Structure for peptidase S01.015: tryptase beta

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1A0L	Homo sapiens	3.00 Å	tetramer
Only one monomer of the homotetramer is shown. Catalytic residues are shown in ball-and-stick representation: His74 in purple, Asp121 in pink and Ser224 in orange.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
tetramer	3.00 Å	1A0L	1A0L	1A0L	1A0L	1A0L	1A0L	Pereira et al., 1998
theoretical model	0.00 Å	1AAO	1AAO	1AAO	1AAO	1AAO	1AAO
human beta-ii tryptase in complex with 4-(3-aminomethyl- phenyl)-piperidin-1-yl-(5-phenethyl- pyridin-3-yl)- methanone	2.20 Å	2BM2	2BM2	2BM2	2BM2	2BM2	2BM2	Levell et al., 2005
human tryptase with 2-amino benzimidazole	2.00 Å	2FPZ	2FPZ	2FPZ	2FPZ	2FPZ	2FPZ	McGrath et al., 2006
human beta-tryptase ii with inhibitor cra-29382	2.50 Å	2FS8	2FS8	2FS8	2FS8	2FS8	2FS8	McGrath et al., 2006
human beta tryptase ii with inhibitor cra-28427	2.30 Å	2FS9	2FS9	2FS9	2FS9	2FS9	2FS9	McGrath et al., 2006
complex with 4-piperidinebutyrate to make acylenzyme	2.25 Å	2FWW	2FWW	2FWW	2FWW	2FWW	2FWW	McGrath et al., 2006
complex with activated ketone inhibitor cra-29382	2.50 Å	2FXR	2FXR	2FXR	2FXR	2FXR	2FXR	McGrath et al., 2006
human beta ii tryptase with inhibitor cra-27592	2.35 Å	2GDD	2GDD	2GDD	2GDD	2GDD	2GDD
complex with (5-(aminomethyl)-2H-spiro[benzofuran-3,4'- piperidine]-1'-yl)(5-(phenylethynyl)furan- 2-yl)methanone	2.30 Å	2ZA5	2ZA5	2ZA5	2ZA5	2ZA5	2ZA5	Costanzo et al., 2003
potent, nonpeptide inhibitors of human mast cell tryptase	2.50 Å	2ZEB	2ZEB	2ZEB	2ZEB	2ZEB	2ZEB	Costanzo et al., 2008
potent, nonpeptide inhibitors of human mast cell tryptase	2.06 Å	2ZEC	2ZEC	2ZEC	2ZEC	2ZEC	2ZEC	Costanzo et al., 2008
mature peptidase	2.09 Å	3V7T	3V7T	3V7T	3V7T	3V7T	3V7T	Liang et al., 2012
complex with 5-(3-aminomethyl-phenoxymethyl)-3-[3-(2- chloro-pyridin-3-ylethynyl)-phenyl]-oxazolidin-2-one; compound with trifluoro-acetic acid	1.94 Å	5F03	5F03	5F03	5F03	5F03	5F03