Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M01.003: aminopeptidase A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, P Specificity, K Knockout, I Inhibitor, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Mizutani,S., Mizutani,H., Mizutani,E., Arita,H. and Kajiyama,H.
    The Fate of Angiotensin II in Placental Tissue and Blood
    Horm Metab Res56, 477-481. PubMed  Europe PubMed DOI
  2. Sharma,P., Sharma,S., Paliwal,S. and Jain,S.
    Aminopeptidase A: A Novel Therapeutic Target for Hypertension Management
    Cell Biochem Funct42, e70008-e70008. PubMed  Europe PubMed DOI
    3. 2021
  3. Hmazzou,R., Marc,Y., Flahault,A., Gerbier,R., de Mota,N. and Llorens-Cortes,C.
    Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension
    Clin Sci (Lond)135, 775-791. PubMed  Europe PubMed DOI
    4. 2020
  4. Aung,M., Konoshita,T., Moodley,J., Naicker,T., Connolly,C., Khaliq,O.P. and Gathiram,P.
    Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis
    Eur J Obstet Gynecol Reprod Biol258, 70-74. PubMed  Europe PubMed DOI
  5. Marahrens,B., Schulze,A., Wysocki,J., Lin,M.H., Ye,M., Kanwar,Y.S., Bader,M., Velez,J.C.Q., Miner,J.H. and Batlle,D.
    Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys
    Kidney Int PubMed  Europe PubMed DOI
  6. Marc,Y., Boitard,S.E., Balavoine,F., Azizi,M. and Llorens-Cortes,C.
    Targeting brain aminopeptidase A: a new strategy for the treatment of hypertension and heart failure
    Can J Cardiol36, 721-731. PubMed  Europe PubMed DOI  I
  7. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.
    Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas
    Brain Res Bull168, 1-7. PubMed  Europe PubMed DOI
  8. Seco-Calvo,J., Sanchez-Herraez,S., Casis,L., Valdivia,A., Perez-Urzelai,I., Gil,J. and Echevarria,E.
    Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
    Bone Joint Res9, 789-797. PubMed  Europe PubMed DOI
    9. 2019
  9. Azizi,M., Courand,P.Y., Denolle,T., Delsart,P., Zhygalina,V., Amar,L., Lantelme,P., Mounier-Vehier,C., de Mota,N., Balavoine,F. and Llorens-Cortes,C.
    A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension
    J Hypertens37, 1722-1728. PubMed  Europe PubMed DOI  I
  10. Keck,M., de Almeida,H., Compere,D., Inguimbert,N., Flahault,A., Balavoine,F., Roques,B. and Llorens-Cortes,C.
    NI956/QGC006, a Potent orally active, brain-penetrating aminopeptidase A inhibitor for treating hypertension
    Hypertension73, 1300-1307. PubMed  Europe PubMed DOI  I
    11. 2017
  11. Chuang,H.Y., Jiang,J.K., Yang,M.H., Wang,H.W., Li,M.C., Tsai,C.Y., Jhang,Y.Y. and Huang,J.C.
    Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer
    Oncotarget8, 21266-21280. PubMed  Europe PubMed DOI
  12. Couvineau,P., de Almeida,H., Maigret,B., Llorens-Cortes,C. and Iturrioz,X.
    Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues
    PLoS ONE12, e0184237-e0184237. PubMed  Europe PubMed DOI  I
  13. Morais,R.L., Hilzendeger,A.M., Visniauskas,B., Todiras,M., Alenina,N., Mori,M.A., Araujo,R.C., Nakaie,C.R., Chagas,J.R., Carmona,A.K., Bader,M. and Pesquero,J.B.
    High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism
    Am J Physiol Heart Circ Physiol312, H437-H445. PubMed  Europe PubMed DOI
  14. Nakamura,T., Yamazato,M., Ishida,A. and Ohya,Y.
    Excess of aminopeptidase A in the brain elevates blood pressure via the angiotensin II type 1 and bradykinin B2 receptors without dipsogenic effect
    Int J Hypertens2017, 3967595-3967595. PubMed  Europe PubMed DOI  I
  15. Velez,J.C.Q., Arif,E., Rodgers,J., Hicks,M.P., Arthur,J.M., Nihalani,D., Bruner,E.T., Budisavljevic,M.N., Atkinson,C., Fitzgibbon,W.R. and Janech,M.G.
