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Literature for peptidase S01.015: tryptase beta

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Alheraky,A., Wierenga,A.T.J., Simpelaar,A., Hesp,L.B., Minovic,I., Bagheri,N., Roozendaal,C., Span,L.F.R., Oude Elberink,H.N.G., Kema,I.P. and Mulder,A.B.
    Hereditary Alpha Tryptasemia: Validation of a Single-Well Multiplex Digital Droplet PCR Assay in a Cohort of Symptomatic Patients
    Clin Chem70, 425-433. PubMed  Europe PubMed DOI
  2. Ma,Y., Li,B., Zhao,X., Lu,Y., Li,X., Zhang,J., Wang,Y., Zhang,J., Wang,L., Meng,S. and Hao,J.
    Computational modeling of mast cell tryptase family informs selective inhibitor development
    iScience27, 110739-110739. PubMed  Europe PubMed DOI
  3. Shin,H. and Lyons,J.J.
    Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell-Mediated Reactions
    Curr Allergy Asthma Rep24, 199-209. PubMed  Europe PubMed DOI  V
  4. Svetina,M., Selb,J., Lyons,J.J., Korosec,P. and Rijavec,M.
    Clinically accessible amplitude-based multiplex ddPCR assay for tryptase genotyping
    Sci Rep14, 2416-2416. PubMed  Europe PubMed DOI
    5. 2022
  5. Bonadonna,P., Nalin,F. and Olivieri,F.
    Hereditary alpha-tryptasemia
    Curr Opin Allergy Clin Immunol22, 277-282. PubMed  Europe PubMed DOI  V
  6. O'Connell,M.P. and Lyons,J.J.
    Resolving the genetics of human tryptases: implications for health, disease, and clinical use as a biomarker
    Curr Opin Allergy Clin Immunol22, 143-152. PubMed  Europe PubMed DOI  V
    7. 2021
  7. Lyons,J.J.
    On the complexities of tryptase genetics and impact on clinical phenotypes
    J Allergy Clin Immunol PubMed  Europe PubMed DOI
    8. 2020
  8. Alanazi,S., Grujic,M., Lampinen,M., Rollman,O., Sommerhoff,C.P., Pejler,G. and Melo,F.R.
    Mast Cell beta-Tryptase Is Enzymatically Stabilized by DNA
    Int J Mol Sci21, PubMed  Europe PubMed DOI
  9. Giardina,S.F., Werner,D.S., Pingle,M., Feinberg,P.B., Foreman,K.W., Bergstrom,D.E., Arnold,L.D. and Barany,F.
    Novel, self-assembling dimeric inhibitors of human beta tryptase
    J Med Chem63, 3004-3027. PubMed  Europe PubMed DOI  I
  10. Lobbes,H., Reynaud,Q., Mainbourg,S., Lega,J.C., Durieu,I. and Durupt,S.
    [Tryptase: A practical guide for the physician]
    Rev Med Interne PubMed  Europe PubMed DOI
  11. Maun,H.R., Vij,R., Walters,B.T., Morando,A., Jackman,J.K., Wu,P., Estevez,A., Chen,X., Franke,Y., Lipari,M.T., Dennis,M.S., Kirchhofer,D., Ciferri,C., Loyet,K.M., Yi,T., Eigenbrot,C., Lazarus,R.A. and Koerber,J.T.
    Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge
    Nat Commun11, 6435-6435. PubMed  Europe PubMed DOI
    12. 2019
  12. Le,Q.T., Lyons,J.J., Naranjo,A.N., Olivera,A., Lazarus,R.A., Metcalfe,D.D., Milner,J.D. and Schwartz,L.B.
    Impact of naturally forming human alpha/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia
    J Exp Med216, 2348-2361. PubMed  Europe PubMed DOI
  13. Shim,J.K., Kennedy,R.H., Weatherly,L.M., Abovian,A.V., Hashmi,H.N., Rajaei,A. and Gosse,J.A.
    Searching for tryptase in the RBL-2H3 mast cell model: preparation for comparative mast cell toxicology studies with zebrafish
    J Appl Toxicol39, 473-484. PubMed  Europe PubMed DOI
    14. 2018
  14. Giardina,S.F., Werner,D.S., Pingle,M., Foreman,K.W., Bergstrom,D.E., Arnold,L.D. and Barany,F.
    Target-directed self-assembly of homodimeric drugs against beta-tryptase
    ACS Med Chem Lett9, 827-831. PubMed  Europe PubMed DOI  I
  15. Giardina,S.F., Werner,D.S., Pingle,M., Bergstrom,D.E., Arnold,L.D. and Barany,F.
    A novel, nonpeptidic, orally active bivalent inhibitor of human beta-tryptase
    Pharmacology102, 233-243. PubMed  Europe PubMed DOI  S  I
  16. Marinelli,E. and Ciallella,C.
    Post mortem determination of (beta)-tryptase for the diagnosis of anaphylaxis: looking for a reasonable cut-off
    Clin Ter169, e60-e60. PubMed  Europe PubMed DOI
  17. Maun,H.R., Liu,P.S., Franke,Y., Eigenbrot,C., Forrest,W.F., Schwartz,L.B. and Lazarus,R.A.
    Dual functionality of beta-tryptase protomers as both proteases and cofactors in the active tetramer
    J Biol Chem293, 9614-9628. PubMed  Europe PubMed DOI
    18. 2016
  18. Caughey,G.H.
    Mast cell proteases as pharmacological targets
    Eur J Pharmacol778, 44-55. PubMed  Europe PubMed DOI
    19. 2015
  19. Jiang,Q.-Q., Sicking,W., Ehlers,M. and Schmuck,C.
    Discovery of potent inhibitors of human beta-tryptase from pre-equilibrated dynamic combinatorial libraries
    Chem Sci6, 1792-1800. PubMed  Europe PubMed DOI  I
  20. Vitte,J.
    Human mast cell tryptase in biology and medicine
    Mol Immunol63, 18-24. PubMed  Europe PubMed DOI
  21. Wang,Y., Zheng,Q.C., Kong,C.P., Tian,Y., Zhan,J., Zhang,J.L. and Zhang,H.X.
    Heparin makes differences: a molecular dynamics simulation study on the human betaII-tryptase monomer
    Mol Biosyst11, 252-261. PubMed  Europe PubMed DOI
    22. 2014
  22. Abdelmotelb,A.M., Rose-Zerilli,M.J., Barton,S.J., Holgate,S.T., Walls,A.F. and Holloway,J.W.
    Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma
    Clin Exp Allergy44, 822-830. PubMed  Europe PubMed DOI  M
  23. Le,Q.T., Lotfi-Emran,S., Min,H.K. and Schwartz,L.B.
    A simple, sensitive and safe method to determine the human alpha/beta-tryptase genotype
    PLoS ONE9, e114944-e114944. PubMed  Europe PubMed DOI  M
  24. Prieto-Garcia,A., Castells,M.C. and Stevens,R.L.
    Mast cell-derived htryptase-beta functions as a potent anticoagulant by proteolytically damaging fibrinogen
