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Literature for peptidase S01.258: trypsin-2 type A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: M Mutation, P Specificity, K Knockout, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Lu,H., Zhao,Z., Yu,H., Iqbal,A. and Jiang,P.<br>The serine protease 2 gene regulates lipid metabolism through the LEP/ampkalpha1/SREBP1 pathway in bovine mammary epithelial cells<br>Biochem Biophys Res Commun (2024) 698, 149558-149558. PubMed  Europe PubMed DOI
  2. Moreau,T., Recoules,E., De Pauw,M., Labas,V. and Rehault-Godbert,S.<br>Evidence that the Bowman-Birk inhibitor from Pisum sativum affects intestinal proteolytic activities in chickens<br>Poult Sci (2024) 103, 103182-103182. PubMed  Europe PubMed DOI  PMC  EPMC  L
    3. 2023
  3. Barresi,V., Di Bella,V., Lo Nigro,L., Privitera,A.P., Bonaccorso,P., Scuderi,C. and Condorelli,D.F.<br>Temporary serine protease inhibition and the role of SPINK2 in human bone marrow<br>iScience (2023) 26, 106949-106949. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2022
  4. Chen,Y., Wang,B., Zhao,Z., Li,M. and Wang,F.<br>PRSS2 overexpression relates to poor prognosis and promotes proliferation, migration and invasion in gastric cancer<br>Tissue Cell (2022) 79, 101949-101949. PubMed  Europe PubMed DOI  K
  5. Sui,L., Wang,S., Ganguly,D., El Rayes,T.P., Askeland,C., Borretzen,A., Sim,D., Halvorsen,O.J., Knutsvik,G., Arnes,J., Aziz,S., Haukaas,S., Foulkes,W.D., Bielenberg,D.R., Ziemys,A., Mittal,V., Brekken,R.A., Akslen,L.A. and Watnick,R.S.<br>PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression<br>Nat Commun (2022) 13, 7959-7959. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2018
  6. Schilling,O., Biniossek,M.L., Mayer,B., Elsasser,B., Brandstetter,H., Goettig,P., Stenman,U.H. and Koistinen,H.<br>Specificity profiling of human trypsin-isoenzymes<br>Biol Chem (2018) 399, 997-1007. PubMed  Europe PubMed DOI  P
    7. 2016
  7. Jancso,Z. and Sahin-Toth,M.<br>Tighter control by chymotrypsin C (CTRC) explains lack of association between human anionic trypsinogen and hereditary pancreatitis<br>J Biol Chem (2016) 291, 12897-12905. PubMed  Europe PubMed DOI
    8. 2012
  8. Chen,J.M., Radisky,E.S. and Ferec,C.<br>Human trypsins<br>[ISSN:978-0-12-407742-3] (2012) 3, 2600-2609. DOI
  9. Chen,J.M. and Ferec,C.<br>Anionic trypsin (human)<br>[ISSN:978-0-12-407742-3] (2012) 3, 2614-2616. DOI
  10. Petronella,N. and Drouin,G.<br>Strong purifying selection against gene conversions in the trypsin genes of primates<br>Hum Genet (2012) 131, 1739-1749. PubMed  Europe PubMed DOI
  11. Vilen,S.T., Suojanen,J., Salas,F., Risteli,J., Ylipalosaari,M., Itkonen,O., Koistinen,H., Baumann,M., Stenman,U.H., Sorsa,T., Salo,T. and Nyberg,P.<br>Trypsin-2 enhances carcinoma invasion by processing tight junctions and activating proMT1-MMP<br>Cancer Invest (2012) 30, 583-592. PubMed  Europe PubMed DOI
    12. 2011
  12. Felderbauer,P., Karakas,E., Fendrich,V., Lebert,R., Bartsch,D.K. and Bulut,K.<br>Multifactorial genesis of pancreatitis in primary hyperparathyroidism: evidence for "protective" (PRSS2) and "destructive" (CTRC) genetic factors<br>Exp Clin Endocrinol Diabetes (2011) 119, 26-29. PubMed  Europe PubMed DOI
