PDBe 1mwp

X-ray diffraction
1.8Å resolution

N-TERMINAL DOMAIN OF THE AMYLOID PRECURSOR PROTEIN

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-APP Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 11.05 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05067 (Residues: 28-123; Coverage: 13%)
Gene names: A4, AD1, APP
Structure domains: A heparin-binding domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 31.2Å b: 48.6Å c: 67.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.242
Expression system: Komagataella pastoris