Literature for peptidase S01.218: protein C (activated)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Qin,H., Orduna-Castillo,L.B., Molinar-Inglis,O., Gonzalez Ramirez,M.L., Lopez-Ramirez,M.A., Bardeleben,C. and Trejo,J. Activated protein C drives beta-arrestin-2- and c-Src-dependent phosphorylation of Cav1 and modulates Cav1 association with PAR1 and GRK5 J Biol Chem (2026) 302, 111190-111190. PubMed Europe PubMed DOI

2025

Biswas,I., Kudo,M. and Rezaie,A.R. Endothelial Protein C Receptor and Thrombomodulin Facilitate Protease-Activated Receptor 1 Cleavage at Arginine-46 by Thrombin and Activated Protein C J Biol Chem (2025) , 110339-110339. PubMed Europe PubMed DOI
Gupta,A. and Patibandla,S. Protein C Deficiency (2025) PubMed Europe PubMed
Huntington,J.A., Reckless,J., Polderdijk,S.G.I., Hextall,P. and Baglin,T. The preclinical profile of SerpinPC- a potential new treatment for hemophilia Blood Adv (2025) PubMed Europe PubMed DOI
Leon,G., Klavina,P.A., Rehill,A.M., Cooper,S.E.J., Dominik,A., Basavarajappa,S.C., O'Donnell,J.S., Hussey,S., Walsh,P.T. and Preston,R.J.S. Tissue factor-dependent colitogenic CD4(+) T cell thrombogenicity is regulated by activated protein C signalling Nat Commun (2025) 16, 1677-1677. PubMed Europe PubMed DOI PMC EPMC
Maruo,K., Tsubota,M., Tajima,K., Matsunaga,H., Sekiguchi,F., Minami,T., Ito,A., Tomono,Y., Nishibori,M. and Kawabata,A. Thrombomodulin-Induced Prevention of Peripheral Neuropathy in Oxaliplatin-Treated Mice Involves Complement C5a Inactivation and PAR1 Activation in Addition To HMGB1 Degradation J Neuroimmune Pharmacol (2025) 20, 100-100. PubMed Europe PubMed DOI

2024

Aliyeva,N., Akgonullu,S., Erdem,A. and Denizli,A. Specific DNA aptamer-immobilized cryogel membranes as novel bioaffinity supports and their potential for the purification of activated protein C Biomed Chromatogr (2024) , e5995-e5995. PubMed Europe PubMed DOI
Biswas,I., Giri,H., Panicker,S.R. and Rezaie,A.R. Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin Arterioscler Thromb Vasc Biol (2024) 44, 603-616. PubMed Europe PubMed DOI PMC EPMC
Togashi,T., Baatartsogt,N., Nagao,Y., Kashiwakura,Y., Hayakawa,M., Hiramoto,T., Fujiwara,T., Morishita,E., Nureki,O. and Ohmori,T. Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice Arterioscler Thromb Vasc Biol (2024) PubMed Europe PubMed DOI
Zhou,S., Wu,X., Song,Y., Li,L., Shi,C., Lai,Z., Ding,Q., Wu,W., Dai,J., Wang,X. and Lu,Y. Ser252Asn Mutation Introduces a New N-Linked Glycosylation Site and Causes Type IIb Protein C Deficiency Thromb Haemost (2024) 124, 459-470. PubMed Europe PubMed DOI

2023

Farajzadeh-Dehkordi,M., Mafakher,L., Harifi,A., Samiee-Rad,F. and Rahmani,B. Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C PLoS ONE (2023) 18, e0294417-e0294417. PubMed Europe PubMed DOI PMC EPMC
Giri,H., Biswas,I. and Rezaie,A.R. Activated protein C inhibits mesothelial-to-mesenchymal transition in experimental peritoneal fibrosis J Thromb Haemost (2023) 21, 133-144. PubMed Europe PubMed DOI
Huckriede,J.B., Beurskens,D.M.H., Wildhagen,K.C.C.A., Reutelingsperger,C.P.M., Wichapong,K. and Nicolaes,G.A.F. Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3 J Thromb Haemost (2023) 21, 3557-3567. PubMed Europe PubMed DOI
Li,X., Song,X., Mahmood,D.F.D., Sim,M.M.S., Bidarian,S.J. and Wood,J.P. Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation Thromb Res (2023) 230, 84-93. PubMed Europe PubMed DOI PMC EPMC
Sim,D.S., Shukla,M., Mallari,C.R., Fernandez,J.A., Xu,X., Schneider,D., Bauzon,M., Hermiston,T.W. and Mosnier,L.O. Selective Modulation of Activated Protein C Activities by a Non-Active Site Targeting Nanobody Library Blood Adv (2023) 7, 3036-3048. PubMed Europe PubMed DOI

