Literature for peptidase S01.277: HtrA1 peptidase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: T Target, M Mutation, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Hagemeier,B., Ripkens,K., Schulze,N., Bluemke,A., Strzala,M., Koci,M., Kaschani,F., Kaiser,M., Erkelenz,M., Schluecker,S., Merdanovic,M., Poepsel,S., Hellerschmied,D., Burston,S.G. and Ehrmann,M. The serine protease HTRA1 targets Tau fibrils and provides a proteolytic barrier against pathogenic protein conformations J Biol Chem (2025) , 110729-110729. PubMed Europe PubMed DOI
Hulleman,J.D., Jeon,S., Bali,S., DiCesare,S.M., Abbas,A., Daniel,S., Ortega,A.J., Collier,G.E., Yang,J., Bhattacharyaa,A., McCoy,M.K., Joachimiak,L.A. and Posner,B.A. Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface ACS Chem Biol (2025) 20, 1849-1862. PubMed Europe PubMed DOI
Yoshimoto,T., Yamagami,H. and Matsumaru,Y. Recent Advances in Stroke Genetics-Unraveling the Complexity of Cerebral Infarction: A Brief Review Genes (Basel) (2025) 16 PubMed Europe PubMed DOI PMC EPMC V

2024

Beaufort,N., Ingendahl,L., Merdanovic,M., Schmidt,A., Podlesainski,D., Richter,T., Neumann,T., Kuszner,M., Vetter,I.R., Stege,P., Burston,S.G., Filipovic,A., Ruiz-Blanco,Y.B., Bravo-Rodriguez,K., Mieres-Perez,J., Beuck,C., Uebel,S., Zobawa,M., Schillinger,J., Malik,R., Todorov-Volgyi,K., Rey,J., Roberti,A., Hagemeier,B., Wefers,B., Muller,S.A., Wurst,W., Sanchez-Garcia,E., Zimmermann,A., Hu,X.Y., Clausen,T., Huber,R., Lichtenthaler,S.F., Schmuck,C., Giese,M., Kaiser,M., Ehrmann,M. and Dichgans,M. Rational correction of pathogenic conformational defects in HTRA1 Nat Commun (2024) 15, 5944-5944. PubMed Europe PubMed DOI PMC EPMC
Chen,S., Puri,A., Bell,B., Fritsche,J., Palacios,H.H., Balch,M., Sprunger,M.L., Howard,M.K., Ryan,J.J., Haines,J.N., Patti,G.J., Davis,A.A. and Jackrel,M.E. HTRA1 disaggregates alpha-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species Nat Commun (2024) 15, 2436-2436. PubMed Europe PubMed DOI PMC EPMC
Dennis,D.G., Joo Sun,Y., Parsons,D.E., Mahajan,V.B. and Smith,M. Identification of highly potent and selective HTRA1 inhibitors Bioorg Med Chem Lett (2024) 109, 129814-129814. PubMed Europe PubMed DOI I
Li,Y., Wei,Y., Ultsch,M., Li,W., Tang,W., Tombling,B., Gao,X., Dimitrova,Y., Gampe,C., Fuhrmann,J., Zhang,Y., Hannoush,R.N. and Kirchhofer,D. Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region Nat Commun (2024) 15, 4359-4359. PubMed Europe PubMed DOI PMC EPMC
Malik,R., Beaufort,N., Li,J., Tanaka,K., Georgakis,M.K., He,Y., Koido,M., Terao,C., Japan,B., Anderson,C.D., Kamatani,Y., Zand,R. and Dichgans,M. Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease Nat Cardiovasc Res (2024) 3, 701-713. PubMed Europe PubMed DOI
Rosochowicz,M.A., Kulcenty,K. and Suchorska,W.M. Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review Mol Diagn Ther (2024) 28, 347-377. PubMed Europe PubMed DOI V
Schillinger,J., Koci,M., Bravo-Rodriguez,K., Heilmann,G., Kaschani,F., Kaiser,M., Beuck,C., Luecke,H., Huber,R., Hellerschmied,D., Burston,S.G. and Ehrmann,M. High resolution analysis of proteolytic substrate processing J Biol Chem (2024) , 107812-107812. PubMed Europe PubMed DOI
Song,S., Li,X., Xue,X., Dong,W. and Li,C. Progress in the Study of the Role and Mechanism of HTRA1 in Diseases Related to Vascular Abnormalities Int J Gen Med (2024) 17, 1479-1491. PubMed Europe PubMed DOI PMC EPMC

2023

Chang,Y.J., Jenny,L.A., Li,Y.S., Cui,X., Kong,Y., Li,Y., Sparrow,J.R. and Tsang,S.H. CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1-related AMD Proc Natl Acad Sci U S A (2023) 120, e2215005120-e2215005120. PubMed Europe PubMed DOI PMC EPMC
He,Z., Wang,L., Zhang,Y., Yin,C. and Niu,Y. Clinical features and pathogenicity assessment in patients with HTRA1-autosomal dominant disease Neurol Sci (2023) 44, 639-647. PubMed Europe PubMed DOI
Murayama,M., Hirata,H., Shiraki,M., Iovanna,J.L., Yamaza,T., Kukita,T., Komori,T., Moriishi,T., Ueno,M., Morimoto,T., Mawatari,M. and Kukita,A. Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice J Cell Physiol (2023) 238, 566-581. PubMed Europe PubMed DOI
Uemura,M., Hatano,Y., Nozaki,H., Ando,S., Kondo,H., Hanazono,A., Iwanaga,A., Murota,H., Osakada,Y., Osaki,M., Kanazawa,M., Kanai,M., Shibata,Y., Saika,R., Miyatake,T., Aizawa,H., Ikeuchi,T., Tomimoto,H., Mizuta,I., Mizuno,T., Ishihara,T. and Onodera,O. High frequency of HTRA1 AND ABCC6 mutations in Japanese patients with adult-onset cerebral small vessel disease J Neurol Neurosurg Psychiatry (2023) 94, 74-81. PubMed Europe PubMed DOI PMC EPMC
Xu,S.Y., Li,H.J., Li,S., Ren,Q.Q., Liang,J.L. and Li,C.X. Heterozygous Pathogenic and Likely Pathogenic Symptomatic HTRA1 Variant Carriers in Cerebral Small Vessel Disease Int J Gen Med (2023) 16, 1149-1162. PubMed Europe PubMed DOI PMC EPMC V

