Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P02778

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
21	unknown peptidase	1-98	P	release of a signal peptide	NT	Tensen et al., 1999
23	dipeptidyl-peptidase IV (eukaryote)	22-98	P			Lambeir et al., 2001
23	dipeptidyl-peptidase 8	22-98	P			Ajami et al., 2008
89	matrix metallopeptidase-9	22-98	P	normal turnover		Van den Steen et al., 2003
92	matrix metallopeptidase-8	22-98	P		NT	Van den Steen et al., 2003
92	matrix metallopeptidase-12	22-98	P	normal turnover		Cox et al., 2008
94	matrix metallopeptidase-8	22-98	P		NT	Van den Steen et al., 2003
94	matrix metallopeptidase-12	22-98	P	release of an amino acid		Van den Steen et al., 2003