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Literature for peptidase S01.160: kallikrein 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Curry,J., Su,X.T., Wu,Q., Maeoka,Y., Yang,C.L., Delpire,E., Fenton,R.A., Welling,P.A. and Ellison,D.H.<br>Kidney kallikrein-1 contributes to cleavage of gamma-ENaC in vivo<br>bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2022
  2. Sohaei,D., Hollenberg,M., Janket,S.J., Diamandis,E.P., Poda,G. and Prassas,I.<br>The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology<br>Crit Rev Clin Lab Sci (2022) , 1-16. PubMed  Europe PubMed DOI  V
    3. 2021
  3. Huang,S., Chen,M., Yu,H., Lin,K., Guo,Y. and Zhu,P.<br>Coexpression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemiareperfusion injury by promoting angiogenesis and inhibiting oxidative stress<br>Mol Med Rep (2021) 23 PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2020
  4. De Marco Verissimo,C., Jewhurst,H.L., Tikhonova,I.G., Urbanus,R.T., Maule,A.G., Dalton,J.P. and Cwiklinski,K.<br>Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases<br>PLoS Negl Trop Dis (2020) 14, e0008510-e0008510. PubMed  Europe PubMed DOI
  5. Marceau,F., Rivard,G.E., Gauthier,J.M., Binkley,K.E., Bonnefoy,A., Boccon-Gibod,I., Bouillet,L., Picard,M., Levesque,G., Elfassy,H.L., Bachelard,H., Hebert,J. and Bork,K.<br>Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants<br>Front Med (Lausanne) (2020) 7, 358-358. PubMed  Europe PubMed DOI  PMC  EPMC  I
    6. 2019
  6. Adamopoulos,P.G., Kontos,C.K. and Scorilas,A.<br>Discovery of novel transcripts of the human tissue kallikrein (KLK1) and kallikrein-related peptidase 2 (KLK2) in human cancer cells, exploiting Next-Generation Sequencing technology<br>Genomics (2019) 111, 642-652. PubMed  Europe PubMed DOI  M
  7. Alexander-Curtis,M., Pauls,R., Chao,J., Volpi,J.J., Bath,P.M. and Verdoorn,T.A.<br>Human tissue kallikrein in the treatment of acute ischemic stroke<br>Ther Adv Neurol Disord (2019) 12, 1756286418821918-1756286418821918. PubMed  Europe PubMed DOI  PMC  EPMC  U
  8. Magnen,M., Gueugnon,F., Petit-Courty,A., Baranek,T., Sizaret,D., Brewah,Y.A., Humbles,A.A., Si-Tahar,M. and Courty,Y.<br>Tissue kallikrein regulates alveolar macrophage apoptosis early in influenza virus infection<br>Am J Physiol Lung Cell Mol Physiol (2019) 316, L1127-L1127. PubMed  Europe PubMed DOI  K
    9. 2017
  9. Barros,T.G., Santos,J.A., de Souza,B.E., Sodero,A.C., de Souza,A.M., da Silva,D.P., Rodrigues,C.R., Pinheiro,S., Dias,L.R., Abrahim-Vieira,B., Puzer,L. and Muri,E.M.<br>Discovery of a new isomannide-based peptidomimetic synthetized by Ugi multicomponent reaction as human tissue kallikrein 1 inhibitor<br>Bioorg Med Chem Lett (2017) 27, 314-318. PubMed  Europe PubMed DOI  I
  10. Hong,Z., Pan,L., Fei,J., Ma,Z. and Hong,Z.<br>A positive association between the human tissue kallikerin gene A2233C polymorphism and blood pressure response to benazepril<br>Clin Exp Hypertens (2017) 39, 389-393. PubMed  Europe PubMed DOI  M  I
    11. 2016
  11. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.<br>Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays<br>Mol Cell Proteomics (2016) 15, 2863-2876. PubMed  Europe PubMed DOI  A
    12. 2014
  12. Dong,Y., Harrington,B.S., Adams,M.N., Wortmann,A., Stephenson,S.A., Lisle,J., Herington,A., Hooper,J.D. and Clements,J.A.<br>Activation of membrane-bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases<br>Biol Chem (2014) 395, 977-990. PubMed  Europe PubMed DOI  V
