Literature for peptidase S01.015: tryptase beta

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

Alheraky,A., Wierenga,A.T.J., Simpelaar,A., Hesp,L.B., Minovic,I., Bagheri,N., Roozendaal,C., Span,L.F.R., Oude Elberink,H.N.G., Kema,I.P. and Mulder,A.B. Hereditary Alpha Tryptasemia: Validation of a Single-Well Multiplex Digital Droplet PCR Assay in a Cohort of Symptomatic Patients Clin Chem (2024) 70, 425-433. PubMed Europe PubMed DOI
Ma,Y., Li,B., Zhao,X., Lu,Y., Li,X., Zhang,J., Wang,Y., Zhang,J., Wang,L., Meng,S. and Hao,J. Computational modeling of mast cell tryptase family informs selective inhibitor development iScience (2024) 27, 110739-110739. PubMed Europe PubMed DOI PMC EPMC
Shin,H. and Lyons,J.J. Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell-Mediated Reactions Curr Allergy Asthma Rep (2024) 24, 199-209. PubMed Europe PubMed DOI V
Svetina,M., Selb,J., Lyons,J.J., Korosec,P. and Rijavec,M. Clinically accessible amplitude-based multiplex ddPCR assay for tryptase genotyping Sci Rep (2024) 14, 2416-2416. PubMed Europe PubMed DOI PMC EPMC

2023

Das,N., de Almeida,L.G.N., Derakhshani,A., Young,D., Mehdinejadiani,K., Salo,P., Rezansoff,A., Jay,G.D., Sommerhoff,C.P., Schmidt,T.A., Krawetz,R. and Dufour,A. Tryptase beta regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis Nat Commun (2023) 14, 1910-1910. PubMed Europe PubMed DOI PMC EPMC

2022

Bonadonna,P., Nalin,F. and Olivieri,F. Hereditary alpha-tryptasemia Curr Opin Allergy Clin Immunol (2022) 22, 277-282. PubMed Europe PubMed DOI V
O'Connell,M.P. and Lyons,J.J. Resolving the genetics of human tryptases: implications for health, disease, and clinical use as a biomarker Curr Opin Allergy Clin Immunol (2022) 22, 143-152. PubMed Europe PubMed DOI V

2021

Lyons,J.J. On the complexities of tryptase genetics and impact on clinical phenotypes J Allergy Clin Immunol (2021) PubMed Europe PubMed DOI

2020

Alanazi,S., Grujic,M., Lampinen,M., Rollman,O., Sommerhoff,C.P., Pejler,G. and Melo,F.R. Mast Cell beta-Tryptase Is Enzymatically Stabilized by DNA Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI
Giardina,S.F., Werner,D.S., Pingle,M., Feinberg,P.B., Foreman,K.W., Bergstrom,D.E., Arnold,L.D. and Barany,F. Novel, self-assembling dimeric inhibitors of human beta tryptase J Med Chem (2020) 63, 3004-3027. PubMed Europe PubMed DOI I
Lobbes,H., Reynaud,Q., Mainbourg,S., Lega,J.C., Durieu,I. and Durupt,S. [Tryptase: A practical guide for the physician] Rev Med Interne (2020) PubMed Europe PubMed DOI
Maun,H.R., Vij,R., Walters,B.T., Morando,A., Jackman,J.K., Wu,P., Estevez,A., Chen,X., Franke,Y., Lipari,M.T., Dennis,M.S., Kirchhofer,D., Ciferri,C., Loyet,K.M., Yi,T., Eigenbrot,C., Lazarus,R.A. and Koerber,J.T. Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge Nat Commun (2020) 11, 6435-6435. PubMed Europe PubMed DOI PMC EPMC

