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Literature for peptidase S01.258: trypsin-2 type A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: M Mutation, P Specificity, K Knockout, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Lu,H., Zhao,Z., Yu,H., Iqbal,A. and Jiang,P.
    The serine protease 2 gene regulates lipid metabolism through the LEP/ampkalpha1/SREBP1 pathway in bovine mammary epithelial cells
    Biochem Biophys Res Commun698, 149558-149558. PubMed  Europe PubMed DOI
  2. Moreau,T., Recoules,E., De Pauw,M., Labas,V. and Rehault-Godbert,S.
    Evidence that the Bowman-Birk inhibitor from Pisum sativum affects intestinal proteolytic activities in chickens
    Poult Sci103, 103182-103182. PubMed  Europe PubMed DOI  L
    3. 2023
  3. Barresi,V., Di Bella,V., Lo Nigro,L., Privitera,A.P., Bonaccorso,P., Scuderi,C. and Condorelli,D.F.
    Temporary serine protease inhibition and the role of SPINK2 in human bone marrow
    iScience26, 106949-106949. PubMed  Europe PubMed DOI
    4. 2022
  4. Chen,Y., Wang,B., Zhao,Z., Li,M. and Wang,F.
    PRSS2 overexpression relates to poor prognosis and promotes proliferation, migration and invasion in gastric cancer
    Tissue Cell79, 101949-101949. PubMed  Europe PubMed DOI  K
  5. Sui,L., Wang,S., Ganguly,D., El Rayes,T.P., Askeland,C., Borretzen,A., Sim,D., Halvorsen,O.J., Knutsvik,G., Arnes,J., Aziz,S., Haukaas,S., Foulkes,W.D., Bielenberg,D.R., Ziemys,A., Mittal,V., Brekken,R.A., Akslen,L.A. and Watnick,R.S.
    PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression
    Nat Commun13, 7959-7959. PubMed  Europe PubMed DOI
    6. 2018
  6. Schilling,O., Biniossek,M.L., Mayer,B., Elsasser,B., Brandstetter,H., Goettig,P., Stenman,U.H. and Koistinen,H.
    Specificity profiling of human trypsin-isoenzymes
    Biol Chem399, 997-1007. PubMed  Europe PubMed DOI  P
    7. 2016
  7. Jancso,Z. and Sahin-Toth,M.
    Tighter control by chymotrypsin C (CTRC) explains lack of association between human anionic trypsinogen and hereditary pancreatitis
    J Biol Chem291, 12897-12905. PubMed  Europe PubMed DOI
    8. 2012
  8. Chen,J.M. and Ferec,C.
    Anionic trypsin (human)
    [ISSN:978-0-12-407742-3]3, 2614-2616. DOI
  9. Chen,J.M., Radisky,E.S. and Ferec,C.
    Human trypsins
    [ISSN:978-0-12-407742-3]3, 2600-2609. DOI
  10. Petronella,N. and Drouin,G.
    Strong purifying selection against gene conversions in the trypsin genes of primates
    Hum Genet131, 1739-1749. PubMed  Europe PubMed DOI
  11. Vilen,S.T., Suojanen,J., Salas,F., Risteli,J., Ylipalosaari,M., Itkonen,O., Koistinen,H., Baumann,M., Stenman,U.H., Sorsa,T., Salo,T. and Nyberg,P.
    Trypsin-2 enhances carcinoma invasion by processing tight junctions and activating proMT1-MMP
    Cancer Invest30, 583-592. PubMed  Europe PubMed DOI
    12. 2011
  12. Felderbauer,P., Karakas,E., Fendrich,V., Lebert,R., Bartsch,D.K. and Bulut,K.
    Multifactorial genesis of pancreatitis in primary hyperparathyroidism: evidence for "protective" (PRSS2) and "destructive" (CTRC) genetic factors
    Exp Clin Endocrinol Diabetes119, 26-29. PubMed  Europe PubMed DOI
    13. 2010
  13. Ou,C.M., Lin,S.R., Lin,H.J., Luo,C.W. and Chen,Y.H.
    Exclusive expression of a membrane-bound spink3-interacting serine protease-like protein TESPL in mouse testis
    J Cell Biochem110, 620-629. PubMed  Europe PubMed DOI
    14. 2008
  14. Teich,N. and Mossner,J.
    Hereditary chronic pancreatitis
    Best Pract Res Clin Gastroenterol22, 115-130. PubMed  Europe PubMed DOI  V
    15. 2006
  15. Witt,H., Sahin-Toth,M., Landt,O., Chen,J.M., Kahne,T., Drenth,J.P., Kukor,Z., Szepessy,E., Halangk,W., Dahm,S., Rohde,K., Schulz,H.U., Le Marechal,C., Akar,N., Ammann,R.W., Truninger,K., Bargetzi,M., Bhatia,E., Castellani,C., Cavestro,G.M., Cerny,M., Destro-Bisol,G., Spedini,G., Eiberg,H., Jansen,J.B., Koudova,M., Rausova,E., Macek,M., Jr., Malats,N., Real,F.X., Menzel,H.J., Moral,P., Galavotti,R., Pignatti,P.F., Rickards,O., Spicak,J., Zarnescu,N.O., Bock,W., Gress,T.M., Friess,H., Ockenga,J., Schmidt,H., Pfutzer,R., Lohr,M., Simon,P., Weiss,F.U., Lerch,M.M., Teich,N., Keim,V., Berg,T., Wiedenmann,B., Luck,W., Groneberg,D.A., Becker,M., Keil,T., Kage,A., Bernardova,J., Braun,M., Guldner,C., Halangk,J., Rosendahl,J., Witt,U., Treiber,M., Nickel,R. and Ferec,C.