  13. Kolodka,T., Charles,M.L., Raghavan,A., Radichev,I.A., Amatya,C., Ellefson,J., Savinov,A.Y., Nag,A., Williams,M.S. and Robbins,M.S.<br>Preclinical characterization of recombinant human tissue kallikrein-1 as a novel treatment for type 2 diabetes mellitus<br>PLoS ONE (2014) 9, e103981-e103981. PubMed  Europe PubMed DOI  PMC  EPMC  U
  14. Yu,Y., Prassas,I. and Diamandis,E.P.<br>Putative kallikrein substrates and their (patho)biological functions<br>Biol Chem (2014) 395, 931-943. PubMed  Europe PubMed DOI
    15. 2013
  15. Fujita,T., Yasuda,S., Kamata,M., Kamata,Y., Kumagai,Y. and Majima,M.<br>A common polymorphism in the tissue kallikrein gene is associated with increased urinary excretions of calcium and sodium in Japanese volunteers<br>J Hum Genet (2013) 58, 758-761. PubMed  Europe PubMed DOI  M
  16. Gao,L., Bledsoe,G., Yin,H., Shen,B., Chao,L. and Chao,J.<br>Tissue kallikrein-modified mesenchymal stem cells provide enhanced protection against ischemic cardiac injury after myocardial infarction<br>Circ J (2013) 77, 2134-2144. PubMed  Europe PubMed DOI  U
  17. Lundwall,A.<br>Old genes and new genes: The evolution of the kallikrein locus<br>Thromb Haemost (2013) 110, 469-475. PubMed  Europe PubMed DOI  V
    18. 2012
  18. Chao,J.<br>Human kallikrein 1, tissue kallikrein<br>[ISSN:978-0-12-407742-3] (2012) 3, 2757-2761. DOI
  19. Clements,J.A., Hooper,J.D. and Dong,Y.<br>The human tissue kallikrein and kallikrein-related peptidase family<br>[ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
    20. 2011
  20. Biros,E., Norman,P.E., Walker,P.J., Nataatmadja,M., West,M. and Golledge,J.<br>A single nucleotide polymorphism in exon 3 of the kallikrein 1 gene is associated with large but not small abdominal aortic aneurysm<br>Atherosclerosis (2011) 217, 452-457. PubMed  Europe PubMed DOI  M
    21. 2010
  21. Chao,J., Shen,B., Gao,L., Xia,C.F., Bledsoe,G. and Chao,L.<br>Tissue kallikrein in cardiovascular, cerebrovascular and renal diseases and skin wound healing<br>Biol Chem (2010) 391, 345-355. PubMed  Europe PubMed DOI
  22. Gao,L., Chao,L. and Chao,J.<br>A novel signaling pathway of tissue kallikrein in promoting keratinocyte migration: activation of proteinase-activated receptor 1 and epidermal growth factor receptor<br>Exp Cell Res (2010) 316, 376-389. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Gao,L., Smith,R.S., Chen,L.M., Chai,K.X., Chao,L. and Chao,J.<br>Tissue kallikrein promotes prostate cancer cell migration and invasion via a protease-activated receptor-1-dependent signaling pathway<br>Biol Chem (2010) 391, 803-812. PubMed  Europe PubMed DOI
  24. Pavlopoulou,A., Pampalakis,G., Michalopoulos,I. and Sotiropoulou,G.<br>Evolutionary history of tissue kallikreins<br>PLoS ONE (2010) 5, e13781-e13781. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2009
  25. Sexton,D.J., Chen,T., Martik,D., Kuzmic,P., Kuang,G., Chen,J., Nixon,A.E., Zuraw,B.L., Forteza,R.M., Abraham,W.M. and Wood,C.R.<br>Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases<br>Biochem J (2009) 422, 383-392. PubMed  Europe PubMed DOI
    26. 2008
  26. Clements,J.A.<br>Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?<br>Biol Chem (2008) 389, 1447-1454. PubMed  Europe PubMed DOI  V
