Substrates for peptidase S07.001: flavivirin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Leu-Lys-Arg-Arg-NHPhNO2			Ac-Leu-Lys-Arg-Arg+NPhNO2	S		Leu	Lys	Arg	Arg	NAN	-	-	-	Li et al., 2005
Ac-Leu-Lys-Lys-Arg-NHPhNO2			Ac-Leu-Lys-Arg-Arg+NPhNO2	S		Leu	Lys	Lys	Arg	NAN	-	-	-	Chappell et al., 2006
Boc-Arg-Val-Arg-Arg-NHMec			Boc-Arg-Val-Arg-Arg+NHMec	S		Arg	Val	Arg	Arg	AMC	-	-	-	Shiryaev et al., 2006
flavivirus polyprotein	P03314	2-3411	peptide-Arg1354+Ser-peptide	P		Phe	Gly	Arg	Arg	Ser	Ile	Pro	Val	Kummerer et al., 2004	17469
flavivirus polyprotein	P03314	2-3411	peptide-Arg1484+Ser-peptide	P		Gly	Ala	Arg	Arg	Ser	Gly	Asp	Val	Kummerer et al., 2004	17470
flavivirus polyprotein	P03314	2-3411	peptide-Arg2107+Gly-peptide	P		Glu	Gly	Arg	Arg	Gly	Ala	Ala	Glu	Kummerer et al., 2004	17471
flavivirus polyprotein	P03314	2-3411	peptide-Arg2506+Gly-peptide	P		Thr	Gly	Arg	Arg	Gly	Ser	Ala	Asn	Kummerer et al., 2004	17472
genome polyprotein	P06935	2-3430	peptide-Arg1370+Gly-peptide	P		Asn	Arg	Lys	Arg	Gly	Trp	Pro	Ala	Chappell et al., 2006
genome polyprotein	P06935	2-3430	peptide-Arg1501+Gly-peptide	P		Tyr	Thr	Lys	Arg	Gly	Gly	Val	Leu	Chappell et al., 2006
genome polyprotein	P06935	2-3430	peptide-Arg2120+Ser-peptide	N		Ser	Gly	Lys	Arg	Ser	Gln	Ile	Gly	Chappell et al., 2006
genome polyprotein	P06935	2-3430	peptide-Arg2525+Gly-peptide	P		Gly	Leu	Lys	Arg	Gly	Gly	Ala	Lys	Chappell et al., 2006
genome polyprotein	P06935	2-3430	peptide-Arg212+Ser-peptide	P	MS	His	Ser	Arg	Arg	Ser	Arg	Arg	Ser	Shiryaev et al., 2006
genome polyprotein	P06935	2-3430	peptide-Arg105+Gly-peptide	P	MS	Gln	Lys	Lys	Arg	Gly	Gly	Thr	Ala	Shiryaev et al., 2006
genome polyprotein	P27395	118-137	Leu-Ala-Val-Val-Ile-Ala-Cys-Ala-Gly-Ala+Met-Lys-Leu-Ser-Asn-Phe-Gln-Gly-Lys-Leu	P	NT	Cys	Ala	Gly	Ala	Met	Lys	Leu	Ser	Wahaab et al., 2021
genome polyprotein	P27395	1363-1383	peptide-Arg1373+Gly-peptide	P	NT	Asn	Lys	Lys	Arg	Gly	Trp	Pro	Ala	Wahaab et al., 2021
genome polyprotein	P27395	1494-1514	peptide-Arg1504+Gly-peptide	P	NT	Thr	Thr	Lys	Arg	Gly	Gly	Val	Phe	Wahaab et al., 2021
genome polyprotein	P27395	2114-2133	Trp-Phe-Lys-Asp-Phe-Ala-Ala-Gly-Lys-Arg+Ser-Ala-Val-Ser-Phe-Ile-Glu-Val-Leu-Gly	P	NT	Ala	Gly	Lys	Arg	Ser	Ala	Val	Ser	Wahaab et al., 2021
grpE protein homolog 1, mitochondrial	Q9HAV7	28-217	peptide-Arg80+Ala-peptide	P	NT	Lys	Tyr	Lys	Arg	Ala	Leu	Ala	Asp	Gandikota et al., 2020
grpE protein homolog 1, mitochondrial	Q9HAV7	28-217	peptide-Arg91+Ser-peptide	P	NT	Leu	Arg	Gln	Arg	Ser	Gln	Lys	Leu	Gandikota et al., 2020
myelin basic protein	P02686	134-304	peptide-Arg188+Gly-peptide	P	MS	Ala	Pro	Lys	Arg	Gly	Ser	Gly	Lys	Shiryaev et al., 2006
myelin basic protein	P02686	134-304	peptide-Arg241+Gly-peptide	P	NT	Gly	Lys	Gly	Arg	Gly	Leu	Ser	Leu	Shiryaev et al., 2006
non-structural protein NS4A	P03314	2108-2233	peptide-Lys+Gly-peptide	P		Leu	Ala	Lys	Lys	Gly	Gly	Glu	Ala	Kummerer et al., 2004	17473
polyprotein (Dengue virus)	P29990	1-3391	peptide-Lys2093+Ser-peptide	N		Ala	Gly	Arg	Lys	Ser	Leu	Thr	Leu	Cahour et al., 1992
polyprotein (Dengue virus)	P29990	1-3391	peptide-Arg2491+Gly-peptide	N		Asn	Ala	Arg	Arg	Gly	Thr	Gly	Asn	Cahour et al., 1992
protective antigen	P13423	30-764	peptide-Arg196+Ser-peptide	N		Arg	Lys	Lys	Arg	Ser	Thr	Ser	Ala	Shiryaev et al., 2006
Pyr-Arg-Thr-Lys-Arg-NHMec			Pyr-Arg-Thr-Lys-Arg+NHMec	S		Arg	Thr	Lys	Arg	AMC	-	-	-	Shiryaev et al., 2006
stimulator of interferon genes protein {ECO:0000303\|PubMed:18724357}	Q86WV6	1-379	peptide-Arg78+Gly-peptide	N	NT	Ser	Arg	Tyr	Arg	Gly	Ser	Tyr	Trp	Su et al., 2020
stimulator of interferon genes protein {ECO:0000303\|PubMed:18724357}	Q86WV6	1-379	peptide-Arg95+Gly-peptide	N	NT	Pro	Leu	Arg	Arg	Gly	Ala	Leu	Leu	Su et al., 2020
Z-Arg-Arg-NHMec			Z-Arg-Arg+NHMec	S		-	Z	Arg	Arg	AMC	-	-	-	Shiryaev et al., 2006