2022

Ayombil,F., Petrillo,T., Kim,H. and Camire,R.M. Regulation of factor V by the anticoagulant protease activated protein C: Influence of the B-domain and TFPIalpha J Biol Chem (2022) 298, 102558-102558. PubMed Europe PubMed DOI PMC EPMC
Damodara,S., Arora,J., Dwivedi,D.J., Liaw,P.C., Fox-Robichaud,A.E., Selvaganapathy,P.R. and Canadian Critical Care Translational Biology Group Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis Lab Chip (2022) 22, 2566-2577. PubMed Europe PubMed DOI
De Simone,I., Baaten,C.C.F.M., Jandrot-Perrus,M., Gibbins,J.M., ten Cate,H., Heemskerk,J.W.M., Jones,C.I. and van der Meijden,P.E.J. Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1 Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Dons-Jensen,A., Horup,S.S., Hvas,A.M., Vestergaard,E.T. and Johansen,R.F. Ghrelin, growth hormone and insulin-like growth Factor-I levels in people with protein C deficiency Scand J Clin Lab Invest (2022) 82, 435-438. PubMed Europe PubMed DOI
Huuskonen,M.T., Wang,Y., Nikolakopoulou,A.M., Montagne,A., Dai,Z., Lazic,D., Sagare,A.P., Zhao,Z., Fernandez,J.A., Griffin,J.H. and Zlokovic,B.V. Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C J Exp Med (2022) 219 PubMed Europe PubMed DOI PMC EPMC
Kohli,S., Shahzad,K., Jouppila,A., Holthofer,H., Isermann,B. and Lassila,R. Thrombosis and Inflammation-A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C Front Cardiovasc Med (2022) 9, 866751-866751. PubMed Europe PubMed DOI PMC EPMC V
Modrzycka,S., Kolt,S., Polderdijk,S.G.I., Adams,T.E., Potoczek,S., Huntington,J.A., Kasperkiewicz,P. and Drag,M. Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma Chem Sci (2022) 13, 6813-6829. PubMed Europe PubMed DOI PMC EPMC
Morimont,L., Donis,N., Bouvy,C., Mullier,F., Dogne,J.M. and Douxfils,J. Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance Semin Thromb Hemost (2022) 48, 680-689. PubMed Europe PubMed DOI V
Xu,Q.Y., Yang,L.L., Xie,H.X., Jin,Y.H., Li,X.L., Zhou,X.X., Liu,M.N. and Wang,M.S. [Clinical phenotype and gene mutation analysis of 12 patients with hereditary protein C deficiency in different families] Zhonghua Xue Ye Xue Za Zhi (2022) 43, 35-40. PubMed Europe PubMed DOI PMC EPMC

2021

Lu,Y., Biswas,I., Villoutreix,B.O. and Rezaie,A.R. Role of Gly197 in the structure and function of protein C Biochim Biophys Acta Gen Subj (2021) 1865, 129892-129892. PubMed Europe PubMed DOI PMC EPMC
Reda,S., Ruhl,H., Witkowski,J., Muller,J., Pavlova,A., Oldenburg,J. and Potzsch,B. PC Deficiency Testing: Thrombin-Thrombomodulin as PC Activator and Aptamer-Based Enzyme Capturing Increase Diagnostic Accuracy Front Cardiovasc Med (2021) 8, 755281-755281. PubMed Europe PubMed DOI PMC EPMC

2020

Lu,Y., Mehta-D'souza,P., Biswas,I., Villoutreix,B.O., Wang,X., Ding,Q. and Rezaie,A.R. Ile73Asn mutation in protein C introduces a new N-linked glycosylation site on the first EGF-domain of protein C and causes thrombosis Haematologica (2020) 105, 1712-1722. PubMed Europe PubMed DOI M
Madhusudhan,T., Ghosh,S., Wang,H., Dong,W., Gupta,D., Elwakiel,A., Stoyanov,S., Al-Dabet,M.M., Krishnan,S., Biemann,R., Nazir,S., Zimmermann,S., Mathew,A., Gadi,I., Rana,R., Zeng-Brouwers,J., Moeller,M.J., Schaefer,L., Esmon,C.T., Kohli,S., Reiser,J., Rezaie,A.R., Ruf,W. and Isermann,B. Podocyte Integrin-beta 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy J Am Soc Nephrol (2020) 31, 1762-1780. PubMed Europe PubMed DOI
Okada,M., Tominaga,N., Honda,G., Nishioka,J., Akita,N., Hayashi,T., Suzuki,K. and Moriuchi,H. A case of thrombomodulin mutation causing defective thrombin binding with absence of protein C and TAFI activation Blood Adv (2020) 4, 2631-2639. PubMed Europe PubMed DOI PMC EPMC
Sriwastva,M.K., Kunjunni,R., Andrabi,M., Prasad,K., Saxena,R. and Subbiah,V. Neuroprotective Effects of Activated Protein C Involve the PARP/AIF Pathway against Oxygen-Glucose Deprivation in SH-SY5Y Cells Brain Sci (2020) 10 PubMed Europe PubMed DOI PMC EPMC
Stojanovski,B.M., Pelc,L.A., Zuo,X. and Di Cera,E. Zymogen and activated protein C have similar structural architecture J Biol Chem (2020) 295, 15236-15244. PubMed Europe PubMed DOI
Stojanovski,B.M., Pelc,L.A. and Di Cera,E. Role of the activation peptide in the mechanism of protein C activation Sci Rep (2020) 10, 11079-11079. PubMed Europe PubMed DOI PMC EPMC
Zhao,X.Y., Wilmen,A., Wang,D., Wang,X., Bauzon,M., Kim,J.Y., Linden,L., Li,L., Egner,U., Marquardt,T., Moosmayer,D., Tebbe,J., Gluck,J.M., Ellinger,P., McLean,K., Yuan,S., Yegneswaran,S., Jiang,X., Evans,V., Gu,J.M., Schneider,D., Zhu,Y., Xu,Y., Mallari,C., Hesslein,A., Wang,Y., Schmidt,N., Gutberlet,K., Ruehl-Fehlert,C., Freyberger,A., Hermiston,T., Patel,C., Sim,D., Mosnier,L.O. and Laux,V. Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia Nat Commun (2020) 11, 2992-2992. PubMed Europe PubMed DOI PMC EPMC