    13. 2010
  13. Ou,C.M., Lin,S.R., Lin,H.J., Luo,C.W. and Chen,Y.H.<br>Exclusive expression of a membrane-bound spink3-interacting serine protease-like protein TESPL in mouse testis<br>J Cell Biochem (2010) 110, 620-629. PubMed  Europe PubMed DOI
    14. 2008
  14. Teich,N. and Mossner,J.<br>Hereditary chronic pancreatitis<br>Best Pract Res Clin Gastroenterol (2008) 22, 115-130. PubMed  Europe PubMed DOI  V
    15. 2006
  15. Witt,H., Sahin-Toth,M., Landt,O., Chen,J.M., Kahne,T., Drenth,J.P., Kukor,Z., Szepessy,E., Halangk,W., Dahm,S., Rohde,K., Schulz,H.U., Le Marechal,C., Akar,N., Ammann,R.W., Truninger,K., Bargetzi,M., Bhatia,E., Castellani,C., Cavestro,G.M., Cerny,M., Destro-Bisol,G., Spedini,G., Eiberg,H., Jansen,J.B., Koudova,M., Rausova,E., Macek,M., Jr., Malats,N., Real,F.X., Menzel,H.J., Moral,P., Galavotti,R., Pignatti,P.F., Rickards,O., Spicak,J., Zarnescu,N.O., Bock,W., Gress,T.M., Friess,H., Ockenga,J., Schmidt,H., Pfutzer,R., Lohr,M., Simon,P., Weiss,F.U., Lerch,M.M., Teich,N., Keim,V., Berg,T., Wiedenmann,B., Luck,W., Groneberg,D.A., Becker,M., Keil,T., Kage,A., Bernardova,J., Braun,M., Guldner,C., Halangk,J., Rosendahl,J., Witt,U., Treiber,M., Nickel,R. and Ferec,C.<br>A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis<br>Nat Genet (2006) 38, 668-673. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2005
  16. Chen,Y.T., Chen,C.C., Wang,S.S., Chang,F.Y. and Lee,S.D.<br>Rapid urinary trypsinogen-2 test strip in the diagnosis of acute pancreatitis<br>Pancreas (2005) 30, 243-247. PubMed  Europe PubMed DOI
  17. Idris,M.M., Bhaskar,S., Reddy,D.N., Mani,K.R., Rao,G.V., Singh,L. and Chandak,G.R.<br>Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis<br>Gut (2005) 54, 728-729. PubMed  Europe PubMed DOI  PMC  EPMC  M
  18. Stenman,M., Ainola,M., Valmu,L., Bjartell,A., Ma,G., Stenman,U.H., Sorsa,T., Luukkainen,R. and Konttinen,Y.T.<br>Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue<br>Am J Pathol (2005) 167, 1119-1124. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2004
  19. Chen,J.M. and Ferec,C.<br>Human trypsins<br>[ISSN:0-12-079610-4] (2004) 2, 1489-1493.  V
  20. [YEAR:15-7-2004]Paju,A., Vartiainen,J., Haglund,C., Itkonen,O., von Boguslawski,K., Leminen,A., Wahlstrom,T. and Stenman,U.H.<br>Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum<br>Clin Cancer Res (15-7-2004) 10, 4761-4768. PubMed  Europe PubMed DOI
  21. Teich,N., Le Marechal,C., Kukor,Z., Caca,K., Witzigmann,H., Chen,J.M., Toth,M., Mossner,J., Keim,V., Ferec,C. and Sahin-Toth,M.<br>Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)<br>Hum Mutat (2004) 23, 22-31. PubMed  Europe PubMed DOI
    22. 2003
  22. Kukor,Z., Toth,M. and Sahin-Toth,M.<br>Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases<br>Eur J Biochem (2003) 270, 2047-2058. PubMed  Europe PubMed DOI
