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CHEBI:4659 - disulfiram
| Formula | C10H20N2S4 |
| Net Charge | 0 |
| Average Mass | 296.552 |
| Monoisotopic Mass | 296.05093 |
| SMILES | CCN(CC)C(=S)SSC(=S)N(CC)CC |
| InChI | InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3 |
| InChIKey | AUZONCFQVSMFAP-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | NF-kappaB inhibitor An inhibitor of NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. EC 3.1.1.8 (cholinesterase) inhibitor An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8). EC 5.99.1.2 (DNA topoisomerase) inhibitor A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. EC 3.1.1.1 (carboxylesterase) inhibitor Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of carboxylesterase (EC 3.1.1.1 ). fungicide A substance used to destroy fungal pests. EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor An EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of aldehyde dehydrogenase (NAD+), EC 1.2.1.3. ferroptosis inducer Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. fungicide A substance used to destroy fungal pests. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. acaricide A substance used to destroy pests of the subclass Acari (mites and ticks). pesticide Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests. pesticide Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| disulfiram (CHEBI:4659) has role angiogenesis inhibitor (CHEBI:48422) |
| disulfiram (CHEBI:4659) has role antineoplastic agent (CHEBI:35610) |
| disulfiram (CHEBI:4659) has role apoptosis inducer (CHEBI:68495) |
| disulfiram (CHEBI:4659) has role EC 1.2.1.3 [aldehyde dehydrogenase (NAD+)] inhibitor (CHEBI:35487) |
| disulfiram (CHEBI:4659) has role EC 3.1.1.1 (carboxylesterase) inhibitor (CHEBI:78444) |
| disulfiram (CHEBI:4659) has role EC 3.1.1.8 (cholinesterase) inhibitor (CHEBI:37733) |
| disulfiram (CHEBI:4659) has role EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) |
| disulfiram (CHEBI:4659) has role ferroptosis inducer (CHEBI:173085) |
| disulfiram (CHEBI:4659) has role fungicide (CHEBI:24127) |
| disulfiram (CHEBI:4659) has role NF-κB inhibitor (CHEBI:73240) |
| disulfiram (CHEBI:4659) is a organic disulfide (CHEBI:35489) |
| disulfiram (CHEBI:4659) is a organosulfur acaricide (CHEBI:39298) |
| IUPAC Name |
|---|
| 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane |
| Synonyms | Source |
|---|---|
| Disulfiram | KEGG COMPOUND |
| Antabuse | KEGG DRUG |
| 1,1'-dithiobis(N,N-diethylthioformamide) | ChemIDplus |
| bis(diethylthiocarbamoyl) disulfide | ChemIDplus |
| tetraethylthiuram disulfide | ChemIDplus |
| tetraethylthiuram disulphide | NIST Chemistry WebBook |
| Manual Xrefs | Databases |
|---|---|
| C01692 | KEGG COMPOUND |
| D00131 | KEGG DRUG |
| Disulfiram | Wikipedia |
| DB00822 | DrugBank |
| HMDB0014960 | HMDB |
| LSM-5467 | LINCS |
| 928 | DrugCentral |
| DISULFIRAM | MetaCyc |
| disulfiram | Alan Wood's Pesticides |
| Citations |
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