2019

Le,Q.T., Lyons,J.J., Naranjo,A.N., Olivera,A., Lazarus,R.A., Metcalfe,D.D., Milner,J.D. and Schwartz,L.B. Impact of naturally forming human alpha/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia J Exp Med (2019) 216, 2348-2361. PubMed Europe PubMed DOI
Shim,J.K., Kennedy,R.H., Weatherly,L.M., Abovian,A.V., Hashmi,H.N., Rajaei,A. and Gosse,J.A. Searching for tryptase in the RBL-2H3 mast cell model: preparation for comparative mast cell toxicology studies with zebrafish J Appl Toxicol (2019) 39, 473-484. PubMed Europe PubMed DOI

2018

Giardina,S.F., Werner,D.S., Pingle,M., Foreman,K.W., Bergstrom,D.E., Arnold,L.D. and Barany,F. Target-directed self-assembly of homodimeric drugs against beta-tryptase ACS Med Chem Lett (2018) 9, 827-831. PubMed Europe PubMed DOI PMC EPMC I
Giardina,S.F., Werner,D.S., Pingle,M., Bergstrom,D.E., Arnold,L.D. and Barany,F. A novel, nonpeptidic, orally active bivalent inhibitor of human beta-tryptase Pharmacology (2018) 102, 233-243. PubMed Europe PubMed DOI S I
Marinelli,E. and Ciallella,C. Post mortem determination of (beta)-tryptase for the diagnosis of anaphylaxis: looking for a reasonable cut-off Clin Ter (2018) 169, e60-e60. PubMed Europe PubMed DOI
Maun,H.R., Liu,P.S., Franke,Y., Eigenbrot,C., Forrest,W.F., Schwartz,L.B. and Lazarus,R.A. Dual functionality of beta-tryptase protomers as both proteases and cofactors in the active tetramer J Biol Chem (2018) 293, 9614-9628. PubMed Europe PubMed DOI

2016

Caughey,G.H. Mast cell proteases as pharmacological targets Eur J Pharmacol (2016) 778, 44-55. PubMed Europe PubMed DOI

2015

Jiang,Q.-Q., Sicking,W., Ehlers,M. and Schmuck,C. Discovery of potent inhibitors of human beta-tryptase from pre-equilibrated dynamic combinatorial libraries Chem Sci (2015) 6, 1792-1800. PubMed Europe PubMed DOI I
Vitte,J. Human mast cell tryptase in biology and medicine Mol Immunol (2015) 63, 18-24. PubMed Europe PubMed DOI
Wang,Y., Zheng,Q.C., Kong,C.P., Tian,Y., Zhan,J., Zhang,J.L. and Zhang,H.X. Heparin makes differences: a molecular dynamics simulation study on the human betaII-tryptase monomer Mol Biosyst (2015) 11, 252-261. PubMed Europe PubMed DOI

2014

Abdelmotelb,A.M., Rose-Zerilli,M.J., Barton,S.J., Holgate,S.T., Walls,A.F. and Holloway,J.W. Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma Clin Exp Allergy (2014) 44, 822-830. PubMed Europe PubMed DOI M
Le,Q.T., Lotfi-Emran,S., Min,H.K. and Schwartz,L.B. A simple, sensitive and safe method to determine the human alpha/beta-tryptase genotype PLoS ONE (2014) 9, e114944-e114944. PubMed Europe PubMed DOI M
Prieto-Garcia,A., Castells,M.C. and Stevens,R.L. Mast cell-derived htryptase-beta functions as a potent anticoagulant by proteolytically damaging fibrinogen J Investig Allergol Clin Immunol (2014) 24, 286-287. PubMed Europe PubMed
Wang,Q., Shi,X., Zhu,X., Ehlers,M., Wu,J. and Schmuck,C. A fluorescent light-up probe as an inhibitor of intracellular beta-tryptase Chem Commun (Camb) (2014) 50, 6120-6122. PubMed Europe PubMed DOI L I

