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Literature for inhibitor I02.015: protease nexin-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

(Topics flags: S Structure, M Mutation, P Specificity, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Sananes,A., Cohen,I., Allon,I., Ben-David,O., Abu Shareb,R., Yegodayev,K.M., Stepensky,D., Elkabets,M. and Papo,N.
    Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers
    Mol Oncol (2023) 17, 2337-2355. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2022
  2. Hitschler,L. and Lang,T.
    The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10
    J Biol Chem (2022) 298, 101911-101911. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Januario,Y.C., Eden,J., de Oliveira,L.S., De Pace,R., Tavares,L.A., da Silva-Januario,M.E., Apolloni,V.B., Wilby,E.L., Altmeyer,R., Burgos,P.V., Correa,S.A.L., Gershlick,D.C. and daSilva,L.L.P.
    Clathrin adaptor AP-1-mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments
    J Biol Chem (2022) 298, 102172-102172. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2020
  4. Boix,C.P., Lopez-Font,I., Cuchillo-Ibanez,I. and Saez-Valero,J.
    Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer's disease
    Alzheimers Res Ther (2020) 12, 96-96. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Escamilla-Ayala,A.A., Sannerud,R., Mondin,M., Poersch,K., Vermeire,W., Paparelli,L., Berlage,C., Koenig,M., Chavez-Gutierrez,L., Ulbrich,M.H., Munck,S., Mizuno,H. and Annaert,W.
    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/gamma-secretase at the cell surface
    elife (2020) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Lauer,A.A., Mett,J., Janitschke,D., Thiel,A., Stahlmann,C.P., Bachmann,C.M., Ritzmann,F., Schrul,B., Muller,U.C., Stein,R., Riemenschneider,M., Grimm,H.S., Hartmann,T. and Grimm,M.O.W.
    Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease
    Aging Cell (2020) , e13264-e13264. PubMed  Europe PubMed DOI
  7. Trambauer,J., Fukumori,A. and Steiner,H.
    Pathogenic Abeta generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications
    Curr Opin Neurobiol (2020) 61, 73-81. PubMed  Europe PubMed DOI
    8. 2019
  8. Cohen,I., Coban,M., Shahar,A., Sankaran,B., Hockla,A., Lacham,S., Caulfield,T.R., Radisky,E.S. and Papo,N.
    Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin
    J Biol Chem (2019) 294, 5105-5120. PubMed  Europe PubMed DOI  S
  9. Menon,P.K., Koistinen,N.A., Iverfeldt,K. and Strom,A.L.
    Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin beta
    J Biol Chem (2019) 294, 17768-17776. PubMed  Europe PubMed DOI
  10. Zhou,R., Yang,G., Guo,X., Zhou,Q., Lei,J. and Shi,Y.
    Recognition of the amyloid precursor protein by human gamma-secretase
    Science (2019) 363, eaaw0930-eaaw0930. PubMed  Europe PubMed DOI  S
    11. 2018
  11. Cohen,I., Naftaly,S., Ben-Zeev,E., Hockla,A., Radisky,E.S. and Papo,N.
    Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases
    Biochem J (2018) 475, 1335-1352. PubMed  Europe PubMed DOI
  12. Sheffield,W.P., Eltringham-Smith,L.J. and Bhakta,V.
    Fusion to human serum albumin extends the circulatory half-life and duration of antithrombotic action of the Kunitz protease inhibitor domain of protease nexin 2
    Cell Physiol Biochem (2018) 45, 772-782. PubMed  Europe PubMed DOI  U
    13. 2016
  13. Beckmann,A.M., Glebov,K., Walter,J., Merkel,O., Mangold,M., Schmidt,F., Becker-Pauly,C., Gutschow,M. and Stirnberg,M.
