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Literature for peptidase M01.003: aminopeptidase A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, T Target, P Specificity, K Knockout, I Inhibitor, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Mizutani,S., Mizutani,H., Mizutani,E., Arita,H. and Kajiyama,H.<br>The Fate of Angiotensin II in Placental Tissue and Blood<br>Horm Metab Res (2024) 56, 477-481. PubMed  Europe PubMed DOI
  2. Sharma,P., Sharma,S., Paliwal,S. and Jain,S.<br>Aminopeptidase A: A Novel Therapeutic Target for Hypertension Management<br>Cell Biochem Funct (2024) 42, e70008-e70008. PubMed  Europe PubMed DOI
    3. 2021
  3. Hmazzou,R., Marc,Y., Flahault,A., Gerbier,R., de Mota,N. and Llorens-Cortes,C.<br>Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension<br>Clin Sci (Lond) (2021) 135, 775-791. PubMed  Europe PubMed DOI
    4. 2020
  4. Aung,M., Konoshita,T., Moodley,J., Naicker,T., Connolly,C., Khaliq,O.P. and Gathiram,P.<br>Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis<br>Eur J Obstet Gynecol Reprod Biol (2020) 258, 70-74. PubMed  Europe PubMed DOI
  5. Marahrens,B., Schulze,A., Wysocki,J., Lin,M.H., Ye,M., Kanwar,Y.S., Bader,M., Velez,J.C.Q., Miner,J.H. and Batlle,D.<br>Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys<br>Kidney Int (2020) PubMed  Europe PubMed DOI
  6. Marc,Y., Boitard,S.E., Balavoine,F., Azizi,M. and Llorens-Cortes,C.<br>Targeting brain aminopeptidase A: a new strategy for the treatment of hypertension and heart failure<br>Can J Cardiol (2020) 36, 721-731. PubMed  Europe PubMed DOI  I
  7. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.<br>Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas<br>Brain Res Bull (2020) 168, 1-7. PubMed  Europe PubMed DOI
  8. Seco-Calvo,J., Sanchez-Herraez,S., Casis,L., Valdivia,A., Perez-Urzelai,I., Gil,J. and Echevarria,E.<br>Synovial fluid peptidase activity as a biomarker for knee osteoarthritis clinical progression<br>Bone Joint Res (2020) 9, 789-797. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2019
  9. Azizi,M., Courand,P.Y., Denolle,T., Delsart,P., Zhygalina,V., Amar,L., Lantelme,P., Mounier-Vehier,C., de Mota,N., Balavoine,F. and Llorens-Cortes,C.<br>A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension<br>J Hypertens (2019) 37, 1722-1728. PubMed  Europe PubMed DOI  I
  10. Keck,M., de Almeida,H., Compere,D., Inguimbert,N., Flahault,A., Balavoine,F., Roques,B. and Llorens-Cortes,C.<br>NI956/QGC006, a Potent orally active, brain-penetrating aminopeptidase A inhibitor for treating hypertension<br>Hypertension (2019) 73, 1300-1307. PubMed  Europe PubMed DOI  I
    11. 2017
  11. Chuang,H.Y., Jiang,J.K., Yang,M.H., Wang,H.W., Li,M.C., Tsai,C.Y., Jhang,Y.Y. and Huang,J.C.<br>Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer<br>Oncotarget (2017) 8, 21266-21280. PubMed  Europe PubMed DOI
  12. Couvineau,P., de Almeida,H., Maigret,B., Llorens-Cortes,C. and Iturrioz,X.<br>Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues<br>PLoS ONE (2017) 12, e0184237-e0184237. PubMed  Europe PubMed DOI  I
