Substrates for peptidase M12.301: procollagen I N-peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
collagen alpha-1(I) chain P02452 162-1218 peptide-Pro161+Gln-peptide N Asn Phe Ala Pro Gln Leu Ser Tyr 16961
collagen alpha-1(II) chain precursor P02458 26-1487 peptide-Ala181+Gln-peptide P Asn Phe Ala Ala Gln Met Ala Gly Fukui et al., 2002
procollagen alpha 1(I) chain P02457 23-1453 peptide-Pro129+Gln-peptide P Asn Phe Ala Pro Gln Met Ser Tyr Bruckner-Tuderman, 1998
procollagen alpha 2(I) chain P02467 23-1100 peptide-Ala77+Gln-peptide P Asn Phe Ala Ala Gln Tyr Asp Pro Bruckner-Tuderman, 1998 16963