  27. Horrevoets,A.J.<br>Kallikrein teams up with GSK-3beta in heart failure prevention<br>Cardiovasc Res (2008) 80, 328-329. PubMed  Europe PubMed DOI
  28. Huang,X., Wang,S., Chen,P., Wang,J., Chen,Y., Pan,X. and Cao,Z.<br>[High level expression, purification and characterization of human kallikrein-1 in Pichia pastoris]<br>Sheng Wu Gong Cheng Xue Bao (2008) 24, 1186-1193. PubMed  Europe PubMed  E
  29. Li,H.X., Hwang,B.Y., Laxmikanthan,G., Blaber,S.I., Blaber,M., Golubkov,P.A., Ren,P., Iverson,B.L. and Georgiou,G.<br>Substrate specificity of human kallikreins 1 and 6 determined by phage display<br>Protein Sci (2008) 17, 664-672. PubMed  Europe PubMed DOI  PMC  EPMC  P
  30. Lima,A.R., Alves,F.M., Angelo,P.F., Andrade,D., Blaber,S.I., Blaber,M., Juliano,L. and Juliano,M.A.<br>S(1)' and S(2)' subsite specificities of human plasma kallikrein and tissue kallikrein 1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen<br>Biol Chem (2008) 389, 1487-1494. PubMed  Europe PubMed DOI  P
  31. Lundwall,A. and Brattsand,M.<br>Kallikrein-related peptidases<br>Cell Mol Life Sci (2008) 65, 2019-2038. PubMed  Europe PubMed DOI
  32. Pizard,A., Richer,C., Bouby,N., Picard,N., Meneton,P., Azizi,M. and Alhenc-Gelas,F.<br>Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney<br>Biol Chem (2008) 389, 701-706. PubMed  Europe PubMed DOI  K
  33. Yan,J.T., Wang,T., Li,J., Xiao,X. and Wang,D.W.<br>Recombinant adeno-associated virus-mediated human kallikrein gene therapy prevents high-salt diet-induced hypertension without effect on basal blood pressure<br>Acta Pharmacol Sin (2008) 29, 808-814. PubMed  Europe PubMed DOI  U
  34. Yao,Y.Y., Yin,H., Shen,B., Smith,R.S., Jr., Liu,Y., Gao,L., Chao,L. and Chao,J.<br>Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway<br>Cardiovasc Res (2008) 80, 354-364. PubMed  Europe PubMed DOI  PMC  EPMC  U
    35. 2007
  35. Blanchard,A., Azizi,M., Peyrard,S., Stern,N., Alhenc-Gelas,F., Houillier,P. and Jeunemaitre,X.<br>Partial human genetic deficiency in tissue kallikrein activity and renal calcium handling<br>Clin J Am Soc Nephrol (2007) 2, 320-325. PubMed  Europe PubMed DOI  M
  36. Dai,Y., Peng,W., Li,T., Du,H., Sun,W., Chen,D. and Xu,Z.<br>Construction and identification of human tissue kallikrein gene eukaryotic expressing vector<br>J Huazhong Univ Sci Technolog Med Sci (2007) 27, 164-166. PubMed  Europe PubMed DOI
  37. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.<br>Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis<br>Genomics (2007) 89, 429-438. PubMed  Europe PubMed DOI
  38. Messadi-Laribi,E., Griol-Charhbili,V., Pizard,A., Vincent,M.P., Heudes,D., Meneton,P., Alhenc-Gelas,F. and Richer,C.<br>Tissue kallikrein is involved in the cardioprotective effect of AT1-receptor blockade in acute myocardial ischemia<br>J Pharmacol Exp Ther (2007) 323, 210-216. PubMed  Europe PubMed DOI  K
  39. Rosenblum,G., Meroueh,S., Toth,M., Fisher,J.F., Fridman,R., Mobashery,S. and Sagi,I.<br>Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma<br>J Am Chem Soc (2007) 129, 13566-13574. PubMed  Europe PubMed DOI
  40. Yao,Y.Y., Yin,H., Shen,B., Chao,L. and Chao,J.<br>Tissue kallikrein infusion prevents cardiomyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction<br>Regul Pept (2007) 140, 12-20. PubMed  Europe PubMed DOI  PMC  EPMC  U