  13. Morais,R.L., Hilzendeger,A.M., Visniauskas,B., Todiras,M., Alenina,N., Mori,M.A., Araujo,R.C., Nakaie,C.R., Chagas,J.R., Carmona,A.K., Bader,M. and Pesquero,J.B.<br>High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism<br>Am J Physiol Heart Circ Physiol (2017) 312, H437-H445. PubMed  Europe PubMed DOI
  14. Nakamura,T., Yamazato,M., Ishida,A. and Ohya,Y.<br>Excess of aminopeptidase A in the brain elevates blood pressure via the angiotensin II type 1 and bradykinin B2 receptors without dipsogenic effect<br>Int J Hypertens (2017) 2017, 3967595-3967595. PubMed  Europe PubMed DOI  PMC  EPMC  I
  15. Velez,J.C.Q., Arif,E., Rodgers,J., Hicks,M.P., Arthur,J.M., Nihalani,D., Bruner,E.T., Budisavljevic,M.N., Atkinson,C., Fitzgibbon,W.R. and Janech,M.G.<br>Deficiency of the angiotensinase aminopeptidase A increases susceptibility to glomerular injury<br>J Am Soc Nephrol (2017) 28, 2119-2132. PubMed  Europe PubMed DOI  K
    16. 2016
  16. Hmazzou,R., Flahault,A., Marc,Y. and Llorens-Cortes,C.<br>[OP.6D.03] Mode of action of RB150, an aminopeptidase A inhibitor prodrug as a centrally-acting antihypertensive agent in DOCA-salt hypertensive rats<br>J Hypertens (2016) 34 Suppl 2, e75-e75. DOI  I
    17. 2015
  17. Wysocki,J., Ye,M. and Batlle,D.<br>Plasma and kidney angiotensin peptides: importance of the aminopeptidase A/angiotensin III axis<br>Am J Hypertens (2015) 28, 1418-1426. PubMed  Europe PubMed DOI  I
    18. 2014
  18. Alghamri,M.S., Morris,M., Meszaros,J.G., Elased,K.M. and Grobe,N.<br>Novel role of aminopeptidase-A in angiotensin-(1-7) metabolism post myocardial infarction<br>Am J Physiol Heart Circ Physiol (2014) 306, H1032-H1040. PubMed  Europe PubMed DOI
  19. Gao,J., Marc,Y., Iturrioz,X., Leroux,V., Balavoine,F. and Llorens-Cortes,C.<br>A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors<br>Clin Sci (Lond) (2014) 127, 135-148. PubMed  Europe PubMed DOI  I
    20. 2013
  20. Schwacke,J.H., Spainhour,J.C., Ierardi,J.L., Chaves,J.M., Arthur,J.M., Janech,M.G. and Velez,J.C.<br>Network modeling reveals steps in angiotensin peptide processing<br>Hypertension (2013) 61, 690-700. PubMed  Europe PubMed DOI
  21. Yang,Y., Liu,C., Lin,Y.L. and Li,F.<br>Structural insights into central hypertension regulation by human aminopeptidase A<br>J Biol Chem (2013) 288, 25638-25645. PubMed  Europe PubMed DOI  S  I
    22. 2012
  22. Marc,Y., Gao,J., Balavoine,F., Michaud,A., Roques,B.P. and Llorens-Cortes,C.<br>Central antihypertensive effects of orally active aminopeptidase A inhibitors in spontaneously hypertensive rats<br>Hypertension (2012) 60, 411-418. PubMed  Europe PubMed DOI  I
  23. Wang,J., Cooper,M.D., Iturrioz,X. and Llorens-Cortes,C.<br>Glutamyl aminopeptidase<br>[ISSN:978-0-12-407744-7] (2012) 3, 410-414. DOI
    24. 2010
  24. Kubota,R., Numaguchi,Y., Ishii,M., Niwa,M., Okumura,K., Naruse,K. and Murohara,T.<br>Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1alpha<br>Biochem Biophys Res Commun (2010) 402, 396-401. PubMed  Europe PubMed DOI  K
  25. Vaiyapuri,S., Wagstaff,S.C., Watson,K.A., Harrison,R.A., Gibbins,J.M. and Hutchinson,E.G.<br>Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros<br>PLoS Negl Trop Dis (2010) 4, e796-e796. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2009