2019

Lazic,D., Sagare,A.P., Nikolakopoulou,A.M., Griffin,J.H., Vassar,R. and Zlokovic,B.V. 3K3A-Activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice J Exp Med (2019) 216, 279-293. PubMed Europe PubMed DOI

2017

Barranco-Medina,S., Murphy,M., Pelc,L., Chen,Z., Di Cera,E. and Pozzi,N. Rational design of protein C activators Sci Rep (2017) 7, 44596-44596. PubMed Europe PubMed DOI PMC EPMC
Chen,C., Yang,L., Villoutreix,B.O., Wang,X., Ding,Q. and Rezaie,A.R. Gly74Ser mutation in protein C causes thrombosis due to a defect in protein S-dependent anticoagulant function Thromb Haemost (2017) 117, 1358-1369. PubMed Europe PubMed DOI M
Polderdijk,S.G.I., Baglin,T.P. and Huntington,J.A. Targeting activated protein C to treat hemophilia Curr Opin Hematol (2017) 24, 446-452. PubMed Europe PubMed DOI

2015

Dursi,P., Orro,A., Morra,G., Moscatelli,M., Trombetti,G., Milanesi,L. and Rovida,E. Molecular dynamics and docking simulation of a natural variant of activated protein C with impaired protease activity: Implications for integrin-mediated antiseptic function J Biomol Struct Dyn (2015) 33, 85-92. PubMed Europe PubMed DOI M
Griffin,J.H., Zlokovic,B.V. and Mosnier,L.O. Activated protein C: biased for translation Blood (2015) 125, 2898-2907. PubMed Europe PubMed DOI
Satou,M., Nishi,Y., Hishinuma,A., Hosoda,H., Kangawa,K. and Sugimoto,H. Identification of activated protein C as a ghrelin endopeptidase in bovine plasma J Endocrinol (2015) 224, 61-73. PubMed Europe PubMed DOI

2013

Ding,Q., Yang,L., Hassanian,S.M. and Rezaie,A.R. Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population Thromb Haemost (2013) 109, 614-624. PubMed Europe PubMed DOI M
Hepner,M. and Karlaftis,V. Protein C Methods Mol Biol (2013) 992, 365-372. PubMed Europe PubMed DOI M V
Muratsu,J., Morishima,A., Mizoguchi,K., Ataka,K., Yamamoto,H., Fan,X., Miyata,T. and Sakaguchi,K. Budd-Chiari syndrome with multiple thrombi due to a familial Arg42Ser mutation in the protein C gene Case Rep Med (2013) 2013, 270419-270419. PubMed Europe PubMed DOI PMC EPMC M

2012

Cheng,A.C., Wu,H.L., Shi,G.Y. and Tsai,I.H. A novel heparin-dependent inhibitor of activated protein C that potentiates consumptive coagulopathy in Russell's viper envenomation J Biol Chem (2012) 287, 15739-15748. PubMed Europe PubMed DOI
Mosnier,L.O., Sinha,R.K., Burnier,L., Bouwens,E.A. and Griffin,J.H. Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 Blood (2012) 120, 5237-5246. PubMed Europe PubMed DOI P
Muller,J., Friedrich,M., Becher,T., Braunstein,J., Kupper,T., Berdel,P., Gravius,S., Rohrbach,F., Oldenburg,J., Mayer,G. and Potzsch,B. Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay J Thromb Haemost (2012) 10, 390-398. PubMed Europe PubMed DOI A
Shen,L. and Dahlback,B. Protein C [ISSN:978-0-12-407742-3] (2012) 3, 2932-2938. DOI

2011

Brummel-Ziedins,K.E., Whelihan,M.F., Rivard,G.E. and Butenas,S. Activated protein C inhibitor for correction of thrombin generation in hemophilia A blood and plasma J Thromb Haemost (2011) 9, 2262-2267. PubMed Europe PubMed DOI I