  41. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.<br>Activation profiles and regulatory cascades of the human kallikrein-related peptidases<br>J Biol Chem (2007) 282, 31852-31864. PubMed  Europe PubMed DOI  V
  42. Zhao,W., Wang,L., Lu,X., Yang,W., Huang,J., Chen,S. and Gu,D.<br>A coding polymorphism of the kallikrein 1 gene is associated with essential hypertension: a tagging SNP-based association study in a Chinese Han population<br>J Hypertens (2007) 25, 1821-1827. PubMed  Europe PubMed DOI  M
    43. 2006
  43. Lundwall,A., Clauss,A. and Olsson,A.Y.<br>Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitors<br>Biol Chem (2006) 387, 243-249. PubMed  Europe PubMed DOI
    44. 2005
  44. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.<br>A survey of alternative transcripts of human tissue kallikrein genes<br>Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed  Europe PubMed DOI  R
  45. [YEAR:13-1-2005]Laxmikanthan,G., Blaber,S.I., Bernett,M.J., Scarisbrick,I.A., Juliano,M.A. and Blaber,M.<br>1.70 A X-ray structure of human apo kallikrein 1: Structural changes upon peptide inhibitor/substrate binding<br>Proteins (13-1-2005) 58, 802-814. PubMed  Europe PubMed DOI  S
  46. [YEAR:13-1-2005]Michael,I.P., Kurlender,L., Memari,N., Yousef,G.M., Du,D., Grass,L., Stephan,C., Jung,K. and Diamandis,E.P.<br>Intron retention: a common splicing event within the human kallikrein gene family<br>Clin Chem (13-1-2005) 51, 506-515. PubMed  Europe PubMed DOI  R
  47. Montanari,D., Yin,H., Dobrzynski,E., Agata,J., Yoshida,H., Chao,J. and Chao,L.<br>Kallikrein gene delivery improves serum glucose and lipid profiles and cardiac function in streptozotocin-induced diabetic rats<br>Diabetes (2005) 54, 1573-1580. PubMed  Europe PubMed DOI  U
    48. 2004
  48. Chao,J.<br>Human kallikrein 1, tissue kallikrein<br>[ISSN:0-12-079610-4] (2004) 2, 1577-1580.  V
  49. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.<br>The tissue kallikrein gene cluster<br>[ISSN:0-12-079610-4] (2004) 2, 1569-1577.  V
  50. De Sousa,M.O., Santoro,M.M. and De Souza Figueiredo,A.F.<br>The effect of cations on the amidase activity of human tissue kallikrein: 1-linear competitive inhibition by sodium, potassium, calcium and magnesium. 2-linear mixed inhibition by aluminium<br>J Enzyme Inhib Med Chem (2004) 19, 317-325. PubMed  Europe PubMed
  51. [YEAR:25-3-2004]Fogaca,S.E., Melo,R.L., Pimenta,D.C., Hosoi,K., Juliano,L. and Juliano,M.A.<br>Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins<br>Biochem J (25-3-2004) 380, 775-781. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Olsson,A.Y., Lilja,H. and Lundwall,A.<br>Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen<br>Genomics (2004) 84, 147-156. PubMed  Europe PubMed DOI
  53. [YEAR:22-12-2004]Olsson,A.Y., Valtonen-Andre,C., Lilja,H. and Lundwall,A.<br>The evolution of the glandular kallikrein locus: identification of orthologs and pseudogenes in the cotton-top tamarin<br>Gene (22-12-2004) 343, 347-355. PubMed  Europe PubMed DOI
  54. [YEAR:3-6-2004]Wang,T., Li,H., Zhao,C., Chen,C., Li,J., Chao,J., Chao,L., Xiao,X. and Wang,D.W.<br>Recombinant adeno-associated virus-mediated kallikrein gene therapy reduces hypertension and attenuates its cardiovascular injuries<br>Gene Ther (3-6-2004) 11, 1342-1350. PubMed  Europe PubMed DOI  U
    55. 2003