  26. Claperon,C., Banegas-Font,I., Iturrioz,X., Rozenfeld,R., Maigret,B. and Llorens-Cortes,C.<br>Identification of threonine 348 as a residue involved in aminopeptidase A substrate specificity<br>J Biol Chem (2009) 284, 10618-10626. PubMed  Europe PubMed DOI  PMC  EPMC  I
  27. Ishii,M., Hattori,A., Numaguchi,Y., Ma,X., Nagasaka,T., Tsujimoto,M., Murohara,T., Kobayashi,H. and Mizutani,S.<br>The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs)<br>Early Hum Dev (2009) 85, 589-594. PubMed  Europe PubMed DOI  U
    28. 2008
  28. Bodineau,L., Frugiere,A., Marc,Y., Inguimbert,N., Fassot,C., Balavoine,F., Roques,B. and Llorens-Cortes,C.<br>Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension<br>Hypertension (2008) 51, 1318-1325. PubMed  Europe PubMed DOI  I
  29. Bodineau,L., Frugiere,A., Marc,Y., Claperon,C. and Llorens-Cortes,C.<br>Aminopeptidase A inhibitors as centrally acting antihypertensive agents<br>Heart Fail Rev (2008) 13, 311-319. PubMed  Europe PubMed DOI  T  I
  30. Claperon,C., Rozenfeld,R., Iturrioz,X., Inguimbert,N., Okada,M., Roques,B., Maigret,B. and Llorens-Cortes,C.<br>Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity<br>Biochem J (2008) 416, 37-46. PubMed  Europe PubMed DOI
  31. de Mota,N., Iturrioz,X., Claperon,C., Bodineau,L., Fassot,C., Roques,B.P., Palkovits,M. and Llorens-Cortes,C.<br>Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei<br>J Neurochem (2008) 106, 416-428. PubMed  Europe PubMed DOI  I
  32. Ferreira,A.J. and Raizada,M.K.<br>Aminopeptidase A: could it be a novel target for neurogenic hypertension?<br>Hypertension (2008) 51, 1273-1274. PubMed  Europe PubMed DOI  T
  33. Ishii,M., Hattori,A., Numaguchi,Y., Tsujimoto,M., Ishiura,S., Kobayashi,H., Murohara,T., Wright,J.W. and Mizutani,S.<br>The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan<br>Horm Metab Res (2008) 40, 887-891. PubMed  Europe PubMed DOI  U
  34. Mizutani,S., Ishii,M., Hattori,A., Nomura,S., Numaguchi,Y., Tsujimoto,M., Kobayshi,H., Murohara,T. and Wright,J.W.<br>New insights into the importance of aminopeptidase A in hypertension<br>Heart Fail Rev (2008) 13, 273-284. PubMed  Europe PubMed DOI
    35. 2007
  35. Goto,Y., Hattori,A., Mizutani,S. and Tsujimoto,M.<br>Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A<br>J Biol Chem (2007) 282, 37074-37081. PubMed  Europe PubMed DOI
  36. Ogawa,Y., Murayama,N., Fujita,Y. and Yanoshita,R.<br>Characterization and cDNA cloning of aminopeptidase A from the venom of Gloydius blomhoffi brevicaudus<br>Toxicon (2007) 49, 1172-1181. PubMed  Europe PubMed DOI
    37. 2006
  37. [YEAR:1-8-2006]Faber,F., Gembardt,F., Sun,X., Mizutani,S., Siems,W.E. and Walther,T.<br>Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice<br>Regul Pept (1-8-2006) 136, 130-137. PubMed  Europe PubMed DOI  K
  38. Goto,Y., Hattori,A., Ishii,Y., Mizutani,S. and Tsujimoto,M.<br>Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV<br>J Biol Chem (2006) 281, 23503-23513. PubMed  Europe PubMed DOI  P
    39. 2005
  39. Inguimbert,N., Coric,P., Dhotel,H., Bonnard,E., Llorens-Cortes,C., Mota,N., Fournie-Zaluski,M.C. and Roques,B.P.<br>Synthesis and in vitro activities of new non-peptidic APA inhibitors<br>J Pept Res (2005) 65, 175-188. PubMed  Europe PubMed DOI  I