    J Investig Allergol Clin Immunol24, 286-287. PubMed  Europe PubMed
  25. Wang,Q., Shi,X., Zhu,X., Ehlers,M., Wu,J. and Schmuck,C.
    A fluorescent light-up probe as an inhibitor of intracellular beta-tryptase
    Chem Commun (Camb)50, 6120-6122. PubMed  Europe PubMed DOI  L  I
    26. 2013
  26. Cook,K.M., McNeil,H.P. and Hogg,P.J.
    Allosteric control of betaII-tryptase by a redox active disulfide bond
    J Biol Chem288, 34920-34929. PubMed  Europe PubMed DOI
  27. Jiang,Q.Q., Bartsch,L., Sicking,W., Wich,P.R., Heider,D., Hoffmann,D. and Schmuck,C.
    A new approach to inhibit human beta-tryptase by protein surface binding of four-armed peptide ligands with two different sets of arms
    Org Biomol Chem11, 1631-1639. PubMed  Europe PubMed DOI  I
  28. Magarinos,N.J., Bryant,K.J., Fosang,A.J., Adachi,R., Stevens,R.L. and McNeil,H.P.
    Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens
    J Immunol191, 1404-1412. PubMed  Europe PubMed DOI
    29. 2012
  29. Hernandez-Hernandez,L., Sanz,C., Garcia-Solaesa,V., Padron,J., Garcia-Sanchez,A., Davila,I., Isidoro-Garcia,M. and Lorente,F.
    Tryptase: genetic and functional considerations
    Allergol Immunopathol (Madr)40, 385-389. PubMed  Europe PubMed DOI
  30. Liang,G., Aldous,S., Merriman,G., Levell,J., Pribish,J., Cairns,J., Chen,X., Maignan,S., Mathieu,M., Tsay,J., Sides,K., Rebello,S., Whitely,B., Morize,I. and Pauls,H.W.
    Structure-based library design and the discovery of a potent and selective mast cell beta-tryptase inhibitor as an oral therapeutic agent
    Bioorg Med Chem Lett22, 1049-1054. PubMed  Europe PubMed DOI  I
  31. Liang,G., Choi-Sledeski,Y.M., Shum,P., Chen,X., Poli,G.B., Kumar,V., Minnich,A., Wang,Q., Tsay,J., Sides,K., Kang,J. and Zhang,Y.
    A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity
    Bioorg Med Chem Lett22, 1606-1610. PubMed  Europe PubMed DOI  I
  32. Liang,G., Choi-Sledeski,Y.M., Chen,X., Gong,Y., Macmillan,E.W., Tsay,J., Sides,K., Cairns,J., Kulitzscher,B., Aldous,D.J., Morize,I. and Pauls,H.W.
    Dimerization of beta-tryptase inhibitors, does it work for both basic and neutral P1 groups?
    Bioorg Med Chem Lett22, 3370-3376. PubMed  Europe PubMed DOI  I
  33. Prieto-Garcia,A., Zheng,D., Adachi,R., Xing,W., Lane,W.S., Chung,K., Anderson,P., Hansbro,P.M., Castells,M. and Stevens,R.L.
    Mast cell restricted mouse and human tryptase.heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen
    J Biol Chem287, 7834-7844. PubMed  Europe PubMed DOI
  34. Trivedi,N.N. and Caughey,G.H.
    Human alpha-, beta- and delta-tryptases
    [ISSN:978-0-12-407742-3]3, 2683-2693. DOI
    35. 2011
  35. Janke,D., Sommerhoff,C.P. and Schaschke,N.
    The arginine mimicking beta-amino acid beta3hPhe(3-H2N-CH2) as S1 ligand in cyclotheonamide-based beta-tryptase inhibitors
    Bioorg Med Chem19, 7236-7243. PubMed  Europe PubMed DOI  I
  36. Le,Q.T., Gomez,G., Zhao,W., Hu,J., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B.
    Processing of human protryptase in mast cells involves cathepsins L, B, and C
    J Immunol187, 1912-1918. PubMed  Europe PubMed DOI
  37. Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B.
    Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C
    J Immunol186, 7136-7143. PubMed  Europe PubMed DOI
  38. Liang,G., Choi-Sledeski,Y.M., Poli,G.B., Chen,X., Minnich,A., Wang,Q., Tsay,J., Sides,K. and Vaz,R.J.
    Structure-based design, synthesis, and profiling of a beta-tryptase inhibitor with a spiro-piperidineamide scaffold, benzylamine P1 group, and a substituted indole P4 group
    MedChemComm2, 794-799. DOI  I
  39. Spinnler,K., Frohlich,T., Arnold,G.J., Kunz,L. and Mayerhofer,A.
    Human tryptase cleaves pro-nerve growth factor (pro-NGF): hints of local, mast cell-dependent regulation of NGF/pro-NGF action
    J Biol Chem286, 31707-31713. PubMed  Europe PubMed DOI
    40. 2010
  40. Liang,G., Choi-Sledeski,Y.M., Poli,G., Chen,X., Shum,P., Minnich,A., Wang,Q., Tsay,J., Sides,K., Cairns,J., Stoklosa,G., Nieduzak,T., Zhao,Z., Wang,J. and Vaz,R.J.
