EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
We are looking for a new Chemistry curator to join the ChEBI team. Find out more about it here.
CHEBI:70727 - topoisomerase inhibitor
| ChEBI ID | CHEBI:70727 |
| ChEBI Name | topoisomerase inhibitor |
| Stars | |
| Definition | An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA). |
| Last Modified | 16 July 2020 |
| Submitter | Gareth Owen |
| Wikipedia |
|---|
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| topoisomerase inhibitor (CHEBI:70727) is a EC 5.99.1.* (miscellaneous isomerase) inhibitor (CHEBI:76830) |
| Incoming Relation(s) |
| 2,2,3,3-tetrahydroxy-2,3-dihydronaphthalene-1,4-dione (CHEBI:78857) has role topoisomerase inhibitor (CHEBI:70727) |
| actinodaphnine (CHEBI:2444) has role topoisomerase inhibitor (CHEBI:70727) |
| CP-115953 (CHEBI:232313) has role topoisomerase inhibitor (CHEBI:70727) |
| EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276) is a topoisomerase inhibitor (CHEBI:70727) |
| EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750) is a topoisomerase inhibitor (CHEBI:70727) |
| topoisomerase II inhibitor (CHEBI:156203) is a topoisomerase inhibitor (CHEBI:70727) |
| topoisomerase IV inhibitor (CHEBI:53559) is a topoisomerase inhibitor (CHEBI:70727) |
| Synonym | Source |
|---|---|
| topoisomerase inhibitors | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| Topoisomerase | Wikipedia |