  23. [YEAR:15-5-2003]Lempinen,M., Stenman,U.H., Finne,P., Puolakkainen,P., Haapiainen,R. and Kemppainen,E.<br>Trypsinogen-2 and trypsinogen activation peptide (TAP) in urine of patients with acute pancreatitis<br>J Surg Res (15-5-2003) 111, 267-273. PubMed  Europe PubMed DOI
  24. [YEAR:13-5-2003]Moilanen,M., Sorsa,T., Stenman,M., Nyberg,P., Lindy,O., Vesterinen,J., Paju,A., Konttinen,Y.T., Stenman,U.H. and Salo,T.<br>Tumor-associated trypsinogen-2 (trypsinogen-2) activates procollagenases (MMP-1, -8, -13) and stromelysin-1 (MMP-3) and degrades type I collagen<br>Biochemistry (13-5-2003) 42, 5414-5420. PubMed  Europe PubMed DOI
    25. 2001
  25. Ahsan,M.N. and Watabe,S.<br>Kinetic and structural properties of two isoforms of trypsin isolated from the viscera of Japanese anchovy, Engraulis japonicus<br>J Protein Chem (2001) 20, 49-58. PubMed  Europe PubMed DOI
  26. Lempinen,M., Kylanpaa-Back,M.L., Stenman,U.H., Puolakkainen,P., Haapiainen,R., Finne,P., Korvuo,A. and Kemppainen,E.<br>Predicting the severity of acute pancreatitis by rapid measurement of trypsinogen-2 in urine<br>Clin Chem (2001) 47, 2103-2107. PubMed  Europe PubMed
  27. [YEAR:18-5-2001]Paju,A., Sorsa,T., Tervahartiala,T., Koivunen,E., Haglund,C., Leminen,A., Wahlstrom,T., Salo,T. and Stenman,U.H.<br>The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation<br>Br J Cancer (18-5-2001) 84, 1363-1371. PubMed  Europe PubMed DOI  PMC  EPMC
  28. [YEAR:1-7-2001]Williams,S.J., Gotley,D.C. and Antalis,T.M.<br>Human trypsinogen in colorectal cancer<br>Int J Cancer (1-7-2001) 93, 67-73. PubMed  Europe PubMed DOI
    29. 2000
  29. Chen,J.M. and Ferec,C.<br>Genes, cloned cDNAs, and proteins of human trypsinogens and pancreatitis-associated cationic trypsinogen mutations<br>Pancreas (2000) 21, 57-62. PubMed  Europe PubMed DOI
  30. Kylanpaa-Back,M., Kemppainen,E., Puolakkainen,P., Hedstrom,J., Haapiainen,R., Perhoniemi,V., Kivilaakso,E., Korvuo,A. and Stenman,U.<br>Reliable screening for acute pancreatitis with rapid urine trypsinogen-2 test strip<br>Br J Surg (2000) 87, 49-52. PubMed  Europe PubMed DOI
  31. [YEAR:15-5-2000]Lukkonen,A., Sorsa,T., Salo,T., Tervahartiala,T., Koivunen,E., Golub,L., Simon,S. and Stenman,U.H.<br>Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: Association with reduced cancer cell migration<br>Int J Cancer (15-5-2000) 86, 577-581. PubMed  Europe PubMed DOI
    32. 1999
  32. Miyata,S., Koshikawa,N., Higashi,S., Miyagi,Y., Nagashima,Y., Yanoma,S., Kato,Y., Yasumitsu,H. and Miyazaki,K.<br>Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture<br>J Biochem (1999) 125, 1067-1076. PubMed  Europe PubMed
    33. 1998
  33. Baillie,J.<br>Increased serum trypsinogen 2 and trypsin 2-1 antitrypsin complex values identify endoscopic retrograde cholangiopancreatography (ERCP)-induced pancreatitis with high accuracy<br>Gastrointest Endosc (1998) 47, 554-555. PubMed  Europe PubMed
  34. Konttinen,Y.T., Halinen,S., Hanemaaijer,R., Sorsa,T., Hietanen,J., Ceponis,A., Xu,J.W., Manthorpe,R., Whittington,J., Larsson,A., Salo,T., Kjeldsen,L., Stenman,U.H. and Eisen,A.Z.<br>Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjogren's syndrome<br>Matrix Biol (1998) 17, 335-347. PubMed  Europe PubMed DOI