  55. Zhao,C., Wang,P., Xiao,X., Chao,J., Chao,L., Wang,D.W. and Zeldin,D.C.<br>Gene therapy with human tissue kallikrein reduces hypertension and hyperinsulinemia in fructose-induced hypertensive rats<br>Hypertension (2003) 42, 1026-1033. PubMed  Europe PubMed DOI  U
    56. 2002
  56. Agata,J., Chao,L. and Chao,J.<br>Kallikrein gene delivery improves cardiac reserve and attenuates remodeling after myocardial infarction<br>Hypertension (2002) 40, 653-659. PubMed  Europe PubMed DOI  U
  57. Emanueli,C., Salis,M.B., Pinna,A., Stacca,T., Milia,A.F., Spano,A., Chao,J., Chao,L., Sciola,L. and Madeddu,P.<br>Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer<br>Circulation (2002) 106, 993-999. PubMed  Europe PubMed DOI  U
  58. Griesbacher,T., Rainer,I., Tiran,B. and Evans,D.M.<br>Involvement of tissue kallikrein but not plasma kallikrein in the development of symptoms mediated by endogenous kinins in acute pancreatitis in rats<br>Br J Pharmacol (2002) 137, 692-700. PubMed  Europe PubMed DOI  PMC  EPMC  I
  59. Kurabuchi,S., Hosoi,K. and Gresik,E.W.<br>Developmental and androgenic regulation of the immunocytochemical distribution of mK1, a true tissue kallikrein, in the granular convoluted tubule of the mouse submandibular gland<br>J Histochem Cytochem (2002) 50, 135-145. PubMed  Europe PubMed
  60. Slim,R., Torremocha,F., Moreau,T., Pizard,A., Hunt,S.C., Vuagnat,A., Williams,G.H., Gauthier,F., Jeunemaitre,X. and Alhenc-Gelas,F.<br>Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity<br>J Am Soc Nephrol (2002) 13, 968-976. PubMed  Europe PubMed  M
  61. [YEAR:1-4-2002]Sousa,M.O., Miranda,T.L., Maia,C.N., Bittar,E.R., Santoro,M.M. and Figueiredo,A.F.<br>Kinetic peculiarities of human tissue kallikrein: 1 - Substrate activation in the catalyzed hydrolysis of H-D-valyl-L-leucyl-L-arginine 4-nitroanilide and H-D-valyl-L-leucyl-L-lysine 4-nitroanilide; 2 - Substrate inhibition in the catalyzed hydrolysis of Nalpha-p-tosyl-L-arginine methyl ester<br>Arch Biochem Biophys (1-4-2002) 400, 7-14. PubMed  Europe PubMed DOI
  62. Yu,H., Song,Q., Freedman,B.I., Chao,J., Chao,L., Rich,S.S. and Bowden,D.W.<br>Association of the tissue kallikrein gene promoter with ESRD and hypertension<br>Kidney Int (2002) 61, 1030-1039. PubMed  Europe PubMed DOI  M
    63. 2001
  63. [YEAR:30-3-2001]Bergaya,S., Meneton,P., Bloch-Faure,M., Mathieu,E., Alhenc-Gelas,F., Levy,B.I. and Boulanger,C.M.<br>Decreased flow-dependent dilation in carotid arteries of tissue kallikrein-knockout mice<br>Circ Res (30-3-2001) 88, 593-599. PubMed  Europe PubMed  K
  64. Clements,J., Hooper,J., Dong,Y. and Harvey,T.<br>The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions<br>Biol Chem (2001) 382, 5-14. PubMed  Europe PubMed DOI  V
  65. Dedio,J., Wiemer,G., Rutten,H., Dendorfer,A., Scholkens,B.A., Muller-Esterl,W. and Wohlfart,P.<br>Tissue kallikrein KLK1 is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins<br>Biol Chem (2001) 382, 1483-1490. PubMed  Europe PubMed DOI
  66. Emanueli,C., Salis,M.B., Stacca,T., Gaspa,L., Chao,J., Chao,L., Piana,A. and Madeddu,P.<br>Rescue of impaired angiogenesis in spontaneously hypertensive rats by intramuscular human tissue kallikrein gene transfer<br>Hypertension (2001) 38, 136-141. PubMed  Europe PubMed  U
  67. [YEAR:1-5-2001]Melo,R.L., Barbosa Pozzo,R.C., Pimenta,D.C., Perissutti,E., Caliendo,G., Santagada,V., Juliano,L. and Juliano,M.A.<br>Human tissue kallikrein S1 subsite recognition of non-natural basic amino acids<br>Biochemistry (1-5-2001) 40, 5226-5232. PubMed  Europe PubMed
