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Literature for peptidase S01.015: tryptase beta

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Alheraky,A., Wierenga,A.T.J., Simpelaar,A., Hesp,L.B., Minovic,I., Bagheri,N., Roozendaal,C., Span,L.F.R., Oude Elberink,H.N.G., Kema,I.P. and Mulder,A.B.
    Hereditary Alpha Tryptasemia: Validation of a Single-Well Multiplex Digital Droplet PCR Assay in a Cohort of Symptomatic Patients
    Clin Chem (2024) 70, 425-433. PubMed  Europe PubMed DOI
  2. Ma,Y., Li,B., Zhao,X., Lu,Y., Li,X., Zhang,J., Wang,Y., Zhang,J., Wang,L., Meng,S. and Hao,J.
    Computational modeling of mast cell tryptase family informs selective inhibitor development
    iScience (2024) 27, 110739-110739. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Shin,H. and Lyons,J.J.
    Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell-Mediated Reactions
    Curr Allergy Asthma Rep (2024) 24, 199-209. PubMed  Europe PubMed DOI  V
  4. Svetina,M., Selb,J., Lyons,J.J., Korosec,P. and Rijavec,M.
    Clinically accessible amplitude-based multiplex ddPCR assay for tryptase genotyping
    Sci Rep (2024) 14, 2416-2416. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2023
  5. Das,N., de Almeida,L.G.N., Derakhshani,A., Young,D., Mehdinejadiani,K., Salo,P., Rezansoff,A., Jay,G.D., Sommerhoff,C.P., Schmidt,T.A., Krawetz,R. and Dufour,A.
    Tryptase beta regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis
    Nat Commun (2023) 14, 1910-1910. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2022
  6. Bonadonna,P., Nalin,F. and Olivieri,F.
    Hereditary alpha-tryptasemia
    Curr Opin Allergy Clin Immunol (2022) 22, 277-282. PubMed  Europe PubMed DOI  V
  7. O'Connell,M.P. and Lyons,J.J.
    Resolving the genetics of human tryptases: implications for health, disease, and clinical use as a biomarker
    Curr Opin Allergy Clin Immunol (2022) 22, 143-152. PubMed  Europe PubMed DOI  V
    8. 2021
  8. Lyons,J.J.
    On the complexities of tryptase genetics and impact on clinical phenotypes
    J Allergy Clin Immunol (2021) PubMed  Europe PubMed DOI
    9. 2020
  9. Alanazi,S., Grujic,M., Lampinen,M., Rollman,O., Sommerhoff,C.P., Pejler,G. and Melo,F.R.
    Mast Cell beta-Tryptase Is Enzymatically Stabilized by DNA
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI
  10. Giardina,S.F., Werner,D.S., Pingle,M., Feinberg,P.B., Foreman,K.W., Bergstrom,D.E., Arnold,L.D. and Barany,F.
    Novel, self-assembling dimeric inhibitors of human beta tryptase
    J Med Chem (2020) 63, 3004-3027. PubMed  Europe PubMed DOI  I
  11. Lobbes,H., Reynaud,Q., Mainbourg,S., Lega,J.C., Durieu,I. and Durupt,S.
    [Tryptase: A practical guide for the physician]
    Rev Med Interne (2020) PubMed  Europe PubMed DOI
  12. Maun,H.R., Vij,R., Walters,B.T., Morando,A., Jackman,J.K., Wu,P., Estevez,A., Chen,X., Franke,Y., Lipari,M.T., Dennis,M.S., Kirchhofer,D., Ciferri,C., Loyet,K.M., Yi,T., Eigenbrot,C., Lazarus,R.A. and Koerber,J.T.
    Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge
    Nat Commun (2020) 11, 6435-6435. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2019
  13. Le,Q.T., Lyons,J.J., Naranjo,A.N., Olivera,A., Lazarus,R.A., Metcalfe,D.D., Milner,J.D. and Schwartz,L.B.
    Impact of naturally forming human alpha/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia
    J Exp Med (2019) 216, 2348-2361. PubMed  Europe PubMed DOI
  14. Shim,J.K., Kennedy,R.H., Weatherly,L.M., Abovian,A.V., Hashmi,H.N., Rajaei,A. and Gosse,J.A.
    Searching for tryptase in the RBL-2H3 mast cell model: preparation for comparative mast cell toxicology studies with zebrafish
    J Appl Toxicol (2019) 39, 473-484. PubMed  Europe PubMed DOI
    15. 2018
  15. Giardina,S.F., Werner,D.S., Pingle,M., Foreman,K.W., Bergstrom,D.E., Arnold,L.D. and Barany,F.
    Target-directed self-assembly of homodimeric drugs against beta-tryptase
    ACS Med Chem Lett (2018) 9, 827-831. PubMed  Europe PubMed DOI  PMC  EPMC  I
  16. Giardina,S.F., Werner,D.S., Pingle,M., Bergstrom,D.E., Arnold,L.D. and Barany,F.
    A novel, nonpeptidic, orally active bivalent inhibitor of human beta-tryptase
    Pharmacology (2018) 102, 233-243. PubMed  Europe PubMed DOI  S  I
  17. Marinelli,E. and Ciallella,C.
    Post mortem determination of (beta)-tryptase for the diagnosis of anaphylaxis: looking for a reasonable cut-off
    Clin Ter (2018) 169, e60-e60. PubMed  Europe PubMed DOI
  18. Maun,H.R., Liu,P.S., Franke,Y., Eigenbrot,C., Forrest,W.F., Schwartz,L.B. and Lazarus,R.A.
    Dual functionality of beta-tryptase protomers as both proteases and cofactors in the active tetramer
    J Biol Chem (2018) 293, 9614-9628. PubMed  Europe PubMed DOI
    19. 2016
  19. Caughey,G.H.
    Mast cell proteases as pharmacological targets
    Eur J Pharmacol (2016) 778, 44-55. PubMed  Europe PubMed DOI
    20. 2015
  20. Jiang,Q.-Q., Sicking,W., Ehlers,M. and Schmuck,C.
    Discovery of potent inhibitors of human beta-tryptase from pre-equilibrated dynamic combinatorial libraries
    Chem Sci (2015) 6, 1792-1800. PubMed  Europe PubMed DOI  I
  21. Vitte,J.
    Human mast cell tryptase in biology and medicine
    Mol Immunol (2015) 63, 18-24. PubMed  Europe PubMed DOI
  22. Wang,Y., Zheng,Q.C., Kong,C.P., Tian,Y., Zhan,J., Zhang,J.L. and Zhang,H.X.
    Heparin makes differences: a molecular dynamics simulation study on the human betaII-tryptase monomer
    Mol Biosyst (2015) 11, 252-261. PubMed  Europe PubMed DOI
    23. 2014
  23. Abdelmotelb,A.M., Rose-Zerilli,M.J., Barton,S.J., Holgate,S.T., Walls,A.F. and Holloway,J.W.
    Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma
    Clin Exp Allergy (2014) 44, 822-830. PubMed  Europe PubMed DOI  M
  24. Le,Q.T., Lotfi-Emran,S., Min,H.K. and Schwartz,L.B.
    A simple, sensitive and safe method to determine the human alpha/beta-tryptase genotype
    PLoS ONE (2014) 9, e114944-e114944. PubMed  Europe PubMed DOI  M
  25. Prieto-Garcia,A., Castells,M.C. and Stevens,R.L.
    Mast cell-derived htryptase-beta functions as a potent anticoagulant by proteolytically damaging fibrinogen