    35. 1997
  35. Kemppainen,E., Hedstrom,J., Puolakkainen,P., Halttunen,J., Sainio,V., Haapiainen,R., Kivilaakso,E. and Stenman,U.H.<br>Increased serum trypsinogen 2 and trypsin 2-alpha 1 antitrypsin complex values identify endoscopic retrograde cholangiopancreatography induced pancreatitis with high accuracy<br>Gut (1997) 41, 690-695. PubMed  Europe PubMed  PMC  EPMC
  36. [YEAR:22-8-1997]Sorsa,T., Salo,T., Koivunen,E., Tyynela,J., Konttinen,Y.T., Bergmann,U., Tuuttila,A., Niemi,E., Teronen,O., Heikkila,P., Tschesche,H., Leinonen,J., Osman,S. and Stenman,U.H.<br>Activation of type IV procollagenases by human tumor-associated trypsin-2<br>J Biol Chem (22-8-1997) 272, 21067-21074. PubMed  Europe PubMed DOI
    37. 1996
  37. [YEAR:3-5-1996]Hedstrom,J., Haglund,C., Haapiainen,R. and Stenman,U.H.<br>Serum trypsinogen-2 and trypsin-2-alpha(1)-antitrypsin complex in malignant and benign digestive-tract diseases. Preferential elevation in patients with cholangiocarcinomas<br>Int J Cancer (3-5-1996) 66, 326-331. PubMed  Europe PubMed DOI
  38. [YEAR:10-8-1996]Hedstrom,J., Sainio,V., Kemppainen,E., Haapiainen,R., Kivilaakso,E., Schroder,T., Leinonen,J. and Stenman,U.H.<br>Serum complex of trypsin 2 and alpha 1 antitrypsin as diagnostic and prognostic marker of acute pancreatitis: clinical study in consecutive patients<br>BMJ (10-8-1996) 313, 333-337. PubMed  Europe PubMed  PMC  EPMC
    39. 1994
  39. Hedstrom,J., Leinonen,J., Sainio,V. and Stenman,U.H.<br>Time-resolved immunofluorometric assay of trypsin-2 complexed with alpha 1-antitrypsin in serum<br>Clin Chem (1994) 40, 1761-1765. PubMed  Europe PubMed
    40. 1988
  40. Figarella,C., Miszczuk-Jamska,B. and Barrett,A.J.<br>Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid activation of human trypsinogen I<br>Biol Chem Hoppe Seyler (1988) 369 Suppl, 293-298. PubMed  Europe PubMed
    41. 1986
  41. Emi,M., Nakamura,Y., Ogawa,M., Yamamoto,T., Nishide,T., Mori,T. and Matsubara,K.<br>Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens<br>Gene (1986) 41, 305-310. PubMed  Europe PubMed
    42. 1985
  42. Figarella,C., Amouric,M., Guy-Crotte,O. and Barrett,A.J.<br>Activation of human trypsinogens by cathepsin B and acidic pH<br>Digestion (1985) 32, 176-177.
    43. 1978
  43. Colomb,E., Guy,O., Deprez,P., Michel,R. and Figarella,C.<br>The two human trypsinogens: catalytic properties of the corresponding trypsins<br>Biochim Biophys Acta (1978) 525, 186-193. PubMed  Europe PubMed
    44. 1975
  44. Figarella,C., Negri,G.A. and Guy,O.<br>The two human trypsinogens. Inhibition spectra of the two human trypsins derived from their purified zymogens<br>Eur J Biochem (1975) 53, 457-463. PubMed  Europe PubMed
    45. 1973
  45. Rinderknecht,H. and Geokas,M.C.<br>Anionic and cationic trypsinogens (trypsins) in mammalian pancreas<br>Enzyme (1973) 14, 116-130.
    46. 1969
  46. Figarella,C., Clemente,F. and Guy,O.<br>On zymogens of human pancreatic juice<br>FEBS Lett (1969) 3, 351-353. PubMed  Europe PubMed

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