    Deficiency of the angiotensinase aminopeptidase A increases susceptibility to glomerular injury
    J Am Soc Nephrol28, 2119-2132. PubMed  Europe PubMed DOI  K
    16. 2016
  16. Hmazzou,R., Flahault,A., Marc,Y. and Llorens-Cortes,C.
    [OP.6D.03] Mode of action of RB150, an aminopeptidase A inhibitor prodrug as a centrally-acting antihypertensive agent in DOCA-salt hypertensive rats
    J Hypertens34 Suppl 2, e75-e75. DOI  I
    17. 2015
  17. Wysocki,J., Ye,M. and Batlle,D.
    Plasma and kidney angiotensin peptides: importance of the aminopeptidase A/angiotensin III axis
    Am J Hypertens28, 1418-1426. PubMed  Europe PubMed DOI  I
    18. 2014
  18. Alghamri,M.S., Morris,M., Meszaros,J.G., Elased,K.M. and Grobe,N.
    Novel role of aminopeptidase-A in angiotensin-(1-7) metabolism post myocardial infarction
    Am J Physiol Heart Circ Physiol306, H1032-H1040. PubMed  Europe PubMed DOI
  19. Gao,J., Marc,Y., Iturrioz,X., Leroux,V., Balavoine,F. and Llorens-Cortes,C.
    A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors
    Clin Sci (Lond)127, 135-148. PubMed  Europe PubMed DOI  I
    20. 2013
  20. Schwacke,J.H., Spainhour,J.C., Ierardi,J.L., Chaves,J.M., Arthur,J.M., Janech,M.G. and Velez,J.C.
    Network modeling reveals steps in angiotensin peptide processing
    Hypertension61, 690-700. PubMed  Europe PubMed DOI
  21. Yang,Y., Liu,C., Lin,Y.L. and Li,F.
    Structural insights into central hypertension regulation by human aminopeptidase A
    J Biol Chem288, 25638-25645. PubMed  Europe PubMed DOI  S  I
    22. 2012
  22. Marc,Y., Gao,J., Balavoine,F., Michaud,A., Roques,B.P. and Llorens-Cortes,C.
    Central antihypertensive effects of orally active aminopeptidase A inhibitors in spontaneously hypertensive rats
    Hypertension60, 411-418. PubMed  Europe PubMed DOI  I
  23. Wang,J., Cooper,M.D., Iturrioz,X. and Llorens-Cortes,C.
    Glutamyl aminopeptidase
    [ISSN:978-0-12-407744-7]3, 410-414. DOI
    24. 2010
  24. Kubota,R., Numaguchi,Y., Ishii,M., Niwa,M., Okumura,K., Naruse,K. and Murohara,T.
    Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1alpha
    Biochem Biophys Res Commun402, 396-401. PubMed  Europe PubMed DOI  K
  25. Vaiyapuri,S., Wagstaff,S.C., Watson,K.A., Harrison,R.A., Gibbins,J.M. and Hutchinson,E.G.
    Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros
    PLoS Negl Trop Dis4, e796-e796. PubMed  Europe PubMed DOI
    26. 2009
  26. Claperon,C., Banegas-Font,I., Iturrioz,X., Rozenfeld,R., Maigret,B. and Llorens-Cortes,C.
    Identification of threonine 348 as a residue involved in aminopeptidase A substrate specificity
    J Biol Chem284, 10618-10626. PubMed  Europe PubMed DOI  I
  27. Ishii,M., Hattori,A., Numaguchi,Y., Ma,X., Nagasaka,T., Tsujimoto,M., Murohara,T., Kobayashi,H. and Mizutani,S.
    The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs)
    Early Hum Dev85, 589-594. PubMed  Europe PubMed DOI  U
    28. 2008
  28. Bodineau,L., Frugiere,A., Marc,Y., Claperon,C. and Llorens-Cortes,C.
    Aminopeptidase A inhibitors as centrally acting antihypertensive agents
    Heart Fail Rev13, 311-319. PubMed  Europe PubMed DOI  T  I
  29. Bodineau,L., Frugiere,A., Marc,Y., Inguimbert,N., Fassot,C., Balavoine,F., Roques,B. and Llorens-Cortes,C.
    Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension
    Hypertension51, 1318-1325. PubMed  Europe PubMed DOI  I
  30. Claperon,C., Rozenfeld,R., Iturrioz,X., Inguimbert,N., Okada,M., Roques,B., Maigret,B. and Llorens-Cortes,C.
    Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity
    Biochem J416, 37-46. PubMed  Europe PubMed DOI
  31. de Mota,N., Iturrioz,X., Claperon,C., Bodineau,L., Fassot,C., Roques,B.P., Palkovits,M. and Llorens-Cortes,C.
    Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei
    J Neurochem106, 416-428. PubMed  Europe PubMed DOI  I
  32. Ferreira,A.J. and Raizada,M.K.
    Aminopeptidase A: could it be a novel target for neurogenic hypertension?
    Hypertension51, 1273-1274. PubMed  Europe PubMed DOI  T
  33. Ishii,M., Hattori,A., Numaguchi,Y., Tsujimoto,M., Ishiura,S., Kobayashi,H., Murohara,T., Wright,J.W. and Mizutani,S.
    The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan
    Horm Metab Res40, 887-891. PubMed  Europe PubMed DOI  U
  34. Mizutani,S., Ishii,M., Hattori,A., Nomura,S., Numaguchi,Y., Tsujimoto,M., Kobayshi,H., Murohara,T. and Wright,J.W.
    New insights into the importance of aminopeptidase A in hypertension
    Heart Fail Rev13, 273-284. PubMed  Europe PubMed DOI
    35. 2007
  35. Goto,Y., Hattori,A., Mizutani,S. and Tsujimoto,M.
    Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A
    J Biol Chem282, 37074-37081. PubMed  Europe PubMed DOI
  36. Ogawa,Y., Murayama,N., Fujita,Y. and Yanoshita,R.
    Characterization and cDNA cloning of aminopeptidase A from the venom of Gloydius blomhoffi brevicaudus
    Toxicon49, 1172-1181. PubMed  Europe PubMed DOI
    37. 2006
  37. [YEAR:1-8-2006]Faber,F., Gembardt,F., Sun,X., Mizutani,S., Siems,W.E. and Walther,T.
    Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice
    Regul Pept136, 130-137. PubMed  Europe PubMed DOI  K
  38. Goto,Y., Hattori,A., Ishii,Y., Mizutani,S. and Tsujimoto,M.
    Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV
    J Biol Chem281, 23503-23513. PubMed  Europe PubMed DOI  P
    39. 2005
  39. Inguimbert,N., Coric,P., Dhotel,H., Bonnard,E., Llorens-Cortes,C., Mota,N., Fournie-Zaluski,M.C. and Roques,B.P.
    Synthesis and in vitro activities of new non-peptidic APA inhibitors
    J Pept Res65, 175-188. PubMed  Europe PubMed DOI  I
  40. Nomura,M., Nomura,S., Mitsui,T., Suzuki,M., Kobayashi,H., Ito,T., Itakura,A., Kikkawa,F. and Mizutani,S.
    Possible involvement of aminopeptidase A in hypertension and renal damage in Dahl salt-sensitive rats
    Am J Hypertens18, 538-543. PubMed  Europe PubMed DOI
    41. 2004
  41. [YEAR:18-5-2004]Fournie-Zaluski,M.C., Fassot,C., Valentin,B., Djordjijevic,D., Reaux-Le Goazigo,A., Corvol,P., Roques,B.P. and Llorens-Cortes,C.
    Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension
    Proc Natl Acad Sci U S A101, 7775-7780. PubMed  Europe PubMed DOI  I
  42. Marchio,S., Lahdenranta,J., Schlingemann,R.O., Valdembri,D., Wesseling,P., Arap,M.A., Hajitou,A., Ozawa,M.G., Trepel,M., Giordano,R.J., Nanus,D.M., Dijkman,H.B., Oosterwijk,E., Sidman,R.L., Cooper,M.D., Bussolino,F., Pasqualini,R. and Arap,W.
    Aminopeptidase A is a functional target in angiogenic blood vessels
    Cancer Cell5, 151-162. PubMed  Europe PubMed DOI
  43. [YEAR:8-10-2004]Rozenfeld,R., Muller,L., El Messari,S. and Llorens-Cortes,C.
