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EMD-16022
Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42
EMD-16022
Helical reconstruction2.8 Å
Deposition: 27/10/2022Map released: 18/01/2023
Last modified: 05/03/2025
Sample Organism:
Homo sapiens
Sample: Amyloid-beta 42 dimeric filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease
Fitted models: 8bfz
Deposition Authors: Yang Y
,
Zhang WJ,
Murzin AG,
Schweighauser M,
Huang M ,
Lovestam SKA,
Peak-Chew SY,
Macdonald J,
Lavenir I,
Ghetti B,
Graff C ,
Kumar A,
Nordberg A,
Goedert M,
Scheres SHW
Sample: Amyloid-beta 42 dimeric filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease
Fitted models: 8bfz
Deposition Authors: Yang Y
,
Zhang WJ,
Murzin AG,
Schweighauser M,
Huang M ,
Lovestam SKA,
Peak-Chew SY,
Macdonald J,
Lavenir I,
Ghetti B,
Graff C ,
Kumar A,
Nordberg A,
Goedert M,
Scheres SHW
Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.
Yang Y ,
Zhang W ,
Murzin AG,
Schweighauser M,
Huang M ,
Lovestam S,
Peak-Chew SY,
Saito T ,
Saido TC,
Macdonald J,
Lavenir I,
Ghetti B,
Graff C ,
Kumar A,
Nordberg A,
Goedert M,
Scheres SHW
(2023) Acta Neuropathol , 145 , 325 - 333
,
Zhang W ,
Murzin AG,
Schweighauser M,
Huang M ,
Lovestam S,
Peak-Chew SY,
Saito T ,
Saido TC,
Macdonald J,
Lavenir I,
Ghetti B,
Graff C ,
Kumar A,
Nordberg A,
Goedert M,
Scheres SHW
(2023) Acta Neuropathol , 145 , 325 - 333
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_UP_A025-1013 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_U105184291 (United Kingdom)