2013

Cook,K.M., McNeil,H.P. and Hogg,P.J. Allosteric control of betaII-tryptase by a redox active disulfide bond J Biol Chem (2013) 288, 34920-34929. PubMed Europe PubMed DOI
Jiang,Q.Q., Bartsch,L., Sicking,W., Wich,P.R., Heider,D., Hoffmann,D. and Schmuck,C. A new approach to inhibit human beta-tryptase by protein surface binding of four-armed peptide ligands with two different sets of arms Org Biomol Chem (2013) 11, 1631-1639. PubMed Europe PubMed DOI I
Magarinos,N.J., Bryant,K.J., Fosang,A.J., Adachi,R., Stevens,R.L. and McNeil,H.P. Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens J Immunol (2013) 191, 1404-1412. PubMed Europe PubMed DOI

2012

Hernandez-Hernandez,L., Sanz,C., Garcia-Solaesa,V., Padron,J., Garcia-Sanchez,A., Davila,I., Isidoro-Garcia,M. and Lorente,F. Tryptase: genetic and functional considerations Allergol Immunopathol (Madr) (2012) 40, 385-389. PubMed Europe PubMed DOI
Liang,G., Choi-Sledeski,Y.M., Shum,P., Chen,X., Poli,G.B., Kumar,V., Minnich,A., Wang,Q., Tsay,J., Sides,K., Kang,J. and Zhang,Y. A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity Bioorg Med Chem Lett (2012) 22, 1606-1610. PubMed Europe PubMed DOI I
Liang,G., Aldous,S., Merriman,G., Levell,J., Pribish,J., Cairns,J., Chen,X., Maignan,S., Mathieu,M., Tsay,J., Sides,K., Rebello,S., Whitely,B., Morize,I. and Pauls,H.W. Structure-based library design and the discovery of a potent and selective mast cell beta-tryptase inhibitor as an oral therapeutic agent Bioorg Med Chem Lett (2012) 22, 1049-1054. PubMed Europe PubMed DOI I
Liang,G., Choi-Sledeski,Y.M., Chen,X., Gong,Y., Macmillan,E.W., Tsay,J., Sides,K., Cairns,J., Kulitzscher,B., Aldous,D.J., Morize,I. and Pauls,H.W. Dimerization of beta-tryptase inhibitors, does it work for both basic and neutral P1 groups? Bioorg Med Chem Lett (2012) 22, 3370-3376. PubMed Europe PubMed DOI I
Prieto-Garcia,A., Zheng,D., Adachi,R., Xing,W., Lane,W.S., Chung,K., Anderson,P., Hansbro,P.M., Castells,M. and Stevens,R.L. Mast cell restricted mouse and human tryptase.heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen J Biol Chem (2012) 287, 7834-7844. PubMed Europe PubMed DOI
Trivedi,N.N. and Caughey,G.H. Human alpha-, beta- and delta-tryptases [ISSN:978-0-12-407742-3] (2012) 3, 2683-2693. DOI

2011

Janke,D., Sommerhoff,C.P. and Schaschke,N. The arginine mimicking beta-amino acid beta3hPhe(3-H2N-CH2) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors Bioorg Med Chem (2011) 19, 7236-7243. PubMed Europe PubMed DOI I
Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B. Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C J Immunol (2011) 186, 7136-7143. PubMed Europe PubMed DOI
Le,Q.T., Gomez,G., Zhao,W., Hu,J., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B. Processing of human protryptase in mast cells involves cathepsins L, B, and C J Immunol (2011) 187, 1912-1918. PubMed Europe PubMed DOI
Liang,G., Choi-Sledeski,Y.M., Poli,G.B., Chen,X., Minnich,A., Wang,Q., Tsay,J., Sides,K. and Vaz,R.J. Structure-based design, synthesis, and profiling of a beta-tryptase inhibitor with a spiro-piperidineamide scaffold, benzylamine P1 group, and a substituted indole P4 group MedChemComm (2011) 2, 794-799. DOI I
Spinnler,K., Frohlich,T., Arnold,G.J., Kunz,L. and Mayerhofer,A. Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF/pro-NGF action J Biol Chem (2011) 286, 31707-31713. PubMed Europe PubMed DOI

