$VAR1 = undef;
Summary for peptidase S01.160: kallikrein 1
| Names | |
|---|---|
| MEROPS Name | kallikrein 1 |
| Other names | glandular kallikrein, kallikrein hK1 (Homo sapiens), kidney kallikrein, pancreatic kallikrein, KLK1 g.p. (Homo sapiens), submandibular kallikrein, submaxillary kallikrein, urinary kallikrein, kallikrein 1 (Homo sapiens) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.160 |
| Holotype | kallikrein 1 (Sus scrofa) (peptidase unit: 25-262), MERNUM MER0000092 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| Peplist | Included in the Peplist with identifier PL00289 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.35 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (4 cleavages) | ||
| Inhibitors | Not trapped by alpha-2-macroglobulin (Barrett 1981). | ||
| Physiology | Processes kininogen to release hypotensive kinin peptides including kallidin. | ||
| Pharmaceutical relevance | It is reported that vascular kinin-mediated symptoms of experimental oedematous pancreatitis in the rat are caused by the action of tissue kallikrein (Griesbacher et al., 2002). | ||
| Pathways | KEGG | Endocrine and other factor-regulated calcium reabsorption | |
| Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/KLK1 | |
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | -/-/fl/Ry Sr/-/g/- (based on 31 cleavages) | ||
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| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| KLK1 | 19q13.2-q13.4 | ENSG00000167748 | 3816 | KLK1 | 147910 | |