2010

Flight,M.H. Proteases: unravelling the therapeutic activity of activated protein C Nat Rev Drug Discov (2010) 9, 20-21. DOI
Gramling,M.W., Beaulieu,L.M. and Church,F.C. Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction Exp Cell Res (2010) 316, 314-328. PubMed Europe PubMed DOI
Nicolaes,G.A., Bock,P.E., Segers,K., Wildhagen,K.C., Dahlback,B. and Rosing,J. Inhibition of thrombin formation by active site mutated (S360A) activated protein C J Biol Chem (2010) 285, 22890-22900. PubMed Europe PubMed DOI
Petraglia,A.L., Marky,A.H., Walker,C., Thiyagarajan,M. and Zlokovic,B.V. Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact Neurosurgery (2010) 66, 165-171. PubMed Europe PubMed DOI PMC EPMC U

2009

Kuriyama,N., Isaji,S., Hamada,T., Kishiwada,M., Ohsawa,I., Usui,M., Sakurai,H., Tabata,M., Suzuki,K. and Uemoto,S. Activated protein C prevents hepatic ischaemia-reperfusion injury in rats Liver Int (2009) 29, 299-307. PubMed Europe PubMed DOI U
Mann,H.J., Short,M.A. and Schlichting,D.E. Protein C in critical illness Am J Health Syst Pharm (2009) 66, 1089-1096. PubMed Europe PubMed DOI V
Mosnier,L.O., Zampolli,A., Kerschen,E.J., Schuepbach,R.A., Banerjee,Y., Fernandez,J.A., Yang,X.V., Riewald,M., Weiler,H., Ruggeri,Z.M. and Griffin,J.H. Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant Blood (2009) 113, 5970-5978. PubMed Europe PubMed DOI PMC EPMC U
Zhong,Z., Ilieva,H., Hallagan,L., Bell,R., Singh,I., Paquette,N., Thiyagarajan,M., Deane,R., Fernandez,J.A., Lane,S., Zlokovic,A.B., Liu,T., Griffin,J.H., Chow,N., Castellino,F.J., Stojanovic,K., Cleveland,D.W. and Zlokovic,B.V. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells J Clin Invest (2009) 119, 3437-3449. PubMed Europe PubMed DOI PMC EPMC U

2008

Komissarov,A.A., Andreasen,P.A., Declerck,P.J., Kamikubo,Y., Zhou,A. and Gruber,A. Redirection of the reaction between activated protein C and a serpin to the substrate pathway Thromb Res (2008) 122, 397-404. PubMed Europe PubMed DOI
Malm,K., Arnljots,B. and Dahlback,B. Human activated protein C variants in a rat model of arterial thrombosis Thromb J (2008) 6, 16-16. PubMed Europe PubMed DOI PMC EPMC
Qureshi,S.H., Manithody,C., Bae,J.S., Yang,L. and Rezaie,A.R. Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays Biophys Chem (2008) 134, 239-245. PubMed Europe PubMed DOI PMC EPMC
Qureshi,S.H., Yang,L., Manithody,C., Bae,J.S. and Rezaie,A.R. Functional properties and active-site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C Biochim Biophys Acta (2008) 1780, 1080-1086. PubMed Europe PubMed DOI PMC EPMC

2007

D'Ursi,P., Marino,F., Caprera,A., Milanesi,L., Faioni,E.M. and Rovida,E. ProCMD: a database and 3D web resource for protein C mutants BMC Bioinformatics (2007) 8 Suppl 1, S11-S11. PubMed Europe PubMed DOI PMC EPMC M
Mosnier,L.O., Yang,X.V. and Griffin,J.H. Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions J Biol Chem (2007) 282, 33022-33033. PubMed Europe PubMed DOI M
Toltl,L.J., Shin,L.Y. and Liaw,P.C. Activated protein C in sepsis and beyond: update 2006 Front Biosci (2007) 12, 1963-1972. PubMed Europe PubMed DOI V
Yang,L., Manithody,C. and Rezaie,A.R. The role of autolysis loop in determining the specificity of coagulation proteases Braz J Med Biol Res (2007) 40, 1055-1064. PubMed Europe PubMed

2006

[YEAR:24-8-2006]de Nanteuil,G., Gloanec,P., Beguin,S., Giesen,P.L., Hemker,H.C., Mennecier,P., Rupin,A. and Verbeuren,T.J. Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders J Med Chem (24-8-2006) 49, 5047-5050. PubMed Europe PubMed DOI T I
[YEAR:4-2-2006]Griffin,J.H., Fernandez,J.A., Mosnier,L.O., Liu,D., Cheng,T., Guo,H. and Zlokovic,B.V. The promise of protein C Blood Cells Mol Dis (4-2-2006) 36, 211-216. PubMed Europe PubMed DOI V
[YEAR:25-8-2006]Norstrom,E.A., Tran,S., Steen,M. and Dahlback,B. Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va J Biol Chem (25-8-2006) 281, 31486-31494. PubMed Europe PubMed DOI P

