Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-1014 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 34 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 47 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 93 |
matrix metallopeptidase-2 |
79-117 |
N |
|
MS |
Schilling & Overall, 2008 |
| 105 |
granzyme A |
1-1014 |
N |
|
|
Van Damme et al., 2010 |
| 111 |
meprin alpha subunit |
2-1014 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 111 |
meprin beta subunit |
2-1014 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 117 |
chymotrypsin A (cattle-type) |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 142 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 156 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 170 |
cathepsin G |
167-182 |
N |
|
MS |
Schilling & Overall, 2008 |
| 171 |
cathepsin S |
168-182 |
N |
|
MS |
Biniossek et al., 2011 |
| 180 |
matrix metallopeptidase-2 |
175-190 |
N |
|
MS |
Schilling & Overall, 2008 |
| 182 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 185 |
matrix metallopeptidase-2 |
182-197 |
N |
|
MS |
Schilling & Overall, 2008 |
| 190 |
glutamyl endopeptidase I |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 193 |
glutamyl endopeptidase I |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 197 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 213 |
caspase-1 |
2-1014 |
P |
|
|
Lazebnik et al., 1994 |
| 214 |
caspase-3 |
2-1014 |
P |
|
|
Teraoka et al., 1996 |
| 239 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 242 |
meprin alpha subunit |
239-254 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 242 |
LAST_MAM peptidase (Limulus-type) |
239-254 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 243 |
HIV-1 retropepsin |
239-253 |
N |
|
MS |
Schilling & Overall, 2008 |
| 243 |
matrix metallopeptidase-2 |
239-253 |
N |
|
MS |
Schilling & Overall, 2008 |
| 244 |
cathepsin G |
239-253 |
N |
|
MS |
Schilling & Overall, 2008 |
| 253 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 254 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 262 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 269 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 275 |
matrix metallopeptidase-2 |
267-289 |
N |
|
MS |
Schilling & Overall, 2008 |
| 282 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 289 |
chymotrypsin A (cattle-type) |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 304 |
peptidyl-Lys metallopeptidase |
1-1014 |
N |
|
MS |
|
| 309 |
HIV-1 retropepsin |
305-320 |
N |
|
MS |
Schilling & Overall, 2008 |
| 319 |
peptidyl-Lys metallopeptidase |
1-1014 |
N |
|
MS |
|
| 320 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 375 |
LAST peptidase (Limulus-type) |
372-394 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 375 |
LAST_MAM peptidase (Limulus-type) |
372-394 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 379 |
matrix metallopeptidase-2 |
355-394 |
N |
|
MS |
Schilling & Overall, 2008 |
| 380 |
elastase-2 |
355-394 |
N |
|
MS |
Schilling & Overall, 2008 |
| 381 |
cathepsin S |
356-394 |
N |
|
MS |
Biniossek et al., 2011 |
| 381 |
meprin beta subunit |
378-394 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 394 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 456 |
LAST_MAM peptidase (Limulus-type) |
453-467 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 456 |
glutamyl endopeptidase I |
452-467 |
N |
|
MS |
Schilling & Overall, 2008 |
| 457 |
HIV-1 retropepsin |
452-467 |
N |
|
MS |
Schilling & Overall, 2008 |
| 467 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 472 |
HIV-1 retropepsin |
467-486 |
N |
|
MS |
Schilling & Overall, 2008 |
| 476 |
matrix metallopeptidase-2 |
467-486 |
N |
|
MS |
Schilling & Overall, 2008 |
| 486 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 498 |
granzyme A |
1-1014 |
P |
|
|
Zhu et al., 2009 |
| 525 |
chymotrypsin A (cattle-type) |
2-1014 |
N |
|
|
Gobeil et al., 2001 |
| 536 |
meprin beta subunit |
533-548 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 536 |
granzyme B (Homo sapiens-type) |
2-1014 |
P |
|
|
Casciola-Rosen et al., 1999 |
| 594 |
matrix metallopeptidase-2 |
589-614 |
N |
|
MS |
Schilling & Overall, 2008 |
| 603 |
LAST_MAM peptidase (Limulus-type) |
600-616 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 614 |
chymotrypsin A (cattle-type) |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 637 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 642 |
cathepsin K |
637-654 |
N |
|
MS |
Schilling & Overall, 2008 |
| 654 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 655 |
chymotrypsin A (cattle-type) |
2-1014 |
N |
|
|
Gobeil et al., 2001 |
| 688 |
HIV-1 retropepsin |
684-695 |
N |
|
MS |
Schilling & Overall, 2008 |
| 695 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 700 |
matrix metallopeptidase-2 |
692-715 |
N |
|
MS |
Schilling & Overall, 2008 |
| 700 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 715 |
glutamyl endopeptidase I |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 777 |
matrix metallopeptidase-2 |
772-795 |
N |
|
MS |
Schilling & Overall, 2008 |
| 783 |
LAST_MAM peptidase (Limulus-type) |
780-796 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 795 |
glutamyl endopeptidase I |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 865 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 878 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 893 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
| 903 |
trypsin 1 |
2-1014 |
N |
|
MS |
Schilling & Overall, 2008 |
