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Literature for peptidase M01.003: aminopeptidase A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, P Specificity, K Knockout, I Inhibitor, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Mizutani,S., Mizutani,H., Mizutani,E., Arita,H. and Kajiyama,H.
    The Fate of Angiotensin II in Placental Tissue and Blood
    Horm Metab Res (2024) 56, 477-481. PubMed  Europe PubMed DOI
  2. Sharma,P., Sharma,S., Paliwal,S. and Jain,S.
    Aminopeptidase A: A Novel Therapeutic Target for Hypertension Management
    Cell Biochem Funct (2024) 42, e70008-e70008. PubMed  Europe PubMed DOI
    3. 2021
  3. Hmazzou,R., Marc,Y., Flahault,A., Gerbier,R., de Mota,N. and Llorens-Cortes,C.
    Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension
    Clin Sci (Lond) (2021) 135, 775-791. PubMed  Europe PubMed DOI
    4. 2020
  4. Aung,M., Konoshita,T., Moodley,J., Naicker,T., Connolly,C., Khaliq,O.P. and Gathiram,P.
    Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis
    Eur J Obstet Gynecol Reprod Biol (2020) 258, 70-74. PubMed  Europe PubMed DOI
  5. Marahrens,B., Schulze,A., Wysocki,J., Lin,M.H., Ye,M., Kanwar,Y.S., Bader,M., Velez,J.C.Q., Miner,J.H. and Batlle,D.
    Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys
    Kidney Int (2020) PubMed  Europe PubMed DOI
  6. Marc,Y., Boitard,S.E., Balavoine,F., Azizi,M. and Llorens-Cortes,C.
    Targeting brain aminopeptidase A: a new strategy for the treatment of hypertension and heart failure
    Can J Cardiol (2020) 36, 721-731. PubMed  Europe PubMed DOI  I
  7. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.
    Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas
    Brain Res Bull (2020) 168, 1-7. PubMed  Europe PubMed DOI
  8. Seco-Calvo,J., Sanchez-Herraez,S., Casis,L., Valdivia,A., Perez-Urzelai,I., Gil,J. and Echevarria,E.
    Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression
    Bone Joint Res (2020) 9, 789-797. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2019
  9. Azizi,M., Courand,P.Y., Denolle,T., Delsart,P., Zhygalina,V., Amar,L., Lantelme,P., Mounier-Vehier,C., de Mota,N., Balavoine,F. and Llorens-Cortes,C.
    A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension
    J Hypertens (2019) 37, 1722-1728. PubMed  Europe PubMed DOI  I
  10. Keck,M., de Almeida,H., Compere,D., Inguimbert,N., Flahault,A., Balavoine,F., Roques,B. and Llorens-Cortes,C.
    NI956/QGC006, a Potent orally active, brain-penetrating aminopeptidase A inhibitor for treating hypertension
    Hypertension (2019) 73, 1300-1307. PubMed  Europe PubMed DOI  I
    11. 2017
  11. Chuang,H.Y., Jiang,J.K., Yang,M.H., Wang,H.W., Li,M.C., Tsai,C.Y., Jhang,Y.Y. and Huang,J.C.
    Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer
    Oncotarget (2017) 8, 21266-21280. PubMed  Europe PubMed DOI
  12. Couvineau,P., de Almeida,H., Maigret,B., Llorens-Cortes,C. and Iturrioz,X.
    Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues
    PLoS ONE (2017) 12, e0184237-e0184237. PubMed  Europe PubMed DOI  I
  13. Morais,R.L., Hilzendeger,A.M., Visniauskas,B., Todiras,M., Alenina,N., Mori,M.A., Araujo,R.C., Nakaie,C.R., Chagas,J.R., Carmona,A.K., Bader,M. and Pesquero,J.B.
