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Literature for peptidase S01.218: protein C (activated)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Gupta,A. and Patibandla,S.
    Protein C Deficiency
     PubMed  Europe PubMed
  2. Huntington,J.A., Reckless,J., Polderdijk,S.G.I., Hextall,P. and Baglin,T.
    The preclinical profile of SerpinPC- a potential new treatment for hemophilia
    Blood Adv PubMed  Europe PubMed DOI
  3. Leon,G., Klavina,P.A., Rehill,A.M., Cooper,S.E.J., Dominik,A., Basavarajappa,S.C., O'Donnell,J.S., Hussey,S., Walsh,P.T. and Preston,R.J.S.
    Tissue factor-dependent colitogenic CD4(+) T cell thrombogenicity is regulated by activated protein C signalling
    Nat Commun16, 1677-1677. PubMed  Europe PubMed DOI
    4. 2024
  4. Aliyeva,N., Akgonullu,S., Erdem,A. and Denizli,A.
    Specific DNA aptamer-immobilized cryogel membranes as novel bioaffinity supports and their potential for the purification of activated protein C
    Biomed Chromatogre5995-e5995. PubMed  Europe PubMed DOI
  5. Biswas,I., Giri,H., Panicker,S.R. and Rezaie,A.R.
    Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin
    Arterioscler Thromb Vasc Biol44, 603-616. PubMed  Europe PubMed DOI
  6. Togashi,T., Baatartsogt,N., Nagao,Y., Kashiwakura,Y., Hayakawa,M., Hiramoto,T., Fujiwara,T., Morishita,E., Nureki,O. and Ohmori,T.
    Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice
    Arterioscler Thromb Vasc Biol PubMed  Europe PubMed DOI
  7. Zhou,S., Wu,X., Song,Y., Li,L., Shi,C., Lai,Z., Ding,Q., Wu,W., Dai,J., Wang,X. and Lu,Y.
    Ser252Asn Mutation Introduces a New N-Linked Glycosylation Site and Causes Type IIb Protein C Deficiency
    Thromb Haemost124, 459-470. PubMed  Europe PubMed DOI
    8. 2023
  8. Farajzadeh-Dehkordi,M., Mafakher,L., Harifi,A., Samiee-Rad,F. and Rahmani,B.
    Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C
    PLoS ONE18, e0294417-e0294417. PubMed  Europe PubMed DOI
  9. Giri,H., Biswas,I. and Rezaie,A.R.
    Activated protein C inhibits mesothelial-to-mesenchymal transition in experimental peritoneal fibrosis
    J Thromb Haemost21, 133-144. PubMed  Europe PubMed DOI
  10. Huckriede,J.B., Beurskens,D.M.H., Wildhagen,K.C.C.A., Reutelingsperger,C.P.M., Wichapong,K. and Nicolaes,G.A.F.
    Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3
    J Thromb Haemost21, 3557-3567. PubMed  Europe PubMed DOI
  11. Li,X., Song,X., Mahmood,D.F.D., Sim,M.M.S., Bidarian,S.J. and Wood,J.P.
    Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation
    Thromb Res230, 84-93. PubMed  Europe PubMed DOI
  12. Sim,D.S., Shukla,M., Mallari,C.R., Fernandez,J.A., Xu,X., Schneider,D., Bauzon,M., Hermiston,T.W. and Mosnier,L.O.
    Selective Modulation of Activated Protein C Activities by a Non-Active Site Targeting Nanobody Library
    Blood Adv7, 3036-3048. PubMed  Europe PubMed DOI
    13. 2022
  13. Ayombil,F., Petrillo,T., Kim,H. and Camire,R.M.
    Regulation of factor V by the anticoagulant protease activated protein C: Influence of the B-domain and TFPIalpha
    J Biol Chem298, 102558-102558. PubMed  Europe PubMed DOI
  14. Damodara,S., Arora,J., Dwivedi,D.J., Liaw,P.C., Fox-Robichaud,A.E., Selvaganapathy,P.R. and Canadian Critical Care Translational Biology Group
    Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis
    Lab Chip22, 2566-2577. PubMed  Europe PubMed DOI
  15. De Simone,I., Baaten,C.C.F.M., Jandrot-Perrus,M., Gibbins,J.M., ten Cate,H., Heemskerk,J.W.M., Jones,C.I. and van der Meijden,P.E.J.
    Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1
    Int J Mol Sci23, PubMed  Europe PubMed DOI
  16. Dons-Jensen,A., Horup,S.S., Hvas,A.M., Vestergaard,E.T. and Johansen,R.F.
    Ghrelin, growth hormone and insulin-like growth Factor-I levels in people with protein C deficiency
    Scand J Clin Lab Invest82, 435-438. PubMed  Europe PubMed DOI
  17. Huuskonen,M.T., Wang,Y., Nikolakopoulou,A.M., Montagne,A., Dai,Z., Lazic,D., Sagare,A.P., Zhao,Z., Fernandez,J.A., Griffin,J.H. and Zlokovic,B.V.
    Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C
    J Exp Med219, PubMed  Europe PubMed DOI
  18. Kohli,S., Shahzad,K., Jouppila,A., Holthofer,H., Isermann,B. and Lassila,R.
    Thrombosis and Inflammation-A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C
    Front Cardiovasc Med9, 866751-866751. PubMed  Europe PubMed DOI  V
  19. Modrzycka,S., Kolt,S., Polderdijk,S.G.I., Adams,T.E., Potoczek,S., Huntington,J.A., Kasperkiewicz,P. and Drag,M.
    Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma
    Chem Sci13, 6813-6829. PubMed  Europe PubMed DOI
  20. Morimont,L., Donis,N., Bouvy,C., Mullier,F., Dogne,J.M. and Douxfils,J.
    Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance
    Semin Thromb Hemost48, 680-689. PubMed  Europe PubMed DOI  V
  21. Xu,Q.Y., Yang,L.L., Xie,H.X., Jin,Y.H., Li,X.L., Zhou,X.X., Liu,M.N. and Wang,M.S.
    [Clinical phenotype and gene mutation analysis of 12 patients with hereditary protein C deficiency in different families]
    Zhonghua Xue Ye Xue Za Zhi43, 35-40. PubMed  Europe PubMed DOI
    22. 2021
  22. Lu,Y., Biswas,I., Villoutreix,B.O. and Rezaie,A.R.
    Role of Gly197 in the structure and function of protein C
    Biochim Biophys Acta Gen Subj1865, 129892-129892. PubMed  Europe PubMed DOI
  23. Reda,S., Ruhl,H., Witkowski,J., Muller,J., Pavlova,A., Oldenburg,J. and Potzsch,B.
    PC Deficiency Testing: Thrombin-Thrombomodulin as PC Activator and Aptamer-Based Enzyme Capturing Increase Diagnostic Accuracy
    Front Cardiovasc Med8, 755281-755281. PubMed  Europe PubMed DOI
    24. 2020
  24. Lu,Y., Mehta-D'souza,P., Biswas,I., Villoutreix,B.O., Wang,X., Ding,Q. and Rezaie,A.R.
    Ile73Asn mutation in protein C introduces a new N-linked glycosylation site on the first EGF-domain of protein C and causes thrombosis
    Haematologica105, 1712-1722. PubMed  Europe PubMed DOI  M
  25. Madhusudhan,T., Ghosh,S., Wang,H., Dong,W., Gupta,D., Elwakiel,A., Stoyanov,S., Al-Dabet,M.M., Krishnan,S., Biemann,R., Nazir,S., Zimmermann,S., Mathew,A., Gadi,I., Rana,R., Zeng-Brouwers,J., Moeller,M.J., Schaefer,L., Esmon,C.T., Kohli,S., Reiser,J., Rezaie,A.R., Ruf,W. and Isermann,B.
