Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-18509
Amyloid-beta 40 doublet filament from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy
EMD-18509
Helical reconstruction2.7 Å
Deposition: 25/09/2023Map released: 13/12/2023
Last modified: 31/01/2024
Sample Organism:
Homo sapiens
Sample: Amyloid-beta 40 doublet filament extracted from the human brain with Alzheimer's disease and cerebral amyloid angiopathy
Fitted models: 8qn7
Deposition Authors: Yang Y
,
Murzin AS,
Peak-Chew SY,
Franco C,
Newell KL,
Ghetti B ,
Goedert M ,
Scheres SHW
Sample: Amyloid-beta 40 doublet filament extracted from the human brain with Alzheimer's disease and cerebral amyloid angiopathy
Fitted models: 8qn7
Deposition Authors: Yang Y
,
Murzin AS,
Peak-Chew SY,
Franco C,
Newell KL,
Ghetti B ,
Goedert M ,
Scheres SHW
Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy.
Yang Y ,
Murzin AG,
Peak-Chew S,
Franco C,
Garringer HJ ,
Newell KL,
Ghetti B ,
Goedert M ,
Scheres SHW
(2023) Acta Neuropathol , 11 , 191 - 191
,
Murzin AG,
Peak-Chew S,
Franco C,
Garringer HJ ,
Newell KL,
Ghetti B ,
Goedert M ,
Scheres SHW
(2023) Acta Neuropathol , 11 , 191 - 191
Grant Support:
- Medical Research Council (MRC, United Kingdom): (United Kingdom)
- Wellcome Trust: (United Kingdom)
- Biotechnology and Biological Sciences Research Council (BBSRC): (United Kingdom)