    The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of this monozinc aminopeptidase
    J Biol Chem279, 43285-43295. PubMed  Europe PubMed DOI
  44. Wang,J. and Cooper,M.D.
    Aminopeptidase A
    [ISSN:0-12-079610-4]2, 299-303.  V
    45. 2003
  45. Ito,N., Nomura,S., Iwase,A., Ito,T., Ino,K., Nagasaka,T., Tsujimoto,M., Kobayashi,M. and Mizutani,S.
    Ultrastructural localization of aminopeptidase A/angiotensinase and placental leucine aminopeptidase/oxytocinase in chorionic villi of human placenta
    Early Hum Dev71, 29-37. PubMed  Europe PubMed DOI
  46. [YEAR:23-12-2003]Rozenfeld,R., Iturrioz,X., Okada,M., Maigret,B. and Llorens-Cortes,C.
    Contribution of molecular modeling and site-directed mutagenesis to the identification of a new residue, glutamate 215, involved in the exopeptidase specificity of aminopeptidase A
    Biochemistry42, 14785-14793. PubMed  Europe PubMed DOI
  47. Rozenfeld,R., Reaux,A., Iturrioz,X., Fassot,C., Fournie-Zaluski,M.C., David,C., Maigret,B., Roques,B.P., Corvol,P. and Llorens-Cortes,C.
    Aminopeptidase A, generating one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, plays a key role in central control of blood pressure
    Proc West Pharmacol Soc46, 39-44. PubMed  Europe PubMed
    48. 2002
  48. [YEAR:15-2-2002]Ofner,L.D. and Hooper,N.M.
    The C-terminal domain, but not the interchain disulphide, is required for the activity and intracellular trafficking of aminopeptidase A
    Biochem J362, 191-197. PubMed  Europe PubMed DOI
  49. [YEAR:9-8-2002]Rozenfeld,R., Iturrioz,X., Maigret,B. and Llorens-Cortes,C.
    Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A
    J Biol Chem277, 29242-29252. PubMed  Europe PubMed DOI
    50. 2001
  50. David-Basei,C., Fournie-Zaluski,M.C. and Roques,B.P.
    Aminopeptidase A inhibitors
    Expert Opin Ther Pat11, 431-444.  I
  51. David-Basei,C., Bischoff,L., Fournie-Zaluski,M.C. and Roques,B.P.
    Synthesis of [3(R)-amino-2(S)-sulfhydryl-5-sulfonate]-pentanoyl-(S)-3-[I-125]-iodotyrosyl-(S)-aspartic acid: a radiolabelled inhibitor of aminopeptidase A
    J Labelled Comp Radiopharm44, 89-98. DOI  I
  52. [YEAR:4-12-2001]Iturrioz,X., Rozenfeld,R., Michaud,A., Corvol,P. and Llorens-Cortes,C.
    Study of asparagine 353 in aminopeptidase A: Characterization of a novel motif (GXMEN) implicated in exopeptidase specificity of monozinc aminopeptidases
    Biochemistry40, 14440-14448. PubMed  Europe PubMed DOI
    53. 2000
  53. Fujimura,H., Ino,K., Nagasaka,T., Nakashima,N., Nakazato,H., Kikkawa,F. and Mizutani,S.
    Aminopeptidase A expression in cervical neoplasia and its relationship to neoplastic transformation and progression
    Oncology58, 342-352. PubMed  Europe PubMed
  54. [YEAR:8-2-2000]Georgiadis,D., Vazeux,G., Llorens-Cortes,C., Yiotakis,A. and Dive,V.
    Potent and selective inhibition of zinc aminopeptidase A (EC 3.4.11.7, APA) by glutamyl aminophosphinic peptides: Importance of glutamyl aminophosphinic residue in the P1 position
    Biochemistry39, 1152-1155. PubMed  Europe PubMed DOI
  55. [YEAR:21-3-2000]Iturrioz,X., Vazeux,G., Celerier,J.M., Corvol,P. and Llorens-Cortes,C.
    Histidine 450 plays a critical role in catalysis and, with Ca2+, contributes to the substrate specificity of aminopeptidase A
    Biochemistry39, 3061-3068. PubMed  Europe PubMed DOI
  56. Jiang,Q.P., Troyanovskaya,M., Jayaraman,G. and Healy,D.P.
    Aminopeptidase-A. II. Genomic cloning and characterization of the rat promoter
    Am J Physiol Regul Integr Comp Physiol278, R425-R434. PubMed  Europe PubMed
  57. Reaux,A., Iturrioz,X., Vazeux,G., Fournie-Zaluski,M.C., David,C., Roques,B.P., Corvol,P. and Llorens-Cortes,C.
    Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure
    Biochem Soc Trans28, 435-440. PubMed  Europe PubMed  I
  58. Troyanovskaya,M., Jayaraman,G., Song,L. and Healy,D.P.
    Aminopeptidase-A. I. cDNA cloning and expression and localization in rat tissues
    Am J Physiol Regul Integr Comp Physiol278, R413-R424. PubMed  Europe PubMed
    59. 1999
  59. [YEAR:16-12-1999]David,C., Bischoff,L., Meudal,H., Mothe,A., de Mota,N., Danascimento,S., Llorens-Cortes,C., Fournie-Zaluski,M.C. and Roques,B.P.
    Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme
    J Med Chem42, 5197-5211. PubMed  Europe PubMed DOI  I
  60. [YEAR:9-11-1999]Reaux,A., Fournie-Zaluski,M.C., David,C., Zini,S., Roques,B.P., Corvol,P. and Llorens-Cortes,C.
    Aminopeptidase A inhibitors as potential central antihypertensive agents
    Proc Natl Acad Sci U S A96, 13415-13420. PubMed  Europe PubMed DOI  I
    61. 1998
  61. [YEAR:15-5-1998]Lin,Q., Taniuchi,I., Kitamura,D., Wang,J., Kearney,J.F., Watanabe,T. and Cooper,M.D.
    T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice
    J Immunol160, 4681-4687. PubMed  Europe PubMed  K
  62. [YEAR:1-9-1998]Vazeux,G., Iturrioz,X., Corvol,P. and Llorens-Cortes,C.
    A glutamate residue contributes to the exopeptidase specificity in aminopeptidase A
    Biochem J334, 407-413. PubMed  Europe PubMed
  63. [YEAR:15-6-1998]Vazeux,G., Wilk,S., Wilk,E., Corvol,P. and Llorens-Cortes,C.
    Production and properties of a recombinant soluble form of aminopeptidase A
    Eur J Biochem254, 671-678. PubMed  Europe PubMed  E
    64. 1997
  64. Hesp,J.R. and Hooper,N.M.
    Proteolytic fragmentation reveals the oligomeric and domain structure of porcine aminopeptidase A
    Biochemistry36, 3000-3007. PubMed  Europe PubMed DOI
  65. Li,L., Wu,Q., Barnoski,B.L. and Cooper,M.D.
    High-resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP)
    Genomics43, 380-383. PubMed  Europe PubMed DOI
  66. Song,L., Wilk,S. and Healy,D.P.
    Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses
    Brain Res744, 1-6. PubMed  Europe PubMed DOI  I
  67. Tian,B., Meng,Q.C., Chen,Y.F., Krege,J.H., Smithies,O. and Oparil,S.
    Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function
    Hypertension30, 128-133. PubMed  Europe PubMed  K
  68. [YEAR:1-11-1997]Vazeux,G., Iturrioz,X., Corvol,P. and Llorens-Cortes,C.
    A tyrosine residue essential for catalytic activity in aminopeptidase A
    Biochem J327, 883-889. PubMed  Europe PubMed
  69. Wolf,G., Mentzel,S. and Assmann,K.J.
    Aminopeptidase A: A key enzyme in the intrarenal degradation of angiotensin II
    Exp Nephrol5, 364-369. PubMed  Europe PubMed
  70. Zini,S., Masdehors,P., Lenkei,Z., Fournie-Zaluski,M.C., Roques,B.P., Corvol,P. and Llorens-Cortes,C.
    Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats
    Neuroscience78, 1187-1193. PubMed  Europe PubMed DOI  I
    71. 1996
  71. Arechaga,G., Sanchez,B., Alba,F., Luna,J.D., Prieto,I., Martinez,J.M. and Ramirez,M.
    Developmental changes of soluble and membrane-bound aspartate aminopeptidase activities in rat brain
    J Physiol Biochem[ISSN:00349402]52, 149-154.
  72. Mentzel,S., Assmann,K.J., Dijkman,H.B., De Jong,A.S., van Son,J.P., Wetzels,J.F. and Koene,R.A.
    Inhibition of aminopeptidase A activity causes an acute albuminuria in mice: an angiotensin II-mediated effect?