  68. [YEAR:27-2-2001]Meneton,P., Bloch-Faure,M., Hagege,A.A., Ruetten,H., Huang,W., Bergaya,S., Ceiler,D., Gehring,D., Martins,I., Salmon,G., Boulanger,C.M., Nussberger,J., Crozatier,B., Gasc,J.M., Heudes,D., Bruneval,P., Doetschman,T., Menard,J. and Alhenc-Gelas,F.<br>Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice<br>Proc Natl Acad Sci U S A (27-2-2001) 98, 2634-2639. PubMed  Europe PubMed DOI  PMC  EPMC  K
  69. Wolf,W.C., Evans,D.M., Chao,L. and Chao,J.<br>A synthetic tissue kallikrein inhibitor suppresses cancer cell invasiveness<br>Am J Pathol (2001) 159, 1797-1805. PubMed  Europe PubMed DOI  PMC  EPMC  I
    70. 2000
  70. [YEAR:15-6-2000]Chen,V.C., Chao,L. and Chao,J.<br>Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis<br>Biochim Biophys Acta (15-6-2000) 1479, 237-246. PubMed  Europe PubMed DOI
  71. Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.<br>The new human kallikrein gene family: implications in carcinogenesis<br>Trends Endocrinol Metab (2000) 11, 54-60. PubMed  Europe PubMed DOI
  72. [YEAR:17-10-2000]Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J., Moss,P., Paeper,B. and Wang,K.<br>Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region<br>Gene (17-10-2000) 257, 119-130. PubMed  Europe PubMed DOI
  73. Hecquet,C., Tan,F., Marcic,B.M. and Erdos,E.G.<br>Human bradykinin B(2) receptor is activated by kallikrein and other serine proteases<br>Mol Pharmacol (2000) 58, 828-836. PubMed  Europe PubMed
  74. Silva,J.A., Jr., Araujo,R.C., Baltatu,O., Oliveira,S.M., Tschope,C., Fink,E., Hoffmann,S., Plehm,R., Chai,K.X., Chao,L., Chao,J., Ganten,D., Pesquero,J.B. and Bader,M.<br>Reduced cardiac hypertrophy and altered blood pressure control in transgenic rats with the human tissue kallikrein gene<br>FASEB J (2000) 14, 1858-1860. PubMed  Europe PubMed DOI
  75. Yoshida,H., Zhang,J.J., Chao,L. and Chao,J.<br>Kallikrein gene delivery attenuates myocardial infarction and apoptosis after myocardial ischemia and reperfusion<br>Hypertension (2000) 35, 25-31. PubMed  Europe PubMed
  76. [YEAR:16-9-2000]Yousef,G.M., Chang,A., Scorilas,A. and Diamandis,E.P.<br>Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4<br>Biochem Biophys Res Commun (16-9-2000) 276, 125-133. PubMed  Europe PubMed DOI
    77. 1999
  77. Del Nery,E., Chagas,J.R., Juliano,M.A., Juliano,L. and Prado,E.S.<br>Comparison of human and porcine tissue kallikrein substrate specificities<br>Immunopharmacology (1999) 45, 151-157. PubMed  Europe PubMed DOI
  78. Fiedler,F., Betz,G., Hinz,H., Lottspeich,F., Raidoo,D.M. and Bhoola,K.D.<br>Not more than three tissue kallikreins identified from organs of the guinea pig<br>Biol Chem (1999) 380, 63-73. PubMed  Europe PubMed DOI
  79. [YEAR:15-4-1999]Pimenta,D.C., Chao,J., Chao,L., Juliano,M.A. and Juliano,L.<br>Specificity of human tissue kallikrein towards substrates containing Phe-Phe pair of amino acids<br>Biochem J (15-4-1999) 339, 473-479. PubMed  Europe PubMed DOI  PMC  EPMC  P
  80. Rae,F., Bulmer,B., Nicol,D. and Clements,J.<br>The human tissue kallikreins (KLKs 1-3) and a novel KLK1 mRNA transcript are expressed in a renal cell carcinoma cDNA library<br>Immunopharmacology (1999) 45, 83-88. PubMed  Europe PubMed DOI
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