Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P01024

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
22	unknown peptidase	1-1663	P	release of a signal peptide	MS	Adamski et al., 2005
667	unknown peptidase	1-1663	P		NT	<%Agarwal et al., 2012[]%>
671	unknown peptidase	1-1663	P		NT	<%Agarwal et al., 2012[]%>
747	carboxypeptidase N	672-748	P
747	carboxypeptidase B2	672-748	N		NT	Myles et al., 2003
748	interpain A	672-1663	N		NT	Potempa et al., 2009
748	flavoxobin	23-1663	P			Yamamoto et al., 2002
748	cathepsin G	23-1663	P			Maison et al., 1991
748	complement component C2a	23-1663	P			Kerr, 2004
748	complement factor Bb	23-1663	P			Kerr, 2004
748	plasmin	672-1663	P		MS	Amara et al.,2010
750	coccolysin	672-1663	N		NT	Park et al., 2007
750	aureolysin	672-1663	N		NT	Laarman et al., 2011
751	cathepsin G	23-1663	P			Maison et al., 1991
758	complement factor Bb	672-1663	N		AA	O'Keefe et al., 1988
954	unknown peptidase	1-1663	P		NT	<%Agarwal et al., 2012[]%>
987	elastase-2	23-1663	P		NT	Claesson et al., 2010
989	complement factor Bb	672-1663	N		AA	O'Keefe et al., 1988
1001	unknown peptidase	1-1663	P		NT	<%Agarwal et al., 2012[]%>
1303	leishmanolysin	672-1663	N		AB	Brittingham et al.,2005
1303	complement factor I	23-1663	P			de Bruijn & Fey, 1985
1320	leishmanolysin	672-1663	N		AB	Brittingham et al.,2005
1320	complement factor I	23-1663	P			de Bruijn & Fey, 1985
1350	elastase-2	23-1663	P		NT	Claesson et al., 2010
1353	complement factor Bb	672-1663	N		AA	O'Keefe et al., 1988
1512	interpain A	672-1663	N		NT	Potempa et al., 2009