  40. Nomura,M., Nomura,S., Mitsui,T., Suzuki,M., Kobayashi,H., Ito,T., Itakura,A., Kikkawa,F. and Mizutani,S.<br>Possible involvement of aminopeptidase A in hypertension and renal damage in Dahl salt-sensitive rats<br>Am J Hypertens (2005) 18, 538-543. PubMed  Europe PubMed DOI
    41. 2004
  41. [YEAR:18-5-2004]Fournie-Zaluski,M.C., Fassot,C., Valentin,B., Djordjijevic,D., Reaux-Le Goazigo,A., Corvol,P., Roques,B.P. and Llorens-Cortes,C.<br>Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension<br>Proc Natl Acad Sci U S A (18-5-2004) 101, 7775-7780. PubMed  Europe PubMed DOI  PMC  EPMC  I
  42. Marchio,S., Lahdenranta,J., Schlingemann,R.O., Valdembri,D., Wesseling,P., Arap,M.A., Hajitou,A., Ozawa,M.G., Trepel,M., Giordano,R.J., Nanus,D.M., Dijkman,H.B., Oosterwijk,E., Sidman,R.L., Cooper,M.D., Bussolino,F., Pasqualini,R. and Arap,W.<br>Aminopeptidase A is a functional target in angiogenic blood vessels<br>Cancer Cell (2004) 5, 151-162. PubMed  Europe PubMed DOI
  43. [YEAR:8-10-2004]Rozenfeld,R., Muller,L., El Messari,S. and Llorens-Cortes,C.<br>The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of this monozinc aminopeptidase<br>J Biol Chem (8-10-2004) 279, 43285-43295. PubMed  Europe PubMed DOI
  44. Wang,J. and Cooper,M.D.<br>Aminopeptidase A<br>[ISSN:0-12-079610-4] (2004) 2, 299-303.  V
    45. 2003
  45. Ito,N., Nomura,S., Iwase,A., Ito,T., Ino,K., Nagasaka,T., Tsujimoto,M., Kobayashi,M. and Mizutani,S.<br>Ultrastructural localization of aminopeptidase A/angiotensinase and placental leucine aminopeptidase/oxytocinase in chorionic villi of human placenta<br>Early Hum Dev (2003) 71, 29-37. PubMed  Europe PubMed DOI
  46. Rozenfeld,R., Reaux,A., Iturrioz,X., Fassot,C., Fournie-Zaluski,M.C., David,C., Maigret,B., Roques,B.P., Corvol,P. and Llorens-Cortes,C.<br>Aminopeptidase A, generating one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, plays a key role in central control of blood pressure<br>Proc West Pharmacol Soc (2003) 46, 39-44. PubMed  Europe PubMed
  47. [YEAR:23-12-2003]Rozenfeld,R., Iturrioz,X., Okada,M., Maigret,B. and Llorens-Cortes,C.<br>Contribution of molecular modeling and site-directed mutagenesis to the identification of a new residue, glutamate 215, involved in the exopeptidase specificity of aminopeptidase A<br>Biochemistry (23-12-2003) 42, 14785-14793. PubMed  Europe PubMed DOI
    48. 2002
  48. [YEAR:15-2-2002]Ofner,L.D. and Hooper,N.M.<br>The C-terminal domain, but not the interchain disulphide, is required for the activity and intracellular trafficking of aminopeptidase A<br>Biochem J (15-2-2002) 362, 191-197. PubMed  Europe PubMed DOI  PMC  EPMC
  49. [YEAR:9-8-2002]Rozenfeld,R., Iturrioz,X., Maigret,B. and Llorens-Cortes,C.<br>Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A<br>J Biol Chem (9-8-2002) 277, 29242-29252. PubMed  Europe PubMed DOI
    50. 2001
  50. David-Basei,C., Bischoff,L., Fournie-Zaluski,M.C. and Roques,B.P.<br>Synthesis of [3(R)-amino-2(S)-sulfhydryl-5-sulfonate]-pentanoyl-(S)-3-[I-125]-iodotyrosyl-(S)-aspartic acid: a radiolabelled inhibitor of aminopeptidase A<br>J Labelled Comp Radiopharm (2001) 44, 89-98. DOI  I
  51. David-Basei,C., Fournie-Zaluski,M.C. and Roques,B.P.<br>Aminopeptidase A inhibitors<br>Expert Opin Ther Pat (2001) 11, 431-444.  I