2022

Gerhardy,S., Ultsch,M., Tang,W., Green,E., Holden,J.K., Li,W., Estevez,A., Arthur,C., Tom,I., Rohou,A. and Kirchhofer,D. Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration Nat Commun (2022) 13, 5222-5222. PubMed Europe PubMed DOI PMC EPMC
Guo,H., Guo,X. and Jiang,S. Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL) Bioengineered (2022) 13, 12248-12260. PubMed Europe PubMed DOI PMC EPMC K
Hidalgo Mayoral,I., Martinez-Salio,A., Llamas-Velasco,S., Gomez-Majon,I., Arteche-Lopez,A., Quesada-Espinosa,J.F., Palma Milla,C., Lezana Rosales,J.M., Perez de la Fuente,R., Juarez Rufian,A., Sierra Tomillo,O., Sanchez Calvin,M.T., Gomez Rodriguez,M.J., Ramos Gomez,P., Villarejo-Galende,A., Diaz-Guzman,J., Ortega-Casarrubios,M.A., Calleja-Castano,P. and Moreno-Garcia,M. Hereditary cerebral small vessel disease: Assessment of a HTRA1 variant using protein stability predictors and 3D modelling Eur J Med Genet (2022) 65, 104539-104539. PubMed Europe PubMed DOI
Oka,C., Saleh,R., Bessho,Y. and Reza,H.M. Interplay between HTRA1 and classical signalling pathways in organogenesis and diseases Saudi J Biol Sci (2022) 29, 1919-1927. PubMed Europe PubMed DOI PMC EPMC V
Pan,Y., Fu,Y., Baird,P.N., Guymer,R.H., Das,T. and Iwata,T. Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration Prog Retin Eye Res (2022) , 101159-101159. PubMed Europe PubMed DOI V
Rey,J., Breiden,M., Lux,V., Bluemke,A., Steindel,M., Ripkens,K., Mollers,B., Bravo Rodriguez,K., Boisguerin,P., Volkmer,R., Mieres-Perez,J., Clausen,T., Sanchez-Garcia,E. and Ehrmann,M. An allosteric HTRA1-calpain 2 complex with restricted activation profile Proc Natl Acad Sci U S A (2022) 119, e2113520119-e2113520119. PubMed Europe PubMed DOI
Tossetta,G., Fantone,S., Licini,C., Marzioni,D. and Mattioli-Belmonte,M. The multifaced role of HtrA1 in the development of joint and skeletal disorders Bone (2022) 157, 116350-116350. PubMed Europe PubMed DOI V
Wilkinson,D.J. The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing? Osteoarthritis Cartilage (2022) PubMed Europe PubMed DOI
Yao,T., Zhu,J., Wu,X., Li,X., Fu,Y., Wang,Y., Wang,Z., Xu,F., Lai,H., He,A., Teng,L., Wang,C. and Song,H. Heterozygous HTRA1 Mutations Cause Cerebral Small Vessel Diseases: Genetic, Clinical, and Pathologic Findings From 3 Chinese Pedigrees Neurol Genet (2022) 8, e200044-e200044. PubMed Europe PubMed DOI PMC EPMC
Yoshida,K., Kusama,K., Azumi,M., Yoshie,M., Kato,K. and Tamura,K. Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts J Pharmacol Sci (2022) 150, 267-274. PubMed Europe PubMed DOI
Zhang,C., Zheng,H., Li,X., Li,S., Li,W., Wang,Z., Niu,S., Wang,X. and Zhang,Z. Novel mutations in HTRA1-related cerebral small vessel disease and comparison with CADASIL Ann Clin Transl Neurol (2022) 9, 1586-1595. PubMed Europe PubMed DOI PMC EPMC
Zhou,H., Jiao,B., Ouyang,Z., Wu,Q., Shen,L. and Fang,L. Report of two pedigrees with heterozygous HTRA1 variants-related cerebral small vessel disease and literature review Mol Genet Genomic Med (2022) 10, e2032-e2032. PubMed Europe PubMed DOI PMC EPMC