    A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
    Nat Genet38, 668-673. PubMed  Europe PubMed DOI
    16. 2005
  16. Chen,Y.T., Chen,C.C., Wang,S.S., Chang,F.Y. and Lee,S.D.
    Rapid urinary trypsinogen-2 test strip in the diagnosis of acute pancreatitis
    Pancreas30, 243-247. PubMed  Europe PubMed DOI
  17. Idris,M.M., Bhaskar,S., Reddy,D.N., Mani,K.R., Rao,G.V., Singh,L. and Chandak,G.R.
    Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis
    Gut54, 728-729. PubMed  Europe PubMed DOI  M
  18. Stenman,M., Ainola,M., Valmu,L., Bjartell,A., Ma,G., Stenman,U.H., Sorsa,T., Luukkainen,R. and Konttinen,Y.T.
    Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue
    Am J Pathol167, 1119-1124. PubMed  Europe PubMed DOI
    19. 2004
  19. Chen,J.M. and Ferec,C.
    Human trypsins
    [ISSN:0-12-079610-4]2, 1489-1493.  V
  20. [YEAR:15-7-2004]Paju,A., Vartiainen,J., Haglund,C., Itkonen,O., von Boguslawski,K., Leminen,A., Wahlstrom,T. and Stenman,U.H.
    Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum
    Clin Cancer Res10, 4761-4768. PubMed  Europe PubMed DOI
  21. Teich,N., Le Marechal,C., Kukor,Z., Caca,K., Witzigmann,H., Chen,J.M., Toth,M., Mossner,J., Keim,V., Ferec,C. and Sahin-Toth,M.
    Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)
    Hum Mutat23, 22-31. PubMed  Europe PubMed DOI
    22. 2003
  22. Kukor,Z., Toth,M. and Sahin-Toth,M.
    Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases
    Eur J Biochem270, 2047-2058. PubMed  Europe PubMed DOI
  23. [YEAR:15-5-2003]Lempinen,M., Stenman,U.H., Finne,P., Puolakkainen,P., Haapiainen,R. and Kemppainen,E.
    Trypsinogen-2 and trypsinogen activation peptide (TAP) in urine of patients with acute pancreatitis
    J Surg Res111, 267-273. PubMed  Europe PubMed DOI
  24. [YEAR:13-5-2003]Moilanen,M., Sorsa,T., Stenman,M., Nyberg,P., Lindy,O., Vesterinen,J., Paju,A., Konttinen,Y.T., Stenman,U.H. and Salo,T.
    Tumor-associated trypsinogen-2 (trypsinogen-2) activates procollagenases (MMP-1, -8, -13) and stromelysin-1 (MMP-3) and degrades type I collagen
    Biochemistry42, 5414-5420. PubMed  Europe PubMed DOI
    25. 2001
  25. Ahsan,M.N. and Watabe,S.
    Kinetic and structural properties of two isoforms of trypsin isolated from the viscera of Japanese anchovy, Engraulis japonicus
    J Protein Chem20, 49-58. PubMed  Europe PubMed DOI
  26. Lempinen,M., Kylanpaa-Back,M.L., Stenman,U.H., Puolakkainen,P., Haapiainen,R., Finne,P., Korvuo,A. and Kemppainen,E.
    Predicting the severity of acute pancreatitis by rapid measurement of trypsinogen-2 in urine
    Clin Chem47, 2103-2107. PubMed  Europe PubMed
  27. [YEAR:18-5-2001]Paju,A., Sorsa,T., Tervahartiala,T., Koivunen,E., Haglund,C., Leminen,A., Wahlstrom,T., Salo,T. and Stenman,U.H.
    The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation
    Br J Cancer84, 1363-1371. PubMed  Europe PubMed DOI
  28. [YEAR:1-7-2001]Williams,S.J., Gotley,D.C. and Antalis,T.M.
    Human trypsinogen in colorectal cancer
    Int J Cancer93, 67-73. PubMed  Europe PubMed DOI
    29. 2000
  29. Chen,J.M. and Ferec,C.
    Genes, cloned cDNAs, and proteins of human trypsinogens and pancreatitis-associated cationic trypsinogen mutations
    Pancreas21, 57-62. PubMed  Europe PubMed DOI
  30. Kylanpaa-Back,M., Kemppainen,E., Puolakkainen,P., Hedstrom,J., Haapiainen,R., Perhoniemi,V., Kivilaakso,E., Korvuo,A. and Stenman,U.
