CHEBI:50276 - EC 5.99.1.2 (DNA topoisomerase) inhibitor

ChEBI IDCHEBI:50276
ChEBI NameEC 5.99.1.2 (DNA topoisomerase) inhibitor
Stars
DefinitionA topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
Last Modified3 July 2019
SubmitterMarcus Ennis
ChEBI Ontology
Outgoing Relation(s)
EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) is a topoisomerase inhibitor (CHEBI:70727)
Incoming Relation(s)
(R)-homocamptothecin (CHEBI:144047) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
(S)-scoulerine (CHEBI:17129) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
amarogentin (CHEBI:2622) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
camptothecin (CHEBI:27656) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
diflomotecan (CHEBI:144046) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
dihydrobetulinic acid (CHEBI:65485) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
disulfiram (CHEBI:4659) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
ellagic acid (CHEBI:4775) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
feruloylagmatine (CHEBI:75544) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
irinotecan (CHEBI:80630) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
irinotecan hydrochloride (anhydrous) (CHEBI:5971) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
irinotecan hydrochloride hydrate (CHEBI:90881) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
kaempferol 3-O-(5-O-acetyl-α-D-apiofuranosyl)-7-O-α-L-rhamnopyranoside (CHEBI:68877) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
kaempferol 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-galactopyranosyl]-7-O-α-L-rhamnopyranoside (CHEBI:68880) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
kaempferol 3-O-[α-L-rhamnopyranosyl(1→2)-β-D-glucopyranosyl]-7-O-α-L-rhamnopyranoside (CHEBI:68879) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
kaempferol 3-O-α-L-arabinopyranosyl-7-O-α-L-rhamnopyranoside (CHEBI:68878) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
kaempferol 3-O-β-D-galactopyranosyl-7-O-α-L-rhamnopyranoside (CHEBI:68881) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
kaempferol 3-O-β-D-glucopyranosyl-7-O-α-L-rhamnopyranoside (CHEBI:68882) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
lucanthone (CHEBI:51052) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
manoalide (CHEBI:66666) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
methyl brevifolincarboxylate (CHEBI:66711) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
morin (CHEBI:75092) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
rubitecan (CHEBI:90225) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
saintopin (CHEBI:91276) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
SN-38 (CHEBI:8988) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
topopyrone A (CHEBI:66252) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
topopyrone B (CHEBI:66253) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
topopyrone C (CHEBI:66254) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
topopyrone D (CHEBI:66255) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
topotecan (CHEBI:63632) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
topotecan hydrochloride (CHEBI:232548) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
Synonyms  Source
topoisomerase I inhibitorsChEBI
type I DNA topoisomerase inhibitorChEBI
type I DNA topoisomerase inhibitorsChEBI
EC 5.99.1.2 inhibitorsChEBI
EC 5.99.1.2 inhibitorChEBI
topoisomerase I (EC 5.99.1.2) inhibitorChEBI