EMD-16189
Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy
EMD-16189
Helical reconstruction2.3 Å
Deposition: 18/01/2023Map released: 22/02/2023
Last modified: 24/07/2024
Sample Organism:
Homo sapiens
Sample: Alpha-synuclein doublet filament extracted from the human brain with JOS
Fitted models: 8bqw
Deposition Authors: Yang Y
,
Garringer JH,
Shi Y,
Zhang XJ,
Kotecha A ,
Bacioglu M,
Koto A,
Takao M,
Spillantini GM,
Ghetti B,
Vidal R ,
Murzin GA,
Scheres HWS,
Goedert M,
Ghetti B,
Hasegawa M,
Lashley T,
Scheres HWS,
Goedert M
Sample: Alpha-synuclein doublet filament extracted from the human brain with JOS
Fitted models: 8bqw
Deposition Authors: Yang Y
,
Garringer JH,
Shi Y,
Zhang XJ,
Kotecha A ,
Bacioglu M,
Koto A,
Takao M,
Spillantini GM,
Ghetti B,
Vidal R ,
Murzin GA,
Scheres HWS,
Goedert M,
Ghetti B,
Hasegawa M,
Lashley T,
Scheres HWS,
Goedert M
New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Yang Y ,
Garringer HJ ,
Shi Y,
Lovestam S,
Peak-Chew S,
Zhang X,
Kotecha A ,
Bacioglu M,
Koto A,
Takao M,
Spillantini MG,
Ghetti B,
Vidal R ,
Murzin AG,
Scheres SHW,
Goedert M
(2023) Acta Neuropathol , 145 , 561 - 572
,
Garringer HJ ,
Shi Y,
Lovestam S,
Peak-Chew S,
Zhang X,
Kotecha A ,
Bacioglu M,
Koto A,
Takao M,
Spillantini MG,
Ghetti B,
Vidal R ,
Murzin AG,
Scheres SHW,
Goedert M
(2023) Acta Neuropathol , 145 , 561 - 572
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_UP_A025_1013 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_U105184291 to M.G. (United Kingdom)
- Alzheimers Research UK (ARUK): (United Kingdom)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): (United States)