  52. [YEAR:4-12-2001]Iturrioz,X., Rozenfeld,R., Michaud,A., Corvol,P. and Llorens-Cortes,C.<br>Study of asparagine 353 in aminopeptidase A: Characterization of a novel motif (GXMEN) implicated in exopeptidase specificity of monozinc aminopeptidases<br>Biochemistry (4-12-2001) 40, 14440-14448. PubMed  Europe PubMed DOI
    53. 2000
  53. Fujimura,H., Ino,K., Nagasaka,T., Nakashima,N., Nakazato,H., Kikkawa,F. and Mizutani,S.<br>Aminopeptidase A expression in cervical neoplasia and its relationship to neoplastic transformation and progression<br>Oncology (2000) 58, 342-352. PubMed  Europe PubMed
  54. [YEAR:8-2-2000]Georgiadis,D., Vazeux,G., Llorens-Cortes,C., Yiotakis,A. and Dive,V.<br>Potent and selective inhibition of zinc aminopeptidase A (EC 3.4.11.7, APA) by glutamyl aminophosphinic peptides: Importance of glutamyl aminophosphinic residue in the P1 position<br>Biochemistry (8-2-2000) 39, 1152-1155. PubMed  Europe PubMed DOI
  55. [YEAR:21-3-2000]Iturrioz,X., Vazeux,G., Celerier,J.M., Corvol,P. and Llorens-Cortes,C.<br>Histidine 450 plays a critical role in catalysis and, with Ca2+, contributes to the substrate specificity of aminopeptidase A<br>Biochemistry (21-3-2000) 39, 3061-3068. PubMed  Europe PubMed DOI
  56. Jiang,Q.P., Troyanovskaya,M., Jayaraman,G. and Healy,D.P.<br>Aminopeptidase-A. II. Genomic cloning and characterization of the rat promoter<br>Am J Physiol Regul Integr Comp Physiol (2000) 278, R425-R434. PubMed  Europe PubMed
  57. Reaux,A., Iturrioz,X., Vazeux,G., Fournie-Zaluski,M.C., David,C., Roques,B.P., Corvol,P. and Llorens-Cortes,C.<br>Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure<br>Biochem Soc Trans (2000) 28, 435-440. PubMed  Europe PubMed  I
  58. Troyanovskaya,M., Jayaraman,G., Song,L. and Healy,D.P.<br>Aminopeptidase-A. I. cDNA cloning and expression and localization in rat tissues<br>Am J Physiol Regul Integr Comp Physiol (2000) 278, R413-R424. PubMed  Europe PubMed
    59. 1999
  59. [YEAR:16-12-1999]David,C., Bischoff,L., Meudal,H., Mothe,A., de Mota,N., Danascimento,S., Llorens-Cortes,C., Fournie-Zaluski,M.C. and Roques,B.P.<br>Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme<br>J Med Chem (16-12-1999) 42, 5197-5211. PubMed  Europe PubMed DOI  I
  60. [YEAR:9-11-1999]Reaux,A., Fournie-Zaluski,M.C., David,C., Zini,S., Roques,B.P., Corvol,P. and Llorens-Cortes,C.<br>Aminopeptidase A inhibitors as potential central antihypertensive agents<br>Proc Natl Acad Sci U S A (9-11-1999) 96, 13415-13420. PubMed  Europe PubMed DOI  PMC  EPMC  I
    61. 1998
  61. [YEAR:15-5-1998]Lin,Q., Taniuchi,I., Kitamura,D., Wang,J., Kearney,J.F., Watanabe,T. and Cooper,M.D.<br>T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice<br>J Immunol (15-5-1998) 160, 4681-4687. PubMed  Europe PubMed  K
  62. [YEAR:15-6-1998]Vazeux,G., Wilk,S., Wilk,E., Corvol,P. and Llorens-Cortes,C.<br>Production and properties of a recombinant soluble form of aminopeptidase A<br>Eur J Biochem (15-6-1998) 254, 671-678. PubMed  Europe PubMed  E
  63. [YEAR:1-9-1998]Vazeux,G., Iturrioz,X., Corvol,P. and Llorens-Cortes,C.<br>A glutamate residue contributes to the exopeptidase specificity in aminopeptidase A<br>Biochem J (1-9-1998) 334, 407-413. PubMed  Europe PubMed  PMC  EPMC
    64. 1997
