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Literature for peptidase S01.277: HtrA1 peptidase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: T Target, M Mutation, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Yoshimoto,T., Yamagami,H. and Matsumaru,Y.
    Recent Advances in Stroke Genetics-Unraveling the Complexity of Cerebral Infarction: A Brief Review
    Genes (Basel)16, PubMed  Europe PubMed DOI  V
    2. 2024
  2. Beaufort,N., Ingendahl,L., Merdanovic,M., Schmidt,A., Podlesainski,D., Richter,T., Neumann,T., Kuszner,M., Vetter,I.R., Stege,P., Burston,S.G., Filipovic,A., Ruiz-Blanco,Y.B., Bravo-Rodriguez,K., Mieres-Perez,J., Beuck,C., Uebel,S., Zobawa,M., Schillinger,J., Malik,R., Todorov-Volgyi,K., Rey,J., Roberti,A., Hagemeier,B., Wefers,B., Muller,S.A., Wurst,W., Sanchez-Garcia,E., Zimmermann,A., Hu,X.Y., Clausen,T., Huber,R., Lichtenthaler,S.F., Schmuck,C., Giese,M., Kaiser,M., Ehrmann,M. and Dichgans,M.
    Rational correction of pathogenic conformational defects in HTRA1
    Nat Commun15, 5944-5944. PubMed  Europe PubMed DOI
  3. Chen,S., Puri,A., Bell,B., Fritsche,J., Palacios,H.H., Balch,M., Sprunger,M.L., Howard,M.K., Ryan,J.J., Haines,J.N., Patti,G.J., Davis,A.A. and Jackrel,M.E.
    HTRA1 disaggregates alpha-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species
    Nat Commun15, 2436-2436. PubMed  Europe PubMed DOI
  4. Dennis,D.G., Joo Sun,Y., Parsons,D.E., Mahajan,V.B. and Smith,M.
    Identification of highly potent and selective HTRA1 inhibitors
    Bioorg Med Chem Lett109, 129814-129814. PubMed  Europe PubMed DOI  I
  5. Li,Y., Wei,Y., Ultsch,M., Li,W., Tang,W., Tombling,B., Gao,X., Dimitrova,Y., Gampe,C., Fuhrmann,J., Zhang,Y., Hannoush,R.N. and Kirchhofer,D.
    Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region
    Nat Commun15, 4359-4359. PubMed  Europe PubMed DOI
  6. Malik,R., Beaufort,N., Li,J., Tanaka,K., Georgakis,M.K., He,Y., Koido,M., Terao,C., Japan,B., Anderson,C.D., Kamatani,Y., Zand,R. and Dichgans,M.
    Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease
    Nat Cardiovasc Res3, 701-713. PubMed  Europe PubMed DOI
  7. Rosochowicz,M.A., Kulcenty,K. and Suchorska,W.M.
    Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review
    Mol Diagn Ther28, 347-377. PubMed  Europe PubMed DOI  V
  8. Schillinger,J., Koci,M., Bravo-Rodriguez,K., Heilmann,G., Kaschani,F., Kaiser,M., Beuck,C., Luecke,H., Huber,R., Hellerschmied,D., Burston,S.G. and Ehrmann,M.
    High resolution analysis of proteolytic substrate processing
    J Biol Chem107812-107812. PubMed  Europe PubMed DOI
  9. Song,S., Li,X., Xue,X., Dong,W. and Li,C.
    Progress in the Study of the Role and Mechanism of HTRA1 in Diseases Related to Vascular Abnormalities
    Int J Gen Med17, 1479-1491. PubMed  Europe PubMed DOI
    10. 2023
  10. Chang,Y.J., Jenny,L.A., Li,Y.S., Cui,X., Kong,Y., Li,Y., Sparrow,J.R. and Tsang,S.H.
    CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1-related AMD
    Proc Natl Acad Sci U S A120, e2215005120-e2215005120. PubMed  Europe PubMed DOI
  11. He,Z., Wang,L., Zhang,Y., Yin,C. and Niu,Y.
    Clinical features and pathogenicity assessment in patients with HTRA1-autosomal dominant disease
    Neurol Sci44, 639-647. PubMed  Europe PubMed DOI
  12. Murayama,M., Hirata,H., Shiraki,M., Iovanna,J.L., Yamaza,T., Kukita,T., Komori,T., Moriishi,T., Ueno,M., Morimoto,T., Mawatari,M. and Kukita,A.
    Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice
    J Cell Physiol238, 566-581. PubMed  Europe PubMed DOI
  13. Uemura,M., Hatano,Y., Nozaki,H., Ando,S., Kondo,H., Hanazono,A., Iwanaga,A., Murota,H., Osakada,Y., Osaki,M., Kanazawa,M., Kanai,M., Shibata,Y., Saika,R., Miyatake,T., Aizawa,H., Ikeuchi,T., Tomimoto,H., Mizuta,I., Mizuno,T., Ishihara,T. and Onodera,O.
    High frequency of HTRA1 AND ABCC6 mutations in Japanese patients with adult-onset cerebral small vessel disease
    J Neurol Neurosurg Psychiatry94, 74-81. PubMed  Europe PubMed DOI
  14. Xu,S.Y., Li,H.J., Li,S., Ren,Q.Q., Liang,J.L. and Li,C.X.
    Heterozygous Pathogenic and Likely Pathogenic Symptomatic HTRA1 Variant Carriers in Cerebral Small Vessel Disease
    Int J Gen Med16, 1149-1162. PubMed  Europe PubMed DOI  V
    15. 2022
  15. Gerhardy,S., Ultsch,M., Tang,W., Green,E., Holden,J.K., Li,W., Estevez,A., Arthur,C., Tom,I., Rohou,A. and Kirchhofer,D.
    Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration
    Nat Commun13, 5222-5222. PubMed  Europe PubMed DOI
  16. Guo,H., Guo,X. and Jiang,S.
    Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL)
    Bioengineered13, 12248-12260. PubMed  Europe PubMed DOI  K
  17. Hidalgo Mayoral,I., Martinez-Salio,A., Llamas-Velasco,S., Gomez-Majon,I., Arteche-Lopez,A., Quesada-Espinosa,J.F., Palma Milla,C., Lezana Rosales,J.M., Perez de la Fuente,R., Juarez Rufian,A., Sierra Tomillo,O., Sanchez Calvin,M.T., Gomez Rodriguez,M.J., Ramos Gomez,P., Villarejo-Galende,A., Diaz-Guzman,J., Ortega-Casarrubios,M.A., Calleja-Castano,P. and Moreno-Garcia,M.
    Hereditary cerebral small vessel disease: Assessment of a HTRA1 variant using protein stability predictors and 3D modelling
    Eur J Med Genet65, 104539-104539. PubMed  Europe PubMed DOI
  18. Oka,C., Saleh,R., Bessho,Y. and Reza,H.M.
    Interplay between HTRA1 and classical signalling pathways in organogenesis and diseases
    Saudi J Biol Sci29, 1919-1927. PubMed  Europe PubMed DOI  V
  19. Pan,Y., Fu,Y., Baird,P.N., Guymer,R.H., Das,T. and Iwata,T.
    Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration
    Prog Retin Eye Res101159-101159. PubMed  Europe PubMed DOI  V
  20. Rey,J., Breiden,M., Lux,V., Bluemke,A., Steindel,M., Ripkens,K., Mollers,B., Bravo Rodriguez,K., Boisguerin,P., Volkmer,R., Mieres-Perez,J., Clausen,T., Sanchez-Garcia,E. and Ehrmann,M.
    An allosteric HTRA1-calpain 2 complex with restricted activation profile
    Proc Natl Acad Sci U S A119, e2113520119-e2113520119. PubMed  Europe PubMed DOI
  21. Tossetta,G., Fantone,S., Licini,C., Marzioni,D. and Mattioli-Belmonte,M.
    The multifaced role of HtrA1 in the development of joint and skeletal disorders
    Bone157, 116350-116350. PubMed  Europe PubMed DOI  V
  22. Wilkinson,D.J.
    The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing?
