$VAR1 = undef;
Summary for peptidase M04.003: vibriolysin
| Names | |
|---|---|
| MEROPS Name | vibriolysin |
| Other names | Aeromonas proteolytica neutral proteinase, aeromonolysin, ahyB g.p. (Aeromonas hydrophila), EmpA peptidase (Vibrio anguillarum), hap g.p. (Vibrio cholerae), haemagglutinin proteinase, non-membrane-damaging cytotoxin, MCP-02 (Pseudoalteromonas sp.), vEP peptidase Vibrio vulnificus, vEP-45 (Vibrio vulnificus), VtpA (Vibrio tubiashii), VvP protease Vibrio vulnificus, VvpE g.p. Vibrio vulnificus |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(E) >> Family M4 >> Subfamily (none) >> M04.003 |
| Holotype | vibriolysin (Vibrio proteolyticus), Uniprot accession Q00971 (peptidase unit: 202-499), MERNUM MER0001043 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| Peplist | Included in the Peplist with identifier PL00144 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.25 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (4 cleavages) | ||
| Physiology | Plays a role in attachment of the bacterium to intestinal epithelium. May activate Vibrio toxins. | ||
| Pharmaceutical relevance | Damage to the connective tissues caused by V. vulnificus is at least partly attributable to this peptidase (Chuan et al., 1997). Has hemagglutinating activity that seems to be mediated by both the N-terminal peptidase unit and the C-terminal domain of the protein (Miyoshi et al., 1999). | ||
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | -/-/-/- fla/-/sg/- (based on 17 cleavages) | ||
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| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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