2021

Al-Rabadi,L.F., Caza,T., Trivin-Avillach,C., Rodan,A.R., Andeen,N., Hayashi,N., Williams,B., Revelo,M.P., Clayton,F., Abraham,J., Lin,E., Liou,W., Zou,C.J., Ramkumar,N., Cummins,T., Wilkey,D.W., Kawalit,I., Herzog,C., Storey,A., Edmondson,R., Sjoberg,R., Yang,T., Chien,J., Merchant,M., Arthur,J., Klein,J., Larsen,C. and Beck,L.H., Jr. Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy J Am Soc Nephrol (2021) PubMed Europe PubMed DOI
Campbell,R.A., Campbell,H.D., Bircher,J.S., de Araujo,C.V., Denorme,F., Crandell,J.L., Rustad,J.L., Monts,J., Cody,M.J., Kosaka,Y. and Yost,C.C. Placental HTRA1 cleaves alpha-1-antitrypsin to generate a NET-Inhibitory Peptide Blood (2021) PubMed Europe PubMed DOI
Chen,M., Yang,S., Wu,Y., Zhao,Z., Zhai,X. and Dong,D. High temperature requirement A1 in cancer: biomarker and therapeutic target Cancer Cell Int (2021) 21, 513-513. PubMed Europe PubMed DOI PMC EPMC
Fantone,S., Giannubilo,S.R., Marzioni,D. and Tossetta,G. HTRA family proteins in pregnancy outcome Tissue Cell (2021) 72, 101549-101549. PubMed Europe PubMed DOI
Grigaite,J., Siauryte,K., Audronyte,E., Preiksaitiene,E., Burnyte,B., Pranckeviciene,E., Ekkert,A., Utkus,A. and Jatuzis,D. Novel In-Frame Deletion in HTRA1 Gene, Responsible for Stroke at a Young Age and Dementia-A Case Study Genes (Basel) (2021) 12 PubMed Europe PubMed DOI PMC EPMC
Lu,Z.G., May,A., Dinh,B., Lin,V., Su,F., Tran,C., Adivikolanu,H., Ehlen,R., Che,B., Wang,Z.H., Shaw,D.H., Borooah,S. and Shaw,P.X. The interplay of oxidative stress and ARMS2-HTRA1 genetic risk in neovascular AMD Vessel Plus (2021) 5 PubMed Europe PubMed DOI PMC EPMC V
Malik,R., Beaufort,N., Frerich,S., Gesierich,B., Georgakis,M.K., Rannikmae,K., Ferguson,A.C., Haffner,C., Traylor,M., Ehrmann,M., Sudlow,C.L.M. and Dichgans,M. Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities Brain (2021) 144, 2670-2682. PubMed Europe PubMed DOI PMC EPMC
Pan,Y., Iejima,D., Nakayama,M., Suga,A., Noda,T., Kaur,I., Das,T., Chakrabarti,S., Guymer,R.H., Deangelis,M.M., Yamamoto,M., Baird,P.N. and Iwata,T. Binding of Gtf2i-beta/delta transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro J Biol Chem (2021) , 100456-100456. PubMed Europe PubMed DOI
Williams,B.L., Seager,N.A., Gardiner,J.D., Pappas,C.M., Cronin,M.C., Amat di San Filippo,C., Anstadt,R.A., Liu,J., Toso,M.A., Nichols,L., Parnell,T.J., Eve,J.R., Bartel,P.L., Zouache,M.A., Richards,B.T. and Hageman,G.S. Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI PMC EPMC M

2020

Fasano,A., Formichi,P., Taglia,I., Bianchi,S., Di Donato,I., Battisti,C., Federico,A. and Dotti,M.T. HTRA1 expression profile and activity on TGF-beta signaling in HTRA1 mutation carriers J Cell Physiol (2020) PubMed Europe PubMed DOI M
Merdanovic,M., Burston,S.G., Schmitz,A.L., Kocher,S., Knapp,S., Clausen,T., Kaiser,M., Huber,R. and Ehrmann,M. Activation by substoichiometric inhibition Proc Natl Acad Sci U S A (2020) 117, 1414-1418. PubMed Europe PubMed DOI
Nam,H.Y., Song,D., Eo,J., Choi,N.E., Hong,J.A., Hong,K.T., Lee,J.S., Seo,J. and Lee,J. Activity-Based Probes for the High Temperature Requirement A Serine Proteases ACS Chem Biol (2020) PubMed Europe PubMed DOI
Ohta,K., Ozawa,T., Fujinaka,H., Goto,K. and Nakajima,T. Cerebral small vessel disease related to a heterozygous nonsense mutation in HTRA1 Intern Med (2020) 59, 1309-1313. PubMed Europe PubMed DOI M
Sabino,F., Madzharova,E. and auf dem Keller,U. Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival Cell Death Dis (2020) 11, 674-674. PubMed Europe PubMed DOI PMC EPMC
Uemura,M., Nozaki,H., Kato,T., Koyama,A., Sakai,N., Ando,S., Kanazawa,M., Hishikawa,N., Nishimoto,Y., Polavarapu,K., Nalini,A., Hanazono,A., Kuzume,D., Shindo,A., El-Ghanem,M., Abe,A., Sato,A., Yoshida,M., Ikeuchi,T., Mizuta,I., Mizuno,T. and Onodera,O. HTRA1-Related Cerebral Small Vessel Disease: A Review of the Literature Front Neurol (2020) 11, 545-545. PubMed Europe PubMed DOI PMC EPMC V
Zhuo,Z.L., Cong,L., Zhang,J. and Zhao,X.T. A novel heterozygous HTRA1 mutation is associated with autosomal dominant hereditary cerebral small vessel disease Mol Genet Genomic Med (2020) , e1111-e1111. PubMed Europe PubMed DOI M