    High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism
    Am J Physiol Heart Circ Physiol (2017) 312, H437-H445. PubMed  Europe PubMed DOI
  14. Nakamura,T., Yamazato,M., Ishida,A. and Ohya,Y.
    Excess of aminopeptidase A in the brain elevates blood pressure via the angiotensin II type 1 and bradykinin B2 receptors without dipsogenic effect
    Int J Hypertens (2017) 2017, 3967595-3967595. PubMed  Europe PubMed DOI  PMC  EPMC  I
  15. Velez,J.C.Q., Arif,E., Rodgers,J., Hicks,M.P., Arthur,J.M., Nihalani,D., Bruner,E.T., Budisavljevic,M.N., Atkinson,C., Fitzgibbon,W.R. and Janech,M.G.
    Deficiency of the angiotensinase aminopeptidase A increases susceptibility to glomerular injury
    J Am Soc Nephrol (2017) 28, 2119-2132. PubMed  Europe PubMed DOI  K
    16. 2016
  16. Hmazzou,R., Flahault,A., Marc,Y. and Llorens-Cortes,C.
    [OP.6D.03] Mode of action of RB150, an aminopeptidase A inhibitor prodrug as a centrally-acting antihypertensive agent in DOCA-salt hypertensive rats
    J Hypertens (2016) 34 Suppl 2, e75-e75. DOI  I
    17. 2015
  17. Wysocki,J., Ye,M. and Batlle,D.
    Plasma and kidney angiotensin peptides: importance of the aminopeptidase A/angiotensin III axis
    Am J Hypertens (2015) 28, 1418-1426. PubMed  Europe PubMed DOI  I
    18. 2014
  18. Alghamri,M.S., Morris,M., Meszaros,J.G., Elased,K.M. and Grobe,N.
    Novel role of aminopeptidase-A in angiotensin-(1-7) metabolism post myocardial infarction
    Am J Physiol Heart Circ Physiol (2014) 306, H1032-H1040. PubMed  Europe PubMed DOI
  19. Gao,J., Marc,Y., Iturrioz,X., Leroux,V., Balavoine,F. and Llorens-Cortes,C.
    A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors
    Clin Sci (Lond) (2014) 127, 135-148. PubMed  Europe PubMed DOI  I
    20. 2013
  20. Schwacke,J.H., Spainhour,J.C., Ierardi,J.L., Chaves,J.M., Arthur,J.M., Janech,M.G. and Velez,J.C.
    Network modeling reveals steps in angiotensin peptide processing
    Hypertension (2013) 61, 690-700. PubMed  Europe PubMed DOI
  21. Yang,Y., Liu,C., Lin,Y.L. and Li,F.
    Structural insights into central hypertension regulation by human aminopeptidase A
    J Biol Chem (2013) 288, 25638-25645. PubMed  Europe PubMed DOI  S  I
    22. 2012
  22. Marc,Y., Gao,J., Balavoine,F., Michaud,A., Roques,B.P. and Llorens-Cortes,C.
    Central antihypertensive effects of orally active aminopeptidase A inhibitors in spontaneously hypertensive rats
    Hypertension (2012) 60, 411-418. PubMed  Europe PubMed DOI  I
  23. Wang,J., Cooper,M.D., Iturrioz,X. and Llorens-Cortes,C.
    Glutamyl aminopeptidase
    [ISSN:978-0-12-407744-7] (2012) 3, 410-414. DOI
    24. 2010
  24. Kubota,R., Numaguchi,Y., Ishii,M., Niwa,M., Okumura,K., Naruse,K. and Murohara,T.
    Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1alpha
    Biochem Biophys Res Commun (2010) 402, 396-401. PubMed  Europe PubMed DOI  K
  25. Vaiyapuri,S., Wagstaff,S.C., Watson,K.A., Harrison,R.A., Gibbins,J.M. and Hutchinson,E.G.
    Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros
    PLoS Negl Trop Dis (2010) 4, e796-e796. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2009
  26. Claperon,C., Banegas-Font,I., Iturrioz,X., Rozenfeld,R., Maigret,B. and Llorens-Cortes,C.
    Identification of threonine 348 as a residue involved in aminopeptidase A substrate specificity
