Substrates for peptidase M12.338: BmooMPalpha-I (Bothrops sp.)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Abz-Gly-Phe-Gln-Pro-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe-Gln-Pro+Phe-Arg-Gln-EDDnp	S		Gly	Phe	Gln	Pro	Phe	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Glu-Pro-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe-Glu-Pro+Phe-Arg-Gln-EDDnp	S		Gly	Phe	Glu	Pro	Phe	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Leu-Pro-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe-Leu-Pro+Phe-Arg-Gln-EDDnp	S		Gly	Phe	Leu	Pro	Phe	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Ala-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe-Ser-Ala+Phe-Arg-Gln-EDDnp	S		Gly	Phe	Ser	Ala	Phe	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Asp-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe-Ser-Asp+Phe-Arg-Gln-EDDnp	S		Gly	Phe	Ser	Asp	Phe	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Gln-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe-Ser-Gln+Phe-Arg-Gln-EDDnp	S		Gly	Phe	Ser	Gln	Phe	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Glu-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe-Ser-Glu+Phe-Arg-Gln-EDDnp	S		Gly	Phe	Ser	Glu	Phe	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Pro-Gln-Arg-Gln-EDDnp			Abz-Gly-Phe-Ser-Pro+Gln-Arg-Gln-EDDnp	S		Gly	Phe	Ser	Pro	Gln	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Pro-Leu-Arg-Gln-EDDnp			Abz-Gly-Phe-Ser-Pro+Leu-Arg-Gln-EDDnp	S		Gly	Phe	Ser	Pro	Leu	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Pro-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe-Ser-Pro+Phe-Arg-Gln-EDDnp	S		Gly	Phe	Ser	Pro	Phe	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-Gln-EDDnp			Abz-Gly-Phe-Ser-Pro+Phe-Arg-Ser-Ser-Arg-Ile-Gln-EDDnp	S		Gly	Phe	Ser	Pro	Phe	Arg	Ser	Ser	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-Gln-EDDnp			Abz-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg+Ile-Gln-EDDnp	S		Arg	Ser	Ser	Arg	Ile	Gln	EDD	-	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Pro-Phe-Gln-Gln-EDDnp			Abz-Gly-Phe-Ser-Pro+Phe-Gln-Gln-EDDnp	S		Gly	Phe	Ser	Pro	Phe	Gln	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Pro-Phe-Glu-Gln-EDDnp			Abz-Gly-Phe-Ser-Pro+Phe-Glu-Gln-EDDnp	S		Gly	Phe	Ser	Pro	Phe	Glu	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Pro-Phe-Leu-Gln-EDDnp			Abz-Gly-Phe-Ser-Pro+Phe-Leu-Gln-EDDnp	S		Gly	Phe	Ser	Pro	Phe	Leu	Gln	EDD	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Pro-Phe-Leu-Gln-EDDnp			Abz-Gly-Phe-Ser-Pro-Phe+Leu-Gln-EDDnp	S		Phe	Ser	Pro	Phe	Leu	Gln	EDD	-	Okamoto et al., 2014
Abz-Gly-Phe-Ser-Ser-Phe-Arg-Gln-EDDnp			Abz-Gly-Phe-Ser-Ser+Phe-Arg-Gln-EDDnp	S		Gly	Phe	Ser	Ser	Phe	Arg	Gln	EDD	Okamoto et al., 2014
