Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.277: HtrA1 peptidase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: T Target, M Mutation, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hagemeier,B., Ripkens,K., Schulze,N., Bluemke,A., Strzala,M., Koci,M., Kaschani,F., Kaiser,M., Erkelenz,M., Schluecker,S., Merdanovic,M., Poepsel,S., Hellerschmied,D., Burston,S.G. and Ehrmann,M.
    The serine protease HTRA1 targets Tau fibrils and provides a proteolytic barrier against pathogenic protein conformations
    J Biol Chem (2025) , 110729-110729. PubMed  Europe PubMed DOI
  2. Hulleman,J.D., Jeon,S., Bali,S., DiCesare,S.M., Abbas,A., Daniel,S., Ortega,A.J., Collier,G.E., Yang,J., Bhattacharyaa,A., McCoy,M.K., Joachimiak,L.A. and Posner,B.A.
    Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface
    ACS Chem Biol (2025) 20, 1849-1862. PubMed  Europe PubMed DOI
  3. Yoshimoto,T., Yamagami,H. and Matsumaru,Y.
    Recent Advances in Stroke Genetics-Unraveling the Complexity of Cerebral Infarction: A Brief Review
    Genes (Basel) (2025) 16 PubMed  Europe PubMed DOI  PMC  EPMC  V
    4. 2024
  4. Beaufort,N., Ingendahl,L., Merdanovic,M., Schmidt,A., Podlesainski,D., Richter,T., Neumann,T., Kuszner,M., Vetter,I.R., Stege,P., Burston,S.G., Filipovic,A., Ruiz-Blanco,Y.B., Bravo-Rodriguez,K., Mieres-Perez,J., Beuck,C., Uebel,S., Zobawa,M., Schillinger,J., Malik,R., Todorov-Volgyi,K., Rey,J., Roberti,A., Hagemeier,B., Wefers,B., Muller,S.A., Wurst,W., Sanchez-Garcia,E., Zimmermann,A., Hu,X.Y., Clausen,T., Huber,R., Lichtenthaler,S.F., Schmuck,C., Giese,M., Kaiser,M., Ehrmann,M. and Dichgans,M.
    Rational correction of pathogenic conformational defects in HTRA1
    Nat Commun (2024) 15, 5944-5944. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Chen,S., Puri,A., Bell,B., Fritsche,J., Palacios,H.H., Balch,M., Sprunger,M.L., Howard,M.K., Ryan,J.J., Haines,J.N., Patti,G.J., Davis,A.A. and Jackrel,M.E.
    HTRA1 disaggregates alpha-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species
    Nat Commun (2024) 15, 2436-2436. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Dennis,D.G., Joo Sun,Y., Parsons,D.E., Mahajan,V.B. and Smith,M.
    Identification of highly potent and selective HTRA1 inhibitors
    Bioorg Med Chem Lett (2024) 109, 129814-129814. PubMed  Europe PubMed DOI  I
  7. Li,Y., Wei,Y., Ultsch,M., Li,W., Tang,W., Tombling,B., Gao,X., Dimitrova,Y., Gampe,C., Fuhrmann,J., Zhang,Y., Hannoush,R.N. and Kirchhofer,D.
    Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region
    Nat Commun (2024) 15, 4359-4359. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Malik,R., Beaufort,N., Li,J., Tanaka,K., Georgakis,M.K., He,Y., Koido,M., Terao,C., Japan,B., Anderson,C.D., Kamatani,Y., Zand,R. and Dichgans,M.
    Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease
    Nat Cardiovasc Res (2024) 3, 701-713. PubMed  Europe PubMed DOI
  9. Rosochowicz,M.A., Kulcenty,K. and Suchorska,W.M.
    Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review
    Mol Diagn Ther (2024) 28, 347-377. PubMed  Europe PubMed DOI  V
  10. Schillinger,J., Koci,M., Bravo-Rodriguez,K., Heilmann,G., Kaschani,F., Kaiser,M., Beuck,C., Luecke,H., Huber,R., Hellerschmied,D., Burston,S.G. and Ehrmann,M.
    High resolution analysis of proteolytic substrate processing
    J Biol Chem (2024) , 107812-107812. PubMed  Europe PubMed DOI
  11. Song,S., Li,X., Xue,X., Dong,W. and Li,C.
    Progress in the Study of the Role and Mechanism of HTRA1 in Diseases Related to Vascular Abnormalities
    Int J Gen Med (2024) 17, 1479-1491. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2023
  12. Chang,Y.J., Jenny,L.A., Li,Y.S., Cui,X., Kong,Y., Li,Y., Sparrow,J.R. and Tsang,S.H.
    CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1-related AMD
    Proc Natl Acad Sci U S A (2023) 120, e2215005120-e2215005120. PubMed  Europe PubMed DOI  PMC  EPMC
  13. He,Z., Wang,L., Zhang,Y., Yin,C. and Niu,Y.
    Clinical features and pathogenicity assessment in patients with HTRA1-autosomal dominant disease
    Neurol Sci (2023) 44, 639-647. PubMed  Europe PubMed DOI
  14. Murayama,M., Hirata,H., Shiraki,M., Iovanna,J.L., Yamaza,T., Kukita,T., Komori,T., Moriishi,T., Ueno,M., Morimoto,T., Mawatari,M. and Kukita,A.
    Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice
    J Cell Physiol (2023) 238, 566-581. PubMed  Europe PubMed DOI
  15. Uemura,M., Hatano,Y., Nozaki,H., Ando,S., Kondo,H., Hanazono,A., Iwanaga,A., Murota,H., Osakada,Y., Osaki,M., Kanazawa,M., Kanai,M., Shibata,Y., Saika,R., Miyatake,T., Aizawa,H., Ikeuchi,T., Tomimoto,H., Mizuta,I., Mizuno,T., Ishihara,T. and Onodera,O.