    J Investig Allergol Clin Immunol (2014) 24, 286-287. PubMed  Europe PubMed
  26. Wang,Q., Shi,X., Zhu,X., Ehlers,M., Wu,J. and Schmuck,C.
    A fluorescent light-up probe as an inhibitor of intracellular beta-tryptase
    Chem Commun (Camb) (2014) 50, 6120-6122. PubMed  Europe PubMed DOI  L  I
    27. 2013
  27. Cook,K.M., McNeil,H.P. and Hogg,P.J.
    Allosteric control of betaII-tryptase by a redox active disulfide bond
    J Biol Chem (2013) 288, 34920-34929. PubMed  Europe PubMed DOI
  28. Jiang,Q.Q., Bartsch,L., Sicking,W., Wich,P.R., Heider,D., Hoffmann,D. and Schmuck,C.
    A new approach to inhibit human beta-tryptase by protein surface binding of four-armed peptide ligands with two different sets of arms
    Org Biomol Chem (2013) 11, 1631-1639. PubMed  Europe PubMed DOI  I
  29. Magarinos,N.J., Bryant,K.J., Fosang,A.J., Adachi,R., Stevens,R.L. and McNeil,H.P.
    Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens
    J Immunol (2013) 191, 1404-1412. PubMed  Europe PubMed DOI
    30. 2012
  30. Hernandez-Hernandez,L., Sanz,C., Garcia-Solaesa,V., Padron,J., Garcia-Sanchez,A., Davila,I., Isidoro-Garcia,M. and Lorente,F.
    Tryptase: genetic and functional considerations
    Allergol Immunopathol (Madr) (2012) 40, 385-389. PubMed  Europe PubMed DOI
  31. Liang,G., Choi-Sledeski,Y.M., Shum,P., Chen,X., Poli,G.B., Kumar,V., Minnich,A., Wang,Q., Tsay,J., Sides,K., Kang,J. and Zhang,Y.
    A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity
    Bioorg Med Chem Lett (2012) 22, 1606-1610. PubMed  Europe PubMed DOI  I
  32. Liang,G., Aldous,S., Merriman,G., Levell,J., Pribish,J., Cairns,J., Chen,X., Maignan,S., Mathieu,M., Tsay,J., Sides,K., Rebello,S., Whitely,B., Morize,I. and Pauls,H.W.
    Structure-based library design and the discovery of a potent and selective mast cell beta-tryptase inhibitor as an oral therapeutic agent
    Bioorg Med Chem Lett (2012) 22, 1049-1054. PubMed  Europe PubMed DOI  I
  33. Liang,G., Choi-Sledeski,Y.M., Chen,X., Gong,Y., Macmillan,E.W., Tsay,J., Sides,K., Cairns,J., Kulitzscher,B., Aldous,D.J., Morize,I. and Pauls,H.W.
    Dimerization of beta-tryptase inhibitors, does it work for both basic and neutral P1 groups?
    Bioorg Med Chem Lett (2012) 22, 3370-3376. PubMed  Europe PubMed DOI  I
  34. Prieto-Garcia,A., Zheng,D., Adachi,R., Xing,W., Lane,W.S., Chung,K., Anderson,P., Hansbro,P.M., Castells,M. and Stevens,R.L.
    Mast cell restricted mouse and human tryptase.heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen
    J Biol Chem (2012) 287, 7834-7844. PubMed  Europe PubMed DOI
  35. Trivedi,N.N. and Caughey,G.H.
    Human alpha-, beta- and delta-tryptases
    [ISSN:978-0-12-407742-3] (2012) 3, 2683-2693. DOI
    36. 2011
  36. Janke,D., Sommerhoff,C.P. and Schaschke,N.
    The arginine mimicking beta-amino acid beta3hPhe(3-H2N-CH2) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors
    Bioorg Med Chem (2011) 19, 7236-7243. PubMed  Europe PubMed DOI  I
  37. Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B.
    Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C
    J Immunol (2011) 186, 7136-7143. PubMed  Europe PubMed DOI
  38. Le,Q.T., Gomez,G., Zhao,W., Hu,J., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B.
    Processing of human protryptase in mast cells involves cathepsins L, B, and C
    J Immunol (2011) 187, 1912-1918. PubMed  Europe PubMed DOI
  39. Liang,G., Choi-Sledeski,Y.M., Poli,G.B., Chen,X., Minnich,A., Wang,Q., Tsay,J., Sides,K. and Vaz,R.J.
    Structure-based design, synthesis, and profiling of a beta-tryptase inhibitor with a spiro-piperidineamide scaffold, benzylamine P1 group, and a substituted indole P4 group
    MedChemComm (2011) 2, 794-799. DOI  I
  40. Spinnler,K., Frohlich,T., Arnold,G.J., Kunz,L. and Mayerhofer,A.
    Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF/pro-NGF action
    J Biol Chem (2011) 286, 31707-31713. PubMed  Europe PubMed DOI
    41. 2010
  41. Liang,G., Choi-Sledeski,Y.M., Poli,G., Chen,X., Shum,P., Minnich,A., Wang,Q., Tsay,J., Sides,K., Cairns,J., Stoklosa,G., Nieduzak,T., Zhao,Z., Wang,J. and Vaz,R.J.
    A conformationally constrained inhibitor with an enhanced potency for beta-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO)
    Bioorg Med Chem Lett (2010) 20, 6721-6724. PubMed  Europe PubMed DOI  I
  42. Reimer,J.M., Samollow,P.B. and Hellman,L.
    High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution
    Immunogenetics (2010) 62, 369-382. PubMed  Europe PubMed DOI
  43. Sommerhoff,C.P., Avrutina,O., Schmoldt,H.U., Gabrijelcic-Geiger,D., Diederichsen,U. and Kolmar,H.
    Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta
    J Mol Biol (2010) 395, 167-175. PubMed  Europe PubMed DOI
  44. Wich,P.R. and Schmuck,C.
    Reversible and noncompetitive inhibition of beta-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library
    Angew Chem Int Ed Engl (2010) 49, 4113-4116. PubMed  Europe PubMed DOI  I
    45. 2009
  45. Trivedi,N.N., Tamraz,B., Chu,C., Kwok,P.Y. and Caughey,G.H.
    Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations
    J Allergy Clin Immunol (2009) 124, 1099-1105. PubMed  Europe PubMed DOI  M
    46. 2008
  46. Fukuoka,Y., Xia,H.Z., Sanchez-Munoz,L.B., Dellinger,A.L., Escribano,L. and Schwartz,L.B.
    Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5
    J Immunol (2008) 180, 6307-6316. PubMed  Europe PubMed  PMC  EPMC
  47. Jackson,N.E., Wang,H.W., Bryant,K.J., McNeil,H.P., Husain,A., Liu,K., Tedla,N., Thomas,P.S., King,G.C., Hettiaratchi,A., Cairns,J. and Hunt,J.E.
    Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation
    J Biol Chem (2008) 283, 34178-34187. PubMed  Europe PubMed DOI  PMC  EPMC  R
  48. Rauter,I., Krauth,M.T., Westritschnig,K., Horak,F., Flicker,S., Gieras,A., Repa,A., Balic,N., Spitzauer,S., Huss-Marp,J., Brockow,K., Darsow,U., Behrendt,H., Ring,J., Kricek,F., Valent,P. and Valenta,R.
    Mast cell-derived proteases control allergic inflammation through cleavage of IgE
    J Allergy Clin Immunol (2008) 121, 197-202. PubMed  Europe PubMed DOI
  49. Spichalska,B., Lesner,A., Wysocka,M., Sledz,M., Legowska,A., Jaskiewicz,A., Miecznikowska,H. and Rolka,K.
    The influence of substrate peptide length on human beta-tryptase specificity
    J Pept Sci (2008) 14, 917-923. PubMed  Europe PubMed DOI  A  P
    50. 2007
  50. Fukuoka,Y. and Schwartz,L.B.
    Active monomers of human beta-tryptase have expanded substrate specificities
    Int Immunopharmacol (2007) 7, 1900-1908. PubMed  Europe PubMed DOI  PMC  EPMC  P
  51. Schechter,N.M., Choi,E.J., Selwood,T. and McCaslin,D.R.
    Characterization of three distinct catalytic forms of human tryptase-beta: their interrelationships and relevance