2019

Klose,R., Prinz,A., Tetzlaff,F., Weis,E.M., Moll,I., Rodriguez-Vita,J., Oka,C., Korff,T. and Fischer,A. Loss of the serine protease HTRA1 impairs smooth muscle cells maturation Sci Rep (2019) 9, 18224-18224. PubMed Europe PubMed DOI
Li,C., Jin,W., Wang,X., Li,T., Wang,M. and Cao,B. Establishment and identification of a novel HTRA1 mutation mice model Rev Cardiovasc Med (2019) 20, 179-186. PubMed Europe PubMed DOI M
Li,Y., Yuan,J., Rothzerg,E., Wu,X., Xu,H., Zhu,S. and Xu,J. Molecular structure and the role of high-temperature requirement protein 1 in skeletal disorders and cancers Cell Prolif (2019) , e12746-e12746. PubMed Europe PubMed DOI
Ochiai,N., Nakachi,Y., Yokoo,T., Ichihara,T., Eriksson,T., Yonemoto,Y., Kato,T., Ogata,H., Fujimoto,N., Kobayashi,Y., Udagawa,N., Kaku,S., Ueki,T., Okazaki,Y., Takahashi,N. and Suda,T. Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment Commun Biol (2019) 2, 86-86. PubMed Europe PubMed DOI PMC EPMC
Poulsen,E.T., Nielsen,N.S., Scavenius,C., Mogensen,E.H., Risor,M.W., Runager,K., Lukassen,M.V., Rasmussen,C.B., Christiansen,G., Richner,M., Vorum,H. and Enghild,J.J. The serine protease HtrA1 cleaves misfolded transforming growth factor beta-induced protein (TGFBIp) and induces amyloid formation J Biol Chem (2019) 294, 11817-11828. PubMed Europe PubMed DOI
Uemura,M., Nozaki,H., Koyama,A., Sakai,N., Ando,S., Kanazawa,M., Kato,T. and Onodera,O. HTRA1 Mutations identified in symptomatic carriers have the property of interfering the trimer-dependent activation cascade Front Neurol (2019) 10, 693-693. PubMed Europe PubMed DOI PMC EPMC M

2018

Ito,J., Nozaki,H., Toyoshima,Y., Abe,T., Sato,A., Hashidate,H., Igarashi,S., Onodera,O., Takahashi,H. and Kakita,A. Histopathologic features of an autopsied patient with cerebral small vessel disease and a heterozygous HTRA1 mutation Neuropathology (2018) PubMed Europe PubMed DOI M
Klose,R., Adam,M.G., Weis,E.M., Moll,I., Wustehube-Lausch,J., Tetzlaff,F., Oka,C., Ehrmann,M. and Fischer,A. Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis Oncogene (2018) 37, 4260-4272. PubMed Europe PubMed DOI K
Kono,Y., Nishioka,K., Li,Y., Komatuzaki,Y., Ito,Y., Yoshino,H., Tanaka,R., Iguchi,Y. and Hattori,N. Heterozygous HTRA1 mutations with mimicking symptoms of CARASIL in two families Clin Neurol Neurosurg (2018) 172, 174-176. PubMed Europe PubMed DOI M
Lee,Y.C., Chung,C.P., Chao,N.C., Fuh,J.L., Chang,F.C., Soong,B.W. and Liao,Y.C. Characterization of heterozygous HTRA1 mutations in Taiwanese patients with cerebral small vessel disease Stroke (2018) 49, 1593-1601. PubMed Europe PubMed DOI M
Lin,M.K., Yang,J., Hsu,C.W., Gore,A., Bassuk,A.G., Brown,L.M., Colligan,R., Sengillo,J.D., Mahajan,V.B. and Tsang,S.H. HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1 Aging Cell (2018) , e12710-e12710. PubMed Europe PubMed DOI M
Melo,E., Oertle,P., Trepp,C., Meistermann,H., Burgoyne,T., Sborgi,L., Cabrera,A.C., Chen,C.Y., Hoflack,J.C., Kam-Thong,T., Schmucki,R., Badi,L., Flint,N., Ghiani,Z.E., Delobel,F., Stucki,C., Gromo,G., Einhaus,A., Hornsperger,B., Golling,S., Siebourg-Polster,J., Gerber,F., Bohrmann,B., Futter,C., Dunkley,T., Hiller,S., Schilling,O., Enzmann,V., Fauser,S., Plodinec,M. and Iacone,R. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model EBioMedicine (2018) 27, 258-274. PubMed Europe PubMed DOI
Sun,M.L., Sun,L.M. and Wang,Y.Q. Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes J Mol Recognit (2018) 31, e2698-e2698. PubMed Europe PubMed DOI I
Wu,X., Li,C., Mao,J., Li,L., Liu,Y. and Hou,Y. Heterozygous HTRA1 missense mutation in CADASIL-like family disease Braz J Med Biol Res (2018) 51, e6632-e6632. PubMed Europe PubMed DOI M
Yamawaki,S., Naitoh,M., Kubota,H., Aya,R., Katayama,Y., Ishiko,T., Tamura,T., Yoshikawa,K., Enoshiri,T., Ikeda,M. and Suzuki,S. HtrA1 Is specifically up-regulated in active keloid lesions and stimulates keloid development Int J Mol Sci (2018) 19 PubMed Europe PubMed DOI
Zellner,A., Scharrer,E., Arzberger,T., Oka,C., Domenga-Denier,V., Joutel,A., Lichtenthaler,S.F., Muller,S.A., Dichgans,M. and Haffner,C. CADASIL brain vessels show a HTRA1 loss-of-function profile Acta Neuropathol (2018) 136, 111-125. PubMed Europe PubMed DOI

2017

Cabrera,A.C., Melo,E., Roth,D., Topp,A., Delobel,F., Stucki,C., Chen,C.Y., Jakob,P., Banfai,B., Dunkley,T., Schilling,O., Huber,S., Iacone,R. and Petrone,P. HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication Sci Rep (2017) 7, 14804-14804. PubMed Europe PubMed DOI PMC EPMC
Kocher,S., Rey,J., Bongard,J., Tiaden,A.N., Meltzer,M., Richards,P.J., Ehrmann,M. and Kaiser,M. Tailored Ahp-cyclodepsipeptides as potent non-covalent serine protease inhibitors Angew Chem Int Ed Engl (2017) 56, 8555-8558. PubMed Europe PubMed DOI I
Zurawa-Janicka,D., Wenta,T., Jarzab,M., Skorko-Glonek,J., Glaza,P., Gieldon,A., Ciarkowski,J. and Lipinska,B. Structural insights into the activation mechanisms of human HtrA serine proteases Arch Biochem Biophys (2017) 621, 6-23. PubMed Europe PubMed DOI V