    High frequency of HTRA1 AND ABCC6 mutations in Japanese patients with adult-onset cerebral small vessel disease
    J Neurol Neurosurg Psychiatry (2023) 94, 74-81. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Xu,S.Y., Li,H.J., Li,S., Ren,Q.Q., Liang,J.L. and Li,C.X.
    Heterozygous Pathogenic and Likely Pathogenic Symptomatic HTRA1 Variant Carriers in Cerebral Small Vessel Disease
    Int J Gen Med (2023) 16, 1149-1162. PubMed  Europe PubMed DOI  PMC  EPMC  V
    17. 2022
  17. Gerhardy,S., Ultsch,M., Tang,W., Green,E., Holden,J.K., Li,W., Estevez,A., Arthur,C., Tom,I., Rohou,A. and Kirchhofer,D.
    Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration
    Nat Commun (2022) 13, 5222-5222. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Guo,H., Guo,X. and Jiang,S.
    Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL)
    Bioengineered (2022) 13, 12248-12260. PubMed  Europe PubMed DOI  PMC  EPMC  K
  19. Hidalgo Mayoral,I., Martinez-Salio,A., Llamas-Velasco,S., Gomez-Majon,I., Arteche-Lopez,A., Quesada-Espinosa,J.F., Palma Milla,C., Lezana Rosales,J.M., Perez de la Fuente,R., Juarez Rufian,A., Sierra Tomillo,O., Sanchez Calvin,M.T., Gomez Rodriguez,M.J., Ramos Gomez,P., Villarejo-Galende,A., Diaz-Guzman,J., Ortega-Casarrubios,M.A., Calleja-Castano,P. and Moreno-Garcia,M.
    Hereditary cerebral small vessel disease: Assessment of a HTRA1 variant using protein stability predictors and 3D modelling
    Eur J Med Genet (2022) 65, 104539-104539. PubMed  Europe PubMed DOI
  20. Oka,C., Saleh,R., Bessho,Y. and Reza,H.M.
    Interplay between HTRA1 and classical signalling pathways in organogenesis and diseases
    Saudi J Biol Sci (2022) 29, 1919-1927. PubMed  Europe PubMed DOI  PMC  EPMC  V
  21. Pan,Y., Fu,Y., Baird,P.N., Guymer,R.H., Das,T. and Iwata,T.
    Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration
    Prog Retin Eye Res (2022) , 101159-101159. PubMed  Europe PubMed DOI  V
  22. Rey,J., Breiden,M., Lux,V., Bluemke,A., Steindel,M., Ripkens,K., Mollers,B., Bravo Rodriguez,K., Boisguerin,P., Volkmer,R., Mieres-Perez,J., Clausen,T., Sanchez-Garcia,E. and Ehrmann,M.
    An allosteric HTRA1-calpain 2 complex with restricted activation profile
    Proc Natl Acad Sci U S A (2022) 119, e2113520119-e2113520119. PubMed  Europe PubMed DOI
  23. Tossetta,G., Fantone,S., Licini,C., Marzioni,D. and Mattioli-Belmonte,M.
    The multifaced role of HtrA1 in the development of joint and skeletal disorders
    Bone (2022) 157, 116350-116350. PubMed  Europe PubMed DOI  V
  24. Wilkinson,D.J.
    The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing?
    Osteoarthritis Cartilage (2022) PubMed  Europe PubMed DOI
  25. Yao,T., Zhu,J., Wu,X., Li,X., Fu,Y., Wang,Y., Wang,Z., Xu,F., Lai,H., He,A., Teng,L., Wang,C. and Song,H.
    Heterozygous HTRA1 Mutations Cause Cerebral Small Vessel Diseases: Genetic, Clinical, and Pathologic Findings From 3 Chinese Pedigrees
    Neurol Genet (2022) 8, e200044-e200044. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Yoshida,K., Kusama,K., Azumi,M., Yoshie,M., Kato,K. and Tamura,K.
    Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts
    J Pharmacol Sci (2022) 150, 267-274. PubMed  Europe PubMed DOI
  27. Zhang,C., Zheng,H., Li,X., Li,S., Li,W., Wang,Z., Niu,S., Wang,X. and Zhang,Z.
    Novel mutations in HTRA1-related cerebral small vessel disease and comparison with CADASIL
    Ann Clin Transl Neurol (2022) 9, 1586-1595. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Zhou,H., Jiao,B., Ouyang,Z., Wu,Q., Shen,L. and Fang,L.
    Report of two pedigrees with heterozygous HTRA1 variants-related cerebral small vessel disease and literature review
    Mol Genet Genomic Med (2022) 10, e2032-e2032. PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2021
  29. Al-Rabadi,L.F., Caza,T., Trivin-Avillach,C., Rodan,A.R., Andeen,N., Hayashi,N., Williams,B., Revelo,M.P., Clayton,F., Abraham,J., Lin,E., Liou,W., Zou,C.J., Ramkumar,N., Cummins,T., Wilkey,D.W., Kawalit,I., Herzog,C., Storey,A., Edmondson,R., Sjoberg,R., Yang,T., Chien,J., Merchant,M., Arthur,J., Klein,J., Larsen,C. and Beck,L.H., Jr.
    Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy
    J Am Soc Nephrol (2021) PubMed  Europe PubMed DOI
  30. Campbell,R.A., Campbell,H.D., Bircher,J.S., de Araujo,C.V., Denorme,F., Crandell,J.L., Rustad,J.L., Monts,J., Cody,M.J., Kosaka,Y. and Yost,C.C.
    Placental HTRA1 cleaves alpha-1-antitrypsin to generate a NET-Inhibitory Peptide
    Blood (2021) PubMed  Europe PubMed DOI
  31. Chen,M., Yang,S., Wu,Y., Zhao,Z., Zhai,X. and Dong,D.
    High temperature requirement A1 in cancer: biomarker and therapeutic target
    Cancer Cell Int (2021) 21, 513-513. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Fantone,S., Giannubilo,S.R., Marzioni,D. and Tossetta,G.