2005

[YEAR:14-2-2005]Finigan,J.H., Dudek,S.M., Singleton,P.A., Chiang,E.T., Jacobson,J.R., Camp,S.M., Ye,S.Q. and Garcia,J.G. Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation J Biol Chem (14-2-2005) 280, 17286-17293. PubMed Europe PubMed DOI
[YEAR:15-11-2005]Koeppe,J.R., Seitova,A., Mather,T. and Komives,E.A. Thrombomodulin tightens the thrombin active site loops to promote protein C activation Biochemistry (15-11-2005) 44, 14784-14791. PubMed Europe PubMed DOI
Zlokovic,B.V., Zhang,C., Liu,D., Fernandez,J., Griffin,J.H. and Chopp,M. Functional recovery after embolic stroke in rodents by activated protein C Ann Neurol (2005) 58, 474-477. PubMed Europe PubMed DOI

2004

Chan,A.K., Patel,S., Male,C., Berry,L.R. and Mitchell,L.G. Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium Thromb Haemost (2004) 91, 238-247. PubMed Europe PubMed DOI
[YEAR:15-2-2004]Gale,A.J. and Griffin,J.H. Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va Proteins (15-2-2004) 54, 433-441. PubMed Europe PubMed DOI
[YEAR:19-2-2004]Guo,H., Liu,D., Gelbard,H., Cheng,T., Insalaco,R., Fernandez,J.A., Griffin,J.H. and Zlokovic,B.V. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 Neuron (19-2-2004) 41, 563-572. PubMed Europe PubMed DOI
McLeay,A.M. Drotrecogin alfa: A role in emergency department treatment of severe sepsis? Emerg Med Australas (2004) 16, 324-335. PubMed Europe PubMed DOI
[YEAR:3-6-2004]Mosnier,L.O., Gale,A.J., Yegneswaran,S. and Griffin,J.H. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Blood (3-6-2004) 104, 1740-1744. PubMed Europe PubMed DOI
Shen,L. and Dahlback,B. Protein C [ISSN:0-12-079610-4] (2004) 2, 1673-1677. V
[YEAR:27-8-2004]Sun,Y.H., Tran,S., Norstrom,E.A. and Dahlback,B. Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C J Biol Chem (27-8-2004) 279, 47528-47535. PubMed Europe PubMed DOI
[YEAR:14-7-2004]Yang,L., Prasad,S., Di Cera,E. and Rezaie,A.R. The conformation of the activation peptide of protein C is influenced by Ca2+ and Na+ binding J Biol Chem (14-7-2004) 279, 38519-38524. PubMed Europe PubMed DOI

2003

[YEAR:15-4-2003]Berg,D.T., Gerlitz,B., Shang,J., Smith,T., Santa,P., Richardson,M.A., Kurz,K.D., Grinnell,B.W., Mace,K. and Jones,B.E. Engineering the proteolytic specificity of activated protein C improves its pharmacological properties Proc Natl Acad Sci U S A (15-4-2003) 100, 4423-4428. PubMed Europe PubMed DOI PMC EPMC
Esmon,C.T. The protein C pathway Chest (2003) 124, 26S-32S. PubMed Europe PubMed

2002

Esmon,C.T. Protein C pathway in sepsis Ann Med (2002) 34, 598-605. PubMed Europe PubMed
Lind,B., Gedde-Dahl,T., Tjonnfjord,G., Villoutreix,B.O. and Brosstad,F. Protein C deficiency caused by homozygosity for a novel PROC D180G mutation - in vitro expression and structural analysis of the mutation Thromb Haemost (2002) 88, 632-638. PubMed Europe PubMed DOI K

2001

[YEAR:8-3-2001]Bernard,G.R., Vincent,J.L., Laterre,P.F., LaRosa,S.P., Dhainaut,J.F., Lopez-Rodriguez,A., Steingrub,J.S., Garber,G.E., Helterbrand,J.D., Ely,E.W. and Fisher,C.J., Jr. Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med (8-3-2001) 344, 699-709. PubMed Europe PubMed DOI
Cvirn,G., Gallistl,S. and Muntean,W. Alpha-2-macroglobulin inhibits the anticoagulant action of activated protein C in cord and adult plasma Haemostasis (2001) 31, 1-11. PubMed Europe PubMed
[YEAR:22-6-2001]Friedrich,U., Nicolaes,G.A., Villoutreix,B.O. and Dahlback,B. Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va J Biol Chem (22-6-2001) 276, 23105-23108. PubMed Europe PubMed DOI
Grinnell,B.W. and Joyce,D. Recombinant human activated protein C: a system modulator of vascular function for treatment of severe sepsis Crit Care Med (2001) 29, S53-S60. PubMed Europe PubMed
Jackson,C., Nguyen,M., Arkell,J. and Sambrook,P. Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis - Targetting gelatinase A activation Inflamm Res (2001) 50, 183-186. PubMed Europe PubMed DOI
[YEAR:6-4-2001]Joyce,D.E., Gelbert,L., Ciaccia,A., DeHoff,B. and Grinnell,B.W. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis J Biol Chem (6-4-2001) 276, 11199-11203. PubMed Europe PubMed DOI
Lind,B., Koefoed,P. and Thorsen,S. Symptomatic type 1 protein C deficiency caused by a de novo Ser270Leu mutation in the catalytic domain Br J Haematol (2001) 113, 642-648. PubMed Europe PubMed DOI M
Mosnier,L.O., Meijers,J.C. and Bouma,B.N. The role of protein S in the activation of thrombin activatable fibrinolysis inhibitor (TAFI) and regulation of fibrinolysis Thromb Haemost (2001) 86, 1040-1046. PubMed Europe PubMed
Mosnier,L.O., Elisen,M.G., Bouma,B.N. and Meijers,J.C. Protein C inhibitor regulates the thrombin-thrombomodulin complex in the up- and down regulation of TAFI activation Thromb Haemost (2001) 86, 1057-1064. PubMed Europe PubMed
[YEAR:15-3-2001]Taylor,F.B., Jr., Peer,G.T., Lockhart,M.S., Ferrell,G. and Esmon,C.T. Endothelial cell protein C receptor plays an important role in protein C activation in vivo Blood (15-3-2001) 97, 1685-1688. PubMed Europe PubMed DOI

