$VAR1 = undef;
Summary for peptidase S01.258: trypsin-2 type A
| Names | |
|---|---|
| MEROPS Name | trypsin-2 type A |
| Other names | anionic trypsin (Homo sapiens), PRSS2 g.p. (Homo sapiens), trypsin 2, trypsinogen-2 (Homo sapiens), trypsin 8 (Homo sapiens), tumor-associated trypsin-2 |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.258 |
| Holotype | trypsin-2 type A (Homo sapiens), Uniprot accession P07478 (peptidase unit: 24-246), MERNUM MER0000021 |
| History | Identifier created: MEROPS 3.1 (22 December 1998) |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Proteolytic events | CutDB database (1 cleavage) | ||
| Pharmaceutical relevance | Measurement of the concentration of trypsinogen 2 in urine may allow rapid detection of acute panreatitis (Lempinen et al., 2001). | ||
| Pathways | KEGG | Influenza A | |
| KEGG | Neuroactive ligand-receptor interaction | ||
| KEGG | Pancreatic secretion | ||
| KEGG | Protein digestion and absorption | ||
| Other databases | PANTHER | http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR24264:SF15 | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| PRSS2 | 7q35 | ENSG00000173636 | 5645 | PRSS2 | 601564 | |