    Osteoarthritis Cartilage PubMed  Europe PubMed DOI
  23. Yao,T., Zhu,J., Wu,X., Li,X., Fu,Y., Wang,Y., Wang,Z., Xu,F., Lai,H., He,A., Teng,L., Wang,C. and Song,H.
    Heterozygous HTRA1 Mutations Cause Cerebral Small Vessel Diseases: Genetic, Clinical, and Pathologic Findings From 3 Chinese Pedigrees
    Neurol Genet8, e200044-e200044. PubMed  Europe PubMed DOI
  24. Yoshida,K., Kusama,K., Azumi,M., Yoshie,M., Kato,K. and Tamura,K.
    Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts
    J Pharmacol Sci150, 267-274. PubMed  Europe PubMed DOI
  25. Zhang,C., Zheng,H., Li,X., Li,S., Li,W., Wang,Z., Niu,S., Wang,X. and Zhang,Z.
    Novel mutations in HTRA1-related cerebral small vessel disease and comparison with CADASIL
    Ann Clin Transl Neurol9, 1586-1595. PubMed  Europe PubMed DOI
  26. Zhou,H., Jiao,B., Ouyang,Z., Wu,Q., Shen,L. and Fang,L.
    Report of two pedigrees with heterozygous HTRA1 variants-related cerebral small vessel disease and literature review
    Mol Genet Genomic Med10, e2032-e2032. PubMed  Europe PubMed DOI
    27. 2021
  27. Al-Rabadi,L.F., Caza,T., Trivin-Avillach,C., Rodan,A.R., Andeen,N., Hayashi,N., Williams,B., Revelo,M.P., Clayton,F., Abraham,J., Lin,E., Liou,W., Zou,C.J., Ramkumar,N., Cummins,T., Wilkey,D.W., Kawalit,I., Herzog,C., Storey,A., Edmondson,R., Sjoberg,R., Yang,T., Chien,J., Merchant,M., Arthur,J., Klein,J., Larsen,C. and Beck,L.H., Jr.
    Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy
    J Am Soc Nephrol PubMed  Europe PubMed DOI
  28. Campbell,R.A., Campbell,H.D., Bircher,J.S., de Araujo,C.V., Denorme,F., Crandell,J.L., Rustad,J.L., Monts,J., Cody,M.J., Kosaka,Y. and Yost,C.C.
    Placental HTRA1 cleaves alpha-1-antitrypsin to generate a NET-Inhibitory Peptide
    Blood PubMed  Europe PubMed DOI
  29. Chen,M., Yang,S., Wu,Y., Zhao,Z., Zhai,X. and Dong,D.
    High temperature requirement A1 in cancer: biomarker and therapeutic target
    Cancer Cell Int21, 513-513. PubMed  Europe PubMed DOI
  30. Fantone,S., Giannubilo,S.R., Marzioni,D. and Tossetta,G.
    HTRA family proteins in pregnancy outcome
    Tissue Cell72, 101549-101549. PubMed  Europe PubMed DOI
  31. Grigaite,J., Siauryte,K., Audronyte,E., Preiksaitiene,E., Burnyte,B., Pranckeviciene,E., Ekkert,A., Utkus,A. and Jatuzis,D.
    Novel In-Frame Deletion in HTRA1 Gene, Responsible for Stroke at a Young Age and Dementia-A Case Study
    Genes (Basel)12, PubMed  Europe PubMed DOI
  32. Lu,Z.G., May,A., Dinh,B., Lin,V., Su,F., Tran,C., Adivikolanu,H., Ehlen,R., Che,B., Wang,Z.H., Shaw,D.H., Borooah,S. and Shaw,P.X.
    The interplay of oxidative stress and ARMS2-HTRA1 genetic risk in neovascular AMD
    Vessel Plus5, PubMed  Europe PubMed DOI  V
  33. Malik,R., Beaufort,N., Frerich,S., Gesierich,B., Georgakis,M.K., Rannikmae,K., Ferguson,A.C., Haffner,C., Traylor,M., Ehrmann,M., Sudlow,C.L.M. and Dichgans,M.
    Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities
    Brain144, 2670-2682. PubMed  Europe PubMed DOI
  34. Pan,Y., Iejima,D., Nakayama,M., Suga,A., Noda,T., Kaur,I., Das,T., Chakrabarti,S., Guymer,R.H., Deangelis,M.M., Yamamoto,M., Baird,P.N. and Iwata,T.
    Binding of Gtf2i-beta/delta transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro
    J Biol Chem100456-100456. PubMed  Europe PubMed DOI
  35. Williams,B.L., Seager,N.A., Gardiner,J.D., Pappas,C.M., Cronin,M.C., Amat di San Filippo,C., Anstadt,R.A., Liu,J., Toso,M.A., Nichols,L., Parnell,T.J., Eve,J.R., Bartel,P.L., Zouache,M.A., Richards,B.T. and Hageman,G.S.
    Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI  M
    36. 2020
  36. Fasano,A., Formichi,P., Taglia,I., Bianchi,S., Di Donato,I., Battisti,C., Federico,A. and Dotti,M.T.
    HTRA1 expression profile and activity on TGF-beta signaling in HTRA1 mutation carriers
    J Cell Physiol PubMed  Europe PubMed DOI  M
  37. Merdanovic,M., Burston,S.G., Schmitz,A.L., Kocher,S., Knapp,S., Clausen,T., Kaiser,M., Huber,R. and Ehrmann,M.
    Activation by substoichiometric inhibition
    Proc Natl Acad Sci U S A117, 1414-1418. PubMed  Europe PubMed DOI
  38. Nam,H.Y., Song,D., Eo,J., Choi,N.E., Hong,J.A., Hong,K.T., Lee,J.S., Seo,J. and Lee,J.
    Activity-Based Probes for the High Temperature Requirement A Serine Proteases
    ACS Chem Biol PubMed  Europe PubMed DOI
  39. Ohta,K., Ozawa,T., Fujinaka,H., Goto,K. and Nakajima,T.
    Cerebral small vessel disease related to a heterozygous nonsense mutation in HTRA1
    Intern Med59, 1309-1313. PubMed  Europe PubMed DOI  M
  40. Sabino,F., Madzharova,E. and auf dem Keller,U.
    Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival
    Cell Death Dis11, 674-674. PubMed  Europe PubMed DOI
  41. Uemura,M., Nozaki,H., Kato,T., Koyama,A., Sakai,N., Ando,S., Kanazawa,M., Hishikawa,N., Nishimoto,Y., Polavarapu,K., Nalini,A., Hanazono,A., Kuzume,D., Shindo,A., El-Ghanem,M., Abe,A., Sato,A., Yoshida,M., Ikeuchi,T., Mizuta,I., Mizuno,T. and Onodera,O.
    HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature
    Front Neurol11, 545-545. PubMed  Europe PubMed DOI  V
  42. Zhuo,Z.L., Cong,L., Zhang,J. and Zhao,X.T.
    A novel heterozygous HTRA1 mutation is associated with autosomal dominant hereditary cerebral small vessel disease
    Mol Genet Genomic Mede1111-e1111. PubMed  Europe PubMed DOI  M
    43. 2019
  43. Klose,R., Prinz,A., Tetzlaff,F., Weis,E.M., Moll,I., Rodriguez-Vita,J., Oka,C., Korff,T. and Fischer,A.
    Loss of the serine protease HTRA1 impairs smooth muscle cells maturation
    Sci Rep9, 18224-18224. PubMed  Europe PubMed DOI
  44. Li,C., Jin,W., Wang,X., Li,T., Wang,M. and Cao,B.
    Establishment and identification of a novel HTRA1 mutation mice model
    Rev Cardiovasc Med20, 179-186. PubMed  Europe PubMed DOI  M
  45. Li,Y., Yuan,J., Rothzerg,E., Wu,X., Xu,H., Zhu,S. and Xu,J.
    Molecular structure and the role of high-temperature requirement protein 1 in skeletal disorders and cancers
    Cell Prolife12746-e12746. PubMed  Europe PubMed DOI
  46. Ochiai,N., Nakachi,Y., Yokoo,T., Ichihara,T., Eriksson,T., Yonemoto,Y., Kato,T., Ogata,H., Fujimoto,N., Kobayashi,Y., Udagawa,N., Kaku,S., Ueki,T., Okazaki,Y., Takahashi,N. and Suda,T.
    Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment
    Commun Biol2, 86-86. PubMed  Europe PubMed DOI
  47. Poulsen,E.T., Nielsen,N.S., Scavenius,C., Mogensen,E.H., Risor,M.W., Runager,K., Lukassen,M.V., Rasmussen,C.B., Christiansen,G., Richner,M., Vorum,H. and Enghild,J.J.