2016

Chu,Q., Diedrich,J.K., Vaughan,J.M., Donaldson,C.J., Nunn,M.F., Lee,K.F. and Saghatelian,A. HtrA1 proteolysis of ApoE in vitro is allele selective J Am Chem Soc (2016) 138, 9473-9478. PubMed Europe PubMed DOI P
Nozaki,H., Kato,T., Nihonmatsu,M., Saito,Y., Mizuta,I., Noda,T., Koike,R., Miyazaki,K., Kaito,M., Ito,S., Makino,M., Koyama,A., Shiga,A., Uemura,M., Sekine,Y., Murakami,A., Moritani,S., Hara,K., Yokoseki,A., Kuwano,R., Endo,N., Momotsu,T., Yoshida,M., Nishizawa,M., Mizuno,T. and Onodera,O. Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL Neurology (2016) 86, 1964-1974. PubMed Europe PubMed DOI M

2015

Cai,B., Zeng,J., Lin,Y., Lin,Y., Lin,W., Lin,W., Li,Z. and Wang,N. A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population Neurol Sci (2015) 36, 1387-1391. PubMed Europe PubMed DOI M
Ciferri,C., Lipari,M.T., Liang,W.-C., Estevez,A., Hang,J., Stawicki,S., Wu,Y., Moran,P., Elliott,M., Eigenbrot,C., Katschke,K.J., VanLookeren Campagne,M. and Kirchhofer,D. The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody Biochem J (2015) 472, 169-181. PubMed Europe PubMed DOI
Khaleeli,Z., Jaunmuktane,Z., Beaufort,N., Houlden,H., Haffner,C., Brandner,S., Dichgans,M. and Werring,D. A novel HTRA1 exon 2 mutation causes loss of protease activity in a Pakistani CARASIL patient J Neurol (2015) 262, 1369-1372. PubMed Europe PubMed DOI M
Pei,X., Ma,K., Xu,J., Wang,N. and Liu,N. Inhibition of cell proliferation and migration after HTRA1 knockdown in retinal pigment epithelial cells Graefes Arch Clin Exp Ophthalmol (2015) 253, 565-572. PubMed Europe PubMed DOI K
Verdura,E., Herve,D., Scharrer,E., Amador,M.M., Guyant-Marechal,L., Philippi,A., Corlobe,A., Bergametti,F., Gazal,S., Prieto-Morin,C., Beaufort,N., Le Bail,B., Viakhireva,I., Dichgans,M., Chabriat,H., Haffner,C. and Tournier-Lasserve,E. Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease Brain (2015) 138, 2347-2358. PubMed Europe PubMed DOI M

2014

Beaufort,N., Scharrer,E., Kremmer,E., Lux,V., Ehrmann,M., Huber,R., Houlden,H., Werring,D., Haffner,C. and Dichgans,M. Cerebral small vessel disease-related protease HtrA1 processes latent TGF-beta binding protein 1 and facilitates TGF-beta signaling Proc Natl Acad Sci U S A (2014) 111, 16496-16501. PubMed Europe PubMed DOI
Bianchi,S., Di Palma,C., Gallus,G.N., Taglia,I., Poggiani,A., Rosini,F., Rufa,A., Muresanu,D.F., Cerase,A., Dotti,M.T. and Federico,A. Two novel HTRA1 mutations in a European CARASIL patient Neurology (2014) 82, 898-900. PubMed Europe PubMed DOI M
Chen,Y.Y., Chuang,P.Y., Chen,C.P., Chiu,Y.H., Lo,H.F., Cheong,M.L., Huang,J.Y., Kuo,P.L. and Chen,H. Functional antagonism between high temperature requirement protein A (HtrA) family members regulates trophoblast invasion J Biol Chem (2014) 289, 22958-22968. PubMed Europe PubMed DOI
Frochaux,V., Hildebrand,D., Talke,A., Linscheid,M.W. and Schluter,H. Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue PLoS ONE (2014) 9, e109483-e109483. PubMed Europe PubMed DOI PMC EPMC
Jo,H., Patterson,V., Stoessel,S., Kuan,C.Y. and Hoh,J. Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease PLoS ONE (2014) 9, e115362-e115362. PubMed Europe PubMed DOI
Risor,M.W., Poulsen,E.T., Thomsen,L.R., Dyrlund,T.F., Nielsen,T.A., Nielsen,N.C., Sanggaard,K.W. and Enghild,J.J. The autolysis of human HtrA1 is governed by the redox state of its N-terminal domain Biochemistry (2014) 53, 3851-3857. PubMed Europe PubMed DOI

