$VAR1 = undef;

Summary for peptidase S01.172: kallikrein 1-related peptidase c2 (Rattus norvegicus)

Names
MEROPS Name	kallikrein 1-related peptidase c2 (Rattus norvegicus)
Other names	kallikrein klk1c2 (Rattus sp.), kallikrein rk2 (Rattus sp.), tonin

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.172
Holotype	kallikrein 1-related peptidase c2 (Rattus norvegicus), Uniprot accession P00759 (peptidase unit: 25-258), MERNUM MER0000107
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00294
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Physiology	Liberates angiotensin II directly from precursors.
Pathways	KEGG	Endocrine and other factor-regulated calcium reabsorption
Other databases	TREEFAM	http://www.treefam.org/family/TF331065
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	i/-/p/Rfyhg/L/l/- (based on 21 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	2	2	0	3	1	2	2
Pro	1	1	5	0	0	0	0	0
Ala	1	0	0	1	0	0	0	1
Val	3	3	0	0	0	0	1	1
Leu	2	0	0	0	1	7	4	0
Ile	4	0	0	0	0	0	0	1
Met	0	0	0	0	0	0	1	1
Phe	1	1	3	5	1	1	1	0
Tyr	1	0	0	2	0	1	0	2
Trp	0	0	0	0	1	1	0	0
Ser	0	1	1	0	1	0	0	1
Thr	0	0	1	0	0	0	0	0
Cys	0	0	0	0	1	0	1	0
Asn	0	1	1	0	0	0	0	2
Gln	1	2	1	1	0	0	0	0
Asp	0	0	0	0	0	0	0	0
Glu	0	0	2	0	0	1	0	0
Lys	0	1	1	0	0	0	0	0
Arg	0	1	0	12	0	0	0	0
His	0	3	0	0	4	0	0	0