2010

Liang,G., Choi-Sledeski,Y.M., Poli,G., Chen,X., Shum,P., Minnich,A., Wang,Q., Tsay,J., Sides,K., Cairns,J., Stoklosa,G., Nieduzak,T., Zhao,Z., Wang,J. and Vaz,R.J. A conformationally constrained inhibitor with an enhanced potency for beta-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO) Bioorg Med Chem Lett (2010) 20, 6721-6724. PubMed Europe PubMed DOI I
Reimer,J.M., Samollow,P.B. and Hellman,L. High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution Immunogenetics (2010) 62, 369-382. PubMed Europe PubMed DOI
Sommerhoff,C.P., Avrutina,O., Schmoldt,H.U., Gabrijelcic-Geiger,D., Diederichsen,U. and Kolmar,H. Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta J Mol Biol (2010) 395, 167-175. PubMed Europe PubMed DOI
Wich,P.R. and Schmuck,C. Reversible and noncompetitive inhibition of beta-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library Angew Chem Int Ed Engl (2010) 49, 4113-4116. PubMed Europe PubMed DOI I

2009

Trivedi,N.N., Tamraz,B., Chu,C., Kwok,P.Y. and Caughey,G.H. Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations J Allergy Clin Immunol (2009) 124, 1099-1105. PubMed Europe PubMed DOI M

2008

Fukuoka,Y., Xia,H.Z., Sanchez-Munoz,L.B., Dellinger,A.L., Escribano,L. and Schwartz,L.B. Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5 J Immunol (2008) 180, 6307-6316. PubMed Europe PubMed PMC EPMC
Jackson,N.E., Wang,H.W., Bryant,K.J., McNeil,H.P., Husain,A., Liu,K., Tedla,N., Thomas,P.S., King,G.C., Hettiaratchi,A., Cairns,J. and Hunt,J.E. Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation J Biol Chem (2008) 283, 34178-34187. PubMed Europe PubMed DOI PMC EPMC R
Rauter,I., Krauth,M.T., Westritschnig,K., Horak,F., Flicker,S., Gieras,A., Repa,A., Balic,N., Spitzauer,S., Huss-Marp,J., Brockow,K., Darsow,U., Behrendt,H., Ring,J., Kricek,F., Valent,P. and Valenta,R. Mast cell-derived proteases control allergic inflammation through cleavage of IgE J Allergy Clin Immunol (2008) 121, 197-202. PubMed Europe PubMed DOI
Spichalska,B., Lesner,A., Wysocka,M., Sledz,M., Legowska,A., Jaskiewicz,A., Miecznikowska,H. and Rolka,K. The influence of substrate peptide length on human beta-tryptase specificity J Pept Sci (2008) 14, 917-923. PubMed Europe PubMed DOI A P

2007

Fukuoka,Y. and Schwartz,L.B. Active monomers of human beta-tryptase have expanded substrate specificities Int Immunopharmacol (2007) 7, 1900-1908. PubMed Europe PubMed DOI PMC EPMC P
Schechter,N.M., Choi,E.J., Selwood,T. and McCaslin,D.R. Characterization of three distinct catalytic forms of human tryptase-beta: their interrelationships and relevance Biochemistry (2007) 46, 9615-9629. PubMed Europe PubMed DOI
Sommerhoff,C.P. and Schaschke,N. Mast cell tryptase beta as a target in allergic inflammation: an evolving story Curr Pharm Des (2007) 13, 313-332. PubMed Europe PubMed DOI V T
Trivedi,N.N., Tong,Q., Raman,K., Bhagwandin,V.J. and Caughey,G.H. Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates J Immunol (2007) 179, 6072-6079. PubMed Europe PubMed PMC EPMC