    HTRA family proteins in pregnancy outcome
    Tissue Cell (2021) 72, 101549-101549. PubMed  Europe PubMed DOI
  33. Grigaite,J., Siauryte,K., Audronyte,E., Preiksaitiene,E., Burnyte,B., Pranckeviciene,E., Ekkert,A., Utkus,A. and Jatuzis,D.
    Novel In-Frame Deletion in HTRA1 Gene, Responsible for Stroke at a Young Age and Dementia-A Case Study
    Genes (Basel) (2021) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  34. Lu,Z.G., May,A., Dinh,B., Lin,V., Su,F., Tran,C., Adivikolanu,H., Ehlen,R., Che,B., Wang,Z.H., Shaw,D.H., Borooah,S. and Shaw,P.X.
    The interplay of oxidative stress and ARMS2-HTRA1 genetic risk in neovascular AMD
    Vessel Plus (2021) 5 PubMed  Europe PubMed DOI  PMC  EPMC  V
  35. Malik,R., Beaufort,N., Frerich,S., Gesierich,B., Georgakis,M.K., Rannikmae,K., Ferguson,A.C., Haffner,C., Traylor,M., Ehrmann,M., Sudlow,C.L.M. and Dichgans,M.
    Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities
    Brain (2021) 144, 2670-2682. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Pan,Y., Iejima,D., Nakayama,M., Suga,A., Noda,T., Kaur,I., Das,T., Chakrabarti,S., Guymer,R.H., Deangelis,M.M., Yamamoto,M., Baird,P.N. and Iwata,T.
    Binding of Gtf2i-beta/delta transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro
    J Biol Chem (2021) , 100456-100456. PubMed  Europe PubMed DOI
  37. Williams,B.L., Seager,N.A., Gardiner,J.D., Pappas,C.M., Cronin,M.C., Amat di San Filippo,C., Anstadt,R.A., Liu,J., Toso,M.A., Nichols,L., Parnell,T.J., Eve,J.R., Bartel,P.L., Zouache,M.A., Richards,B.T. and Hageman,G.S.
    Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium
    Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI  PMC  EPMC  M
    38. 2020
  38. Fasano,A., Formichi,P., Taglia,I., Bianchi,S., Di Donato,I., Battisti,C., Federico,A. and Dotti,M.T.
    HTRA1 expression profile and activity on TGF-beta signaling in HTRA1 mutation carriers
    J Cell Physiol (2020) PubMed  Europe PubMed DOI  M
  39. Merdanovic,M., Burston,S.G., Schmitz,A.L., Kocher,S., Knapp,S., Clausen,T., Kaiser,M., Huber,R. and Ehrmann,M.
    Activation by substoichiometric inhibition
    Proc Natl Acad Sci U S A (2020) 117, 1414-1418. PubMed  Europe PubMed DOI
  40. Nam,H.Y., Song,D., Eo,J., Choi,N.E., Hong,J.A., Hong,K.T., Lee,J.S., Seo,J. and Lee,J.
    Activity-Based Probes for the High Temperature Requirement A Serine Proteases
    ACS Chem Biol (2020) PubMed  Europe PubMed DOI
  41. Ohta,K., Ozawa,T., Fujinaka,H., Goto,K. and Nakajima,T.
    Cerebral small vessel disease related to a heterozygous nonsense mutation in HTRA1
    Intern Med (2020) 59, 1309-1313. PubMed  Europe PubMed DOI  M
  42. Sabino,F., Madzharova,E. and auf dem Keller,U.
    Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival
    Cell Death Dis (2020) 11, 674-674. PubMed  Europe PubMed DOI  PMC  EPMC
  43. Uemura,M., Nozaki,H., Kato,T., Koyama,A., Sakai,N., Ando,S., Kanazawa,M., Hishikawa,N., Nishimoto,Y., Polavarapu,K., Nalini,A., Hanazono,A., Kuzume,D., Shindo,A., El-Ghanem,M., Abe,A., Sato,A., Yoshida,M., Ikeuchi,T., Mizuta,I., Mizuno,T. and Onodera,O.
    HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature
    Front Neurol (2020) 11, 545-545. PubMed  Europe PubMed DOI  PMC  EPMC  V
  44. Zhuo,Z.L., Cong,L., Zhang,J. and Zhao,X.T.
    A novel heterozygous HTRA1 mutation is associated with autosomal dominant hereditary cerebral small vessel disease
    Mol Genet Genomic Med (2020) , e1111-e1111. PubMed  Europe PubMed DOI  M
    45. 2019
  45. Klose,R., Prinz,A., Tetzlaff,F., Weis,E.M., Moll,I., Rodriguez-Vita,J., Oka,C., Korff,T. and Fischer,A.
    Loss of the serine protease HTRA1 impairs smooth muscle cells maturation
    Sci Rep (2019) 9, 18224-18224. PubMed  Europe PubMed DOI
  46. Li,C., Jin,W., Wang,X., Li,T., Wang,M. and Cao,B.
    Establishment and identification of a novel HTRA1 mutation mice model
    Rev Cardiovasc Med (2019) 20, 179-186. PubMed  Europe PubMed DOI  M
  47. Li,Y., Yuan,J., Rothzerg,E., Wu,X., Xu,H., Zhu,S. and Xu,J.
    Molecular structure and the role of high-temperature requirement protein 1 in skeletal disorders and cancers
    Cell Prolif (2019) , e12746-e12746. PubMed  Europe PubMed DOI
  48. Ochiai,N., Nakachi,Y., Yokoo,T., Ichihara,T., Eriksson,T., Yonemoto,Y., Kato,T., Ogata,H., Fujimoto,N., Kobayashi,Y., Udagawa,N., Kaku,S., Ueki,T., Okazaki,Y., Takahashi,N. and Suda,T.
    Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment
    Commun Biol (2019) 2, 86-86. PubMed  Europe PubMed DOI  PMC  EPMC
  49. Poulsen,E.T., Nielsen,N.S., Scavenius,C., Mogensen,E.H., Risor,M.W., Runager,K., Lukassen,M.V., Rasmussen,C.B., Christiansen,G., Richner,M., Vorum,H. and Enghild,J.J.
    The serine protease HtrA1 cleaves misfolded transforming growth factor beta-induced protein (TGFBIp) and induces amyloid formation
    J Biol Chem (2019) 294, 11817-11828. PubMed  Europe PubMed DOI
  50. Uemura,M., Nozaki,H., Koyama,A., Sakai,N., Ando,S., Kanazawa,M., Kato,T. and Onodera,O.
    HTRA1 Mutations identified in symptomatic carriers have the property of interfering the trimer-dependent activation cascade
    Front Neurol (2019) 10, 693-693. PubMed  Europe PubMed DOI  PMC  EPMC  M
    51. 2018
  51. Ito,J., Nozaki,H., Toyoshima,Y., Abe,T., Sato,A., Hashidate,H., Igarashi,S., Onodera,O., Takahashi,H. and Kakita,A.
    Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation
    Neuropathology (2018) PubMed  Europe PubMed DOI  M
  52. Klose,R., Adam,M.G., Weis,E.M., Moll,I., Wustehube-Lausch,J., Tetzlaff,F., Oka,C., Ehrmann,M. and Fischer,A.
    Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis
    Oncogene (2018) 37, 4260-4272. PubMed  Europe PubMed DOI  K
  53. Kono,Y., Nishioka,K., Li,Y., Komatuzaki,Y., Ito,Y., Yoshino,H., Tanaka,R., Iguchi,Y. and Hattori,N.
    Heterozygous HTRA1 mutations with mimicking symptoms of CARASIL in two families
    Clin Neurol Neurosurg (2018) 172, 174-176. PubMed  Europe PubMed DOI  M
  54. Lee,Y.C., Chung,C.P., Chao,N.C., Fuh,J.L., Chang,F.C., Soong,B.W. and Liao,Y.C.
    Characterization of heterozygous HTRA1 mutations in Taiwanese patients with cerebral small vessel disease
    Stroke (2018) 49, 1593-1601. PubMed  Europe PubMed DOI  M
  55. Lin,M.K., Yang,J., Hsu,C.W., Gore,A., Bassuk,A.G., Brown,L.M., Colligan,R., Sengillo,J.D., Mahajan,V.B. and Tsang,S.H.
    HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1
    Aging Cell (2018) , e12710-e12710. PubMed  Europe PubMed DOI  M
  56. Melo,E., Oertle,P., Trepp,C., Meistermann,H., Burgoyne,T., Sborgi,L., Cabrera,A.C., Chen,C.Y., Hoflack,J.C., Kam-Thong,T., Schmucki,R., Badi,L., Flint,N., Ghiani,Z.E., Delobel,F., Stucki,C., Gromo,G., Einhaus,A., Hornsperger,B., Golling,S., Siebourg-Polster,J., Gerber,F., Bohrmann,B., Futter,C., Dunkley,T., Hiller,S., Schilling,O., Enzmann,V., Fauser,S., Plodinec,M. and Iacone,R.
    HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
    EBioMedicine (2018) 27, 258-274. PubMed  Europe PubMed DOI
  57. Sun,M.L., Sun,L.M. and Wang,Y.Q.
    Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes
    J Mol Recognit (2018) 31, e2698-e2698. PubMed  Europe PubMed DOI  I
  58. Wu,X., Li,C., Mao,J., Li,L., Liu,Y. and Hou,Y.
    Heterozygous HTRA1 missense mutation in CADASIL-like family disease
    Braz J Med Biol Res (2018) 51, e6632-e6632. PubMed  Europe PubMed DOI  M
  59. Yamawaki,S., Naitoh,M., Kubota,H., Aya,R., Katayama,Y., Ishiko,T., Tamura,T., Yoshikawa,K., Enoshiri,T., Ikeda,M. and Suzuki,S.
    HtrA1 Is specifically up-regulated in active keloid lesions and stimulates keloid development
    Int J Mol Sci (2018) 19 PubMed  Europe PubMed DOI
  60. Zellner,A., Scharrer,E., Arzberger,T., Oka,C., Domenga-Denier,V., Joutel,A., Lichtenthaler,S.F., Muller,S.A., Dichgans,M. and Haffner,C.
    CADASIL brain vessels show a HTRA1 loss-of-function profile
    Acta Neuropathol (2018) 136, 111-125. PubMed  Europe PubMed DOI
    61. 2017
  61. Cabrera,A.C., Melo,E., Roth,D., Topp,A., Delobel,F., Stucki,C., Chen,C.Y., Jakob,P., Banfai,B., Dunkley,T., Schilling,O., Huber,S., Iacone,R. and Petrone,P.
    HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
    Sci Rep (2017) 7, 14804-14804. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Kocher,S., Rey,J., Bongard,J., Tiaden,A.N., Meltzer,M., Richards,P.J., Ehrmann,M. and Kaiser,M.
