Substrates for peptidase C25.003: gingipain RgpB

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Bz-Arg-NHPhNO2			Bz-Arg+NHPhNO2	S		-	-	Bz	Arg	NAN	-	-	-	Chen et al., 2013
coagulation factor X light chain	P00742	41-488	peptide-Arg469+Gly-peptide	P	CS	Met	Lys	Thr	Arg	Gly	Leu	Pro	Lys	Imamura et al., 1997	20582
coagulation factor X light chain	P00742	41-488	peptide-Arg227+Gly-peptide	P	CS	Gln	Pro	Glu	Arg	Gly	Asp	Asn	Asn	Imamura et al., 1997	20583
coagulation factor X light chain	P00742	41-488	peptide-Arg234+Ile-peptide	P	CS	Asn	Leu	Thr	Arg	Ile	Val	Gly	Gly	Imamura et al., 1997	20584
Histatin 5	P15516	19-43	Peptide-Lys24+Arg-Peptide	N	MS	Ser	His	Ala	Lys	Arg	His	His	Gly	Chen et al., 2013
Histatin 5	P15516	19-43	Peptide-Arg25+His-Peptide	N	MS	His	Ala	Lys	Arg	His	His	Gly	Tyr	Chen et al., 2013
Histatin 5	P15516	19-43	Peptide-Lys30+Arg-Peptide	N	MS	His	Gly	Tyr	Lys	Arg	Lys	Phe	His	Chen et al., 2013
Histatin 5	P15516	19-43	Peptide-Arg31+Lys-peptide	N	MS	Gly	Tyr	Lys	Arg	Lys	Phe	His	Glu	Chen et al., 2013
Histatin 5	P15516	19-43	Peptide-Lys32+Phe-Peptide	N	MS	Tyr	Lys	Arg	Lys	Phe	His	Glu	Lys	Chen et al., 2013
Histatin 5	P15516	19-43	Peptide-Lys36+His-Peptide	N	MS	Phe	His	Glu	Lys	His	His	Ser	His	Chen et al., 2013
Histatin 5	P15516	19-43	Peptide-Arg41+Gly-Tyr	N	MS	His	Ser	His	Arg	Gly	Tyr	-	-	Chen et al., 2013
Mucin-2	Q02817	4198-5179	Peptide-Arg4321+Thr-Peptide	N	NT	Ser	Ile	Ile	Arg	Thr	Thr	Gly	Leu	van der Post etal, 2013
Mucin-2	Q02817	4198-5179	Peptide-Arg4566-Gln-Peptide	N	NT	Gln	Val	Asn	Arg	Gln	Ala	Val	Ala	van der Post etal, 2013
tumor necrosis factor	P01375	77-233	peptide-Arg78+Ser-peptide	P		-	-	Val	Arg	Ser	Ser	Ser	Arg	Calkins et al., 1998	20522
tumor necrosis factor	P01375	77-233	peptide-Arg82+Thr-peptide	P		Ser	Ser	Ser	Arg	Thr	Pro	Ser	Asp	Calkins et al., 1998	20532
tumor necrosis factor	P01375	77-233	peptide-Arg108+Ala-peptide	P		Leu	Asn	Arg	Arg	Ala	Asn	Ala	Leu	Calkins et al., 1998	20533