2006

Caughey,G.H. Tryptase genetics and anaphylaxis J Allergy Clin Immunol (2006) 117, 1411-1414. PubMed Europe PubMed DOI PMC EPMC
[YEAR:19-5-2006]Lee,C.S., Liu,W., Sprengeler,P.A., Somoza,J.R., Janc,J.W., Sperandio,D., Spencer,J.R., Green,M.J. and McGrath,M.E. Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles Bioorg Med Chem Lett (19-5-2006) 16, 4036-4040. PubMed Europe PubMed DOI
[YEAR:16-5-2006]McGrath,M.E., Sprengeler,P.A., Hirschbein,B., Somoza,J.R., Lehoux,I., Janc,J.W., Gjerstad,E., Graupe,M., Estiarte,A., Venkataramani,C., Liu,Y., Yee,R., Ho,J.D., Green,M.J., Lee,C.S., Liu,L., Tai,V., Spencer,J., Sperandio,D. and Katz,B.A. Structure-guided design of peptide-based tryptase inhibitors Biochemistry (16-5-2006) 45, 5964-5973. PubMed Europe PubMed DOI I
[YEAR:13-3-2006]Miyazaki,Y., Kato,Y., Manabe,T., Shimada,H., Mizuno,M., Egusa,T., Ohkouchi,M., Shiromizu,I., Matsusue,T. and Yamamoto,I. Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors Bioorg Med Chem Lett (13-3-2006) 16, 2986-2990. PubMed Europe PubMed DOI I
Rauter,I., Krauth,M.T., Flicker,S., Gieras,A., Westritschnig,K., Vrtala,S., Balic,N., Spitzauer,S., Huss-Marp,J., Brockow,K., Darsow,U., Ring,J., Behrendt,H., Semper,H., Valent,P. and Valenta,R. Allergen cleavage by effector cell-derived proteases regulates allergic inflammation FASEB J (2006) 20, 967-969. PubMed Europe PubMed DOI P
[YEAR:28-12-2006]Rohr,K.B., Selwood,T., Marquardt,U., Huber,R., Schechter,N.M., Bode,W. and Than,M.E. X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha - >beta-tryptase transition J Mol Biol (28-12-2006) 357, 195-209. PubMed Europe PubMed DOI S I
[YEAR:23-5-2006]Sperandio,D., Tai,V.W., Lohman,J., Hirschbein,B., Mendonca,R., Lee,C.S., Spencer,J.R., Janc,J., Nguyen,M., Beltman,J., Sprengeler,P., Scheerens,H., Lin,T., Liu,L., Gadre,A., Kellogg,A., Green,M.J. and McGrath,M.E. Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors Bioorg Med Chem Lett (23-5-2006) 16, 4085-4089. PubMed Europe PubMed DOI I

2005

Cairns,J.A. Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disorders Pulm Pharmacol Ther (2005) 18, 55-66. PubMed Europe PubMed DOI
[YEAR:7-1-2005]Hallgren,J., Lindahl,S. and Pejler,G. Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase J Mol Biol (7-1-2005) 345, 129-139. PubMed Europe PubMed DOI
[YEAR:15-4-2005]Levell,J., Astles,P., Eastwood,P., Cairns,J., Houille,O., Aldous,S., Merriman,G., Whiteley,B., Pribish,J., Czekaj,M., Liang,G., Maignan,S., Guilloteau,J.P., Dupuy,A., Davidson,J., Harrison,T., Morley,A., Watson,S., Fenton,G., McCarthy,C., Romano,J., Mathew,R., Engers,D., Gardyan,M., Sides,K., Kwong,J., Tsay,J., Rebello,S., Shen,L., Wang,J., Luo,Y., Giardino,O., Lim,H.K., Smith,K. and Pauls,H. Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase Bioorg Med Chem (15-4-2005) 13, 2859-2872. PubMed Europe PubMed DOI I
[YEAR:8-3-2005]Selwood,T., Smolensky,H., McCaslin,D.R. and Schechter,N.M. The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease Biochemistry (8-3-2005) 44, 3580-3590. PubMed Europe PubMed DOI