    Nephrol Dial Transplant11, 2163-2169. PubMed  Europe PubMed
  73. Mentzel,S., Dijkman,H.B., van Son,J.P., Koene,R.A. and Assmann,K.J.
    Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice
    J Histochem Cytochem44, 445-461. PubMed  Europe PubMed
  74. Migaud,M., Durieux,C., Viereck,J., Soroca-Lucas,E., Fournie-Zaluski,M.C. and Roques,B.P.
    The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A
    Peptides17, 601-607. PubMed  Europe PubMed DOI
  75. Vazeux,G., Wang,J., Corvol,P. and Llorens-Cortes,C.
    Identification of glutamate residues essential for catalytic activity and zinc coordination in aminopeptidase A
    J Biol Chem271, 9069-9074. PubMed  Europe PubMed DOI
    76. 1994
  76. Chauvel,E.N., Coric,P., Llorens-Cortes,C., Wilk,S., Roques,B.P. and Fournie-Zaluski,M.C.
    Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors
    J Med Chem37, 1339-1346. PubMed  Europe PubMed DOI  I
  77. Chauvel,E.N., Llorens-Cortes,C., Coric,P., Wilk,S., Roques,B.P. and Fournie-Zaluski,M.C.
    Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols
    J Med Chem37, 2950-2957. PubMed  Europe PubMed  I
    78. 1993
  78. Li,L., Wang,J. and Cooper,M.D.
    cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A)
    Genomics17, 657-664. PubMed  Europe PubMed DOI
  79. Li,L., Wu,Q., Wang,J., Bucy,R.P. and Cooper,M.D.
    Widespread tissue distribution of aminopeptidase A, an evolutionarily conserved ectoenzyme recognized by the BP-1 antibody
    Tissue Antigens42, 488-496. PubMed  Europe PubMed
  80. [YEAR:1-8-1993]Nanus,D.M., Engelstein,D., Gastl,G.A., Gluck,L., Vidal,M.J., Morrison,M., Finstad,C.L., Bander,N.H. and Albino,A.P.
    Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A
    Proc Natl Acad Sci U S A90, 7069-7073. PubMed  Europe PubMed
  81. Wang,J. and Cooper,M.D.
    Histidine residue in the zinc-binding motif of aminopeptidase A is critical for enzymatic activity
    Proc Natl Acad Sci U S A90, 1222-1226. PubMed  Europe PubMed DOI
    82. 1990
  82. Wilk,S. and Thurston,L.S.
    Inhibition of angiotensin III formation by thiol derivatives of acidic amino acids
    Neuropeptides16, 163-168. PubMed  Europe PubMed DOI  I
  83. Wu,Q., Lahti,J.M., Air,G.M., Burrows,P.D. and Cooper,M.D.
    Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family
    Proc Natl Acad Sci U S A87, 993-997. PubMed  Europe PubMed
    84. 1986
  84. Agrawal,Y. and Vanha-Perttula,T.
    Studies on the multiple forms of aminopeptidase A in bovine seminal vesicle secretion
    Int J Biochem18, 465-471. PubMed  Europe PubMed
  85. McDonald,J.K. and Barrett,A.J.
    Mammalian Proteases: a Glossary and Bibliography. Volume 2: Exopeptidases
    [ISSN:ISBN 0-12-079502-7]
    86. 1984
  86. [YEAR:25-9-1984]Lalu,K., Lampelo,S., Nummelin-Kortelainen,M. and Vanha-Perttula,T.
    Purification and partial characterization of aminopeptidase A from the serum of pregnant and non-pregnant women
    Biochim Biophys Acta789, 324-333. PubMed  Europe PubMed DOI
    87. 1983
  87. Sakura,H., Kobayashi,H., Mizutani,S., Sakura,N., Hashimoto,T. and Kawashima,Y.
    Kinetic properties of placental aminopeptidase A: N-terminal degradation of angiotensin II
    Biochem Int6, 609-615. PubMed  Europe PubMed  I
    88. 1982
  88. Kugler,P.
    Aminopeptidase A is angiotensinase A. II. Biochemical studies on aminopeptidase A and M in rat kidney homogenate
    Histochemistry74, 247-261. PubMed  Europe PubMed
  89. Kugler,P.
    Aminopeptidase A is angiotensinase A- I. Quantitative histochemical studies in the kidney glomerulus
    Histochemistry74, 229-245. PubMed  Europe PubMed
  90. Tobe,H., Morishima,H., Aoyagi,T., Umezawa,H., Nakamura,K., Ishiki,K., Yoshioka,T., Shimauchi,Y. and Inui,T.
    Synthesis and structure-activity relationships of amastatin analogues, inhibitors of aminopeptidase A
    Agric Biol Chem46, 1865-1872. DOI  I
    91. 1981
  91. [YEAR:13-3-1981]Feracci,H., Benajiba,A., Gorvel,J.P., Doumeng,C. and Maroux,S.
