Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00450

,

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
19	unknown peptidase	1-1065	P	release of a signal peptide	NT	Takahashi et al., 1984
43	trypsin 1	1-1065	N			Takahashi et al., 1983
62	trypsin 1	1-1065	N			Takahashi et al., 1983
65	trypsin 1	1-1065	N			Takahashi et al., 1983
69	trypsin 1	1-1065	N			Takahashi et al., 1983
81	trypsin 1	1-1065	N			Takahashi et al., 1983
104	trypsin 1	1-1065	N			Takahashi et al., 1983
110	trypsin 1	1-1065	N			Takahashi et al., 1983
115	trypsin 1	1-1065	N			Takahashi et al., 1983
128	trypsin 1	1-1065	N			Takahashi et al., 1983
157	trypsin 1	1-1065	N			Takahashi et al., 1983
177	trypsin 1	1-1065	N			Takahashi et al., 1983
187	trypsin 1	1-1065	N			Takahashi et al., 1983
197	trypsin 1	1-1065	N			Takahashi et al., 1983
237	trypsin 1	1-1065	N			Takahashi et al., 1983
258	trypsin 1	1-1065	N			Takahashi et al., 1983
280	trypsin 1	1-1065	N			Takahashi et al., 1983
310	trypsin 1	1-1065	N			Takahashi et al., 1983
325	trypsin 1	1-1065	N			Takahashi et al., 1983
345	trypsin 1	1-1065	N			Takahashi et al., 1983
359	trypsin 1	1-1065	N			Takahashi et al., 1983
372	trypsin 1	1-1065	N			Takahashi et al., 1983
395	trypsin 1	1-1065	N			Takahashi et al., 1983
405	bothropasin	20-1065	N		MS	Paes Leme et al., 2010
415	trypsin 1	1-1065	N			Takahashi et al., 1983
426	trypsin 1	1-1065	N			Takahashi et al., 1983
436	trypsin 1	1-1065	N			Takahashi et al., 1983
437	trypsin 1	1-1065	N			Takahashi et al., 1983
451	bothropasin	20-1065	N		MS	Paes Leme et al., 2010
500	plasmin	20-1065	P		NT	Kingston et al., 1978
590	bothropasin	20-1065	N		MS	Paes Leme et al., 2010
906	plasmin	20-1065	P		NT	Kingston et al., 1978