K., Koistinen,N.A., Iverfeldt,K. and Strom,A.L.
   Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin beta
   J Biol Chem294, 17768-17776. PubMed  Europe PubMed DOI
10. Zhou,R., Yang,G., Guo,X., Zhou,Q., Lei,J. and Shi,Y.
    Recognition of the amyloid precursor protein by human gamma-secretase
    Science363, eaaw0930-eaaw0930. PubMed  Europe PubMed DOI  S
2018
11. Cohen,I., Naftaly,S., Ben-Zeev,E., Hockla,A., Radisky,E.S. and Papo,N.
    Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases
    Biochem J475, 1335-1352. PubMed  Europe PubMed DOI
12. Sheffield,W.P., Eltringham-Smith,L.J. and Bhakta,V.
    Fusion to human serum albumin extends the circulatory half-life and duration of antithrombotic action of the Kunitz protease inhibitor domain of protease nexin 2
    Cell Physiol Biochem45, 772-782. PubMed  Europe PubMed DOI  U
2016
13. Beckmann,A.M., Glebov,K., Walter,J., Merkel,O., Mangold,M., Schmidt,F., Becker-Pauly,C., Gutschow,M. and Stirnberg,M.
    The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2
    Biol Chem397, 777-790. PubMed  Europe PubMed DOI
14. Cohen,I., Kayode,O., Hockla,A., Sankaran,B., Radisky,D.C., Radisky,E.S. and Papo,N.
    Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy
    Biochem J473, 1329-1341. PubMed  Europe PubMed DOI
15. Xu,T.H., Yan,Y., Kang,Y., Jiang,Y., Melcher,K. and Xu,H.E.
    Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the Abeta42/Abeta40 ratio
    Cell Discov2, 16026-16026. PubMed  Europe PubMed DOI  M
2015
16. Xu,K., Olsen,O., Tzvetkova-Robev,D., Tessier-Lavigne,M. and Nikolov,D.B.
    The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation
    Genes Dev29, 785-790. PubMed  Europe PubMed DOI  S
2013
17. Navaneetham,D., Wu,W., Li,H., Sinha,D., Tuma,R.F. and Walsh,P.N.
    P1 and P2' site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitor
    J Biochem153, 221-231. PubMed  Europe PubMed DOI
2012
18. Ben Khalifa,N., Tyteca,D., Courtoy,P.J., Renauld,J.C., Constantinescu,S.N., Octave,J.N. and Kienlen-Campard,P.
    Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization
    Neurodegener Dis10, 92-95. PubMed  Europe PubMed DOI
19. Wu,W., Li,H., Navaneetham,D., Reichenbach,Z.W., Tuma,R.F. and Walsh,P.N.
    The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis
    Blood120, 671-677. PubMed  Europe PubMed DOI
2010
20. Navaneetham,D., Sinha,D. and Walsh,P.N.
    Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor
    J Biochem148, 467-479. PubMed  Europe PubMed DOI
21. Salameh,M.A., Soares,A.S., Navaneetham,D., Sinha,D., Walsh,P.N. and Radisky,E.S.
    Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin
    J Biol Chem285, 36884-36896. PubMed  Europe PubMed DOI
22. Salameh,M.A., Robinson,J.L., Navaneetham,D., Sinha,D., Madden,B.J., Walsh,P.N. and Radisky,E.S.
    The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin
    J Biol Chem285, 1939-1949. PubMed  Europe PubMed DOI  P
2009
23. Jacobsen,K.T. and Iverfeldt,K.
    Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors
    Cell Mol Life Sci66, 2299-2318. PubMed  Europe PubMed DOI  V
24. Xu,F., Previti,M.L., Nieman,M.T., Davis,J., Schmaier,A.H. and Van Nostrand,W.E.
    AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis
    J Neurosci29, 5666-5670. PubMed  Europe PubMed DOI
2005
25. Barrachina,M., Dalfo,E., Puig,B., Vidal,N., Freixes,M., Castano,E. and Ferrer,I.
    Amyloid-beta deposition in the cerebral cortex in Dementia with Lewy bodies is accompanied by a relative increase in AbetaPP mRNA isoforms containing the Kunitz protease inhibitor
    Neurochem Int46, 253-260. PubMed  Europe PubMed DOI
26. [YEAR:6-8-2005]Navaneetham,D., Jin,L., Pandey,P., Strickler,J.E., Babine,R.E., Abdel-Meguid,S.S. and Walsh,P.N.
    Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2
    J Biol Chem280, 36165-36175. PubMed  Europe PubMed DOI  S
2004
27. [YEAR:24-11-2004]Beyer,K., Lao,J.I., Carrato,C., Mate,J.L., Lopez,D., Ferrer,I. and Ariza,A.
    Upregulation of amyloid precursor protein isoforms containing Kunitz protease inhibitor in dementia with Lewy bodies
    Brain Res Mol Brain Res131, 131-135. PubMed  Europe PubMed DOI
2003
28. [YEAR:18-4-2003]Higashi,S. and Miyazaki,K.
    Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity
    J Biol Chem278, 14020-14028. PubMed  Europe PubMed DOI
29. [YEAR:3-6-2003]Higashi,S. and Miyazaki,K.
    Novel processing of beta-amyloid precursor protein catalyzed by membrane type 1 matrix metalloproteinase releases a fragment lacking the inhibitor domain against gelatinase A
    Biochemistry42, 6514-6526. PubMed  Europe PubMed DOI
2000
30. [YEAR:25-4-2000]Badellino,K.O. and Walsh,P.N.
    Protease nexin II interactions with coagulation factor XIa are contained within the Kunitz protease inhibitor domain of protease nexin II and the factor XIa catalytic domain
    Biochemistry39, 4769-4777. PubMed  Europe PubMed DOI
31. Poulsen,S.A., Watson,A.A., Fairlie,D.P. and Craik,D.J.
    Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F)
    J Struct Biol130, 142-152. PubMed  Europe PubMed DOI  S
1997
32. Scheidig,A.J., Hynes,T.R., Pelletier,L.A., Wells,J.A. and Kossiakoff,A.A.
    Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities
    Protein Sci6, 1806-1824. PubMed  Europe PubMed DOI  S
1995
33. [YEAR:3-1-1995]Kataoka,H., Seguchi,K., Iwamura,T., Moriyama,T., Nabeshima,K. and Koono,M.
    Reverse-zymographic analysis of protease nexin-II/amyloid beta protein precursor of human carcinoma cell lines, with special reference to the grade of differentiation and metastatic phenotype
    Int J Cancer60, 123-128. PubMed  Europe PubMed DOI
1994
34. Petersen,L.C., Bjorn,S.E., Norris,F., Norris,K., Sprecher,C. and Foster,D.C.
    Expression, purification and characterization of a Kunitz-type protease inhibitor domain from human amyloid precursor protein homolog
    FEBS Lett338, 53-57. PubMed  Europe PubMed DOI
1993
35. [YEAR:5-4-1993]Perona,J.J., Tsu,C.A., Craik,C.S. and Fletterick,R.J.
    Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI
    J Mol Biol230, 919-933. PubMed  Europe PubMed DOI  S
36. Perona,J.J., Tsu,C.A., McGrath,M.E., Craik,C.S. and Fletterick,R.J.
    Relocating a negative charge in the binding pocket of trypsin
    J Mol Biol230, 934-949. PubMed  Europe PubMed DOI  S
37. Shimokawa,M., Nakamura,K., Maruyama,K., Tagawa,K., Miyatake,T., Sugita,H., Ishiura,S. and Suzuki,K.
    Inhibitory spectra of purified protease nexin-II and related proteins towards cellular proteinases
    Biochimie75, 911-915. PubMed  Europe PubMed DOI
1992
38. Kim,T., Choi,B.H., Choe,W., Kim,R.C., Van Nostrand,W., Wagner,S. and Cunningham,D.
    Expression of protease nexin-II in human dorsal root ganglia. A correlative immunocytochemical and in situ hybridization study
    Mol Chem Neuropathol16, 225-239. PubMed  Europe PubMed
1991
39. [YEAR:30-9-1991]Itoh,H., Kataoka,H., Koita,H., Nabeshima,K., Inoue,T., Kangawa,K. and Koono,M.
    Establishment of a new human cancer cell line secreting protease nexin-II/amyloid beta protein precursor derived from squamous-cell carcinoma of lung
    Int J Cancer49, 436-443. PubMed  Europe PubMed DOI
1990
40. [YEAR:11-5-1990]Van Nostrand,W.E., Schmaier,A.H., Farrow,J.S. and Cunningham,D.D.
    Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein
    Science248, 745-748. PubMed  Europe PubMed
1989
41. [YEAR:14-9-1989]Oltersdorf,T., Fritz,L.C., Schenk,D.B., Lieberburg,I., Johnson-Wood,K.L., Beattie,E.C., Ward,P.J., Blacher,R.W., Dovey,H.F. and Sinha,S.
    The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II
    Nature341, 144-147. PubMed  Europe PubMed DOI
42. [YEAR:12-10-1989]Van Nostrand,W.E., Wagner,S.L., Suzuki,M., Choi,B.H., Farrow,J.S., Geddes,J.W., Cotman,C.W. and Cunningham,D.D.
    Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor
    Nature341, 546-549. PubMed  Europe PubMed DOI
1987
43. [YEAR:25-6-1987]Van Nostrand,W.E. and Cunningham,D.D.
    Purification of protease nexin II from human fibroblasts
    J Biol Chem262, 8508-8514. PubMed  Europe PubMed
1984
44. Knauer,D.J. and Cunningham,D.D.
    Protease nexins: cell-secreted proteins which regulate extracellular serine proteases
    Trends Biochem Sci9, 231-233. DOI
1983
45. Knauer,D.J., Thompson,J.A. and Cunningham,D.D.
    Protease nexins: cell-secreted proteins that mediate the binding, internalization, and degradation of regulatory serine proteases
    J Cell Physiol117, 385-396. PubMed  Europe PubMed DOI