Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-13800
Type I beta-amyloid 42 Filaments from Human Brain
EMD-13800
Helical reconstruction2.5 Å
Deposition: 30/10/2021Map released: 24/11/2021
Last modified: 09/07/2025
Sample Organism:
Homo sapiens
Sample: beta-amyloid 42 filaments extracted from the human brain with Alzheimer's disease
Fitted models: 7q4b
Deposition Authors: Yang Y
,
Arseni D
Sample: beta-amyloid 42 filaments extracted from the human brain with Alzheimer's disease
Fitted models: 7q4b
Deposition Authors: Yang Y
,
Arseni D
Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Yang Y
,
Arseni D
,
Zhang W
,
Huang M
,
Lovestam S
,
Schweighauser M,
Kotecha A
,
Murzin AG,
Peak-Chew SY,
Macdonald J
,
Lavenir I
,
Garringer HJ
,
Gelpi E
,
Newell KL
,
Kovacs GG
,
Vidal R
,
Ghetti B
,
Ryskeldi-Falcon B
,
Scheres SHW
,
Goedert M
(2022) Science , 375 , 167 - 172
,
Arseni D
,
Zhang W
,
Huang M
,
Lovestam S
,
Schweighauser M,
Kotecha A
,
Murzin AG,
Peak-Chew SY,
Macdonald J
,
Lavenir I
,
Garringer HJ
,
Gelpi E
,
Newell KL
,
Kovacs GG
,
Vidal R
,
Ghetti B
,
Ryskeldi-Falcon B
,
Scheres SHW
,
Goedert M
(2022) Science , 375 , 167 - 172
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_UP_1201/25 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_UP_A025_1013 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_U105184291 (United Kingdom)
- National Institutes of Health/National Institute on Aging (NIH/NIA): P30-AG010133 (United Kingdom)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): U01-NS110437 (United Kingdom)
- National Institutes of Health/National Institute on Aging (NIH/NIA): RF1-AG071177 (United Kingdom)