2013

Akhatib,B., Onnerfjord,P., Gawri,R., Ouellet,J., Jarzem,P., Heinegard,D., Mort,J., Roughley,P. and Haglund,L. Chondroadherin fragmentation mediated by the protease HTRA1 distinguishes human intervertebral disc degeneration from normal aging J Biol Chem (2013) 288, 19280-19287. PubMed Europe PubMed DOI
Chen,Y., He,Z., Meng,S., Li,L., Yang,H. and Zhang,X. A novel mutation of the high-temperature requirement A serine peptidase 1 (HTRA1) gene in a Chinese family with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) J Int Med Res (2013) 41, 1445-1455. PubMed Europe PubMed DOI M
Furtwangler,T., Chan,S.C., Bahrenberg,G., Richards,P.J. and Gantenbein-Ritter,B. Assessment of the matrix degenerative effects of MMP-3, ADAMTS-4, and HTRA1, injected into a bovine Intervertebral disc organ culture model Spine (Phila Pa 1976) (2013) 38, E1377-E1387. PubMed Europe PubMed DOI
Graham,J.R., Chamberland,A., Lin,Q., Li,X.J., Dai,D., Zeng,W., Ryan,M.S., Rivera-Bermudez,M.A., Flannery,C.R. and Yang,Z. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation PLoS ONE (2013) 8, e74094-e74094. PubMed Europe PubMed DOI PMC EPMC
Karring,H., Poulsen,E.T., Runager,K., Thogersen,I.B., Klintworth,G.K., Hojrup,P. and Enghild,J.J. Serine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid deposits Mol Vision (2013) 19, 861-876. PubMed Europe PubMed
Skorko-Glonek,J., Zurawa-Janicka,D., Koper,T., Jarzab,M., Figaj,D., Glaza,P. and Lipinska,B. HtrA protease family as therapeutic targets Curr Pharm Des (2013) 19, 977-1009. PubMed Europe PubMed V
Xia,J., Wang,F., Wang,L. and Fan,Q. Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-kappaB signaling pathway Tumour Biol (2013) 34, 317-328. PubMed Europe PubMed DOI

2012

Chien,J. and Shridhar,V. HtrA1 peptidase [ISSN:978-0-12-407742-3] (2012) 3, 2577-2584. DOI
Eigenbrot,C., Ultsch,M., Lipari,M.T., Moran,P., Lin,S.J., Ganesan,R., Quan,C., Tom,J., Sandoval,W., van Lookeren Campagne,M. and Kirchhofer,D. Structural and functional analysis of HtrA1 and its subdomains Structure (2012) 20, 1040-1050. PubMed Europe PubMed DOI
Nozaki,H. [Consideration of the pathogenesis of CARASIL] Rinsho Shinkeigaku (2012) 52, 1360-1362. PubMed Europe PubMed DOI M
Tennstaedt,A., Popsel,S., Truebestein,L., Hauske,P., Brockmann,A., Schmidt,N., Irle,I., Sacca,B., Niemeyer,C.M., Brandt,R., Ksiezak-Reding,H., Tirniceriu,A.L., Egensperger,R., Baldi,A., Dehmelt,L., Kaiser,M., Huber,R., Clausen,T. and Ehrmann,M. Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates J Biol Chem (2012) 287, 20931-20941. PubMed Europe PubMed DOI
Tiaden,A.N., Klawitter,M., Lux,V., Mirsaidi,A., Bahrenberg,G., Glanz,S., Quero,L., Liebscher,T., Wuertz,K., Ehrmann,M. and Richards,P.J. Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration J Biol Chem (2012) 287, 21335-21345. PubMed Europe PubMed DOI
Tiaden,A.N., Breiden,M., Mirsaidi,A., Weber,F.A., Bahrenberg,G., Glanz,S., Cinelli,P., Ehrmann,M. and Richards,P.J. Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein Stem Cells (2012) 30, 2271-2282. PubMed Europe PubMed DOI

2011

Campioni,M., Severino,A., Manente,L., De Luca,A., La Porta,R., Vitiello,A., Fiore,P., Toldo,S., Spugnini,E.P., Paggi,M.G. and Baldi,A. Identification of protein-protein interactions of human HtrA1 Front Biosci (Elite Ed) (2011) 3, 1493-1499. PubMed Europe PubMed
Clausen,T., Kaiser,M., Huber,R. and Ehrmann,M. HTRA proteases: regulated proteolysis in protein quality control Nat Rev Mol Cell Biol (2011) 12, 152-162. PubMed Europe PubMed DOI V
Fukutake,T. [CARASIL] Brain Nerve (2011) 63, 99-108. PubMed Europe PubMed M
Jones,A., Kumar,S., Zhang,N., Tong,Z., Yang,J.H., Watt,C., Anderson,J., Amrita, Fillerup,H., McCloskey,M., Luo,L., Yang,Z., Ambati,B., Marc,R., Oka,C., Zhang,K. and Fu,Y. Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice Proc Natl Acad Sci U S A (2011) 108, 14578-14583. PubMed Europe PubMed DOI
Mullany,S.A., Moslemi-Kebria,M., Rattan,R., Khurana,A., Clayton,A., Ota,T., Mariani,A., Podratz,K.C., Chien,J. and Shridhar,V. Expression and functional significance of HtrA1 loss in endometrial cancer Clin Cancer Res (2011) 17, 427-436. PubMed Europe PubMed DOI
Onodera,O. [TGF-beta family signaling contributes to human cerebral small vessel disease] Rinsho Shinkeigaku (2011) 51, 943-944. PubMed Europe PubMed DOI M
Shiga,A., Nozaki,H., Yokoseki,A., Nihonmatsu,M., Kawata,H., Kato,T., Koyama,A., Arima,K., Ikeda,M., Katada,S., Toyoshima,Y., Takahashi,H., Tanaka,A., Nakano,I., Ikeuchi,T., Nishizawa,M. and Onodera,O. Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-beta1 via cleavage of proTGF-beta1 Hum Mol Genet (2011) 20, 1800-1810. PubMed Europe PubMed DOI M
Truebestein,L., Tennstaedt,A., Monig,T., Krojer,T., Canellas,F., Kaiser,M., Clausen,T. and Ehrmann,M. Substrate-induced remodeling of the active site regulates human HTRA1 activity Nat Struct Mol Biol (2011) 18, 386-388. PubMed Europe PubMed DOI
Turunen,M., Vepsalainen,S., Makinen,P., Helisalmi,S., Haapasalo,A., Soininen,H. and Hiltunen,M. No association between high temperature requirement 1 (HTRA1) gene polymorphisms and Alzheimer's disease Neurobiol Aging (2011) 32, 547-547. PubMed Europe PubMed DOI