    A conformationally constrained inhibitor with an enhanced potency for beta-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO)
    Bioorg Med Chem Lett20, 6721-6724. PubMed  Europe PubMed DOI  I
  41. Reimer,J.M., Samollow,P.B. and Hellman,L.
    High degree of conservation of the multigene tryptase locus over the past 150-200 million years of mammalian evolution
    Immunogenetics62, 369-382. PubMed  Europe PubMed DOI
  42. Sommerhoff,C.P., Avrutina,O., Schmoldt,H.U., Gabrijelcic-Geiger,D., Diederichsen,U. and Kolmar,H.
    Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta
    J Mol Biol395, 167-175. PubMed  Europe PubMed DOI
  43. Wich,P.R. and Schmuck,C.
    Reversible and noncompetitive inhibition of beta-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library
    Angew Chem Int Ed Engl49, 4113-4116. PubMed  Europe PubMed DOI  I
    44. 2009
  44. Trivedi,N.N., Tamraz,B., Chu,C., Kwok,P.Y. and Caughey,G.H.
    Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations
    J Allergy Clin Immunol124, 1099-1105. PubMed  Europe PubMed DOI  M
    45. 2008
  45. Fukuoka,Y., Xia,H.Z., Sanchez-Munoz,L.B., Dellinger,A.L., Escribano,L. and Schwartz,L.B.
    Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5
    J Immunol180, 6307-6316. PubMed  Europe PubMed
  46. Jackson,N.E., Wang,H.W., Bryant,K.J., McNeil,H.P., Husain,A., Liu,K., Tedla,N., Thomas,P.S., King,G.C., Hettiaratchi,A., Cairns,J. and Hunt,J.E.
    Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation
    J Biol Chem283, 34178-34187. PubMed  Europe PubMed DOI  R
  47. Rauter,I., Krauth,M.T., Westritschnig,K., Horak,F., Flicker,S., Gieras,A., Repa,A., Balic,N., Spitzauer,S., Huss-Marp,J., Brockow,K., Darsow,U., Behrendt,H., Ring,J., Kricek,F., Valent,P. and Valenta,R.
    Mast cell-derived proteases control allergic inflammation through cleavage of IgE
    J Allergy Clin Immunol121, 197-202. PubMed  Europe PubMed DOI
  48. Spichalska,B., Lesner,A., Wysocka,M., Sledz,M., Legowska,A., Jaskiewicz,A., Miecznikowska,H. and Rolka,K.
    The influence of substrate peptide length on human beta-tryptase specificity
    J Pept Sci14, 917-923. PubMed  Europe PubMed DOI  A  P
    49. 2007
  49. Fukuoka,Y. and Schwartz,L.B.
    Active monomers of human beta-tryptase have expanded substrate specificities
    Int Immunopharmacol7, 1900-1908. PubMed  Europe PubMed DOI  P
  50. Schechter,N.M., Choi,E.J., Selwood,T. and McCaslin,D.R.
    Characterization of three distinct catalytic forms of human tryptase-beta: their interrelationships and relevance
    Biochemistry46, 9615-9629. PubMed  Europe PubMed DOI
  51. Sommerhoff,C.P. and Schaschke,N.
    Mast cell tryptase beta as a target in allergic inflammation: an evolving story
    Curr Pharm Des13, 313-332. PubMed  Europe PubMed DOI  V  T
  52. Trivedi,N.N., Tong,Q., Raman,K., Bhagwandin,V.J. and Caughey,G.H.
    Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates
    J Immunol179, 6072-6079. PubMed  Europe PubMed
    53. 2006
  53. Caughey,G.H.
    Tryptase genetics and anaphylaxis
    J Allergy Clin Immunol117, 1411-1414. PubMed  Europe PubMed DOI
  54. [YEAR:19-5-2006]Lee,C.S., Liu,W., Sprengeler,P.A., Somoza,J.R., Janc,J.W., Sperandio,D., Spencer,J.R., Green,M.J. and McGrath,M.E.
    Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles
    Bioorg Med Chem Lett16, 4036-4040. PubMed  Europe PubMed DOI
  55. [YEAR:16-5-2006]McGrath,M.E., Sprengeler,P.A., Hirschbein,B., Somoza,J.R., Lehoux,I., Janc,J.W., Gjerstad,E., Graupe,M., Estiarte,A., Venkataramani,C., Liu,Y., Yee,R., Ho,J.D., Green,M.J., Lee,C.S., Liu,L., Tai,V., Spencer,J., Sperandio,D. and Katz,B.A.
    Structure-guided design of peptide-based tryptase inhibitors
    Biochemistry45, 5964-5973. PubMed  Europe PubMed DOI  I
  56. [YEAR:13-3-2006]Miyazaki,Y., Kato,Y., Manabe,T., Shimada,H., Mizuno,M., Egusa,T., Ohkouchi,M., Shiromizu,I., Matsusue,T. and Yamamoto,I.
    Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors
    Bioorg Med Chem Lett16, 2986-2990. PubMed  Europe PubMed DOI  I
  57. Rauter,I., Krauth,M.T., Flicker,S., Gieras,A., Westritschnig,K., Vrtala,S., Balic,N., Spitzauer,S., Huss-Marp,J., Brockow,K., Darsow,U., Ring,J., Behrendt,H., Semper,H., Valent,P. and Valenta,R.
    Allergen cleavage by effector cell-derived proteases regulates allergic inflammation
    FASEB J20, 967-969. PubMed  Europe PubMed DOI  P
  58. [YEAR:28-12-2006]Rohr,K.B., Selwood,T., Marquardt,U., Huber,R., Schechter,N.M., Bode,W. and Than,M.E.
    X-ray structures of free and leupeptin-complexed human alphaI-tryptase mutants: indication for an alpha - >beta-tryptase transition
    J Mol Biol357, 195-209. PubMed  Europe PubMed DOI  S  I
  59. [YEAR:23-5-2006]Sperandio,D., Tai,V.W., Lohman,J., Hirschbein,B., Mendonca,R., Lee,C.S., Spencer,J.R., Janc,J., Nguyen,M., Beltman,J., Sprengeler,P., Scheerens,H., Lin,T., Liu,L., Gadre,A., Kellogg,A., Green,M.J. and McGrath,M.E.
    Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors
    Bioorg Med Chem Lett16, 4085-4089. PubMed  Europe PubMed DOI  I
    60. 2005
  60. Cairns,J.A.
    Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disorders
    Pulm Pharmacol Ther18, 55-66. PubMed  Europe PubMed DOI
  61. [YEAR:7-1-2005]Hallgren,J., Lindahl,S. and Pejler,G.
    Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase
    J Mol Biol345, 129-139. PubMed  Europe PubMed DOI
  62. [YEAR:15-4-2005]Levell,J., Astles,P., Eastwood,P., Cairns,J., Houille,O., Aldous,S., Merriman,G., Whiteley,B., Pribish,J., Czekaj,M., Liang,G., Maignan,S., Guilloteau,J.P., Dupuy,A., Davidson,J., Harrison,T., Morley,A., Watson,S., Fenton,G., McCarthy,C., Romano,J., Mathew,R., Engers,D., Gardyan,M., Sides,K., Kwong,J., Tsay,J., Rebello,S., Shen,L., Wang,J., Luo,Y., Giardino,O., Lim,H.K., Smith,K. and Pauls,H.
    Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase
    Bioorg Med Chem13, 2859-2872. PubMed  Europe PubMed DOI  I
  63. [YEAR:8-3-2005]Selwood,T., Smolensky,H., McCaslin,D.R. and Schechter,N.M.
