Summary for peptidase M10.016: membrane-type matrix metallopeptidase-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Namemembrane-type matrix metallopeptidase-3
Other namesmatrix metalloproteinase 16, membrane-type matrix metalloproteinase 3, MMP-16, matrix metalloproteinase, membrane-type 3, MT3-MMP, ovary metalloproteinase, membrane-type matrix metalloproteinase (Gallus domesticus), MTMMP-3
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.016
Holotypemembrane-type matrix metallopeptidase-3 (Homo sapiens), Uniprot accession P51512 (peptidase unit: 116-306), MERNUM MER0002384
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (18 cleavages)
Activity statushuman: active (Kang et al., 2000)
mouse: active (Kang et al., 2000)
Pathways KEGGMicroRNAs in cancer
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/MMP16
TREEFAMhttp://www.treefam.org/family/TF352396
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR10201:SF26
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/spv/-/-Scissile bond-/-/-/- (based on 20 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 1 1 3 1 0 3 3
Pro 0 4 0 1 1 0 0 2
Ala 0 1 4 3 0 3 0 4
Val 2 4 0 0 0 0 0 1
Leu 2 2 2 0 4 1 2 0
Ile 0 1 0 0 3 1 0 2
Met 0 1 1 0 2 0 1 0
Phe 0 0 1 0 0 1 1 0
Tyr 0 0 0 1 0 1 0 0
Trp 0 0 1 0 0 1 0 0
Ser 2 5 0 2 4 1 2 0
Thr 0 0 1 1 0 2 3 1
Cys 0 0 0 0 0 0 0 0
Asn 1 0 0 2 1 0 1 0
Gln 2 1 3 0 3 4 2 2
Asp 2 0 1 0 0 0 1 3
Glu 3 0 1 1 0 0 1 1
Lys 1 0 2 2 1 3 1 0
Arg 2 0 1 0 0 2 1 1
His 0 0 1 4 0 0 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MMP16 8q21 ENSG00000156103 4325 MMP16 602262
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mmp16 4:A3 ENSMUSG00000028226 17389 MGI:1276107