2000

[YEAR:7-3-2000]Esmon,C.T. Regulation of blood coagulation Biochim Biophys Acta (7-3-2000) 1477, 349-360. PubMed Europe PubMed DOI
[YEAR:15-7-2000]Gale,A.J., Heeb,M.J. and Griffin,J.H. The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites Blood (15-7-2000) 96, 585-593. PubMed Europe PubMed
Pellequer,J.L., Gale,A.J., Getzoff,E.D. and Griffin,J.H. Three-dimensional model of coagulation factor Va bound to activated protein C Thromb Haemost (2000) 84, 849-857. PubMed Europe PubMed

1999

Esmon,C.T., Gu,J.M., Xu,J., QU,D., Stearns-Kurosawa,D.J. and Kurosawa,S. Regulation and functions of the protein C anticoagulant pathway Haematologica (1999) 84, 363-368. PubMed Europe PubMed
Hosotaki,K., Imamura,T., Potempa,J., Kitamura,N. and Travis,J. Activation of protein C by arginine-specific cysteine proteinases (gingipains-R) from Porphyromonas gingivalis Biol Chem (1999) 380, 75-80. PubMed Europe PubMed DOI
[YEAR:1-5-1999]Knobe,K.E., Berntsdotter,A., Shen,L., Morser,J., Dahlback,B. and Villoutreix,B.O. Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, site-directed mutagenesis, and computer modeling Proteins (1-5-1999) 35, 218-234. PubMed Europe PubMed DOI
Shen,L., Villoutreix,B.O. and Dahlback,B. Interspecies loop grafting in the protease domain of human protein C yielding enhanced catalytic and anticoagulant activity Thromb Haemost (1999) 82, 1078-1087. PubMed Europe PubMed
Shen,L., Villoutreix,B.O. and Dahlback,B. Involvement of Lys 62(217) and Lys 63(218) of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor Thromb Haemost (1999) 82, 72-79. PubMed Europe PubMed
[YEAR:15-4-1999]Thorelli,E., Kaufman,R.J. and Dahlback,B. Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V Blood (15-4-1999) 93, 2552-2558. PubMed Europe PubMed

1998

[YEAR:15-3-1998]Gal,S.W., Amontov,S., Urvil,P.T., Vishnuvardhan,D., Nishikawa,F., Kumar,P.K. and Nishikawa,S. Selection of a RNA aptamer that binds to human activated protein C and inhibits its protease function Eur J Biochem (15-3-1998) 252, 553-562. PubMed Europe PubMed DOI
[YEAR:20-11-1998]Shen,L., Shah,A.M., Dahlback,B. and Nelsestuen,G.L. Enhancement of human protein C function by site-directed mutagenesis of the gamma-carboxyglutamic acid domain J Biol Chem (20-11-1998) 273, 31086-31091. PubMed Europe PubMed DOI
Takeda-Shitaka,M. and Umeyama,H. Effect of exceptional valine replacement for highly conserved alanine-55 on the catalytic site structure of chymotrypsin-like serine protease Chem Pharm Bull (Tokyo) (1998) 46, 1343-1348. PubMed Europe PubMed

