Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P10645

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	unknown peptidase	1-457	P	release of a signal peptide	NT	Wilson et al., 1986
304	aminopeptidase A	304-319	N			Goto et al., 2006
305	aminopeptidase A	305-319	N			Goto et al., 2006
306	aminopeptidase A	306-319	N			Goto et al., 2006
307	aminopeptidase A	307-319	N			Goto et al., 2006
308	aminopeptidase A	308-319	N			Goto et al., 2006
368	plasmin	19-457	P			Yuan et al., 2009
373	plasmin	19-457	P			Yuan et al., 2009
377	plasmin	19-457	P			Jiang et al., 2001
379	plasmin	19-457	P			Yuan et al., 2009
384	plasmin	19-457	P			Yuan et al., 2009
391	plasmin	19-457	P			Jiang et al., 2001