2010

An,E., Sen,S., Park,S.K., Gordish-Dressman,H. and Hathout,Y. Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome Invest Ophthalmol Vis Sci (2010) 51, 3379-3386. PubMed Europe PubMed DOI P
Campioni,M., Severino,A., Manente,L., Tuduce,I.L., Toldo,S., Caraglia,M., Crispi,S., Ehrmann,M., He,X., Maguire,J., De Falco,M., De Luca,A., Shridhar,V. and Baldi,A. The serine protease HtrA1 specifically interacts and degrades the Tuberous Sclerosis Complex 2 protein Mol Cancer Res (2010) 8, 1248-1260. PubMed Europe PubMed DOI
Polur,I., Lee,P.L., Servais,J.M., Xu,L. and Li,Y. Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration Histol Histopathol (2010) 25, 599-608. PubMed Europe PubMed

2009

Chamberland,A., Wang,E., Jones,A.R., Collins-Racie,L.A., LaVallie,E.R., Huang,Y., Liu,L., Morris,E.A., Flannery,C.R. and Yang,Z. Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo J Biol Chem (2009) 284, 27352-27359. PubMed Europe PubMed DOI P
Chien,J., He,X. and Shridhar,V. Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening J Cell Biochem (2009) 107, 253-263. PubMed Europe PubMed DOI P
Chien,J., Campioni,M., Shridhar,V. and Baldi,A. HtrA serine proteases as potential therapeutic targets in cancer Curr Cancer Drug Targets (2009) 9, 451-468. PubMed Europe PubMed DOI T
Chien,J., Ota,T., Aletti,G., Shridhar,R., Boccellino,M., Quagliuolo,L., Baldi,A. and Shridhar,V. Serine protease HtrA1 associates with microtubules and inhibits cell migration Mol Cell Biol (2009) 29, 4177-4187. PubMed Europe PubMed DOI PMC EPMC
Hara,K., Shiga,A., Fukutake,T., Nozaki,H., Miyashita,A., Yokoseki,A., Kawata,H., Koyama,A., Arima,K., Takahashi,T., Ikeda,M., Shiota,H., Tamura,M., Shimoe,Y., Hirayama,M., Arisato,T., Yanagawa,S., Tanaka,A., Nakano,I., Ikeda,S., Yoshida,Y., Yamamoto,T., Ikeuchi,T., Kuwano,R., Nishizawa,M., Tsuji,S. and Onodera,O. Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease N Engl J Med (2009) 360, 1729-1739. PubMed Europe PubMed DOI M

2008

Clawson,G.A., Bui,V., Xin,P., Wang,N. and Pan,W. Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins J Cell Biochem (2008) 105, 81-88. PubMed Europe PubMed DOI
Deangelis,M.M., Ji,F., Adams,S., Morrison,M.A., Harring,A.J., Sweeney,M.O., Capone,A., Jr., Miller,J.W., Dryja,T.P., Ott,J. and Kim,I.K. Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration Ophthalmology (2008) 115, 1209-1215. PubMed Europe PubMed DOI M
Ferrer-Vaquer,A., Maurey,P., Werzowa,J., Firnberg,N., Leibbrandt,A. and Neubuser,A. Expression and regulation of HTRA1 during chick and early mouse development Dev Dyn (2008) 237, 1893-1900. PubMed Europe PubMed DOI
Hadfield,K.D., Rock,C.F., Inkson,C.A., Dallas,S.L., Sudre,L., Wallis,G.A., Boot-Handford,R.P. and Canfield,A.E. HTRA1 inhibits mineral deposition by osteoblasts: requirement for the protease and PDZ domains J Biol Chem (2008) 283, 5928-5938. PubMed Europe PubMed DOI
Launay,S., Maubert,E., Lebeurrier,N., Tennstaedt,A., Campioni,M., Docagne,F., Gabriel,C., Dauphinot,L., Potier,M.C., Ehrmann,M., Baldi,A. and Vivien,D. HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival Cell Death Differ (2008) 15, 1408-1416. PubMed Europe PubMed DOI

2007

Canfield,A.E., Hadfield,K.D., Rock,C.F., Wylie,E.C. and Wilkinson,F.L. HtrA1: a novel regulator of physiological and pathological matrix mineralization? Biochem Soc Trans (2007) 35, 669-671. PubMed Europe PubMed DOI K
DeWan,A., Bracken,M.B. and Hoh,J. Two genetic pathways for age-related macular degeneration Curr Opin Genet Dev (2007) 17, 228-233. PubMed Europe PubMed DOI M
Gallagher,J. Messages in the matrix: proteoglycans go the distance Dev Cell (2007) 13, 166-167. PubMed Europe PubMed DOI
Gilicze,A., Kohalmi,B., Pocza,P., Keszei,M., Jaeger,J., Gorbe,E., Papp,Z., Toth,S., Falus,A. and Wiener,Z. HtrA1 is a novel mast cell serine protease of mice and men Mol Immunol (2007) 44, 2961-2968. PubMed Europe PubMed DOI
Hou,S., Maccarana,M., Min,T.H., Strate,I. and Pera,E.M. The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo Dev Cell (2007) 13, 226-241. PubMed Europe PubMed DOI
Runyon,S.T., Zhang,Y., Appleton,B.A., Sazinsky,S.L., Wu,P., Pan,B., Wiesmann,C., Skelton,N.J. and Sidhu,S.S. Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3 Protein Sci (2007) 16, 2454-2471. PubMed Europe PubMed DOI PMC EPMC