    J Biol Chem (2009) 284, 10618-10626. PubMed  Europe PubMed DOI  PMC  EPMC  I
  27. Ishii,M., Hattori,A., Numaguchi,Y., Ma,X., Nagasaka,T., Tsujimoto,M., Murohara,T., Kobayashi,H. and Mizutani,S.
    The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs)
    Early Hum Dev (2009) 85, 589-594. PubMed  Europe PubMed DOI  U
    28. 2008
  28. Bodineau,L., Frugiere,A., Marc,Y., Inguimbert,N., Fassot,C., Balavoine,F., Roques,B. and Llorens-Cortes,C.
    Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension
    Hypertension (2008) 51, 1318-1325. PubMed  Europe PubMed DOI  I
  29. Bodineau,L., Frugiere,A., Marc,Y., Claperon,C. and Llorens-Cortes,C.
    Aminopeptidase A inhibitors as centrally acting antihypertensive agents
    Heart Fail Rev (2008) 13, 311-319. PubMed  Europe PubMed DOI  T  I
  30. Claperon,C., Rozenfeld,R., Iturrioz,X., Inguimbert,N., Okada,M., Roques,B., Maigret,B. and Llorens-Cortes,C.
    Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity
    Biochem J (2008) 416, 37-46. PubMed  Europe PubMed DOI
  31. de Mota,N., Iturrioz,X., Claperon,C., Bodineau,L., Fassot,C., Roques,B.P., Palkovits,M. and Llorens-Cortes,C.
    Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei
    J Neurochem (2008) 106, 416-428. PubMed  Europe PubMed DOI  I
  32. Ferreira,A.J. and Raizada,M.K.
    Aminopeptidase A: could it be a novel target for neurogenic hypertension?
    Hypertension (2008) 51, 1273-1274. PubMed  Europe PubMed DOI  T
  33. Ishii,M., Hattori,A., Numaguchi,Y., Tsujimoto,M., Ishiura,S., Kobayashi,H., Murohara,T., Wright,J.W. and Mizutani,S.
    The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan
    Horm Metab Res (2008) 40, 887-891. PubMed  Europe PubMed DOI  U
  34. Mizutani,S., Ishii,M., Hattori,A., Nomura,S., Numaguchi,Y., Tsujimoto,M., Kobayshi,H., Murohara,T. and Wright,J.W.
    New insights into the importance of aminopeptidase A in hypertension
    Heart Fail Rev (2008) 13, 273-284. PubMed  Europe PubMed DOI
    35. 2007
  35. Goto,Y., Hattori,A., Mizutani,S. and Tsujimoto,M.
    Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A
    J Biol Chem (2007) 282, 37074-37081. PubMed  Europe PubMed DOI
  36. Ogawa,Y., Murayama,N., Fujita,Y. and Yanoshita,R.
    Characterization and cDNA cloning of aminopeptidase A from the venom of Gloydius blomhoffi brevicaudus
    Toxicon (2007) 49, 1172-1181. PubMed  Europe PubMed DOI
    37. 2006
  37. [YEAR:1-8-2006]Faber,F., Gembardt,F., Sun,X., Mizutani,S., Siems,W.E. and Walther,T.
    Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice
    Regul Pept (1-8-2006) 136, 130-137. PubMed  Europe PubMed DOI  K
  38. Goto,Y., Hattori,A., Ishii,Y., Mizutani,S. and Tsujimoto,M.
    Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV
    J Biol Chem (2006) 281, 23503-23513. PubMed  Europe PubMed DOI  P
    39. 2005
  39. Inguimbert,N., Coric,P., Dhotel,H., Bonnard,E., Llorens-Cortes,C., Mota,N., Fournie-Zaluski,M.C. and Roques,B.P.
    Synthesis and in vitro activities of new non-peptidic APA inhibitors
    J Pept Res (2005) 65, 175-188. PubMed  Europe PubMed DOI  I
  40. Nomura,M., Nomura,S., Mitsui,T., Suzuki,M., Kobayashi,H., Ito,T., Itakura,A., Kikkawa,F. and Mizutani,S.
    Possible involvement of aminopeptidase A in hypertension and renal damage in Dahl salt-sensitive rats
    Am J Hypertens (2005) 18, 538-543. PubMed  Europe PubMed DOI
    41. 2004
  41. [YEAR:18-5-2004]Fournie-Zaluski,M.C., Fassot,C., Valentin,B., Djordjijevic,D., Reaux-Le Goazigo,A., Corvol,P., Roques,B.P. and Llorens-Cortes,C.
    Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension
    Proc Natl Acad Sci U S A (18-5-2004) 101, 7775-7780. PubMed  Europe PubMed DOI  PMC  EPMC  I
  42. Marchio,S., Lahdenranta,J., Schlingemann,R.O., Valdembri,D., Wesseling,P., Arap,M.A., Hajitou,A., Ozawa,M.G., Trepel,M., Giordano,R.J., Nanus,D.M., Dijkman,H.B., Oosterwijk,E., Sidman,R.L., Cooper,M.D., Bussolino,F., Pasqualini,R. and Arap,W.
    Aminopeptidase A is a functional target in angiogenic blood vessels
    Cancer Cell (2004) 5, 151-162. PubMed  Europe PubMed DOI
  43. [YEAR:8-10-2004]Rozenfeld,R., Muller,L., El Messari,S. and Llorens-Cortes,C.
    The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of this monozinc aminopeptidase
    J Biol Chem (8-10-2004) 279, 43285-43295. PubMed  Europe PubMed DOI
  44. Wang,J. and Cooper,M.D.
    Aminopeptidase A
    [ISSN:0-12-079610-4] (2004) 2, 299-303.  V
    45. 2003
  45. Ito,N., Nomura,S., Iwase,A., Ito,T., Ino,K., Nagasaka,T., Tsujimoto,M., Kobayashi,M. and Mizutani,S.
    Ultrastructural localization of aminopeptidase A/angiotensinase and placental leucine aminopeptidase/oxytocinase in chorionic villi of human placenta
    Early Hum Dev (2003) 71, 29-37. PubMed  Europe PubMed DOI
  46. Rozenfeld,R., Reaux,A., Iturrioz,X., Fassot,C., Fournie-Zaluski,M.C., David,C., Maigret,B., Roques,B.P., Corvol,P. and Llorens-Cortes,C.
    Aminopeptidase A, generating one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, plays a key role in central control of blood pressure
    Proc West Pharmacol Soc (2003) 46, 39-44. PubMed  Europe PubMed
  47. [YEAR:23-12-2003]Rozenfeld,R., Iturrioz,X., Okada,M., Maigret,B. and Llorens-Cortes,C.
    Contribution of molecular modeling and site-directed mutagenesis to the identification of a new residue, glutamate 215, involved in the exopeptidase specificity of aminopeptidase A
    Biochemistry (23-12-2003) 42, 14785-14793. PubMed  Europe PubMed DOI
    48. 2002
  48. [YEAR:15-2-2002]Ofner,L.D. and Hooper,N.M.
    The C-terminal domain, but not the interchain disulphide, is required for the activity and intracellular trafficking of aminopeptidase A
    Biochem J (15-2-2002) 362, 191-197. PubMed  Europe PubMed DOI  PMC  EPMC
  49. [YEAR:9-8-2002]Rozenfeld,R., Iturrioz,X., Maigret,B. and Llorens-Cortes,C.
    Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A
    J Biol Chem (9-8-2002) 277, 29242-29252. PubMed  Europe PubMed DOI
    50. 2001
  50. David-Basei,C., Bischoff,L., Fournie-Zaluski,M.C. and Roques,B.P.
    Synthesis of [3(R)-amino-2(S)-sulfhydryl-5-sulfonate]-pentanoyl-(S)-3-[I-125]-iodotyrosyl-(S)-aspartic acid: a radiolabelled inhibitor of aminopeptidase A
    J Labelled Comp Radiopharm (2001) 44, 89-98. DOI  I
  51. David-Basei,C., Fournie-Zaluski,M.C. and Roques,B.P.
    Aminopeptidase A inhibitors
    Expert Opin Ther Pat (2001) 11, 431-444.  I
  52. [YEAR:4-12-2001]Iturrioz,X., Rozenfeld,R., Michaud,A., Corvol,P. and Llorens-Cortes,C.
