$VAR1 = undef;

Summary for peptidase S09.018: dipeptidyl-peptidase 8

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

Names
MEROPS Namedipeptidyl-peptidase 8
Other namesDPP8
Domain architecture
MEROPS Classification
Classification Clan SC >> Subclan (none) >> Family S9 >> Subfamily B >> S09.018
Holotypedipeptidyl-peptidase 8 (Homo sapiens), Uniprot accession Q6V1X1 (peptidase unit: 631-869), MERNUM MER0013484
History Identifier created: MEROPS 5.3 (4 December 2000)
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: active (Chen et al., 2004)
mouse: active (by similarity to human)
Other databases TREEFAMhttp://www.treefam.org/family/TF313309
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/PScissile bond-/-/-/- (based on 10 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 1 0 0 2 0 0
Pro 0 0 0 8 0 0 1 1
Ala 0 0 1 2 0 0 0 0
Val 0 0 1 0 1 0 0 0
Leu 0 0 0 0 1 1 1 0
Ile 0 0 0 0 1 0 0 0
Met 0 0 0 0 1 0 0 0
Phe 0 0 1 0 0 1 0 2
Tyr 0 0 2 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 1 2 1 1
Thr 0 0 0 0 0 0 1 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 1 0 0 1
Glu 0 0 0 0 1 0 0 0
Lys 0 0 1 0 0 1 2 0
Arg 0 0 1 0 0 0 1 1
His 0 0 2 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
DPP8 15q22 ENSG00000074603 54878 DPP8 606819
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Dpp8 9:D ENSMUSG00000032393 74388 MGI:1921638