  64. Hesp,J.R. and Hooper,N.M.<br>Proteolytic fragmentation reveals the oligomeric and domain structure of porcine aminopeptidase A<br>Biochemistry (1997) 36, 3000-3007. PubMed  Europe PubMed DOI
  65. Li,L., Wu,Q., Barnoski,B.L. and Cooper,M.D.<br>High-resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP)<br>Genomics (1997) 43, 380-383. PubMed  Europe PubMed DOI
  66. Song,L., Wilk,S. and Healy,D.P.<br>Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses<br>Brain Res (1997) 744, 1-6. PubMed  Europe PubMed DOI  I
  67. Tian,B., Meng,Q.C., Chen,Y.F., Krege,J.H., Smithies,O. and Oparil,S.<br>Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function<br>Hypertension (1997) 30, 128-133. PubMed  Europe PubMed  K
  68. [YEAR:1-11-1997]Vazeux,G., Iturrioz,X., Corvol,P. and Llorens-Cortes,C.<br>A tyrosine residue essential for catalytic activity in aminopeptidase A<br>Biochem J (1-11-1997) 327, 883-889. PubMed  Europe PubMed  PMC  EPMC
  69. Wolf,G., Mentzel,S. and Assmann,K.J.<br>Aminopeptidase A: A key enzyme in the intrarenal degradation of angiotensin II<br>Exp Nephrol (1997) 5, 364-369. PubMed  Europe PubMed
  70. Zini,S., Masdehors,P., Lenkei,Z., Fournie-Zaluski,M.C., Roques,B.P., Corvol,P. and Llorens-Cortes,C.<br>Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats<br>Neuroscience (1997) 78, 1187-1193. PubMed  Europe PubMed DOI  I
    71. 1996
  71. Arechaga,G., Sanchez,B., Alba,F., Luna,J.D., Prieto,I., Martinez,J.M. and Ramirez,M.<br>Developmental changes of soluble and membrane-bound aspartate aminopeptidase activities in rat brain<br>J Physiol Biochem[ISSN:00349402] (1996) 52, 149-154.
  72. Mentzel,S., Dijkman,H.B., van Son,J.P., Koene,R.A. and Assmann,K.J.<br>Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice<br>J Histochem Cytochem (1996) 44, 445-461. PubMed  Europe PubMed
  73. Mentzel,S., Assmann,K.J., Dijkman,H.B., De Jong,A.S., van Son,J.P., Wetzels,J.F. and Koene,R.A.<br>Inhibition of aminopeptidase A activity causes an acute albuminuria in mice: an angiotensin II-mediated effect?<br>Nephrol Dial Transplant (1996) 11, 2163-2169. PubMed  Europe PubMed
  74. Migaud,M., Durieux,C., Viereck,J., Soroca-Lucas,E., Fournie-Zaluski,M.C. and Roques,B.P.<br>The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A<br>Peptides (1996) 17, 601-607. PubMed  Europe PubMed DOI
  75. Vazeux,G., Wang,J., Corvol,P. and Llorens-Cortes,C.<br>Identification of glutamate residues essential for catalytic activity and zinc coordination in aminopeptidase A<br>J Biol Chem (1996) 271, 9069-9074. PubMed  Europe PubMed DOI
    76. 1994
  76. Chauvel,E.N., Llorens-Cortes,C., Coric,P., Wilk,S., Roques,B.P. and Fournie-Zaluski,M.C.<br>Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols<br>J Med Chem (1994) 37, 2950-2957. PubMed  Europe PubMed  I
  77. Chauvel,E.N., Coric,P., Llorens-Cortes,C., Wilk,S., Roques,B.P. and Fournie-Zaluski,M.C.<br>Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors<br>J Med Chem (1994) 37, 1339-1346. PubMed  Europe PubMed DOI  I
    78. 1993
  78. Li,L., Wu,Q., Wang,J., Bucy,R.P. and Cooper,M.D.<br>Widespread tissue distribution of aminopeptidase A, an evolutionarily conserved ectoenzyme recognized by the BP-1 antibody<br>Tissue Antigens (1993) 42, 488-496. PubMed  Europe PubMed