2004

Caughey,G.H. Tryptases [ISSN:0-12-079610-4] (2004) 2, 1535-1543. V
[YEAR:24-8-2004]Fukuoka,Y. and Schwartz,L.B. Human beta-tryptase: detection and characterization of the active monomer and prevention of tetramer reconstitution by protease inhibitors Biochemistry (24-8-2004) 43, 10757-10764. PubMed Europe PubMed DOI
Payne,V. and Kam,P.C. Mast cell tryptase: a review of its physiology and clinical significance Anaesthesia (2004) 59, 695-703. PubMed Europe PubMed DOI
[YEAR:1-12-2004]Scarpi,D., McBride,J.D. and Leatherbarrow,R.J. Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor Bioorg Med Chem (1-12-2004) 12, 6045-6052. PubMed Europe PubMed DOI
[YEAR:20-12-2004]Vaz,R.J., Gao,Z., Pribish,J., Chen,X., Levell,J., Davis,L., Albert,E., Brollo,M., Ugolini,A., Cramer,D.M., Cairns,J., Sides,K., Liu,F., Kwong,J., Kang,J., Rebello,S., Elliot,M., Lim,H., Chellaraj,V., Singleton,R.W. and Li,Y. Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase Bioorg Med Chem Lett (20-12-2004) 14, 6053-6056. PubMed Europe PubMed DOI I

2003

[YEAR:1-8-2003]Fajardo,I. and Pejler,G. Human mast cell beta-tryptase is a gelatinase J Immunol (1-8-2003) 171, 1493-1499. PubMed Europe PubMed
[YEAR:1-2-2003]Fajardo,I. and Pejler,G. Formation of active monomers from tetrameric human beta-tryptase Biochem J (1-2-2003) 369, 603-610. PubMed Europe PubMed DOI PMC EPMC
Selwood,T., Elrod,K.C. and Schechter,N.M. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor Biol Chem (2003) 384, 1605-1611. PubMed Europe PubMed DOI I

2002

Brown,J.K., Jones,C.A., Rooney,L.A., Caughey,G.H. and Hall,I.P. Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions Am J Physiol Lung Cell Mol Physiol (2002) 282, L197-L206. PubMed Europe PubMed
Scarpi,D., McBride,J.D. and Leatherbarrow,R.J. Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides J Pept Res (2002) 59, 90-93. PubMed Europe PubMed
[YEAR:12-3-2002]Selwood,T., Wang,Z.M., McCaslin,D.R. and Schechter,N.M. Diverse stability and catalytic properties of human tryptase alpha and beta isoforms are mediated by residue differences at the S1 pocket Biochemistry (12-3-2002) 41, 3329-3340. PubMed Europe PubMed DOI
Tremaine,W.J., Brzezinski,A., Katz,J.A., Wolf,D.C., Fleming,T.J., Mordenti,J., Strenkoski-Nix,L.C. and Kurth,M.C. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study Aliment Pharmacol Ther (2002) 16, 407-413. PubMed Europe PubMed DOI I

2001

Buckley,M.G., Variend,S. and Walls,A.F. Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms Clin Exp Allergy (2001) 31, 1696-1704. PubMed Europe PubMed DOI
[YEAR:14-9-2001]Harris,J.L., Niles,A., Burdick,K., Maffitt,M., Backes,B.J., Ellman,J.A., Kuntz,I., Haak-Frendscho,M. and Craik,C.S. Definition of the extended substrate specificity determinants for beta-tryptases I and II J Biol Chem (14-9-2001) 276, 34941-34947. PubMed Europe PubMed DOI
[YEAR:13-7-2001]Huang,C., De Sanctis,G.T., O'Brien,P.J., Mizgerd,J.P., Friend,D.S., Drazen,J.M., Brass,L.F. and Stevens,R.L. Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung J Biol Chem (13-7-2001) 276, 26276-26284. PubMed Europe PubMed DOI
Schaschke,N., Matschiner,G., Zettl,F., Marquardt,U., Bergner,A., Bode,W., Sommerhoff,C.P. and Moroder,L. Bivalent inhibition of human beta-tryptase Chem Biol (2001) 8, 313-327. PubMed Europe PubMed DOI

