Substrates for peptidase C10.004: interpain A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
C4A complement component 4A preproprotein	P0C0L4	680-1446	peptide-Arg756+Ala-peptide	N	NT	Gly	Leu	Gln	Arg	Ala	Leu	Glu	Ile	Potempa et al., 2009	24447
C4A complement component 4A preproprotein	P0C0L4	680-1446	peptide-Thr981+Ala-peptide	N	NT	Val	Arg	Val	Thr	Ala	Ser	Asp	Pro	Potempa et al., 2009	24448
Complement C3 alpha chain	P01024	672-1663	peptide-Arg748+Ser-peptide	N	NT	Gly	Leu	Ala	Arg	Ser	Asn	Leu	Asp	Potempa et al., 2009	24445
Complement C3 alpha chain	P01024	672-1663	peptide-Arg1512+Cys-peptide	N	NT	Glu	Leu	Cys	Arg	Cys	Ala	Glu	Glu	Potempa et al., 2009	24446
Hemoglobin subunit alpha	P01958	2-142	Peptide-Ala124+Ser-Peptide	N	MS	Ala	Val	His	Ala	Ser	Leu	Asp	Lys	Byrne et al., 2010
Hemoglobin subunit alpha	P01958	2-142	Peptide-Ala111+Val-Peptide	N	MS	Ser	Thr	Leu	Ala	Val	His	Leu	Pro	Byrne et al., 2010
Hemoglobin subunit alpha	P01958	2-142	Peptide-Ala27+Glu-Peptide	N	MS	Glu	Tyr	Gly	Ala	Glu	Ala	Leu	Glu	Byrne et al., 2010
Hemoglobin subunit alpha	P01958	2-142	Peptide-Lys8+Thr-Peptide	N	MS	Ala	Ala	Asp	Lys	Thr	Asn	Val	Lys	Byrne et al., 2010
Hemoglobin subunit alpha	P01958	2-142	Peptide-Lys61+Lys-Peptide	N	MS	Ala	His	Gly	Lys	Lys	Val	Gly	Asp	Byrne et al., 2010
Hemoglobin subunit alpha	P01958	2-142	Peptide-Lys41+Thr-Peptide	N	MS	Pro	Thr	Thr	Lys	Thr	Tyr	Phe	Pro	Byrne et al., 2010
Hemoglobin subunit beta	P02062	1-146	Peptide-Arg104+Leu-Peptide	N	MS	Glu	Asn	Phe	Arg	Leu	Leu	Gly	Asn	Byrne et al., 2010
Hemoglobin subunit beta	P02062	1-146	Peptide-Lys95+Leu-Peptide	N	MS	His	Cys	Asp	Lys	Leu	His	Val	Asp	Byrne et al., 2010
Hemoglobin subunit beta	P02062	1-146	Peptide-Lys59+Val-Peptide	N	MS	Gly	Asn	Pro	Lys	Val	Lys	Ala	His	Byrne et al., 2010
Hemoglobin subunit beta	P02062	1-146	Peptide-Phe45+Gly-Peptide	N	MS	Phe	Asp	Ser	Phe	Gly	Asp	Leu	Ser	Byrne et al., 2010
Hemoglobin subunit beta	P02062	1-146	Peptide-Lys61+Ala-Peptide	N	MS	Pro	Lys	Val	Lys	Ala	His	Gly	Lys	Byrne et al., 2010
Hemoglobin subunit beta	P02062	1-146	Peptide-Arg40+Phe-Peptide	N	MS	Trp	Thr	Gln	Arg	Phe	Phe	Asp	Ser	Byrne et al., 2010
Hemoglobin subunit beta	P02062	1-146	Peptide-Phe85+Ala-Peptide	N	MS	Lys	Gly	Thr	Phe	Ala	Ala	Leu	Ser	Byrne et al., 2010
Hemoglobin subunit beta	P02062	1-146	Peptide-Phe103+Arg-Peptide	N	MS	Pro	Glu	Asn	Phe	Arg	Leu	Leu	Gly	Byrne et al., 2010
interpain A	A9J7N5	45-403	peptide-Thr82+Val-peptide	P		Gly	Lys	Arg	Thr	Val	Asn	Gln	Leu	Mallorqui-Fernandez et al., 2008	21031
interpain A	A9J7N5	45-403	peptide-Lys138+Ala-peptide	P		Trp	Trp	Leu	Lys	Ala	Ile	Asp	Glu	Mallorqui-Fernandez et al., 2008	21034
interpain A	A9J7N5	45-403	peptide-Ala139+Ile-peptide	P		Trp	Leu	Lys	Ala	Ile	Asp	Glu	Val	Mallorqui-Fernandez et al., 2008	21033
interpain A	A9J7N5	45-403	peptide-Ser155+Val-peptide	P		Lys	Pro	Leu	Ser	Val	Ile	Lys	Pro	Mallorqui-Fernandez et al., 2008	21032