    Enzymatic and immunological properties of the protease form of aminopeptidase N and A from pig and rabbit intestinal brush border
    Biochim Biophys Acta658, 148-157. PubMed  Europe PubMed
    92. 1980
  92. Benajiba,A. and Maroux,S.
    Purification and characterization of an aminopeptidase A from hog intestinal brush-border membrane
    Eur J Biochem107, 381-388. PubMed  Europe PubMed
  93. Danielsen,E.M., Noren,O., Sjostrom,H., Ingram,J. and Kenny,A.J.
    Proteins of the kidney microvillar membrane. Aspartate aminopeptidase: purification by immunoadsorbent chromatography and properties of the detergent- and proteinase-solubilized forms
    Biochem J189, 591-603. PubMed  Europe PubMed
  94. [YEAR:9-9-1980]Gorvel,J.P., Benajiba,A. and Maroux,S.
    Purification and characterization of the rabbit intestinal brush-border aminopeptidase A
    Biochim Biophys Acta615, 271-274. PubMed  Europe PubMed
  95. Tobe,H., Kojima,F., Aoyagi,T. and Umezawa,H.
    Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney
    Biochim Biophys Acta613, 459-468. PubMed  Europe PubMed  I
    96. 1979
  96. Chulkova,T.M. and Orekhovich,V.N.
    [Molecular structure of aminopeptidase A from bovine kidney]
    Biokhimiia44, 1539-1541. PubMed  Europe PubMed
    97. 1978
  97. Aoyagi,T., Tobe,H., Kojima,F., Hamada,M., Takeuchi,T. and Umezawa,H.
    Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes
    J Antibiot (Tokyo)31, 636-638. PubMed  Europe PubMed  I
  98. Chulkova,T.M. and Orekhovich,V.N.
    Isolation and properties of bovine kidney aminopeptidase A
    Biokhimiia43, 1222-1227. PubMed  Europe PubMed
  99. Chulkova,T.M. and Orekhovich,V.N.
    Isolation and properties of aminopeptidase A from bovine kidneys
    Biochemistry (Mosc)43, 964-969.
    100. 1976
  100. [YEAR:8-1-1976]Andria,G., Marzi,A. and Auricchio,S.
    Alpha-Glutamyl-beta-naphthylamide hydrolase of rabbit small intestine. Localization in the brush border and separation from other brush border peptidases
    Biochim Biophys Acta419, 42-50. PubMed  Europe PubMed
    101. 1970
  101. [YEAR:11-2-1970]Nagatsu,I., Nagatsu,T., Yamamoto,T., Glenner,G.G. and Mehl,J.W.
    Purification of aminopeptidase A in human serum and degradation of angiotensin II by the purified enzyme
    Biochim Biophys Acta198, 255-270. PubMed  Europe PubMed
    102. 1969
  102. Yman,L. and Kulling,B.
    An aminopeptidase from human serum specific for hydrolysis of alpha-L-dicarboxylic amino acid residues. I. Purification from retroplacental serum by preparative polyacrylamide-gel electrophoresis
    Acta Pharm Suec6, 561-568. PubMed  Europe PubMed
  103. Yman,L. and Kulling,B.
    An aminopeptidase from human serum specific for hydrolysis of alpha-L-dicarboxylic amino acid residues. II. Some properties and its relationship to the serum angiotensinase activity
    Acta Pharm Suec6, 569-578. PubMed  Europe PubMed
    104. 1965
  104. [YEAR:18-5-1965]Hess,R.
    Arylamidase activity related to angiotensinase
    Biochim Biophys Acta99, 316-324. PubMed  Europe PubMed
  105. Nagatsu,I., Gillespie,L., George,J.M., Folk,J.E. and Glenner,G.G.
    Serum aminopeptidases, "angiotensinase," and hypertension. II. Amino acid beta-napthylamide hydrolysis by normal and hypertensive serum
    Biochem Pharmacol14, 853-861. PubMed  Europe PubMed
    106. 1963
  106. [YEAR:10-5-1963]Khairallah,P.A., Bumpus,F.M., Page,I.H. and Smeby,R.R.
    Angiotensinase with a high degree of specificity in plasma and red cells
    Science140, 672-674. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use