  79. Li,L., Wang,J. and Cooper,M.D.<br>cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A)<br>Genomics (1993) 17, 657-664. PubMed  Europe PubMed DOI
  80. [YEAR:1-8-1993]Nanus,D.M., Engelstein,D., Gastl,G.A., Gluck,L., Vidal,M.J., Morrison,M., Finstad,C.L., Bander,N.H. and Albino,A.P.<br>Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A<br>Proc Natl Acad Sci U S A (1-8-1993) 90, 7069-7073. PubMed  Europe PubMed  PMC  EPMC
  81. Wang,J. and Cooper,M.D.<br>Histidine residue in the zinc-binding motif of aminopeptidase A is critical for enzymatic activity<br>Proc Natl Acad Sci U S A (1993) 90, 1222-1226. PubMed  Europe PubMed DOI  PMC  EPMC
    82. 1990
  82. Wilk,S. and Thurston,L.S.<br>Inhibition of angiotensin III formation by thiol derivatives of acidic amino acids<br>Neuropeptides (1990) 16, 163-168. PubMed  Europe PubMed DOI  I
  83. Wu,Q., Lahti,J.M., Air,G.M., Burrows,P.D. and Cooper,M.D.<br>Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family<br>Proc Natl Acad Sci U S A (1990) 87, 993-997. PubMed  Europe PubMed  PMC  EPMC
    84. 1986
  84. Agrawal,Y. and Vanha-Perttula,T.<br>Studies on the multiple forms of aminopeptidase A in bovine seminal vesicle secretion<br>Int J Biochem (1986) 18, 465-471. PubMed  Europe PubMed
  85. McDonald,J.K. and Barrett,A.J.<br>Mammalian Proteases: a Glossary and Bibliography. Volume 2: Exopeptidases<br>[ISSN:ISBN 0-12-079502-7] (1986)
    86. 1984
  86. [YEAR:25-9-1984]Lalu,K., Lampelo,S., Nummelin-Kortelainen,M. and Vanha-Perttula,T.<br>Purification and partial characterization of aminopeptidase A from the serum of pregnant and non-pregnant women<br>Biochim Biophys Acta (25-9-1984) 789, 324-333. PubMed  Europe PubMed DOI
    87. 1983
  87. Sakura,H., Kobayashi,H., Mizutani,S., Sakura,N., Hashimoto,T. and Kawashima,Y.<br>Kinetic properties of placental aminopeptidase A: N-terminal degradation of angiotensin II<br>Biochem Int (1983) 6, 609-615. PubMed  Europe PubMed  I
    88. 1982
  88. Kugler,P.<br>Aminopeptidase A is angiotensinase A- I. Quantitative histochemical studies in the kidney glomerulus<br>Histochemistry (1982) 74, 229-245. PubMed  Europe PubMed
  89. Kugler,P.<br>Aminopeptidase A is angiotensinase A. II. Biochemical studies on aminopeptidase A and M in rat kidney homogenate<br>Histochemistry (1982) 74, 247-261. PubMed  Europe PubMed
  90. Tobe,H., Morishima,H., Aoyagi,T., Umezawa,H., Nakamura,K., Ishiki,K., Yoshioka,T., Shimauchi,Y. and Inui,T.<br>Synthesis and structure-activity relationships of amastatin analogues, inhibitors of aminopeptidase A<br>Agric Biol Chem (1982) 46, 1865-1872. DOI  I
    91. 1981
  91. [YEAR:13-3-1981]Feracci,H., Benajiba,A., Gorvel,J.P., Doumeng,C. and Maroux,S.<br>Enzymatic and immunological properties of the protease form of aminopeptidase N and A from pig and rabbit intestinal brush border<br>Biochim Biophys Acta (13-3-1981) 658, 148-157. PubMed  Europe PubMed
    92. 1980
  92. Benajiba,A. and Maroux,S.<br>Purification and characterization of an aminopeptidase A from hog intestinal brush-border membrane<br>Eur J Biochem (1980) 107, 381-388. PubMed  Europe PubMed