    Biochemistry (2007) 46, 9615-9629. PubMed  Europe PubMed DOI
  52. Sommerhoff,C.P. and Schaschke,N.
    Mast cell tryptase beta as a target in allergic inflammation: an evolving story
    Curr Pharm Des (2007) 13, 313-332. PubMed  Europe PubMed DOI  V  T
  53. Trivedi,N.N., Tong,Q., Raman,K., Bhagwandin,V.J. and Caughey,G.H.
    Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates
    J Immunol (2007) 179, 6072-6079. PubMed  Europe PubMed  PMC  EPMC
    54. 2006
  54. Caughey,G.H.
    Tryptase genetics and anaphylaxis
    J Allergy Clin Immunol (2006) 117, 1411-1414. PubMed  Europe PubMed DOI  PMC  EPMC
  55. [YEAR:19-5-2006]Lee,C.S., Liu,W., Sprengeler,P.A., Somoza,J.R., Janc,J.W., Sperandio,D., Spencer,J.R., Green,M.J. and McGrath,M.E.
    Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles
    Bioorg Med Chem Lett (19-5-2006) 16, 4036-4040. PubMed  Europe PubMed DOI
  56. [YEAR:16-5-2006]McGrath,M.E., Sprengeler,P.A., Hirschbein,B., Somoza,J.R., Lehoux,I., Janc,J.W., Gjerstad,E., Graupe,M., Estiarte,A., Venkataramani,C., Liu,Y., Yee,R., Ho,J.D., Green,M.J., Lee,C.S., Liu,L., Tai,V., Spencer,J., Sperandio,D. and Katz,B.A.
    Structure-guided design of peptide-based tryptase inhibitors
    Biochemistry (16-5-2006) 45, 5964-5973. PubMed  Europe PubMed DOI  I
  57. [YEAR:13-3-2006]Miyazaki,Y., Kato,Y., Manabe,T., Shimada,H., Mizuno,M., Egusa,T., Ohkouchi,M., Shiromizu,I., Matsusue,T. and Yamamoto,I.
    Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors
    Bioorg Med Chem Lett (13-3-2006) 16, 2986-2990. PubMed  Europe PubMed DOI  I
  58. Rauter,I., Krauth,M.T., Flicker,S., Gieras,A., Westritschnig,K., Vrtala,S., Balic,N., Spitzauer,S., Huss-Marp,J., Brockow,K., Darsow,U., Ring,J., Behrendt,H., Semper,H., Valent,P. and Valenta,R.
    Allergen cleavage by effector cell-derived proteases regulates allergic inflammation
    FASEB J (2006) 20, 967-969. PubMed  Europe PubMed DOI  P
  59. [YEAR:28-12-2006]Rohr,K.B., Selwood,T., Marquardt,U., Huber,R., Schechter,N.M., Bode,W. and Than,M.E.
    X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha - >beta-tryptase transition
    J Mol Biol (28-12-2006) 357, 195-209. PubMed  Europe PubMed DOI  S  I
  60. [YEAR:23-5-2006]Sperandio,D., Tai,V.W., Lohman,J., Hirschbein,B., Mendonca,R., Lee,C.S., Spencer,J.R., Janc,J., Nguyen,M., Beltman,J., Sprengeler,P., Scheerens,H., Lin,T., Liu,L., Gadre,A., Kellogg,A., Green,M.J. and McGrath,M.E.
    Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors
    Bioorg Med Chem Lett (23-5-2006) 16, 4085-4089. PubMed  Europe PubMed DOI  I
    61. 2005
  61. Cairns,J.A.
    Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disorders
    Pulm Pharmacol Ther (2005) 18, 55-66. PubMed  Europe PubMed DOI
  62. [YEAR:7-1-2005]Hallgren,J., Lindahl,S. and Pejler,G.
    Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase
    J Mol Biol (7-1-2005) 345, 129-139. PubMed  Europe PubMed DOI
  63. [YEAR:15-4-2005]Levell,J., Astles,P., Eastwood,P., Cairns,J., Houille,O., Aldous,S., Merriman,G., Whiteley,B., Pribish,J., Czekaj,M., Liang,G., Maignan,S., Guilloteau,J.P., Dupuy,A., Davidson,J., Harrison,T., Morley,A., Watson,S., Fenton,G., McCarthy,C., Romano,J., Mathew,R., Engers,D., Gardyan,M., Sides,K., Kwong,J., Tsay,J., Rebello,S., Shen,L., Wang,J., Luo,Y., Giardino,O., Lim,H.K., Smith,K. and Pauls,H.
    Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase
    Bioorg Med Chem (15-4-2005) 13, 2859-2872. PubMed  Europe PubMed DOI  I
  64. [YEAR:8-3-2005]Selwood,T., Smolensky,H., McCaslin,D.R. and Schechter,N.M.
    The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease
    Biochemistry (8-3-2005) 44, 3580-3590. PubMed  Europe PubMed DOI
    65. 2004
  65. Caughey,G.H.
    Tryptases
    [ISSN:0-12-079610-4] (2004) 2, 1535-1543.  V
  66. [YEAR:24-8-2004]Fukuoka,Y. and Schwartz,L.B.
    Human beta-tryptase: detection and characterization of the active monomer and prevention of tetramer reconstitution by protease inhibitors
    Biochemistry (24-8-2004) 43, 10757-10764. PubMed  Europe PubMed DOI
  67. Payne,V. and Kam,P.C.
    Mast cell tryptase: a review of its physiology and clinical significance
    Anaesthesia (2004) 59, 695-703. PubMed  Europe PubMed DOI
  68. [YEAR:1-12-2004]Scarpi,D., McBride,J.D. and Leatherbarrow,R.J.
    Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor
    Bioorg Med Chem (1-12-2004) 12, 6045-6052. PubMed  Europe PubMed DOI
  69. [YEAR:20-12-2004]Vaz,R.J., Gao,Z., Pribish,J., Chen,X., Levell,J., Davis,L., Albert,E., Brollo,M., Ugolini,A., Cramer,D.M., Cairns,J., Sides,K., Liu,F., Kwong,J., Kang,J., Rebello,S., Elliot,M., Lim,H., Chellaraj,V., Singleton,R.W. and Li,Y.
    Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase
    Bioorg Med Chem Lett (20-12-2004) 14, 6053-6056. PubMed  Europe PubMed DOI  I
    70. 2003
  70. [YEAR:1-8-2003]Fajardo,I. and Pejler,G.
    Human mast cell beta-tryptase is a gelatinase
    J Immunol (1-8-2003) 171, 1493-1499. PubMed  Europe PubMed
  71. [YEAR:1-2-2003]Fajardo,I. and Pejler,G.
    Formation of active monomers from tetrameric human beta-tryptase
    Biochem J (1-2-2003) 369, 603-610. PubMed  Europe PubMed DOI  PMC  EPMC
  72. Selwood,T., Elrod,K.C. and Schechter,N.M.
    Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor
    Biol Chem (2003) 384, 1605-1611. PubMed  Europe PubMed DOI  I
    73. 2002
  73. Brown,J.K., Jones,C.A., Rooney,L.A., Caughey,G.H. and Hall,I.P.
    Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions
    Am J Physiol Lung Cell Mol Physiol (2002) 282, L197-L206. PubMed  Europe PubMed
  74. Scarpi,D., McBride,J.D. and Leatherbarrow,R.J.
    Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides
    J Pept Res (2002) 59, 90-93. PubMed  Europe PubMed
  75. [YEAR:12-3-2002]Selwood,T., Wang,Z.M., McCaslin,D.R. and Schechter,N.M.
    Diverse stability and catalytic properties of human tryptase alpha and beta isoforms are mediated by residue differences at the S1 pocket
    Biochemistry (12-3-2002) 41, 3329-3340. PubMed  Europe PubMed DOI
  76. Tremaine,W.J., Brzezinski,A., Katz,J.A., Wolf,D.C., Fleming,T.J., Mordenti,J., Strenkoski-Nix,L.C. and Kurth,M.C.
    Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study
    Aliment Pharmacol Ther (2002) 16, 407-413. PubMed  Europe PubMed DOI  I
    77. 2001
  77. Buckley,M.G., Variend,S. and Walls,A.F.
    Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms
    Clin Exp Allergy (2001) 31, 1696-1704. PubMed  Europe PubMed DOI
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