    Podocyte Integrin-beta 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy
    J Am Soc Nephrol31, 1762-1780. PubMed  Europe PubMed DOI
  26. Okada,M., Tominaga,N., Honda,G., Nishioka,J., Akita,N., Hayashi,T., Suzuki,K. and Moriuchi,H.
    A case of thrombomodulin mutation causing defective thrombin binding with absence of protein C and TAFI activation
    Blood Adv4, 2631-2639. PubMed  Europe PubMed DOI
  27. Sriwastva,M.K., Kunjunni,R., Andrabi,M., Prasad,K., Saxena,R. and Subbiah,V.
    Neuroprotective Effects of Activated Protein C Involve the PARP/AIF Pathway against Oxygen-Glucose Deprivation in SH-SY5Y Cells
    Brain Sci10, PubMed  Europe PubMed DOI
  28. Stojanovski,B.M., Pelc,L.A., Zuo,X. and Di Cera,E.
    Zymogen and activated protein C have similar structural architecture
    J Biol Chem295, 15236-15244. PubMed  Europe PubMed DOI
  29. Zhao,X.Y., Wilmen,A., Wang,D., Wang,X., Bauzon,M., Kim,J.Y., Linden,L., Li,L., Egner,U., Marquardt,T., Moosmayer,D., Tebbe,J., Gluck,J.M., Ellinger,P., McLean,K., Yuan,S., Yegneswaran,S., Jiang,X., Evans,V., Gu,J.M., Schneider,D., Zhu,Y., Xu,Y., Mallari,C., Hesslein,A., Wang,Y., Schmidt,N., Gutberlet,K., Ruehl-Fehlert,C., Freyberger,A., Hermiston,T., Patel,C., Sim,D., Mosnier,L.O. and Laux,V.
    Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia
    Nat Commun11, 2992-2992. PubMed  Europe PubMed DOI
    30. 2019
  30. Lazic,D., Sagare,A.P., Nikolakopoulou,A.M., Griffin,J.H., Vassar,R. and Zlokovic,B.V.
    3K3A-Activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice
    J Exp Med216, 279-293. PubMed  Europe PubMed DOI
    31. 2017
  31. Barranco-Medina,S., Murphy,M., Pelc,L., Chen,Z., Di Cera,E. and Pozzi,N.
    Rational design of protein C activators
    Sci Rep7, 44596-44596. PubMed  Europe PubMed DOI
  32. Chen,C., Yang,L., Villoutreix,B.O., Wang,X., Ding,Q. and Rezaie,A.R.
    Gly74Ser mutation in protein C causes thrombosis due to a defect in protein S-dependent anticoagulant function
    Thromb Haemost117, 1358-1369. PubMed  Europe PubMed DOI  M
  33. Polderdijk,S.G.I., Baglin,T.P. and Huntington,J.A.
    Targeting activated protein C to treat hemophilia
    Curr Opin Hematol24, 446-452. PubMed  Europe PubMed DOI
    34. 2015
  34. Dursi,P., Orro,A., Morra,G., Moscatelli,M., Trombetti,G., Milanesi,L. and Rovida,E.
    Molecular dynamics and docking simulation of a natural variant of activated protein C with impaired protease activity: Implications for integrin-mediated antiseptic function
    J Biomol Struct Dyn33, 85-92. PubMed  Europe PubMed DOI  M
  35. Griffin,J.H., Zlokovic,B.V. and Mosnier,L.O.
    Activated protein C: biased for translation
    Blood125, 2898-2907. PubMed  Europe PubMed DOI
  36. Satou,M., Nishi,Y., Hishinuma,A., Hosoda,H., Kangawa,K. and Sugimoto,H.
    Identification of activated protein C as a ghrelin endopeptidase in bovine plasma
    J Endocrinol224, 61-73. PubMed  Europe PubMed DOI
    37. 2013
  37. Ding,Q., Yang,L., Hassanian,S.M. and Rezaie,A.R.
    Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population
    Thromb Haemost109, 614-624. PubMed  Europe PubMed DOI  M
  38. Hepner,M. and Karlaftis,V.
    Protein C
    Methods Mol Biol992, 365-372. PubMed  Europe PubMed DOI  M  V
  39. Muratsu,J., Morishima,A., Mizoguchi,K., Ataka,K., Yamamoto,H., Fan,X., Miyata,T. and Sakaguchi,K.
    Budd-Chiari syndrome with multiple thrombi due to a familial Arg42Ser mutation in the protein C gene
    Case Rep Med2013, 270419-270419. PubMed  Europe PubMed DOI  M
    40. 2012
  40. Cheng,A.C., Wu,H.L., Shi,G.Y. and Tsai,I.H.
    A novel heparin-dependent inhibitor of activated protein C that potentiates consumptive coagulopathy in Russell's viper envenomation
    J Biol Chem287, 15739-15748. PubMed  Europe PubMed DOI
  41. Mosnier,L.O., Sinha,R.K., Burnier,L., Bouwens,E.A. and Griffin,J.H.
    Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46
    Blood120, 5237-5246. PubMed  Europe PubMed DOI  P
  42. Muller,J., Friedrich,M., Becher,T., Braunstein,J., Kupper,T., Berdel,P., Gravius,S., Rohrbach,F., Oldenburg,J., Mayer,G. and Potzsch,B.
    Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay
    J Thromb Haemost10, 390-398. PubMed  Europe PubMed DOI  A
  43. Shen,L. and Dahlback,B.
    Protein C
    [ISSN:978-0-12-407742-3]3, 2932-2938. DOI
    44. 2011
  44. Brummel-Ziedins,K.E., Whelihan,M.F., Rivard,G.E. and Butenas,S.
    Activated protein C inhibitor for correction of thrombin generation in hemophilia A blood and plasma
    J Thromb Haemost9, 2262-2267. PubMed  Europe PubMed DOI  I
    45. 2010
  45. Flight,M.H.
    Proteases: unravelling the therapeutic activity of activated protein C
    Nat Rev Drug Discov9, 20-21. DOI
  46. Gramling,M.W., Beaulieu,L.M. and Church,F.C.
    Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction
    Exp Cell Res316, 314-328. PubMed  Europe PubMed DOI
  47. Nicolaes,G.A., Bock,P.E., Segers,K., Wildhagen,K.C., Dahlback,B. and Rosing,J.
    Inhibition of thrombin formation by active site mutated (S360A) activated protein C
    J Biol Chem285, 22890-22900. PubMed  Europe PubMed DOI
  48. Petraglia,A.L., Marky,A.H., Walker,C., Thiyagarajan,M. and Zlokovic,B.V.
    Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact
    Neurosurgery66, 165-171. PubMed  Europe PubMed DOI  U
    49. 2009
  49. Kuriyama,N., Isaji,S., Hamada,T., Kishiwada,M., Ohsawa,I., Usui,M., Sakurai,H., Tabata,M., Suzuki,K. and Uemoto,S.
    Activated protein C prevents hepatic ischaemia-reperfusion injury in rats
    Liver Int29, 299-307. PubMed  Europe PubMed DOI  U
  50. Mann,H.J., Short,M.A. and Schlichting,D.E.
    Protein C in critical illness
    Am J Health Syst Pharm66, 1089-1096. PubMed  Europe PubMed DOI  V
  51. Mosnier,L.O., Zampolli,A., Kerschen,E.J., Schuepbach,R.A., Banerjee,Y., Fernandez,J.A., Yang,X.V., Riewald,M., Weiler,H., Ruggeri,Z.M. and Griffin,J.H.
    Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
    Blood113, 5970-5978. PubMed  Europe PubMed DOI  U
  52. Zhong,Z., Ilieva,H., Hallagan,L., Bell,R., Singh,I., Paquette,N., Thiyagarajan,M., Deane,R., Fernandez,J.A., Lane,S., Zlokovic,A.B., Liu,T., Griffin,J.H., Chow,N., Castellino,F.J., Stojanovic,K., Cleveland,D.W. and Zlokovic,B.V.
    Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
    J Clin Invest119, 3437-3449. PubMed  Europe PubMed DOI  U
    53. 2008
  53. Komissarov,A.A., Andreasen,P.A., Declerck,P.J., Kamikubo,Y., Zhou,A. and Gruber,A.
    Redirection of the reaction between activated protein C and a serpin to the substrate pathway
