Substrates for peptidase S01.194: complement component C2a

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Gly-Lys-OMe			Ac-Gly-Lys+OMe	S	-	Ac	Gly	Lys	OMe	-	-	-	Kam et al., 1987
Boc-Leu-Gly-Arg-NHPhNO2			Boc-Leu-Gly-Arg+NHPhNO2	S	Boc	Leu	Gly	Arg	NAN	-	-	-
Cobra venom factor		23-1651	peptide-Arg738+Ser-peptide	N	Phe	Leu	Ala	Arg	Ser	Asp	Phe	Glu		17324
complement C3	P01024	23-1663	peptide-Arg77+Ser78-peptide	P	Gly	Leu	Ala	Arg	Ser	Asn	Leu	Asp	Kam et al., 1987	17327
complement C3-1	P98093	1-1640	peptide-Arg722+Ser-peptide	N	Leu	Leu	Ser	Arg	Ser	Glu	Glu	Asp		17326
complement component C3	P01027	23-1663	peptide-Arg748+Ser-peptide	N	Gly	Leu	Ala	Arg	Ser	Glu	Leu	Glu		17325
complement component C5	P01031	19-1676	peptide-Arg74+Leu75-peptide	P	Gln	Leu	Gly	Arg	Leu	His	Met	Lys	Kam et al., 1987	17328
Z-Gly-Leu-Ala-Arg-SBzl			Z-Gly-Leu-Ala-Arg+SBzl	S	Gly	Leu	Ala	Arg	SBz	-	-	-	Kam et al., 1987
Z-Leu-Gly-Leu-Ala-Arg-SBzl			Z-Leu-Gly-Leu-Ala-Arg+SBzl	S	Gly	Leu	Ala	Arg	SBz	-	-	-	Kam et al., 1987