1999

Harvima,R.J., Harvima,I.T., Dull,D., Dunder,U.K. and Schwartz,L.B. Identification and characterization of multiple forms of tryptase from human mast cells Arch Dermatol Res (1999) 291, 73-80. PubMed Europe PubMed DOI
[YEAR:9-7-1999]Huang,C., Li,L., Krilis,S.A., Chanasyk,K., Tang,Y., Li,Z., Hunt,J.E. and Stevens,R.L. Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft J Biol Chem (9-7-1999) 274, 19670-19676. PubMed Europe PubMed DOI
[YEAR:5-2-1999]Pallaoro,M., Fejzo,M.S., Shayesteh,L., Blount,J.L. and Caughey,G.H. Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3 J Biol Chem (5-2-1999) 274, 3355-3362. PubMed Europe PubMed DOI
[YEAR:28-9-1999]Sommerhoff,C.P., Bode,W., Pereira,P.J., Stubbs,M.T., Sturzebecher,J., Piechottka,G.P., Matschiner,G. and Bergner,A. The structure of the human beta II-tryptase tetramer: fo(u)r better or worse Proc Natl Acad Sci U S A (28-9-1999) 96, 10984-10991. PubMed Europe PubMed DOI PMC EPMC S

1998

[YEAR:22-9-1998]Selwood,T., McCaslin,D.R. and Schechter,N.M. Spontaneous inactivation of human tryptase involves conformational changes consistent with conversion of the active site to a zymogen-like structure Biochemistry (22-9-1998) 37, 13174-13183. PubMed Europe PubMed DOI

1996

Molinari,J.F., Scuri,M., Moore,W.R., Clark,J., Tanaka,R. and Abraham,W.M. Inhaled tryptase causes bronchoconstriction in sheep via histamine release Am J Respir Crit Care Med (1996) 154, 649-653. PubMed Europe PubMed DOI I
Sakai,K., Long,S.D., Pettit,D.A., Cabral,G.A. and Schwartz,L.B. Expression and purification of recombinant human tryptase in a baculovirus system Protein Expr Purif (1996) 7, 67-73. PubMed Europe PubMed DOI E

1995

Molinari,J.F., Moore,W.R., Clark,J., Tanaka,R., Butterfield,J.H. and Abraham,W.M. Role of tryptase in immediate cutaneous responses in allergic sheep J Appl Physiol (1995) 79, 1966-1970. PubMed Europe PubMed I

1990

Miller,J.S., Moxley,G. and Schwartz,L.B. Cloning and characterization of a second complementary DNA for human tryptase J Clin Invest (1990) 86, 864-870. PubMed Europe PubMed DOI PMC EPMC
[YEAR:11-12-1990]Moxley,G., Miller,J.S., Diehl,S. and Schwartz,L.B. EcoRV polymorphism detected by cDNA probe for human tryptase beta (TPS2) [corrected] Nucleic Acids Res (11-12-1990) 18, 7197-7197. PubMed Europe PubMed PMC EPMC M
Vanderslice,P., Ballinger,S.M., Tam,E.K., Goldstein,S.M., Craik,C.S. and Caughey,G.H. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family Proc Natl Acad Sci U S A (1990) 87, 3811-3815. PubMed Europe PubMed DOI PMC EPMC

1989

Vanderslice,P., Craik,C.S., Nadel,J.A. and Caughey,G.H. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation Biochemistry (1989) 28, 4148-4155. PubMed Europe PubMed