    Thromb Res122, 397-404. PubMed  Europe PubMed DOI
  54. Malm,K., Arnljots,B. and Dahlback,B.
    Human activated protein C variants in a rat model of arterial thrombosis
    Thromb J6, 16-16. PubMed  Europe PubMed DOI
  55. Qureshi,S.H., Yang,L., Manithody,C., Bae,J.S. and Rezaie,A.R.
    Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C
    Biochim Biophys Acta1780, 1080-1086. PubMed  Europe PubMed DOI
  56. Qureshi,S.H., Manithody,C., Bae,J.S., Yang,L. and Rezaie,A.R.
    Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays
    Biophys Chem134, 239-245. PubMed  Europe PubMed DOI
    57. 2007
  57. D'Ursi,P., Marino,F., Caprera,A., Milanesi,L., Faioni,E.M. and Rovida,E.
    ProCMD: a database and 3D web resource for protein C mutants
    BMC Bioinformatics8 Suppl 1, S11-S11. PubMed  Europe PubMed DOI  M
  58. Mosnier,L.O., Yang,X.V. and Griffin,J.H.
    Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions
    J Biol Chem282, 33022-33033. PubMed  Europe PubMed DOI  M
  59. Toltl,L.J., Shin,L.Y. and Liaw,P.C.
    Activated protein C in sepsis and beyond: update 2006
    Front Biosci12, 1963-1972. PubMed  Europe PubMed DOI  V
  60. Yang,L., Manithody,C. and Rezaie,A.R.
    The role of autolysis loop in determining the specificity of coagulation proteases
    Braz J Med Biol Res40, 1055-1064. PubMed  Europe PubMed
    61. 2006
  61. [YEAR:24-8-2006]de Nanteuil,G., Gloanec,P., Beguin,S., Giesen,P.L., Hemker,H.C., Mennecier,P., Rupin,A. and Verbeuren,T.J.
    Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders
    J Med Chem49, 5047-5050. PubMed  Europe PubMed DOI  T  I
  62. [YEAR:4-2-2006]Griffin,J.H., Fernandez,J.A., Mosnier,L.O., Liu,D., Cheng,T., Guo,H. and Zlokovic,B.V.
    The promise of protein C
    Blood Cells Mol Dis36, 211-216. PubMed  Europe PubMed DOI  V
  63. [YEAR:25-8-2006]Norstrom,E.A., Tran,S., Steen,M. and Dahlback,B.
    Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va
    J Biol Chem281, 31486-31494. PubMed  Europe PubMed DOI  P
    64. 2005
  64. [YEAR:14-2-2005]Finigan,J.H., Dudek,S.M., Singleton,P.A., Chiang,E.T., Jacobson,J.R., Camp,S.M., Ye,S.Q. and Garcia,J.G.
    Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation
    J Biol Chem280, 17286-17293. PubMed  Europe PubMed DOI
  65. [YEAR:15-11-2005]Koeppe,J.R., Seitova,A., Mather,T. and Komives,E.A.
    Thrombomodulin tightens the thrombin active site loops to promote protein C activation
    Biochemistry44, 14784-14791. PubMed  Europe PubMed DOI
  66. Zlokovic,B.V., Zhang,C., Liu,D., Fernandez,J., Griffin,J.H. and Chopp,M.
    Functional recovery after embolic stroke in rodents by activated protein C
    Ann Neurol58, 474-477. PubMed  Europe PubMed DOI
    67. 2004
  67. Chan,A.K., Patel,S., Male,C., Berry,L.R. and Mitchell,L.G.
    Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium
    Thromb Haemost91, 238-247. PubMed  Europe PubMed DOI
  68. [YEAR:15-2-2004]Gale,A.J. and Griffin,J.H.
    Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va
    Proteins54, 433-441. PubMed  Europe PubMed DOI
  69. [YEAR:19-2-2004]Guo,H., Liu,D., Gelbard,H., Cheng,T., Insalaco,R., Fernandez,J.A., Griffin,J.H. and Zlokovic,B.V.
    Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
    Neuron41, 563-572. PubMed  Europe PubMed DOI
  70. McLeay,A.M.
    Drotrecogin alfa: A role in emergency department treatment of severe sepsis?
    Emerg Med Australas16, 324-335. PubMed  Europe PubMed DOI
  71. [YEAR:3-6-2004]Mosnier,L.O., Gale,A.J., Yegneswaran,S. and Griffin,J.H.
    Activated protein C variants with normal cytoprotective but reduced anticoagulant activity
    Blood104, 1740-1744. PubMed  Europe PubMed DOI
  72. Shen,L. and Dahlback,B.
    Protein C
    [ISSN:0-12-079610-4]2, 1673-1677.  V
  73. [YEAR:27-8-2004]Sun,Y.H., Tran,S., Norstrom,E.A. and Dahlback,B.
    Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C
    J Biol Chem279, 47528-47535. PubMed  Europe PubMed DOI
  74. [YEAR:14-7-2004]Yang,L., Prasad,S., Di Cera,E. and Rezaie,A.R.
    The conformation of the activation peptide of protein C is influenced by Ca2+ and Na+ binding
    J Biol Chem279, 38519-38524. PubMed  Europe PubMed DOI
    75. 2003
  75. [YEAR:15-4-2003]Berg,D.T., Gerlitz,B., Shang,J., Smith,T., Santa,P., Richardson,M.A., Kurz,K.D., Grinnell,B.W., Mace,K. and Jones,B.E.
    Engineering the proteolytic specificity of activated protein C improves its pharmacological properties
    Proc Natl Acad Sci U S A100, 4423-4428. PubMed  Europe PubMed DOI
  76. Esmon,C.T.
    The protein C pathway
    Chest124, 26S-32S. PubMed  Europe PubMed
    77. 2002
  77. Esmon,C.T.
    Protein C pathway in sepsis
    Ann Med34, 598-605. PubMed  Europe PubMed
  78. Lind,B., Gedde-Dahl,T., Tjonnfjord,G., Villoutreix,B.O. and Brosstad,F.
    Protein C deficiency caused by homozygosity for a novel PROC D180G mutation - in vitro expression and structural analysis of the mutation
    Thromb Haemost88, 632-638. PubMed  Europe PubMed DOI  K
    79. 2001
  79. [YEAR:8-3-2001]Bernard,G.R., Vincent,J.L., Laterre,P.F., LaRosa,S.P., Dhainaut,J.F., Lopez-Rodriguez,A., Steingrub,J.S., Garber,G.E., Helterbrand,J.D., Ely,E.W. and Fisher,C.J., Jr.
    Efficacy and safety of recombinant human activated protein C for severe sepsis
    N Engl J Med344, 699-709. PubMed  Europe PubMed DOI
  80. Cvirn,G., Gallistl,S. and Muntean,W.
    Alpha-2-macroglobulin inhibits the anticoagulant action of activated protein C in cord and adult plasma
    Haemostasis31, 1-11. PubMed  Europe PubMed
  81. [YEAR:22-6-2001]Friedrich,U., Nicolaes,G.A., Villoutreix,B.O. and Dahlback,B.
    Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va
    J Biol Chem276, 23105-23108. PubMed  Europe PubMed DOI
  82. Grinnell,B.W. and Joyce,D.
    Recombinant human activated protein C: a system modulator of vascular function for treatment of severe sepsis
    Crit Care Med29, S53-S60. PubMed  Europe PubMed
  83. Jackson,C., Nguyen,M., Arkell,J. and Sambrook,P.
    Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis - Targetting gelatinase A activation
    Inflamm Res50, 183-186. PubMed  Europe PubMed DOI
  84. [YEAR:6-4-2001]Joyce,D.E., Gelbert,L., Ciaccia,A., DeHoff,B. and Grinnell,B.W.
    Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
    J Biol Chem276, 11199-11203. PubMed  Europe PubMed DOI
  85. Lind,B., Koefoed,P. and Thorsen,S.
    Symptomatic type 1 protein C deficiency caused by a de novo Ser270Leu mutation in the catalytic domain
    Br J Haematol113, 642-648. PubMed  Europe PubMed DOI  M
  86. Mosnier,L.O., Elisen,M.G., Bouma,B.N. and Meijers,J.C.
    Protein C inhibitor regulates the thrombin-thrombomodulin complex in the up- and down regulation of TAFI activation
    Thromb Haemost86, 1057-1064. PubMed  Europe PubMed
  87. Mosnier,L.O., Meijers,J.C. and Bouma,B.N.
    The role of protein S in the activation of thrombin activatable fibrinolysis inhibitor (TAFI) and regulation of fibrinolysis
    Thromb Haemost86, 1040-1046. PubMed  Europe PubMed
  88. [YEAR:15-3-2001]Taylor,F.B., Jr., Peer,G.T., Lockhart,M.S., Ferrell,G. and Esmon,C.T.
    Endothelial cell protein C receptor plays an important role in protein C activation in vivo
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    89. 2000
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