    Tailored Ahp-cyclodepsipeptides as potent non-covalent serine protease inhibitors
    Angew Chem Int Ed Engl (2017) 56, 8555-8558. PubMed  Europe PubMed DOI  I
  63. Zurawa-Janicka,D., Wenta,T., Jarzab,M., Skorko-Glonek,J., Glaza,P., Gieldon,A., Ciarkowski,J. and Lipinska,B.
    Structural insights into the activation mechanisms of human HtrA serine proteases
    Arch Biochem Biophys (2017) 621, 6-23. PubMed  Europe PubMed DOI  V
    64. 2016
  64. Chu,Q., Diedrich,J.K., Vaughan,J.M., Donaldson,C.J., Nunn,M.F., Lee,K.F. and Saghatelian,A.
    HtrA1 proteolysis of ApoE in vitro is allele selective
    J Am Chem Soc (2016) 138, 9473-9478. PubMed  Europe PubMed DOI  P
  65. Nozaki,H., Kato,T., Nihonmatsu,M., Saito,Y., Mizuta,I., Noda,T., Koike,R., Miyazaki,K., Kaito,M., Ito,S., Makino,M., Koyama,A., Shiga,A., Uemura,M., Sekine,Y., Murakami,A., Moritani,S., Hara,K., Yokoseki,A., Kuwano,R., Endo,N., Momotsu,T., Yoshida,M., Nishizawa,M., Mizuno,T. and Onodera,O.
    Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL
    Neurology (2016) 86, 1964-1974. PubMed  Europe PubMed DOI  M
    66. 2015
  66. Cai,B., Zeng,J., Lin,Y., Lin,Y., Lin,W., Lin,W., Li,Z. and Wang,N.
    A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population
    Neurol Sci (2015) 36, 1387-1391. PubMed  Europe PubMed DOI  M
  67. Ciferri,C., Lipari,M.T., Liang,W.-C., Estevez,A., Hang,J., Stawicki,S., Wu,Y., Moran,P., Elliott,M., Eigenbrot,C., Katschke,K.J., VanLookeren Campagne,M. and Kirchhofer,D.
    The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody
    Biochem J (2015) 472, 169-181. PubMed  Europe PubMed DOI
  68. Khaleeli,Z., Jaunmuktane,Z., Beaufort,N., Houlden,H., Haffner,C., Brandner,S., Dichgans,M. and Werring,D.
    A novel HTRA1 exon 2 mutation causes loss of protease activity in a Pakistani CARASIL patient
    J Neurol (2015) 262, 1369-1372. PubMed  Europe PubMed DOI  M
  69. Pei,X., Ma,K., Xu,J., Wang,N. and Liu,N.
    Inhibition of cell proliferation and migration after HTRA1 knockdown in retinal pigment epithelial cells
    Graefes Arch Clin Exp Ophthalmol (2015) 253, 565-572. PubMed  Europe PubMed DOI  K
  70. Verdura,E., Herve,D., Scharrer,E., Amador,M.M., Guyant-Marechal,L., Philippi,A., Corlobe,A., Bergametti,F., Gazal,S., Prieto-Morin,C., Beaufort,N., Le Bail,B., Viakhireva,I., Dichgans,M., Chabriat,H., Haffner,C. and Tournier-Lasserve,E.
    Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease
    Brain (2015) 138, 2347-2358. PubMed  Europe PubMed DOI  M
    71. 2014
  71. Beaufort,N., Scharrer,E., Kremmer,E., Lux,V., Ehrmann,M., Huber,R., Houlden,H., Werring,D., Haffner,C. and Dichgans,M.
    Cerebral small vessel disease-related protease HtrA1 processes latent TGF-beta binding protein 1 and facilitates TGF-beta signaling
    Proc Natl Acad Sci U S A (2014) 111, 16496-16501. PubMed  Europe PubMed DOI
  72. Bianchi,S., Di Palma,C., Gallus,G.N., Taglia,I., Poggiani,A., Rosini,F., Rufa,A., Muresanu,D.F., Cerase,A., Dotti,M.T. and Federico,A.
    Two novel HTRA1 mutations in a European CARASIL patient
    Neurology (2014) 82, 898-900. PubMed  Europe PubMed DOI  M
  73. Chen,Y.Y., Chuang,P.Y., Chen,C.P., Chiu,Y.H., Lo,H.F., Cheong,M.L., Huang,J.Y., Kuo,P.L. and Chen,H.
    Functional antagonism between high temperature requirement protein A (HtrA) family members regulates trophoblast invasion
    J Biol Chem (2014) 289, 22958-22968. PubMed  Europe PubMed DOI
  74. Frochaux,V., Hildebrand,D., Talke,A., Linscheid,M.W. and Schluter,H.
    Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue
    PLoS ONE (2014) 9, e109483-e109483. PubMed  Europe PubMed DOI  PMC  EPMC
  75. Jo,H., Patterson,V., Stoessel,S., Kuan,C.Y. and Hoh,J.
    Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease
    PLoS ONE (2014) 9, e115362-e115362. PubMed  Europe PubMed DOI
  76. Risor,M.W., Poulsen,E.T., Thomsen,L.R., Dyrlund,T.F., Nielsen,T.A., Nielsen,N.C., Sanggaard,K.W. and Enghild,J.J.
    The autolysis of human HtrA1 is governed by the redox state of its N-terminal domain
    Biochemistry (2014) 53, 3851-3857. PubMed  Europe PubMed DOI
    77. 2013
  77. Akhatib,B., Onnerfjord,P., Gawri,R., Ouellet,J., Jarzem,P., Heinegard,D., Mort,J., Roughley,P. and Haglund,L.
    Chondroadherin fragmentation mediated by the protease HTRA1 distinguishes human intervertebral disc degeneration from normal aging
    J Biol Chem (2013) 288, 19280-19287. PubMed  Europe PubMed DOI
  78. Chen,Y., He,Z., Meng,S., Li,L., Yang,H. and Zhang,X.
    A novel mutation of the high-temperature requirement A serine peptidase 1 (HTRA1) gene in a Chinese family with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)
    J Int Med Res (2013) 41, 1445-1455. PubMed  Europe PubMed DOI  M
  79. Furtwangler,T., Chan,S.C., Bahrenberg,G., Richards,P.J. and Gantenbein-Ritter,B.
    Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine Intervertebral disc organ culture model
    Spine (Phila Pa 1976) (2013) 38, E1377-E1387. PubMed  Europe PubMed DOI
  80. Graham,J.R., Chamberland,A., Lin,Q., Li,X.J., Dai,D., Zeng,W., Ryan,M.S., Rivera-Bermudez,M.A., Flannery,C.R. and Yang,Z.
    Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation
    PLoS ONE (2013) 8, e74094-e74094. PubMed  Europe PubMed DOI  PMC  EPMC
  81. Karring,H., Poulsen,E.T., Runager,K., Thogersen,I.B., Klintworth,G.K., Hojrup,P. and Enghild,J.J.
    Serine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid deposits
    Mol Vision (2013) 19, 861-876. PubMed  Europe PubMed
  82. Skorko-Glonek,J., Zurawa-Janicka,D., Koper,T., Jarzab,M., Figaj,D., Glaza,P. and Lipinska,B.
    HtrA protease family as therapeutic targets
    Curr Pharm Des (2013) 19, 977-1009. PubMed  Europe PubMed  V
  83. Xia,J., Wang,F., Wang,L. and Fan,Q.
    Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-kappaB signaling pathway
    Tumour Biol (2013) 34, 317-328. PubMed  Europe PubMed DOI
    84. 2012
  84. Chien,J. and Shridhar,V.
    HtrA1 peptidase
    [ISSN:978-0-12-407742-3] (2012) 3, 2577-2584. DOI
  85. Eigenbrot,C., Ultsch,M., Lipari,M.T., Moran,P., Lin,S.J., Ganesan,R., Quan,C., Tom,J., Sandoval,W., van Lookeren Campagne,M. and Kirchhofer,D.
    Structural and functional analysis of HtrA1 and its subdomains
    Structure (2012) 20, 1040-1050. PubMed  Europe PubMed DOI
  86. Nozaki,H.
    [Consideration of the pathogenesis of CARASIL]
    Rinsho Shinkeigaku (2012) 52, 1360-1362. PubMed  Europe PubMed DOI  M
  87. Tennstaedt,A., Popsel,S., Truebestein,L., Hauske,P., Brockmann,A., Schmidt,N., Irle,I., Sacca,B., Niemeyer,C.M., Brandt,R., Ksiezak-Reding,H., Tirniceriu,A.L., Egensperger,R., Baldi,A., Dehmelt,L., Kaiser,M., Huber,R., Clausen,T. and Ehrmann,M.
    Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates
    J Biol Chem (2012) 287, 20931-20941. PubMed  Europe PubMed DOI
  88. Tiaden,A.N., Klawitter,M., Lux,V., Mirsaidi,A., Bahrenberg,G., Glanz,S., Quero,L., Liebscher,T., Wuertz,K., Ehrmann,M. and Richards,P.J.
    Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration
    J Biol Chem (2012) 287, 21335-21345. PubMed  Europe PubMed DOI
  89. Tiaden,A.N., Breiden,M., Mirsaidi,A., Weber,F.A., Bahrenberg,G., Glanz,S., Cinelli,P., Ehrmann,M. and Richards,P.J.
    Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein
    Stem Cells (2012) 30, 2271-2282. PubMed  Europe PubMed DOI
    90. 2011
  90. Campioni,M., Severino,A., Manente,L., De Luca,A., La Porta,R., Vitiello,A., Fiore,P., Toldo,S., Spugnini,E.P., Paggi,M.G. and Baldi,A.
    Identification of protein-protein interactions of human HtrA1
    Front Biosci (Elite Ed) (2011) 3, 1493-1499. PubMed  Europe PubMed
  91. Clausen,T., Kaiser,M., Huber,R. and Ehrmann,M.
    HTRA proteases: regulated proteolysis in protein quality control
    Nat Rev Mol Cell Biol (2011) 12, 152-162. PubMed  Europe PubMed DOI  V
  92. Fukutake,T.
    [CARASIL]
    Brain Nerve (2011) 63, 99-108. PubMed  Europe PubMed  M
  93. Jones,A., Kumar,S., Zhang,N., Tong,Z., Yang,J.H., Watt,C., Anderson,J., Amrita, Fillerup,H., McCloskey,M., Luo,L., Yang,Z., Ambati,B., Marc,R., Oka,C., Zhang,K. and Fu,Y.
    Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice
    Proc Natl Acad Sci U S A (2011) 108, 14578-14583. PubMed  Europe PubMed DOI
  94. Mullany,S.A., Moslemi-Kebria,M., Rattan,R., Khurana,A., Clayton,A., Ota,T., Mariani,A., Podratz,K.C., Chien,J. and Shridhar,V.
    Expression and functional significance of HtrA1 loss in endometrial cancer
    Clin Cancer Res (2011) 17, 427-436. PubMed  Europe PubMed DOI
  95. Onodera,O.
    [TGF-beta family signaling contributes to human cerebral small vessel disease]
    Rinsho Shinkeigaku (2011) 51, 943-944. PubMed  Europe PubMed DOI  M
  96. Shiga,A., Nozaki,H., Yokoseki,A., Nihonmatsu,M., Kawata,H., Kato,T., Koyama,A., Arima,K., Ikeda,M., Katada,S., Toyoshima,Y., Takahashi,H., Tanaka,A., Nakano,I., Ikeuchi,T., Nishizawa,M. and Onodera,O.
    Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-beta1 via cleavage of proTGF-beta1
    Hum Mol Genet (2011) 20, 1800-1810. PubMed  Europe PubMed DOI  M
  97. Truebestein,L., Tennstaedt,A., Monig,T., Krojer,T., Canellas,F., Kaiser,M., Clausen,T. and Ehrmann,M.
    Substrate-induced remodeling of the active site regulates human HTRA1 activity
    Nat Struct Mol Biol (2011) 18, 386-388. PubMed  Europe PubMed DOI
  98. Turunen,M., Vepsalainen,S., Makinen,P., Helisalmi,S., Haapasalo,A., Soininen,H. and Hiltunen,M.
    No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease
    Neurobiol Aging (2011) 32, 547-547. PubMed  Europe PubMed DOI
    99. 2010
  99. An,E., Sen,S., Park,S.K., Gordish-Dressman,H. and Hathout,Y.
    Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome
    Invest Ophthalmol Vis Sci (2010) 51, 3379-3386. PubMed  Europe PubMed DOI  P
  100. Campioni,M., Severino,A., Manente,L., Tuduce,I.L., Toldo,S., Caraglia,M., Crispi,S., Ehrmann,M., He,X., Maguire,J., De Falco,M., De Luca,A., Shridhar,V. and Baldi,A.
    The serine protease HtrA1 specifically interacts and degrades the Tuberous Sclerosis Complex 2 protein
    Mol Cancer Res (2010) 8, 1248-1260. PubMed  Europe PubMed DOI
  101. Polur,I., Lee,P.L., Servais,J.M., Xu,L. and Li,Y.
    Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration
    Histol Histopathol (2010) 25, 599-608. PubMed  Europe PubMed
    102. 2009
  102. Chamberland,A., Wang,E., Jones,A.R., Collins-Racie,L.A., LaVallie,E.R., Huang,Y., Liu,L., Morris,E.A., Flannery,C.R. and Yang,Z.
    Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo
    J Biol Chem (2009) 284, 27352-27359. PubMed  Europe PubMed DOI  P
  103. Chien,J., He,X. and Shridhar,V.
    Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening
    J Cell Biochem (2009) 107, 253-263. PubMed  Europe PubMed DOI  P
  104. Chien,J., Campioni,M., Shridhar,V. and Baldi,A.
    HtrA serine proteases as potential therapeutic targets in cancer
    Curr Cancer Drug Targets (2009) 9, 451-468. PubMed  Europe PubMed DOI  T
  105. Chien,J., Ota,T., Aletti,G., Shridhar,R., Boccellino,M., Quagliuolo,L., Baldi,A. and Shridhar,V.
    Serine protease HtrA1 associates with microtubules and inhibits cell migration
    Mol Cell Biol (2009) 29, 4177-4187. PubMed  Europe PubMed DOI  PMC  EPMC
  106. Hara,K., Shiga,A., Fukutake,T., Nozaki,H., Miyashita,A., Yokoseki,A., Kawata,H., Koyama,A., Arima,K., Takahashi,T., Ikeda,M., Shiota,H., Tamura,M., Shimoe,Y., Hirayama,M., Arisato,T., Yanagawa,S., Tanaka,A., Nakano,I., Ikeda,S., Yoshida,Y., Yamamoto,T., Ikeuchi,T., Kuwano,R., Nishizawa,M., Tsuji,S. and Onodera,O.
    Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease
    N Engl J Med (2009) 360, 1729-1739. PubMed  Europe PubMed DOI  M
    107. 2008
  107. Clawson,G.A., Bui,V., Xin,P., Wang,N. and Pan,W.
    Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins
    J Cell Biochem (2008) 105, 81-88. PubMed  Europe PubMed DOI
  108. Deangelis,M.M., Ji,F., Adams,S., Morrison,M.A., Harring,A.J., Sweeney,M.O., Capone,A., Jr., Miller,J.W., Dryja,T.P., Ott,J. and Kim,I.K.
    Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration
    Ophthalmology (2008) 115, 1209-1215. PubMed  Europe PubMed DOI  M
  109. Ferrer-Vaquer,A., Maurey,P., Werzowa,J., Firnberg,N., Leibbrandt,A. and Neubuser,A.
    Expression and regulation of HTRA1 during chick and early mouse development
    Dev Dyn (2008) 237, 1893-1900. PubMed  Europe PubMed DOI
  110. Hadfield,K.D., Rock,C.F., Inkson,C.A., Dallas,S.L., Sudre,L., Wallis,G.A., Boot-Handford,R.P. and Canfield,A.E.
    HTRA1 inhibits mineral deposition by osteoblasts: requirement for the protease and PDZ domains
    J Biol Chem (2008) 283, 5928-5938. PubMed  Europe PubMed DOI
  111. Launay,S., Maubert,E., Lebeurrier,N., Tennstaedt,A., Campioni,M., Docagne,F., Gabriel,C., Dauphinot,L., Potier,M.C., Ehrmann,M., Baldi,A. and Vivien,D.
    HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival
    Cell Death Differ (2008) 15, 1408-1416. PubMed  Europe PubMed DOI
    112. 2007
  112. Canfield,A.E., Hadfield,K.D., Rock,C.F., Wylie,E.C. and Wilkinson,F.L.
    HtrA1: a novel regulator of physiological and pathological matrix mineralization?
    Biochem Soc Trans (2007) 35, 669-671. PubMed  Europe PubMed DOI  K
  113. DeWan,A., Bracken,M.B. and Hoh,J.
    Two genetic pathways for age-related macular degeneration
    Curr Opin Genet Dev (2007) 17, 228-233. PubMed  Europe PubMed DOI  M
  114. Gallagher,J.
    Messages in the matrix: proteoglycans go the distance
    Dev Cell (2007) 13, 166-167. PubMed  Europe PubMed DOI
  115. Gilicze,A., Kohalmi,B., Pocza,P., Keszei,M., Jaeger,J., Gorbe,E., Papp,Z., Toth,S., Falus,A. and Wiener,Z.
    HtrA1 is a novel mast cell serine protease of mice and men
    Mol Immunol (2007) 44, 2961-2968. PubMed  Europe PubMed DOI
  116. Hou,S., Maccarana,M., Min,T.H., Strate,I. and Pera,E.M.
    The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo
    Dev Cell (2007) 13, 226-241. PubMed  Europe PubMed DOI
  117. Runyon,S.T., Zhang,Y., Appleton,B.A., Sazinsky,S.L., Wu,P., Pan,B., Wiesmann,C., Skelton,N.J. and Sidhu,S.S.
    Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3
    Protein Sci (2007) 16, 2454-2471. PubMed  Europe PubMed DOI  PMC  EPMC
    118. 2006
  118. [YEAR:8-6-2006]Chien,J., Aletti,G., Baldi,A., Catalano,V., Muretto,P., Keeney,G.L., Kalli,K.R., Staub,J., Ehrmann,M., Cliby,W.A., Lee,Y.K., Bible,K.C., Hartmann,L.C., Kaufmann,S.H. and Shridhar,V.
    Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity
    J Clin Invest (8-6-2006) 116, 1994-2004. PubMed  Europe PubMed DOI  PMC  EPMC
  119. [YEAR:19-10-2006]DeWan,A., Liu,M., Hartman,S., Zhang,S.S., Liu,D.T., Zhao,C., Tam,P.O., Chan,W.M., Lam,D.S., Snyder,M., Barnstable,C., Pang,C.P. and Hoh,J.
    HTRA1 promoter polymorphism in wet age-related macular degeneration
    Science (19-10-2006) 314, 989-992. PubMed  Europe PubMed DOI  M
  120. [YEAR:19-10-2006]Yang,Z., Camp,N.J., Sun,H., Tong,Z., Gibbs,D., Cameron,D.J., Chen,H., Zhao,Y., Pearson,E., Li,X., Chien,J., DeWan,A., Harmon,J., Bernstein,P.S., Shridhar,V., Zabriskie,N.A., Hoh,J., Howes,K. and Zhang,K.
    A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration
    Science (19-10-2006) 314, 992-993. PubMed  Europe PubMed DOI
    121. 2005
  121. [YEAR:26-4-2005]Grau,S., Baldi,A., Bussani,R., Tian,X., Stefanescu,R., Przybylski,M., Richards,P., Jones,S.A., Shridhar,V., Clausen,T. and Ehrmann,M.
    Implications of the serine protease HtrA1 in amyloid precursor protein processing
    Proc Natl Acad Sci U S A (26-4-2005) 102, 6021-6026. PubMed  Europe PubMed DOI  PMC  EPMC
  122. [YEAR:28-4-2005]Nie,G., Li,Y. and Salamonsen,L.A.
    Serine protease HtrA1 is developmentally regulated in trophoblast and uterine decidual cells during placental formation in the mouse
    Dev Dyn (28-4-2005) 233, 1102-1109. PubMed  Europe PubMed DOI
  123. [YEAR:29-6-2005]Tsuchiya,A., Yano,M., Tocharus,J., Kojima,H., Fukumoto,M., Kawaichi,M. and Oka,C.
    Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis
    Bone (29-6-2005) 37, 323-336. PubMed  Europe PubMed DOI
    124. 2004
  124. [YEAR:26-2-2004]Chien,J., Staub,J., Hu,S.I., Erickson-Johnson,M.R., Couch,F.J., Smith,D.I., Crowl,R.M., Kaufmann,S.H. and Shridhar,V.
    A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer
    Oncogene (26-2-2004) 23, 1636-1644. PubMed  Europe PubMed DOI
  125. De Luca,A., De Falco,M., Fedele,V., Cobellis,L., Mastrogiacomo,A., Laforgia,V., Tuduce,I.L., Campioni,M., Giraldi,D., Paggi,M.G. and Baldi,A.
    The serine protease HtrA1 is upregulated in the human placenta during pregnancy
    J Histochem Cytochem (2004) 52, 885-892. PubMed  Europe PubMed DOI
  126. Dingwall,C. and Holbrook,J.D.
    Human HtrA proteases
    [ISSN:0-12-079610-4] (2004) 2, 1476-1480.  V
  127. [YEAR:22-4-2004]Murwantoko, Yano,M., Ueta,Y., Murasaki,A., Kanda,H., Oka,C. and Kawaichi,M.
    Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease
    Biochem J (22-4-2004) 381, 895-904. PubMed  Europe PubMed DOI  PMC  EPMC
  128. Oka,C., Tsujimoto,R., Kajikawa,M., Koshiba-Takeuchi,K., Ina,J., Yano,M., Tsuchiya,A., Ueta,Y., Soma,A., Kanda,H., Matsumoto,M. and Kawaichi,M.
    HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins
    Development (2004) 131, 1041-1053. PubMed  Europe PubMed DOI
    129. 2003
  129. De Luca,A., De Falco,M., Severino,A., Campioni,M., Santini,D., Baldi,F., Paggi,M.G. and Baldi,A.
    Distribution of the serine protease HtrA1 in normal human tissues
    J Histochem Cytochem (2003) 51, 1279-1284. PubMed  Europe PubMed
  130. Nie,G.Y., Li,Y., Minoura,H., Batten,L., Ooi,G.T., Findlay,J.K. and Salamonsen,L.A.
    A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation
    Mol Hum Reprod (2003) 9, 279-290. PubMed  Europe PubMed
    131. 2002
  131. [YEAR:26-9-2002]Baldi,A., De Luca,A., Morini,M., Battista,T., Felsani,A., Baldi,F., Catricala,C., Amantea,A., Noonan,D.M., Albini,A., Natali,P.G., Lombardi,D. and Paggi,M.G.
    The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells
    Oncogene (26-9-2002) 21, 6684-6688. PubMed  Europe PubMed DOI
    132. 1997
  132. Zumbrunn,J. and Trueb,B.
    Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2
    Genomics (1997) 45, 461-462. PubMed  Europe PubMed DOI
    133. 1996
  133. [YEAR:2-12-1996]Zumbrunn,J. and Trueb,B.
    Primary structure of a putative serine protease specific for IGF-binding proteins
    FEBS Lett (2-12-1996) 398, 187-192. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use