Substrates for peptidase M12.214: ADAM19 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
adamalysin-19	Q9H013	204-956	peptide-Glu586+Ser-peptide	P	Arg	Pro	Leu	Glu	Ser	Asn	Ala	Val	Kang et al., 2002	18751
c-{kit} ligand-1 cleavage site peptide			Leu-Pro-Pro-Val-Ala-Ala+Ser-Ser-Leu-Arg	N	Pro	Val	Ala	Ala	Ser	Ser	Leu	Arg	Zou et al., 2004
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Val	Chesneau et al., 2003
kit ligand	P20826	26-273	peptide-Ala190+Ser-peptide	P	Pro	Val	Ala	Ala	Ser	Ser	Leu	Arg	Kawaguchi et al., 2007	20078
kit ligand	P21583	28-273	peptide-Ala190+Ser-peptide	N	Pro	Val	Ala	Ala	Ser	Ser	Leu	Arg	Chesneau et al., 2003
myelin basic protein	P02687	1-169	peptide-Ala16+Ser-peptide	P	Leu	Ala	Ser	Ala	Ser	Thr	Met	Asp	Chesneau et al., 2003	20199
myelin basic protein	P02687	1-169	peptide-Pro71+Gln-peptide	P	Gly	Ser	Leu	Pro	Gln	Lys	Ala	Gln	Chesneau et al., 2003	20200
myelin basic protein	P02687	1-169	peptide-Ser135+Ala-peptide	P	Asp	Tyr	Lys	Ser	Ala	His	Lys	Gly	Chesneau et al., 2003	20201
myelin basic protein	P02687	1-169	peptide-Leu110+Ser-peptide	P	Gly	Leu	Ser	Leu	Ser	Arg	Phe	Ser	Chesneau et al., 2003	20202
myelin basic protein	P02687	1-169	peptide-Lys73+Ala-peptide	P	Leu	Pro	Gln	Lys	Ala	Gln	Gly	His	Chesneau et al., 2003	20203
tumor necrosis factor	P01375	1-233	peptide-Ser79+Ser-peptide	P	Ala	Val	Arg	Ser	Ser	Ser	Arg	Thr	Chesneau et al., 2003	20934
tumor necrosis factor	P01375	1-233	peptide-Arg78+Ser-peptide	P	Gln	Ala	Val	Arg	Ser	Ser	Ser	Arg	Chesneau et al., 2003	20935
tumor necrosis factor ligand superfamily member 11	O35235	1-316	peptide-Arg138+Phe-peptide	N	Gly	Pro	Gln	Arg	Phe	Ser	Gly	Ala	Chesneau et al., 2003	20079