  93. Danielsen,E.M., Noren,O., Sjostrom,H., Ingram,J. and Kenny,A.J.<br>Proteins of the kidney microvillar membrane. Aspartate aminopeptidase: purification by immunoadsorbent chromatography and properties of the detergent- and proteinase-solubilized forms<br>Biochem J (1980) 189, 591-603. PubMed  Europe PubMed  PMC  EPMC
  94. [YEAR:9-9-1980]Gorvel,J.P., Benajiba,A. and Maroux,S.<br>Purification and characterization of the rabbit intestinal brush-border aminopeptidase A<br>Biochim Biophys Acta (9-9-1980) 615, 271-274. PubMed  Europe PubMed
  95. Tobe,H., Kojima,F., Aoyagi,T. and Umezawa,H.<br>Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney<br>Biochim Biophys Acta (1980) 613, 459-468. PubMed  Europe PubMed  I
    96. 1979
  96. Chulkova,T.M. and Orekhovich,V.N.<br>[Molecular structure of aminopeptidase A from bovine kidney]<br>Biokhimiia (1979) 44, 1539-1541. PubMed  Europe PubMed
    97. 1978
  97. Aoyagi,T., Tobe,H., Kojima,F., Hamada,M., Takeuchi,T. and Umezawa,H.<br>Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes<br>J Antibiot (Tokyo) (1978) 31, 636-638. PubMed  Europe PubMed  I
  98. Chulkova,T.M. and Orekhovich,V.N.<br>Isolation and properties of aminopeptidase A from bovine kidneys<br>Biochemistry (Mosc) (1978) 43, 964-969.
  99. Chulkova,T.M. and Orekhovich,V.N.<br>Isolation and properties of bovine kidney aminopeptidase A<br>Biokhimiia (1978) 43, 1222-1227. PubMed  Europe PubMed
    100. 1976
  100. [YEAR:8-1-1976]Andria,G., Marzi,A. and Auricchio,S.<br>Alpha-Glutamyl-beta-naphthylamide hydrolase of rabbit small intestine. Localization in the brush border and separation from other brush border peptidases<br>Biochim Biophys Acta (8-1-1976) 419, 42-50. PubMed  Europe PubMed
    101. 1970
  101. [YEAR:11-2-1970]Nagatsu,I., Nagatsu,T., Yamamoto,T., Glenner,G.G. and Mehl,J.W.<br>Purification of aminopeptidase A in human serum and degradation of angiotensin II by the purified enzyme<br>Biochim Biophys Acta (11-2-1970) 198, 255-270. PubMed  Europe PubMed
    102. 1969
  102. Yman,L. and Kulling,B.<br>An aminopeptidase from human serum specific for hydrolysis of alpha-L-dicarboxylic amino acid residues. I. Purification from retroplacental serum by preparative polyacrylamide-gel electrophoresis<br>Acta Pharm Suec (1969) 6, 561-568. PubMed  Europe PubMed
  103. Yman,L. and Kulling,B.<br>An aminopeptidase from human serum specific for hydrolysis of alpha-L-dicarboxylic amino acid residues. II. Some properties and its relationship to the serum angiotensinase activity<br>Acta Pharm Suec (1969) 6, 569-578. PubMed  Europe PubMed
    104. 1965
  104. [YEAR:18-5-1965]Hess,R.<br>Arylamidase activity related to angiotensinase<br>Biochim Biophys Acta (18-5-1965) 99, 316-324. PubMed  Europe PubMed
  105. Nagatsu,I., Gillespie,L., George,J.M., Folk,J.E. and Glenner,G.G.<br>Serum aminopeptidases, "angiotensinase," and hypertension. II. Amino acid beta-napthylamide hydrolysis by normal and hypertensive serum<br>Biochem Pharmacol (1965) 14, 853-861. PubMed  Europe PubMed
    106. 1963
  106. [YEAR:10-5-1963]Khairallah,P.A., Bumpus,F.M., Page,I.H. and Smeby,R.R.<br>Angiotensinase with a high degree of specificity in plasma and red cells<br>Science (10-5-1963) 140, 672-674. PubMed  Europe PubMed

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