    Reliable screening for acute pancreatitis with rapid urine trypsinogen-2 test strip
    Br J Surg87, 49-52. PubMed  Europe PubMed DOI
  31. [YEAR:15-5-2000]Lukkonen,A., Sorsa,T., Salo,T., Tervahartiala,T., Koivunen,E., Golub,L., Simon,S. and Stenman,U.H.
    Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: Association with reduced cancer cell migration
    Int J Cancer86, 577-581. PubMed  Europe PubMed DOI
    32. 1999
  32. Miyata,S., Koshikawa,N., Higashi,S., Miyagi,Y., Nagashima,Y., Yanoma,S., Kato,Y., Yasumitsu,H. and Miyazaki,K.
    Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture
    J Biochem125, 1067-1076. PubMed  Europe PubMed
    33. 1998
  33. Baillie,J.
    Increased serum trypsinogen 2 and trypsin 2-1 antitrypsin complex values identify endoscopic retrograde cholangiopancreatography (ERCP)-induced pancreatitis with high accuracy
    Gastrointest Endosc47, 554-555. PubMed  Europe PubMed
  34. Konttinen,Y.T., Halinen,S., Hanemaaijer,R., Sorsa,T., Hietanen,J., Ceponis,A., Xu,J.W., Manthorpe,R., Whittington,J., Larsson,A., Salo,T., Kjeldsen,L., Stenman,U.H. and Eisen,A.Z.
    Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjogren's syndrome
    Matrix Biol17, 335-347. PubMed  Europe PubMed DOI
    35. 1997
  35. Kemppainen,E., Hedstrom,J., Puolakkainen,P., Halttunen,J., Sainio,V., Haapiainen,R., Kivilaakso,E. and Stenman,U.H.
    Increased serum trypsinogen 2 and trypsin 2-alpha 1 antitrypsin complex values identify endoscopic retrograde cholangiopancreatography induced pancreatitis with high accuracy
    Gut41, 690-695. PubMed  Europe PubMed
  36. [YEAR:22-8-1997]Sorsa,T., Salo,T., Koivunen,E., Tyynela,J., Konttinen,Y.T., Bergmann,U., Tuuttila,A., Niemi,E., Teronen,O., Heikkila,P., Tschesche,H., Leinonen,J., Osman,S. and Stenman,U.H.
    Activation of type IV procollagenases by human tumor-associated trypsin-2
    J Biol Chem272, 21067-21074. PubMed  Europe PubMed DOI
    37. 1996
  37. [YEAR:3-5-1996]Hedstrom,J., Haglund,C., Haapiainen,R. and Stenman,U.H.
    Serum trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin complex in malignant and benign digestive-tract diseases. Preferential elevation in patients with cholangiocarcinomas
    Int J Cancer66, 326-331. PubMed  Europe PubMed DOI
  38. [YEAR:10-8-1996]Hedstrom,J., Sainio,V., Kemppainen,E., Haapiainen,R., Kivilaakso,E., Schroder,T., Leinonen,J. and Stenman,U.H.
    Serum complex of trypsin 2 and alpha 1 antitrypsin as diagnostic and prognostic marker of acute pancreatitis: clinical study in consecutive patients
    BMJ313, 333-337. PubMed  Europe PubMed
    39. 1994
  39. Hedstrom,J., Leinonen,J., Sainio,V. and Stenman,U.H.
    Time-resolved immunofluorometric assay of trypsin-2 complexed with alpha 1-antitrypsin in serum
    Clin Chem40, 1761-1765. PubMed  Europe PubMed
    40. 1988
  40. Figarella,C., Miszczuk-Jamska,B. and Barrett,A.J.
    Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid activation of human trypsinogen I
    Biol Chem Hoppe Seyler369 Suppl, 293-298. PubMed  Europe PubMed
    41. 1986
  41. Emi,M., Nakamura,Y., Ogawa,M., Yamamoto,T., Nishide,T., Mori,T. and Matsubara,K.
    Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens
    Gene41, 305-310. PubMed  Europe PubMed
    42. 1985
  42. Figarella,C., Amouric,M., Guy-Crotte,O. and Barrett,A.J.
    Activation of human trypsinogens by cathepsin B and acidic pH
    Digestion32, 176-177.
    43. 1978
  43. Colomb,E., Guy,O., Deprez,P., Michel,R. and Figarella,C.
    The two human trypsinogens: catalytic properties of the corresponding trypsins
    Biochim Biophys Acta525, 186-193. PubMed  Europe PubMed
    44. 1975
  44. Figarella,C., Negri,G.A. and Guy,O.
    The two human trypsinogens. Inhibition spectra of the two human trypsins derived from their purified zymogens
    Eur J Biochem53, 457-463. PubMed  Europe PubMed
    45. 1973
  45. Rinderknecht,H. and Geokas,M.C.
    Anionic and cationic trypsinogens (trypsins) in mammalian pancreas
    Enzyme14, 116-130.
    46. 1969
  46. Figarella,C., Clemente,F. and Guy,O.
    On zymogens of human pancreatic juice
    FEBS Lett3, 351-353. PubMed  Europe PubMed

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