Summary for peptidase S09.018: dipeptidyl-peptidase 8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namedipeptidyl-peptidase 8
Other namesDPP8
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S9 >> Subfamily B >> S09.018
Holotypedipeptidyl-peptidase 8 (Homo sapiens), Uniprot accession Q6V1X1 (peptidase unit: 631-869), MERNUM MER0013484
History Identifier created: MEROPS 5.3 (4 December 2000)
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: active (Chen et al., 2004)
mouse: active (by similarity to human)
Other databases TREEFAMhttp://www.treefam.org/family/TF313309
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR11731:SF98
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/PScissile bond-/-/-/- (based on 10 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 1 0 0 2 0 0
Pro 0 0 0 8 0 0 1 1
Ala 0 0 1 2 0 0 0 0
Val 0 0 1 0 1 0 0 0
Leu 0 0 0 0 1 1 1 0
Ile 0 0 0 0 1 0 0 0
Met 0 0 0 0 1 0 0 0
Phe 0 0 1 0 0 1 0 2
Tyr 0 0 2 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 1 2 1 1
Thr 0 0 0 0 0 0 1 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 1 0 0 1
Glu 0 0 0 0 1 0 0 0
Lys 0 0 1 0 0 1 2 0
Arg 0 0 1 0 0 0 1 1
His 0 0 2 0 0 0 0 0
Relevant inhibitors vildagliptin
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
DPP8 15q22 ENSG00000074603 54878 DPP8 606819
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Dpp8 9:D ENSMUSG00000032393 74388 MGI:1921638