1997

Bode,W., Brandstetter,H., Mather,T. and Stubbs,M.T. Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C Thromb Haemost (1997) 78, 501-511. PubMed Europe PubMed
Butenas,S., DiLorenzo,M.E. and Mann,K.G. Ultrasensitive fluorogenic substrates for serine proteases Thromb Haemost (1997) 78, 1193-1201. PubMed Europe PubMed A
Esmon,C.T., Fukudome,K., Mather,T., Bode,W., Esmon,N.L., Regan,L.M., Stearns-Kurosawa,D.J. and Kurosawa,S. Inflammation. The protein C pathway Fibrinolysis (1997) 11 Suppl. 1, 143-148.
Gale,A.J., Sun,X., Heeb,M.J. and Griffin,J.H. Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va Protein Sci (1997) 6, 132-140. PubMed Europe PubMed DOI PMC EPMC
Lind,B., Johnsen,A.H. and Thorsen,S. Naturally occurring Arg(-1) to His mutation in human protein C leads to aberrant propeptide processing and secretion of dysfunctional protein C Blood (1997) 89, 2807-2816. PubMed Europe PubMed M
[YEAR:3-10-1997]Yegneswaran,S., Wood,G.M., Esmon,C.T. and Johnson,A.E. Protein S alters the active site location of activated protein C above the membrane surface. A fluorescence resonance energy transfer study of topography J Biol Chem (3-10-1997) 272, 25013-25021. PubMed Europe PubMed DOI

1996

Hackeng,T.M., Tans,G., Koppelman,S.J., DE Groot,P.G., Rosing,J. and Bouma,B.N. Protein C activation on endothelial cells by prothrombin activation products generated in situ: meizothrombin is a better protein C activator than alpha-thrombin Biochem J (1996) 319, 399-405. PubMed Europe PubMed PMC EPMC
Lee,T.K., Bangalore,N., Velander,W., Drohan,W.N. and Lubon,H. Activation of recombinant human protein C Thromb Res (1996) 82, 225-234. PubMed Europe PubMed DOI E
Mather,T., Oganessyan,V., Hof,P., Huber,R., Foundling,S., Esmon,C. and Bode,W. The 2.8A crystal structure of Gla-domainless activated protein C EMBO J (1996) 15, 6822-6831. PubMed Europe PubMed PMC EPMC S
Preda,L., Simioni,P., Legnani,C., Palareti,G., Poggio,M., Rossi,E. and Girolami,A. A new global test for the evaluation of the protein C-protein S system Blood Coagul Fibrinolysis (1996) 7, 465-469. PubMed Europe PubMed
[YEAR:1-1-1996]Reitsma,P.H. Protein C deficiency: summary of the 1995 database update Nucleic Acids Res (1-1-1996) 24, 157-159. PubMed Europe PubMed DOI PMC EPMC

1995

[YEAR:1-1-1995]Dahlback,B. The protein C anticoagulant system: inherited defects as basis for venous thrombosis Thromb Res (1-1-1995) 77, 1-43. PubMed Europe PubMed DOI
Esmon,C.T. and Fukudome,K. Cellular regulation of the protein C pathway Semin Cell Biol (1995) 6, 259-268. PubMed Europe PubMed
[YEAR:17-11-1995]Rosing,J., Hoekema,L., Nicolaes,G.A., Thomassen,M.C., Hemker,H.C., Varadi,K., Schwarz,H.P. and Tans,G. Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C J Biol Chem (17-11-1995) 270, 27852-27858. PubMed Europe PubMed DOI

1994

[YEAR:5-5-1994]Bertina,R.M., Koeleman,B.P., Koster,T., Rosendaal,F.R., Dirven,R.J., de Ronde,H., van der Velden,P.A. and Reitsma,P.H. Mutation in blood coagulation factor V associated with resistance to activated protein C Nature (5-5-1994) 369, 64-67. PubMed Europe PubMed DOI
Fisher,C.L., Greengard,J.S. and Griffin,J.H. Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen Protein Sci (1994) 3, 588-599. PubMed Europe PubMed DOI PMC EPMC S
Greengard,J.S., Griffin,J.H. and Fisher,C.L. Possible structural implications of 20 mutations in the protein C protease domain Thromb Haemost (1994) 72, 869-873. PubMed Europe PubMed
Greengard,J.S., Fisher,C.L., Villoutreix,B. and Griffin,J.H. Structural basis for type I and type II deficiencies of antithrombotic plasma protein C: patterns revealed by three-dimensional molecular modelling of mutations of the protease domain Proteins (1994) 18, 367-380. PubMed Europe PubMed DOI S
Varadi,K., Philapitsch,A., Santa,T. and Schwarz,H.P. Activation and inactivation of human protein C by plasmin Thromb Haemost (1994) 71, 615-621. PubMed Europe PubMed

1993

Bakker,H.M., Tans,G., Yukelson,L.Y., Janssen-Claessen,T.W., Bertina,R.M., Hemker,H.C. and Rosing,J. Protein C activation by an activator purified from the venom of Agkistrodon halys halys Blood Coagul Fibrinolysis (1993) 4, 605-614. PubMed Europe PubMed
[YEAR:1-7-1993]Esmon,C.T. Molecular events that control the protein C anticoagulant pathway Thromb Haemost (1-7-1993) 70, 29-35. PubMed Europe PubMed
Esmon,C.T., Esmon,N.L., le Bonniec,B.F. and Johnson,A.E. Protein C activation Methods Enzymol (1993) 222, 359-385. PubMed Europe PubMed DOI V

