$VAR1 = undef;

Summary for peptidase M10.016: membrane-type matrix metallopeptidase-3

Names
MEROPS Name	membrane-type matrix metallopeptidase-3
Other names	matrix metalloproteinase 16, membrane-type matrix metalloproteinase 3, MMP-16, matrix metalloproteinase, membrane-type 3, MT3-MMP, ovary metalloproteinase, membrane-type matrix metalloproteinase (Gallus domesticus), MTMMP-3

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.016
Holotype	membrane-type matrix metallopeptidase-3 (Homo sapiens), Uniprot accession P51512 (peptidase unit: 116-306), MERNUM MER0002384
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (18 cleavages)
Activity status	human: active (Kang et al., 2000) mouse: active (Kang et al., 2000)
Pathways	KEGG	MicroRNAs in cancer
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP16
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/spv/-/--/-/-/- (based on 20 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	1	1	3	1	0	3	3
Pro	0	4	0	1	1	0	0	2
Ala	0	1	4	3	0	3	0	4
Val	2	4	0	0	0	0	0	1
Leu	2	2	2	0	4	1	2	0
Ile	0	1	0	0	3	1	0	2
Met	0	1	1	0	2	0	1	0
Phe	0	0	1	0	0	1	1	0
Tyr	0	0	0	1	0	1	0	0
Trp	0	0	1	0	0	1	0	0
Ser	2	5	0	2	4	1	2	0
Thr	0	0	1	1	0	2	3	1
Cys	0	0	0	0	0	0	0	0
Asn	1	0	0	2	1	0	1	0
Gln	2	1	3	0	3	4	2	2
Asp	2	0	1	0	0	0	1	3
Glu	3	0	1	1	0	0	1	1
Lys	1	0	2	2	1	3	1	0
Arg	2	0	1	0	0	2	1	1
His	0	0	1	4	0	0	1	0