$VAR1 = undef;

Summary for peptidase S01.015: tryptase beta

Names
MEROPS Name	tryptase beta
Other names	tryptase alpha 2 (Homo sapiens), tryptase III, tryptase 3, tryptase beta 2 (Homo sapiens), tryptase 2B, TPSB2 g.p. (Homo sapiens), tryptase 1, tryptase beta 3 (Homo sapiens), tryptase beta 1 (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.015
Holotype	tryptase beta (Homo sapiens), Uniprot accession P20231 (peptidase unit: 31-274), MERNUM MER0000136
History	Identifier created: MEROPS 3.30 (20 July 1999)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00266
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (44 cleavages)
Other databases	PANTHER	http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR24256:SF149
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	p/-/-/KR-/-/-/e (based on 65 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	6	1	0	4	4	4	7
Pro	12	1	3	0	0	0	2	6
Ala	10	13	4	0	8	10	8	8
Val	2	1	5	0	5	3	4	0
Leu	6	2	4	0	4	1	3	0
Ile	2	3	1	0	4	4	1	0
Met	0	1	0	0	0	0	0	0
Phe	2	2	4	0	2	2	1	3
Tyr	0	1	6	0	5	0	2	2
Trp	0	0	3	0	0	0	2	0
Ser	3	3	2	0	2	3	1	1
Thr	2	2	4	0	3	7	7	4
Cys	0	0	0	0	0	0	0	1
Asn	0	1	11	0	1	3	2	0
Gln	1	1	2	0	1	0	1	0
Asp	3	1	3	0	1	6	2	0
Glu	7	7	6	0	1	1	2	9
Lys	0	5	4	44	2	1	3	3
Arg	0	8	0	21	2	1	1	1
His	1	0	0	0	1	0	0	1

Specificity from combinatorial peptides

Organism	comment	P4	P3	P2	P1	P1'	P2'	P3'	P4'	optimal substrate	fluorophore or acceptor-donor pair	Reference
Homo sapiens	recombinant	P/I	R/K/broad	N	K/R	-	-	-	-	PRNK	ACC	Harris et al., 2001
Homo sapiens	recombinant	P/I	R/K/broad	N/H/T	K/R	-	-	-	-	PRNK	ACC	Harris et al., 2001

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
TPSB2	16p13.3		ENSG00000172236	64499	TPSB2	191081