Resolution: 2.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qn6
Q-score: 0.645
Yang Y, Murzin AG, Peak-Chew S, Franco C, Garringer HJ, Newell KL, Ghetti B, Goedert M, Scheres SHW
Acta Neuropathol (2023) 11 pp. 191-191 [ Pubmed: 38049918 DOI: doi:10.1186/s40478-023-01694-8 ]
- Amyloid-beta a4 protein (4 kDa, Protein from Homo sapiens)
- Amyloid-beta 40 (Tissue from Homo sapiens)
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qn7
Q-score: 0.66
Yang Y, Murzin AG, Peak-Chew S, Franco C, Garringer HJ, Newell KL, Ghetti B, Goedert M, Scheres SHW
Acta Neuropathol (2023) 11 pp. 191-191 [ Pubmed: 38049918 DOI: doi:10.1186/s40478-023-01694-8 ]
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ce7
Q-score: 0.606
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy
Resolution: 2.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqv
Q-score: 0.74
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
- Alpha-synuclein (14 kDa, Protein from human)
- Unknown protein (613 Da, Protein from Human)
- Water (18 Da, Ligand)
- Alpha-synuclein singlet filament extracted from the human brain with jos (Tissue from Homo sapiens)
Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqw
Q-score: 0.652
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
- Alpha-synuclein (14 kDa, Protein from human)
- Alpha-synuclein doublet filament extracted from the human brain with jos (Tissue from Homo sapiens)
- Unknown protein (783 Da, Protein from Human)
- Water (18 Da, Ligand)
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bfz
Q-score: 0.621
Yang Y, Zhang W, Murzin AG, Schweighauser M, Huang M, Lovestam S, Peak-Chew SY, Saito T, Saido TC, Macdonald J, Lavenir I, Ghetti B, Graff C, Kumar A, Nordberg A, Goedert M, Scheres SHW
Acta Neuropathol (2023) 145 pp. 325-333 [ DOI: doi:10.1007/s00401-022-02533-1 Pubmed: 36611124 ]
Resolution: 1.99 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bg0
Q-score: 0.743
Yang Y, Zhang W, Murzin AG, Schweighauser M, Huang M, Lovestam S, Peak-Chew SY, Saito T, Saido TC, Macdonald J, Lavenir I, Ghetti B, Graff C, Kumar A, Nordberg A, Goedert M, Scheres SHW
Acta Neuropathol (2023) 145 pp. 325-333 [ DOI: doi:10.1007/s00401-022-02533-1 Pubmed: 36611124 ]
Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bg9
Q-score: 0.527
Yang Y, Zhang W, Murzin AG, Schweighauser M, Huang M, Lovestam S, Peak-Chew SY, Saito T, Saido TC, Macdonald J, Lavenir I, Ghetti B, Graff C, Kumar A, Nordberg A, Goedert M, Scheres SHW
Acta Neuropathol (2023) 145 pp. 325-333 [ DOI: doi:10.1007/s00401-022-02533-1 Pubmed: 36611124 ]
Yang Y, Arseni D, Zhang WJ, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew S, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Falcon B, Scheres SHW, Goedert M
Science (2022) 375 pp. 167-172 [ DOI: 10.1126/science.abm7285 Pubmed: 35025654 ]
Image sets:
Type I beta-amyloid 42 Filaments from Human Brain
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 7q4b
Q-score: 0.688
Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Ryskeldi-Falcon B, Scheres SHW, Goedert M
Science (2022) 375 pp. 167-172 [ Pubmed: 35025654 DOI: doi:10.1126/science.abm7285 ]
- Amyloid-beta precursor protein (4 kDa, Protein from Human)
- Unknown atom or ion (Ligand)
- Water (18 Da, Ligand)
- Beta-amyloid 42 filaments extracted from the human brain with alzheimer's disease (Tissue from Homo sapiens)