    Study of asparagine 353 in aminopeptidase A: Characterization of a novel motif (GXMEN) implicated in exopeptidase specificity of monozinc aminopeptidases
    Biochemistry (4-12-2001) 40, 14440-14448. PubMed  Europe PubMed DOI
    53. 2000
  53. Fujimura,H., Ino,K., Nagasaka,T., Nakashima,N., Nakazato,H., Kikkawa,F. and Mizutani,S.
    Aminopeptidase A expression in cervical neoplasia and its relationship to neoplastic transformation and progression
    Oncology (2000) 58, 342-352. PubMed  Europe PubMed
  54. [YEAR:8-2-2000]Georgiadis,D., Vazeux,G., Llorens-Cortes,C., Yiotakis,A. and Dive,V.
    Potent and selective inhibition of zinc aminopeptidase A (EC 3.4.11.7, APA) by glutamyl aminophosphinic peptides: Importance of glutamyl aminophosphinic residue in the P1 position
    Biochemistry (8-2-2000) 39, 1152-1155. PubMed  Europe PubMed DOI
  55. [YEAR:21-3-2000]Iturrioz,X., Vazeux,G., Celerier,J.M., Corvol,P. and Llorens-Cortes,C.
    Histidine 450 plays a critical role in catalysis and, with Ca2+, contributes to the substrate specificity of aminopeptidase A
    Biochemistry (21-3-2000) 39, 3061-3068. PubMed  Europe PubMed DOI
  56. Jiang,Q.P., Troyanovskaya,M., Jayaraman,G. and Healy,D.P.
    Aminopeptidase-A. II. Genomic cloning and characterization of the rat promoter
    Am J Physiol Regul Integr Comp Physiol (2000) 278, R425-R434. PubMed  Europe PubMed
  57. Reaux,A., Iturrioz,X., Vazeux,G., Fournie-Zaluski,M.C., David,C., Roques,B.P., Corvol,P. and Llorens-Cortes,C.
    Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure
    Biochem Soc Trans (2000) 28, 435-440. PubMed  Europe PubMed  I
  58. Troyanovskaya,M., Jayaraman,G., Song,L. and Healy,D.P.
    Aminopeptidase-A. I. cDNA cloning and expression and localization in rat tissues
    Am J Physiol Regul Integr Comp Physiol (2000) 278, R413-R424. PubMed  Europe PubMed
    59. 1999
  59. [YEAR:16-12-1999]David,C., Bischoff,L., Meudal,H., Mothe,A., de Mota,N., Danascimento,S., Llorens-Cortes,C., Fournie-Zaluski,M.C. and Roques,B.P.
    Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme
    J Med Chem (16-12-1999) 42, 5197-5211. PubMed  Europe PubMed DOI  I
  60. [YEAR:9-11-1999]Reaux,A., Fournie-Zaluski,M.C., David,C., Zini,S., Roques,B.P., Corvol,P. and Llorens-Cortes,C.
    Aminopeptidase A inhibitors as potential central antihypertensive agents
    Proc Natl Acad Sci U S A (9-11-1999) 96, 13415-13420. PubMed  Europe PubMed DOI  PMC  EPMC  I
    61. 1998
  61. [YEAR:15-5-1998]Lin,Q., Taniuchi,I., Kitamura,D., Wang,J., Kearney,J.F., Watanabe,T. and Cooper,M.D.
    T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice
    J Immunol (15-5-1998) 160, 4681-4687. PubMed  Europe PubMed  K
  62. [YEAR:15-6-1998]Vazeux,G., Wilk,S., Wilk,E., Corvol,P. and Llorens-Cortes,C.
    Production and properties of a recombinant soluble form of aminopeptidase A
    Eur J Biochem (15-6-1998) 254, 671-678. PubMed  Europe PubMed  E
  63. [YEAR:1-9-1998]Vazeux,G., Iturrioz,X., Corvol,P. and Llorens-Cortes,C.
