PDBe 5am8

X-ray diffraction
1.9Å resolution

Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 4-10

Released:

Function and Biology Details

Reaction catalysed:
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Amyloid-beta protein 40 Chains: P, Q, R, S
Molecule details ›
Chains: P, Q, R, S
Length: 7 amino acids
Theoretical weight: 883 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 675-681; Coverage: 1%)
Gene names: A4, AD1, APP
Angiotensin-converting enzyme, soluble form Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 629 amino acids
Theoretical weight: 72.59 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P12821 (Residues: 30-658; Coverage: 49%)
Gene names: ACE, DCP, DCP1
Sequence domains: Angiotensin-converting enzyme

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 73.449Å b: 101.76Å c: 114.361Å
α: 85.23° β: 86.07° γ: 81.45°
R-values:
R R work R free
0.187 0.185 0.224
Expression systems:
  • Not provided
  • Cricetulus griseus