Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence O14625

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
21	unknown peptidase	1-94	P	release of a signal peptide	NT	Tensen et al., 1999
23	dipeptidyl-peptidase IV (eukaryote)	22-94	P			Lambeir et al., 2001
23	dipeptidyl-peptidase 8	22-94	P			Ajami et al., 2008
25	matrix metallopeptidase-8	22-94	P	release of an amino acid		Cox et al., 2008
25	matrix metallopeptidase-9	22-94	P	release of an amino acid		Cox et al., 2008
25	matrix metallopeptidase-12	22-94	P	normal turnover		Cox et al., 2008
79	matrix metallopeptidase-8	22-94	P	normal turnover		Cox et al., 2008
79	matrix metallopeptidase-9	22-94	P	normal turnover		Cox et al., 2008
79	matrix metallopeptidase-7	22-94	P	normal turnover		Cox et al., 2008
79	matrix metallopeptidase-12	22-94	P	normal turnover		Cox et al., 2008
84	matrix metallopeptidase-8	22-94	P	normal turnover		Cox et al., 2008