    The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2
    Biol Chem (2016) 397, 777-790. PubMed  Europe PubMed DOI
  14. Cohen,I., Kayode,O., Hockla,A., Sankaran,B., Radisky,D.C., Radisky,E.S. and Papo,N.
    Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy
    Biochem J (2016) 473, 1329-1341. PubMed  Europe PubMed DOI
  15. Xu,T.H., Yan,Y., Kang,Y., Jiang,Y., Melcher,K. and Xu,H.E.
    Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the Abeta42/Abeta40 ratio
    Cell Discov (2016) 2, 16026-16026. PubMed  Europe PubMed DOI  PMC  EPMC  M
    16. 2015
  16. Xu,K., Olsen,O., Tzvetkova-Robev,D., Tessier-Lavigne,M. and Nikolov,D.B.
    The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation
    Genes Dev (2015) 29, 785-790. PubMed  Europe PubMed DOI  PMC  EPMC  S
    17. 2013
  17. Navaneetham,D., Wu,W., Li,H., Sinha,D., Tuma,R.F. and Walsh,P.N.
    P1 and P2' site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitor
    J Biochem (2013) 153, 221-231. PubMed  Europe PubMed DOI
    18. 2012
  18. Ben Khalifa,N., Tyteca,D., Courtoy,P.J., Renauld,J.C., Constantinescu,S.N., Octave,J.N. and Kienlen-Campard,P.
    Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization
    Neurodegener Dis (2012) 10, 92-95. PubMed  Europe PubMed DOI
  19. Wu,W., Li,H., Navaneetham,D., Reichenbach,Z.W., Tuma,R.F. and Walsh,P.N.
    The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis
    Blood (2012) 120, 671-677. PubMed  Europe PubMed DOI
    20. 2010
  20. Navaneetham,D., Sinha,D. and Walsh,P.N.
    Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor
    J Biochem (2010) 148, 467-479. PubMed  Europe PubMed DOI
  21. Salameh,M.A., Robinson,J.L., Navaneetham,D., Sinha,D., Madden,B.J., Walsh,P.N. and Radisky,E.S.
    The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin
    J Biol Chem (2010) 285, 1939-1949. PubMed  Europe PubMed DOI  P
  22. Salameh,M.A., Soares,A.S., Navaneetham,D., Sinha,D., Walsh,P.N. and Radisky,E.S.
    Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin
    J Biol Chem (2010) 285, 36884-36896. PubMed  Europe PubMed DOI
    23. 2009
  23. Jacobsen,K.T. and Iverfeldt,K.
    Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors
    Cell Mol Life Sci (2009) 66, 2299-2318. PubMed  Europe PubMed DOI  V
  24. Xu,F., Previti,M.L., Nieman,M.T., Davis,J., Schmaier,A.H. and Van Nostrand,W.E.
    AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis
    J Neurosci (2009) 29, 5666-5670. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2005
  25. Barrachina,M., Dalfo,E., Puig,B., Vidal,N., Freixes,M., Castano,E. and Ferrer,I.
    Amyloid-beta deposition in the cerebral cortex in Dementia with Lewy bodies is accompanied by a relative increase in AbetaPP mRNA isoforms containing the Kunitz protease inhibitor
    Neurochem Int (2005) 46, 253-260. PubMed  Europe PubMed DOI
  26. [YEAR:6-8-2005]Navaneetham,D., Jin,L., Pandey,P., Strickler,J.E., Babine,R.E., Abdel-Meguid,S.S. and Walsh,P.N.
    Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2
    J Biol Chem (6-8-2005) 280, 36165-36175. PubMed  Europe PubMed DOI  S
    27. 2004
  27. [YEAR:24-11-2004]Beyer,K., Lao,J.I., Carrato,C., Mate,J.L., Lopez,D., Ferrer,I. and Ariza,A.
    Upregulation of amyloid precursor protein isoforms containing Kunitz protease inhibitor in dementia with Lewy bodies
    Brain Res Mol Brain Res (24-11-2004) 131, 131-135. PubMed  Europe PubMed DOI
    28. 2003
  28. [YEAR:3-6-2003]Higashi,S. and Miyazaki,K.
    Novel processing of beta-amyloid precursor protein catalyzed by membrane type 1 matrix metalloproteinase releases a fragment lacking the inhibitor domain against gelatinase A
    Biochemistry (3-6-2003) 42, 6514-6526. PubMed  Europe PubMed DOI
  29. [YEAR:18-4-2003]Higashi,S. and Miyazaki,K.
    Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity
    J Biol Chem (18-4-2003) 278, 14020-14028. PubMed  Europe PubMed DOI
    30. 2000
  30. [YEAR:25-4-2000]Badellino,K.O. and Walsh,P.N.
    Protease nexin II interactions with coagulation factor XIa are contained within the Kunitz protease inhibitor domain of protease nexin II and the factor XIa catalytic domain
    Biochemistry (25-4-2000) 39, 4769-4777. PubMed  Europe PubMed DOI
  31. Poulsen,S.A., Watson,A.A., Fairlie,D.P. and Craik,D.J.
    Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F)
    J Struct Biol (2000) 130, 142-152. PubMed  Europe PubMed DOI  S
    32. 1997
  32. Scheidig,A.J., Hynes,T.R., Pelletier,L.A., Wells,J.A. and Kossiakoff,A.A.
    Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities
    Protein Sci (1997) 6, 1806-1824. PubMed  Europe PubMed DOI  PMC  EPMC  S
    33. 1995
  33. [YEAR:3-1-1995]Kataoka,H., Seguchi,K., Iwamura,T., Moriyama,T., Nabeshima,K. and Koono,M.
