Substrates for peptidase S01.196: complement factor Bb

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Gly-Lys-OMe			Ac-Gly-Lys+OMe	S		-	Ac	Gly	Lys	OMe	-	-	-	Kerr, 2004
complement C3	P01024	23-1663	peptide-Arg77+Ser78-peptide	P		Gly	Leu	Ala	Arg	Ser	Asn	Leu	Asp	Kerr, 2004	17329
Complement C3 alpha chain	P01024	672-1663	peptide-Glu758+Glu-peptide	N	AA	Ile	Ile	Ala	Glu	Glu	Asn	Ile	Val	O'Keefe et al., 1988
Complement C3 alpha chain	P01024	672-1663	peptide-Gln989+Met-peptide	N	AA	Pro	Val	Ala	Gln	Met	Thr	Glu	Asp	O'Keefe et al., 1988
Complement C3 alpha chain	P01024	672-1663	peptide-Lys1353+Asp-peptide	N	AA	Ala	Lys	Ala	Lys	Asp	Gln	Leu	Thr	O'Keefe et al., 1988
complement component C5	P01031	19-1676	peptide-Arg74+Leu75-peptide	P		Gln	Leu	Gly	Arg	Leu	His	Met	Lys	Kerr, 2004	17330
Z-Gly-Leu-Ala-Arg-SBzl			Z-Gly-Leu-Ala-Arg+SBzl	S		Gly	Leu	Ala	Arg	SBz	-	-	-	Kerr, 2004
Z-Lys-Arg-SBzl			Z-Lys-Arg+SBzl	S		-	Z	Lys	Arg	SBz	-	-	-	Kerr, 2004