Abz-Lys-Leu-Ala-Pro-Ser-Lys-Gln-EDDnp			Abz-Lys-Leu-Ala-Pro+Ser-Lys-Gln-EDDnp	S		Lys	Leu	Ala	Pro	Ser	Lys	Gln	EDD	Okamoto et al., 2014
Abz-Lys-Leu-Asp-Pro-Ser-Lys-Gln-EDDnp			Abz-Lys-Leu-Asp-Pro+Ser-Lys-Gln-EDDnp	S		Lys	Leu	Asp	Pro	Ser	Lys	Gln	EDD	Okamoto et al., 2014
Abz-Lys-Leu-Gln-Pro-Ser-Lys-Gln-EDDnp			Abz-Lys-Leu-Gln-Pro+Ser-Lys-Gln-EDDnp	S		Lys	Leu	Gln	Pro	Ser	Lys	Gln	EDD	Okamoto et al., 2014
Abz-Lys-Leu-Glu-Pro-Ser-Lys-Gln-EDDnp			Abz-Lys-Leu-Glu-Pro+Ser-Lys-Gln-EDDnp	S		Lys	Leu	Glu	Pro	Ser	Lys	Gln	EDD	Okamoto et al., 2014
Abz-Lys-Leu-Leu-Pro-Ser-Lys-Gln-EDDnp			Abz-Lys-Leu-Leu-Pro+Ser-Lys-Gln-EDDnp	S		Lys	Leu	Leu	Pro	Ser	Lys	Gln	EDD	Okamoto et al., 2014
Abz-Lys-Leu-Ser-Pro-Ser-Lys-Gln-EDDnp			Abz-Lys-Leu-Ser-Pro+Ser-Lys-Gln-EDDnp	S		Lys	Leu	Ser	Pro	Ser	Lys	Gln	EDD	Okamoto et al., 2014
Abz-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln-EDDnp			Abz-Met-Ile-Ser+Leu-Met-Lys-Arg-Pro-Gln-EDDnp	S		Abz	Met	Ile	Ser	Leu	Met	Lys	Arg	Okamoto et al., 2014
Abz-Met-Ile-Ser-Leu-Met-Lys-Arg-Pro-Gln-EDDnp			Abz-Met-Ile-Ser-Leu+Met-Lys-Arg-Pro-Gln-EDDnp	S		Met	Ile	Ser	Leu	Met	Lys	Arg	Pro	Okamoto et al., 2014
angiotensin 1	P01019	34-43	Asp+Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu	P	NT	'-'	'-'	'-'	Asp	Arg	Val	Tyr	Ile	Okamoto et al., 2014
angiotensin 1	P01019	34-43	Asp-Arg-Val-Tyr-Ile-His-Pro+Phe-His-Leu	P	NT	Tyr	Ile	His	Pro	Phe	His	Leu	'-'	Okamoto et al., 2014
bradykinin	P01042	381-389	Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg	P	NT	Gly	Phe	Ser	Pro	Phe	Arg	'-'	'-'	Okamoto et al., 2014
neurotensin	P30990	151-163	Gln-Leu-Tyr-Glu-Asn+Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu	P	NT	Leu	Tyr	Glu	Asn	Lys	Pro	Arg	Arg	Okamoto et al., 2014
neurotensin	P30990	151-163	Gln-Leu-Tyr-Glu-Asn-Lys-Pro+Arg-Arg-Pro-Tyr-Ile-Leu	P	NT	Glu	Asn	Lys	Pro	Arg	Arg	Pro	Tyr	Okamoto et al., 2014
oxytocin	P01178	20-28	Cys-Tyr-Ile-Gln-Asn-Cys-Pro+Leu-Gly	P	NT	Gln	Asn	Cys	Pro	Leu	Gly	'-'	'-'	Okamoto et al., 2014
substance P	P20366	58-68	Arg-Pro-Lys-Pro+Gln-Gln-Phe-Phe-Gly-Leu-Met	P	NT	Arg	Pro	Lys	Pro	Gln	Gln	Phe	Phe	Okamoto et al., 2014
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln+Gln-Phe-Phe-Gly-Leu-Met	P	NT	Pro	Lys	Pro	Gln	Gln	Phe	Phe	Gly	Okamoto et al., 2014
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln+Phe-Phe-Gly-Leu-Met	P	NT	Lys	Pro	Gln	Gln	Phe	Phe	Gly	Leu	Okamoto et al., 2014
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln-Phe+Phe-Gly-Leu-Met	P	NT	Pro	Gln	Gln	Phe	Phe	Gly	Leu	Met	Okamoto et al., 2014
substance P	P20366	58-68	Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly+Leu-Met	P	NT	Gln	Phe	Phe	Gly	Leu	Met	'-'	'-'	Okamoto et al., 2014