Substrates for peptidase S09.018: dipeptidyl-peptidase 8
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.
| Substrate | Uniprot | Residue range | Cleavage Site | Cleavage type | Evidence | P4 | P3 | P2 | P1 | P1' | P2' | P3' | P4' | Reference | CutDB | MERNUM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ala-Pro-NHPhNO2 | Ala-Pro+NHPhNO2 | S | - | - | Ala | Pro | NAN | - | - | - | Bjelke et al., 2006 | |||||
| Arg-Pro-NHPhNO2 | Arg-Pro+NHPhNO2 | S | - | - | Arg | Pro | NAN | - | - | - | Bjelke et al., 2006 | |||||
| C-X-C motif chemokine 10 | P02778 | 22-98 | Val-Pro23+Leu-peptide | P | - | - | Val | Pro | Leu | Ser | Arg | Thr | Ajami et al., 2008 | |||
| C-X-C motif chemokine 11 | O14625 | 22-94 | Phe-Pro23+Met-peptide | P | - | - | Phe | Pro | Met | Phe | Lys | Arg | Ajami et al., 2008 | |||
| glucagon-like peptide 1 | His-Ala+Glu-peptide | N | - | - | His | Ala | Glu | Gly | Thr | Phe | Bjelke et al., 2006 | |||||
| glucagon-like peptide 2 | His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp | N | - | - | His | Ala | Asp | Gly | Ser | Phe | Bjelke et al., 2006 | |||||
| Gly-Pro-NHPhNO2 | Gly-Pro+NHPhNO2 | S | - | - | Gly | Pro | NAN | - | - | - | Chen et al., 2004 | |||||
| neuropeptide Y | Tyr-Pro+Ser-peptide | N | - | - | Tyr | Pro | Ser | Lys | Pro | Asp | Bjelke et al., 2006 | |||||
| peptide YY | Tyr-Pro-Ile-Leu-Lys-Pro-Gly-Glu-Ala-Pro-Gly-Gly-Glu+Asp-Ala-Ser-Pro-Gly-Glu-Gly-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-VTArg-Gln-Arg-Tyr-NH2 | N | - | - | Tyr | Pro | Ile | Leu | Lys | Pro | Bjelke et al., 2006 | |||||
| stromal cell-derived factor 1 | P48061 | 22-93 | Lys-Pro23+Val-peptide | P | - | - | Lys | Pro | Val | Ser | Leu | Ser | Ajami et al., 2008 |