1992

[YEAR:15-7-1992]Okafuji,T., Maekawa,K., Nawa,K. and Marumoto,Y. The cDNA cloning and mRNA expression of rat protein C Biochim Biophys Acta (15-7-1992) 1131, 329-332. PubMed Europe PubMed DOI
Tada,N., Sato,M., Tsujimura,A., Iwase,R. and Hashimoto-Gotoh,T. Isolation and characterization of a mouse protein C cDNA J Biochem (1992) 111, 491-495. PubMed Europe PubMed

1991

Eckle,I., Seitz,R., Egbring,R., Kolb,G. and Havemann,K. Protein C degradation in vitro by neutrophil elastase Biol Chem Hoppe Seyler (1991) 372, 1007-1013. PubMed Europe PubMed
[YEAR:25-10-1991]Fay,P.J., Smudzin,T.M. and Walker,F.J. Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity J Biol Chem (25-10-1991) 266, 20139-20145. PubMed Europe PubMed
Meijers,J.C. and Chung,D.W. Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14 J Biol Chem (1991) 266, 15028-15034. PubMed Europe PubMed

1990

Yan,S.C., Razzano,P., Chao,Y.B., Walls,J.D., Berg,D.T., McClure,D.B. and Grinnell,B.W. Characterization and novel purification of recombinant human protein C from three mammalian cell lines Biotechnology (N Y) (1990) 8, 655-661. PubMed Europe PubMed DOI

1989

Esmon,C.T. The roles of protein C and thrombomodulin in the regulation of blood coagulation J Biol Chem (1989) 264, 4743-4746. PubMed Europe PubMed
Heeb,M.J., Espana,F. and Griffin,J.H. Inhibition and complexation of activated protein C by two major inhibitors in plasma Blood (1989) 73, 446-454. PubMed Europe PubMed

1987

Francis,R.B., Jr. and Seyfert,U. Rapid amidolytic assay of protein C in whole plasma using an activator from the venom of Agkistrodon contortrix Am J Clin Pathol (1987) 87, 619-625. PubMed Europe PubMed

1986

Plutzky,J., Hoskins,J.A., Long,G.L. and Crabtree,G.R. Evolution and organization of the human protein C gene Proc Natl Acad Sci U S A (1986) 83, 546-550. PubMed Europe PubMed PMC EPMC

1985

[YEAR:21-10-1985]Laurell,M., Ikeda,K., Lindgren,S. and Stenflo,J. Characterization of monoclonal antibodies against human protein C specific for the calcium ion-induced conformation or for the activation peptide region FEBS Lett (21-10-1985) 191, 75-81. PubMed Europe PubMed

1984

[YEAR:1-6-1984]Lijnen,H.R., Uytterhoeven,M. and Collen,D. Inhibition of trypsin-like serine proteinases by tripeptide arginyl and lysyl chloromethylketones Thromb Res (1-6-1984) 34, 431-437. PubMed Europe PubMed I
Long,G.L., Belagaje,R.M. and MacGillivray,R.T. Cloning and sequencing of liver cDNA coding for bovine protein C Proc Natl Acad Sci U S A (1984) 81, 5653-5656. PubMed Europe PubMed PMC EPMC
Sala,N., Owen,W.G. and Collen,D. A functional assay of protein C in human plasma Blood (1984) 63, 671-675. PubMed Europe PubMed

1983

Esmon,C.T. Protein-C: biochemistry, physiology, and clinical implications Blood (1983) 62, 1155-1158. PubMed Europe PubMed V
[YEAR:15-12-1983]Francis,R.B., Jr. and Patch,M.J. A functional assay for protein C in human plasma Thromb Res (15-12-1983) 32, 605-613. PubMed Europe PubMed

1982

[YEAR:25-10-1982]Fernlund,P. and Stenflo,J. Amino acid sequence of the light chain of bovine protein C J Biol Chem (25-10-1982) 257, 12170-12179. PubMed Europe PubMed
[YEAR:25-10-1982]Stenflo,J. and Fernlund,P. Amino acid sequence of the heavy chain of bovine protein C J Biol Chem (25-10-1982) 257, 12180-12190. PubMed Europe PubMed

1981

[YEAR:10-11-1981]Walker,F.J. Regulation of activated protein C by protein S. The role of phospholipid in factor Va inactivation J Biol Chem (10-11-1981) 256, 11128-11131. PubMed Europe PubMed

1977

[YEAR:27-12-1977]Kisiel,W., Canfield,W.M., Ericsson,L.H. and Davie,E.W. Anticoagulant properties of bovine plasma protein C following activation by thrombin Biochemistry (27-12-1977) 16, 5824-5831. PubMed Europe PubMed

1976

Esmon,C.T., Stenflo,J., Suttie,J.W. and Jackson,C.M. A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase J Biol Chem (1976) 251, 3052-3056. PubMed Europe PubMed
Kisiel,W., Ericsson,L.H. and Davie,E.W. Proteolytic activation of protein C from bovine plasma Biochemistry (1976) 15, 4893-4900. PubMed Europe PubMed
Stenflo,J. A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization J Biol Chem (1976) 251, 355-363. PubMed Europe PubMed