    The interaction of human tryptase-beta with small molecule inhibitors provides new insights into the unusual functional instability and quaternary structure of the protease
    Biochemistry44, 3580-3590. PubMed  Europe PubMed DOI
    64. 2004
  64. Caughey,G.H.
    Tryptases
    [ISSN:0-12-079610-4]2, 1535-1543.  V
  65. [YEAR:24-8-2004]Fukuoka,Y. and Schwartz,L.B.
    Human beta-tryptase: detection and characterization of the active monomer and prevention of tetramer reconstitution by protease inhibitors
    Biochemistry43, 10757-10764. PubMed  Europe PubMed DOI
  66. Payne,V. and Kam,P.C.
    Mast cell tryptase: a review of its physiology and clinical significance
    Anaesthesia59, 695-703. PubMed  Europe PubMed DOI
  67. [YEAR:1-12-2004]Scarpi,D., McBride,J.D. and Leatherbarrow,R.J.
    Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor
    Bioorg Med Chem12, 6045-6052. PubMed  Europe PubMed DOI
  68. [YEAR:20-12-2004]Vaz,R.J., Gao,Z., Pribish,J., Chen,X., Levell,J., Davis,L., Albert,E., Brollo,M., Ugolini,A., Cramer,D.M., Cairns,J., Sides,K., Liu,F., Kwong,J., Kang,J., Rebello,S., Elliot,M., Lim,H., Chellaraj,V., Singleton,R.W. and Li,Y.
    Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase
    Bioorg Med Chem Lett14, 6053-6056. PubMed  Europe PubMed DOI  I
    69. 2003
  69. [YEAR:1-2-2003]Fajardo,I. and Pejler,G.
    Formation of active monomers from tetrameric human beta-tryptase
    Biochem J369, 603-610. PubMed  Europe PubMed DOI
  70. [YEAR:1-8-2003]Fajardo,I. and Pejler,G.
    Human mast cell beta-tryptase is a gelatinase
    J Immunol171, 1493-1499. PubMed  Europe PubMed
  71. Selwood,T., Elrod,K.C. and Schechter,N.M.
    Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor
    Biol Chem384, 1605-1611. PubMed  Europe PubMed DOI  I
    72. 2002
  72. Brown,J.K., Jones,C.A., Rooney,L.A., Caughey,G.H. and Hall,I.P.
    Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions
    Am J Physiol Lung Cell Mol Physiol282, L197-L206. PubMed  Europe PubMed
  73. Scarpi,D., McBride,J.D. and Leatherbarrow,R.J.
    Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides
    J Pept Res59, 90-93. PubMed  Europe PubMed
  74. [YEAR:12-3-2002]Selwood,T., Wang,Z.M., McCaslin,D.R. and Schechter,N.M.
    Diverse stability and catalytic properties of human tryptase alpha and beta isoforms are mediated by residue differences at the S1 pocket
    Biochemistry41, 3329-3340. PubMed  Europe PubMed DOI
  75. Tremaine,W.J., Brzezinski,A., Katz,J.A., Wolf,D.C., Fleming,T.J., Mordenti,J., Strenkoski-Nix,L.C. and Kurth,M.C.
    Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study
    Aliment Pharmacol Ther16, 407-413. PubMed  Europe PubMed DOI  I
    76. 2001
  76. Buckley,M.G., Variend,S. and Walls,A.F.
    Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms
    Clin Exp Allergy31, 1696-1704. PubMed  Europe PubMed DOI
  77. [YEAR:14-9-2001]Harris,J.L., Niles,A., Burdick,K., Maffitt,M., Backes,B.J., Ellman,J.A., Kuntz,I., Haak-Frendscho,M. and Craik,C.S.
    Definition of the extended substrate specificity determinants for beta-tryptases I and II
    J Biol Chem276, 34941-34947. PubMed  Europe PubMed DOI
  78. [YEAR:13-7-2001]Huang,C., De Sanctis,G.T., O'Brien,P.J., Mizgerd,J.P., Friend,D.S., Drazen,J.M., Brass,L.F. and Stevens,R.L.
    Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung
    J Biol Chem276, 26276-26284. PubMed  Europe PubMed DOI
  79. Schaschke,N., Matschiner,G., Zettl,F., Marquardt,U., Bergner,A., Bode,W., Sommerhoff,C.P. and Moroder,L.
    Bivalent inhibition of human beta-tryptase
    Chem Biol8, 313-327. PubMed  Europe PubMed DOI
    80. 1999
  80. Harvima,R.J., Harvima,I.T., Dull,D., Dunder,U.K. and Schwartz,L.B.
    Identification and characterization of multiple forms of tryptase from human mast cells
    Arch Dermatol Res291, 73-80. PubMed  Europe PubMed DOI
  81. [YEAR:9-7-1999]Huang,C., Li,L., Krilis,S.A., Chanasyk,K., Tang,Y., Li,Z., Hunt,J.E. and Stevens,R.L.
    Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft
    J Biol Chem274, 19670-19676. PubMed  Europe PubMed DOI
  82. [YEAR:5-2-1999]Pallaoro,M., Fejzo,M.S., Shayesteh,L., Blount,J.L. and Caughey,G.H.
    Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3
    J Biol Chem274, 3355-3362. PubMed  Europe PubMed DOI
  83. [YEAR:28-9-1999]Sommerhoff,C.P., Bode,W., Pereira,P.J., Stubbs,M.T., Sturzebecher,J., Piechottka,G.P., Matschiner,G. and Bergner,A.
    The structure of the human beta II-tryptase tetramer: fo(u)r better or worse
    Proc Natl Acad Sci U S A96, 10984-10991. PubMed  Europe PubMed DOI  S
    84. 1998
  84. [YEAR:22-9-1998]Selwood,T., McCaslin,D.R. and Schechter,N.M.
    Spontaneous inactivation of human tryptase involves conformational changes consistent with conversion of the active site to a zymogen-like structure
    Biochemistry37, 13174-13183. PubMed  Europe PubMed DOI
    85. 1996
  85. Molinari,J.F., Scuri,M., Moore,W.R., Clark,J., Tanaka,R. and Abraham,W.M.
    Inhaled tryptase causes bronchoconstriction in sheep via histamine release
    Am J Respir Crit Care Med154, 649-653. PubMed  Europe PubMed DOI  I
  86. Sakai,K., Long,S.D., Pettit,D.A., Cabral,G.A. and Schwartz,L.B.
    Expression and purification of recombinant human tryptase in a baculovirus system
    Protein Expr Purif7, 67-73. PubMed  Europe PubMed DOI  E
    87. 1995
  87. Molinari,J.F., Moore,W.R., Clark,J., Tanaka,R., Butterfield,J.H. and Abraham,W.M.
    Role of tryptase in immediate cutaneous responses in allergic sheep
    J Appl Physiol79, 1966-1970. PubMed  Europe PubMed  I
    88. 1990
  88. Miller,J.S., Moxley,G. and Schwartz,L.B.
    Cloning and characterization of a second complementary DNA for human tryptase
    J Clin Invest86, 864-870. PubMed  Europe PubMed DOI
  89. [YEAR:11-12-1990]Moxley,G., Miller,J.S., Diehl,S. and Schwartz,L.B.
    EcoRV polymorphism detected by cDNA probe for human tryptase beta (TPS2) [corrected]
    Nucleic Acids Res18, 7197-7197. PubMed  Europe PubMed  M
  90. Vanderslice,P., Ballinger,S.M., Tam,E.K., Goldstein,S.M., Craik,C.S. and Caughey,G.H.
    Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family
    Proc Natl Acad Sci U S A87, 3811-3815. PubMed  Europe PubMed DOI
    91. 1989
  91. Vanderslice,P., Craik,C.S., Nadel,J.A. and Caughey,G.H.
    Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation
    Biochemistry28, 4148-4155. PubMed  Europe PubMed

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