    Reverse-zymographic analysis of protease nexin-II/amyloid beta protein precursor of human carcinoma cell lines, with special reference to the grade of differentiation and metastatic phenotype
    Int J Cancer (3-1-1995) 60, 123-128. PubMed  Europe PubMed DOI
    34. 1994
  34. Petersen,L.C., Bjorn,S.E., Norris,F., Norris,K., Sprecher,C. and Foster,D.C.
    Expression, purification and characterization of a Kunitz-type protease inhibitor domain from human amyloid precursor protein homolog
    FEBS Lett (1994) 338, 53-57. PubMed  Europe PubMed DOI
    35. 1993
  35. Perona,J.J., Tsu,C.A., McGrath,M.E., Craik,C.S. and Fletterick,R.J.
    Relocating a negative charge in the binding pocket of trypsin
    J Mol Biol (1993) 230, 934-949. PubMed  Europe PubMed DOI  S
  36. [YEAR:5-4-1993]Perona,J.J., Tsu,C.A., Craik,C.S. and Fletterick,R.J.
    Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI
    J Mol Biol (5-4-1993) 230, 919-933. PubMed  Europe PubMed DOI  S
  37. Shimokawa,M., Nakamura,K., Maruyama,K., Tagawa,K., Miyatake,T., Sugita,H., Ishiura,S. and Suzuki,K.
    Inhibitory spectra of purified protease nexin-II and related proteins towards cellular proteinases
    Biochimie (1993) 75, 911-915. PubMed  Europe PubMed DOI
    38. 1992
  38. Kim,T., Choi,B.H., Choe,W., Kim,R.C., Van Nostrand,W., Wagner,S. and Cunningham,D.
    Expression of protease nexin-II in human dorsal root ganglia. A correlative immunocytochemical and in situ hybridization study
    Mol Chem Neuropathol (1992) 16, 225-239. PubMed  Europe PubMed
    39. 1991
  39. [YEAR:30-9-1991]Itoh,H., Kataoka,H., Koita,H., Nabeshima,K., Inoue,T., Kangawa,K. and Koono,M.
    Establishment of a new human cancer cell line secreting protease nexin-II/amyloid beta protein precursor derived from squamous-cell carcinoma of lung
    Int J Cancer (30-9-1991) 49, 436-443. PubMed  Europe PubMed DOI
    40. 1990
  40. [YEAR:11-5-1990]Van Nostrand,W.E., Schmaier,A.H., Farrow,J.S. and Cunningham,D.D.
    Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein
    Science (11-5-1990) 248, 745-748. PubMed  Europe PubMed
    41. 1989
  41. [YEAR:14-9-1989]Oltersdorf,T., Fritz,L.C., Schenk,D.B., Lieberburg,I., Johnson-Wood,K.L., Beattie,E.C., Ward,P.J., Blacher,R.W., Dovey,H.F. and Sinha,S.
    The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II
    Nature (14-9-1989) 341, 144-147. PubMed  Europe PubMed DOI
  42. [YEAR:12-10-1989]Van Nostrand,W.E., Wagner,S.L., Suzuki,M., Choi,B.H., Farrow,J.S., Geddes,J.W., Cotman,C.W. and Cunningham,D.D.
    Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor
    Nature (12-10-1989) 341, 546-549. PubMed  Europe PubMed DOI
    43. 1987
  43. [YEAR:25-6-1987]Van Nostrand,W.E. and Cunningham,D.D.
    Purification of protease nexin II from human fibroblasts
    J Biol Chem (25-6-1987) 262, 8508-8514. PubMed  Europe PubMed
    44. 1984
  44. Knauer,D.J. and Cunningham,D.D.
    Protease nexins: cell-secreted proteins which regulate extracellular serine proteases
    Trends Biochem Sci (1984) 9, 231-233. DOI
    45. 1983
  45. Knauer,D.J., Thompson,J.A. and Cunningham,D.D.
    Protease nexins: cell-secreted proteins that mediate the binding, internalization, and degradation of regulatory serine proteases
    J Cell Physiol (1983) 117, 385-396. PubMed  Europe PubMed DOI

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