    A glutamate residue contributes to the exopeptidase specificity in aminopeptidase A
    Biochem J (1-9-1998) 334, 407-413. PubMed  Europe PubMed  PMC  EPMC
    64. 1997
  64. Hesp,J.R. and Hooper,N.M.
    Proteolytic fragmentation reveals the oligomeric and domain structure of porcine aminopeptidase A
    Biochemistry (1997) 36, 3000-3007. PubMed  Europe PubMed DOI
  65. Li,L., Wu,Q., Barnoski,B.L. and Cooper,M.D.
    High-resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP)
    Genomics (1997) 43, 380-383. PubMed  Europe PubMed DOI
  66. Song,L., Wilk,S. and Healy,D.P.
    Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses
    Brain Res (1997) 744, 1-6. PubMed  Europe PubMed DOI  I
  67. Tian,B., Meng,Q.C., Chen,Y.F., Krege,J.H., Smithies,O. and Oparil,S.
    Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function
    Hypertension (1997) 30, 128-133. PubMed  Europe PubMed  K
  68. [YEAR:1-11-1997]Vazeux,G., Iturrioz,X., Corvol,P. and Llorens-Cortes,C.
    A tyrosine residue essential for catalytic activity in aminopeptidase A
    Biochem J (1-11-1997) 327, 883-889. PubMed  Europe PubMed  PMC  EPMC
  69. Wolf,G., Mentzel,S. and Assmann,K.J.
    Aminopeptidase A: A key enzyme in the intrarenal degradation of angiotensin II
    Exp Nephrol (1997) 5, 364-369. PubMed  Europe PubMed
  70. Zini,S., Masdehors,P., Lenkei,Z., Fournie-Zaluski,M.C., Roques,B.P., Corvol,P. and Llorens-Cortes,C.
    Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats
    Neuroscience (1997) 78, 1187-1193. PubMed  Europe PubMed DOI  I
    71. 1996
  71. Arechaga,G., Sanchez,B., Alba,F., Luna,J.D., Prieto,I., Martinez,J.M. and Ramirez,M.
    Developmental changes of soluble and membrane-bound aspartate aminopeptidase activities in rat brain
    J Physiol Biochem[ISSN:00349402] (1996) 52, 149-154.
  72. Mentzel,S., Dijkman,H.B., van Son,J.P., Koene,R.A. and Assmann,K.J.
    Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice
    J Histochem Cytochem (1996) 44, 445-461. PubMed  Europe PubMed
  73. Mentzel,S., Assmann,K.J., Dijkman,H.B., De Jong,A.S., van Son,J.P., Wetzels,J.F. and Koene,R.A.
    Inhibition of aminopeptidase A activity causes an acute albuminuria in mice: an angiotensin II-mediated effect?
    Nephrol Dial Transplant (1996) 11, 2163-2169. PubMed  Europe PubMed
  74. Migaud,M., Durieux,C., Viereck,J., Soroca-Lucas,E., Fournie-Zaluski,M.C. and Roques,B.P.
    The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A
    Peptides (1996) 17, 601-607. PubMed  Europe PubMed DOI
  75. Vazeux,G., Wang,J., Corvol,P. and Llorens-Cortes,C.
    Identification of glutamate residues essential for catalytic activity and zinc coordination in aminopeptidase A
    J Biol Chem (1996) 271, 9069-9074. PubMed  Europe PubMed DOI
    76. 1994
  76. Chauvel,E.N., Llorens-Cortes,C., Coric,P., Wilk,S., Roques,B.P. and Fournie-Zaluski,M.C.
    Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols
    J Med Chem (1994) 37, 2950-2957. PubMed  Europe PubMed  I
  77. Chauvel,E.N., Coric,P., Llorens-Cortes,C., Wilk,S., Roques,B.P. and Fournie-Zaluski,M.C.
    Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors
    J Med Chem (1994) 37, 1339-1346. PubMed  Europe PubMed DOI  I
    78. 1993
  78. Li,L., Wu,Q., Wang,J., Bucy,R.P. and Cooper,M.D.
    Widespread tissue distribution of aminopeptidase A, an evolutionarily conserved ectoenzyme recognized by the BP-1 antibody
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