$VAR1 = undef;

Summary for peptidase M12.140: bothropasin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

 

Names
MEROPS Namebothropasin
Other namesatroxlysin-III (Bothrops atrox), Atr-III, caseinolytic endopeptidase Bothrops jararaca
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.140
Holotypebothropasin (Bothrops jararaca), Uniprot accession O93523 (peptidase unit: 192-394), MERNUM MER0004933
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.49
EnzymologyBRENDA database
PhysiologyLikely role in snake venom toxicity. Hemorrhagic.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bondLvf/-/-/- (based on 62 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 4 11 6 0 1 3 3
Pro 1 2 0 5 0 0 0 4
Ala 2 8 3 7 4 4 2 7
Val 5 5 3 1 10 8 7 3
Leu 7 3 6 6 33 13 6 10
Ile 3 2 1 0 2 1 4 2
Met 2 1 1 1 0 0 0 0
Phe 2 1 0 3 7 4 5 2
Tyr 5 3 1 3 3 5 4 1
Trp 0 1 1 0 0 0 2 0
Ser 5 7 8 12 2 2 4 2
Thr 4 3 2 1 0 8 4 5
Cys 2 2 6 2 0 3 3 3
Asn 3 5 4 0 0 3 4 2
Gln 3 3 3 3 0 3 2 3
Asp 5 3 4 3 0 1 0 8
Glu 6 4 6 5 0 5 7 6
Lys 3 1 1 0 0 0 0 0
Arg 0 1 0 0 0 0 0 0
His 1 3 1 4 1 0 4 1