    The serine protease HtrA1 cleaves misfolded transforming growth factor beta-induced protein (TGFBIp) and induces amyloid formation
    J Biol Chem294, 11817-11828. PubMed  Europe PubMed DOI
  48. Uemura,M., Nozaki,H., Koyama,A., Sakai,N., Ando,S., Kanazawa,M., Kato,T. and Onodera,O.
    HTRA1 Mutations identified in symptomatic carriers have the property of interfering the trimer-dependent activation cascade
    Front Neurol10, 693-693. PubMed  Europe PubMed DOI  M
    49. 2018
  49. Ito,J., Nozaki,H., Toyoshima,Y., Abe,T., Sato,A., Hashidate,H., Igarashi,S., Onodera,O., Takahashi,H. and Kakita,A.
    Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation
    Neuropathology PubMed  Europe PubMed DOI  M
  50. Klose,R., Adam,M.G., Weis,E.M., Moll,I., Wustehube-Lausch,J., Tetzlaff,F., Oka,C., Ehrmann,M. and Fischer,A.
    Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis
    Oncogene37, 4260-4272. PubMed  Europe PubMed DOI  K
  51. Kono,Y., Nishioka,K., Li,Y., Komatuzaki,Y., Ito,Y., Yoshino,H., Tanaka,R., Iguchi,Y. and Hattori,N.
    Heterozygous HTRA1 mutations with mimicking symptoms of CARASIL in two families
    Clin Neurol Neurosurg172, 174-176. PubMed  Europe PubMed DOI  M
  52. Lee,Y.C., Chung,C.P., Chao,N.C., Fuh,J.L., Chang,F.C., Soong,B.W. and Liao,Y.C.
    Characterization of heterozygous HTRA1 mutations in Taiwanese patients with cerebral small vessel disease
    Stroke49, 1593-1601. PubMed  Europe PubMed DOI  M
  53. Lin,M.K., Yang,J., Hsu,C.W., Gore,A., Bassuk,A.G., Brown,L.M., Colligan,R., Sengillo,J.D., Mahajan,V.B. and Tsang,S.H.
    HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1
    Aging Celle12710-e12710. PubMed  Europe PubMed DOI  M
  54. Melo,E., Oertle,P., Trepp,C., Meistermann,H., Burgoyne,T., Sborgi,L., Cabrera,A.C., Chen,C.Y., Hoflack,J.C., Kam-Thong,T., Schmucki,R., Badi,L., Flint,N., Ghiani,Z.E., Delobel,F., Stucki,C., Gromo,G., Einhaus,A., Hornsperger,B., Golling,S., Siebourg-Polster,J., Gerber,F., Bohrmann,B., Futter,C., Dunkley,T., Hiller,S., Schilling,O., Enzmann,V., Fauser,S., Plodinec,M. and Iacone,R.
    HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
    EBioMedicine27, 258-274. PubMed  Europe PubMed DOI
  55. Sun,M.L., Sun,L.M. and Wang,Y.Q.
    Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes
    J Mol Recognit31, e2698-e2698. PubMed  Europe PubMed DOI  I
  56. Wu,X., Li,C., Mao,J., Li,L., Liu,Y. and Hou,Y.
    Heterozygous HTRA1 missense mutation in CADASIL-like family disease
    Braz J Med Biol Res51, e6632-e6632. PubMed  Europe PubMed DOI  M
  57. Yamawaki,S., Naitoh,M., Kubota,H., Aya,R., Katayama,Y., Ishiko,T., Tamura,T., Yoshikawa,K., Enoshiri,T., Ikeda,M. and Suzuki,S.
    HtrA1 Is specifically up-regulated in active keloid lesions and stimulates keloid development
    Int J Mol Sci19, PubMed  Europe PubMed DOI
  58. Zellner,A., Scharrer,E., Arzberger,T., Oka,C., Domenga-Denier,V., Joutel,A., Lichtenthaler,S.F., Muller,S.A., Dichgans,M. and Haffner,C.
    CADASIL brain vessels show a HTRA1 loss-of-function profile
    Acta Neuropathol136, 111-125. PubMed  Europe PubMed DOI
    59. 2017
  59. Cabrera,A.C., Melo,E., Roth,D., Topp,A., Delobel,F., Stucki,C., Chen,C.Y., Jakob,P., Banfai,B., Dunkley,T., Schilling,O., Huber,S., Iacone,R. and Petrone,P.
    HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
    Sci Rep7, 14804-14804. PubMed  Europe PubMed DOI
  60. Kocher,S., Rey,J., Bongard,J., Tiaden,A.N., Meltzer,M., Richards,P.J., Ehrmann,M. and Kaiser,M.
    Tailored Ahp-cyclodepsipeptides as potent non-covalent serine protease inhibitors
    Angew Chem Int Ed Engl56, 8555-8558. PubMed  Europe PubMed DOI  I
  61. Zurawa-Janicka,D., Wenta,T., Jarzab,M., Skorko-Glonek,J., Glaza,P., Gieldon,A., Ciarkowski,J. and Lipinska,B.
    Structural insights into the activation mechanisms of human HtrA serine proteases
    Arch Biochem Biophys621, 6-23. PubMed  Europe PubMed DOI  V
    62. 2016
  62. Chu,Q., Diedrich,J.K., Vaughan,J.M., Donaldson,C.J., Nunn,M.F., Lee,K.F. and Saghatelian,A.
    HtrA1 proteolysis of ApoE in vitro is allele selective
    J Am Chem Soc138, 9473-9478. PubMed  Europe PubMed DOI  P
  63. Nozaki,H., Kato,T., Nihonmatsu,M., Saito,Y., Mizuta,I., Noda,T., Koike,R., Miyazaki,K., Kaito,M., Ito,S., Makino,M., Koyama,A., Shiga,A., Uemura,M., Sekine,Y., Murakami,A., Moritani,S., Hara,K., Yokoseki,A., Kuwano,R., Endo,N., Momotsu,T., Yoshida,M., Nishizawa,M., Mizuno,T. and Onodera,O.
    Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL
    Neurology86, 1964-1974. PubMed  Europe PubMed DOI  M
    64. 2015
  64. Cai,B., Zeng,J., Lin,Y., Lin,Y., Lin,W., Lin,W., Li,Z. and Wang,N.
    A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population
    Neurol Sci36, 1387-1391. PubMed  Europe PubMed DOI  M
  65. Ciferri,C., Lipari,M.T., Liang,W.-C., Estevez,A., Hang,J., Stawicki,S., Wu,Y., Moran,P., Elliott,M., Eigenbrot,C., Katschke,K.J., VanLookeren Campagne,M. and Kirchhofer,D.
    The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody
    Biochem J472, 169-181. PubMed  Europe PubMed DOI
  66. Khaleeli,Z., Jaunmuktane,Z., Beaufort,N., Houlden,H., Haffner,C., Brandner,S., Dichgans,M. and Werring,D.
    A novel HTRA1 exon 2 mutation causes loss of protease activity in a Pakistani CARASIL patient
    J Neurol262, 1369-1372. PubMed  Europe PubMed DOI  M
  67. Pei,X., Ma,K., Xu,J., Wang,N. and Liu,N.
    Inhibition of cell proliferation and migration after HTRA1 knockdown in retinal pigment epithelial cells
    Graefes Arch Clin Exp Ophthalmol253, 565-572. PubMed  Europe PubMed DOI  K
  68. Verdura,E., Herve,D., Scharrer,E., Amador,M.M., Guyant-Marechal,L., Philippi,A., Corlobe,A., Bergametti,F., Gazal,S., Prieto-Morin,C., Beaufort,N., Le Bail,B., Viakhireva,I., Dichgans,M., Chabriat,H., Haffner,C. and Tournier-Lasserve,E.
    Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease
    Brain138, 2347-2358. PubMed  Europe PubMed DOI  M
    69. 2014
  69. Beaufort,N., Scharrer,E., Kremmer,E., Lux,V., Ehrmann,M., Huber,R., Houlden,H., Werring,D., Haffner,C. and Dichgans,M.
    Cerebral small vessel disease-related protease HtrA1 processes latent TGF-beta binding protein 1 and facilitates TGF-beta signaling
    Proc Natl Acad Sci U S A111, 16496-16501. PubMed  Europe PubMed DOI
  70. Bianchi,S., Di Palma,C., Gallus,G.N., Taglia,I., Poggiani,A., Rosini,F., Rufa,A., Muresanu,D.F., Cerase,A., Dotti,M.T. and Federico,A.
    Two novel HTRA1 mutations in a European CARASIL patient
    Neurology82, 898-900. PubMed  Europe PubMed DOI  M
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