2006

[YEAR:8-6-2006]Chien,J., Aletti,G., Baldi,A., Catalano,V., Muretto,P., Keeney,G.L., Kalli,K.R., Staub,J., Ehrmann,M., Cliby,W.A., Lee,Y.K., Bible,K.C., Hartmann,L.C., Kaufmann,S.H. and Shridhar,V. Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity J Clin Invest (8-6-2006) 116, 1994-2004. PubMed Europe PubMed DOI PMC EPMC
[YEAR:19-10-2006]DeWan,A., Liu,M., Hartman,S., Zhang,S.S., Liu,D.T., Zhao,C., Tam,P.O., Chan,W.M., Lam,D.S., Snyder,M., Barnstable,C., Pang,C.P. and Hoh,J. HTRA1 promoter polymorphism in wet age-related macular degeneration Science (19-10-2006) 314, 989-992. PubMed Europe PubMed DOI M
[YEAR:19-10-2006]Yang,Z., Camp,N.J., Sun,H., Tong,Z., Gibbs,D., Cameron,D.J., Chen,H., Zhao,Y., Pearson,E., Li,X., Chien,J., DeWan,A., Harmon,J., Bernstein,P.S., Shridhar,V., Zabriskie,N.A., Hoh,J., Howes,K. and Zhang,K. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration Science (19-10-2006) 314, 992-993. PubMed Europe PubMed DOI

2005

[YEAR:26-4-2005]Grau,S., Baldi,A., Bussani,R., Tian,X., Stefanescu,R., Przybylski,M., Richards,P., Jones,S.A., Shridhar,V., Clausen,T. and Ehrmann,M. Implications of the serine protease HtrA1 in amyloid precursor protein processing Proc Natl Acad Sci U S A (26-4-2005) 102, 6021-6026. PubMed Europe PubMed DOI PMC EPMC
[YEAR:28-4-2005]Nie,G., Li,Y. and Salamonsen,L.A. Serine protease HtrA1 is developmentally regulated in trophoblast and uterine decidual cells during placental formation in the mouse Dev Dyn (28-4-2005) 233, 1102-1109. PubMed Europe PubMed DOI
[YEAR:29-6-2005]Tsuchiya,A., Yano,M., Tocharus,J., Kojima,H., Fukumoto,M., Kawaichi,M. and Oka,C. Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis Bone (29-6-2005) 37, 323-336. PubMed Europe PubMed DOI

2004

[YEAR:26-2-2004]Chien,J., Staub,J., Hu,S.I., Erickson-Johnson,M.R., Couch,F.J., Smith,D.I., Crowl,R.M., Kaufmann,S.H. and Shridhar,V. A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer Oncogene (26-2-2004) 23, 1636-1644. PubMed Europe PubMed DOI
De Luca,A., De Falco,M., Fedele,V., Cobellis,L., Mastrogiacomo,A., Laforgia,V., Tuduce,I.L., Campioni,M., Giraldi,D., Paggi,M.G. and Baldi,A. The serine protease HtrA1 is upregulated in the human placenta during pregnancy J Histochem Cytochem (2004) 52, 885-892. PubMed Europe PubMed DOI
Dingwall,C. and Holbrook,J.D. Human HtrA proteases [ISSN:0-12-079610-4] (2004) 2, 1476-1480. V
[YEAR:22-4-2004]Murwantoko, Yano,M., Ueta,Y., Murasaki,A., Kanda,H., Oka,C. and Kawaichi,M. Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease Biochem J (22-4-2004) 381, 895-904. PubMed Europe PubMed DOI PMC EPMC
Oka,C., Tsujimoto,R., Kajikawa,M., Koshiba-Takeuchi,K., Ina,J., Yano,M., Tsuchiya,A., Ueta,Y., Soma,A., Kanda,H., Matsumoto,M. and Kawaichi,M. HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins Development (2004) 131, 1041-1053. PubMed Europe PubMed DOI

2003

De Luca,A., De Falco,M., Severino,A., Campioni,M., Santini,D., Baldi,F., Paggi,M.G. and Baldi,A. Distribution of the serine protease HtrA1 in normal human tissues J Histochem Cytochem (2003) 51, 1279-1284. PubMed Europe PubMed
Nie,G.Y., Li,Y., Minoura,H., Batten,L., Ooi,G.T., Findlay,J.K. and Salamonsen,L.A. A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation Mol Hum Reprod (2003) 9, 279-290. PubMed Europe PubMed

2002

[YEAR:26-9-2002]Baldi,A., De Luca,A., Morini,M., Battista,T., Felsani,A., Baldi,F., Catricala,C., Amantea,A., Noonan,D.M., Albini,A., Natali,P.G., Lombardi,D. and Paggi,M.G. The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells Oncogene (26-9-2002) 21, 6684-6688. PubMed Europe PubMed DOI

1997

Zumbrunn,J. and Trueb,B. Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2 Genomics (1997) 45, 461-462. PubMed Europe PubMed DOI

1996

[YEAR:2-12-1996]Zumbrunn,J. and Trueb,B. Primary structure of a putative serine protease specific for IGF-binding proteins FEBS Lett (2-12-1996) 398, 187-192. PubMed Europe PubMed DOI