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Literature for peptidase C25.003: gingipain RgpB

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, I Inhibitor, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Amer,L., Retout,M. and Jokerst,J.V.<br>Activatable prodrug for controlled release of an antimicrobial peptide via the proteases overexpressed in Candida albicans and Porphyromonas gingivalis<br>Theranostics (2024) 14, 1781-1793. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2023
  2. Retout,M., Amer,L., Yim,W., Creyer,M.N., Lam,B., Trujillo,D.F., Potempa,J., O'Donoghue,A.J., Chen,C. and Jokerst,J.V.<br>A Protease-Responsive Polymer/Peptide Conjugate and Reversible Assembly of Silver Clusters for the Detection of Porphyromonas gingivalis Enzymatic Activity<br>ACS Nano (2023) 17, 17308-17319. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2022
  3. Dorgan,B., Liu,Y., Wang,S., Aduse-Opoku,J., Whittaker,S.B., Roberts,M.A.J., Lorenz,C.D., Curtis,M.A. and Garnett,J.A.<br>Structural Model of a Porphyromonas gingivalis type IX Secretion System Shuttle Complex<br>J Mol Biol (2022) 434, 167871-167871. PubMed  Europe PubMed DOI
    4. 2020
  4. Mo,W., Luo,H., Wu,J., Xu,N., Zhang,F., Qiu,Q., Zhu,W. and Liang,M.<br>Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin beta3 in RAW264.7 cells<br>J Mol Histol (2020) 51, 147-159. PubMed  Europe PubMed DOI
  5. Seers,C.A., Mahmud,A.S.M., Huq,N.L., Cross,K.J. and Reynolds,E.C.<br>Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains<br>J Oral Microbiol (2020) 13, 1858001-1858001. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Shibata,S., Shoji,M., Okada,K., Matsunami,H., Matthews,M.M., Imada,K., Nakayama,K. and Wolf,M.<br>Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange<br>Nat Microbiol (2020) 5, 830-837. PubMed  Europe PubMed DOI
    7. 2019
  7. Veillard,F., Sztukowska,M., Nowakowska,Z., Mizgalska,D., Thogersen,I.B., Enghild,J.J., Bogyo,M., Potempa,B., Nguyen,K.A. and Potempa,J.<br>Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis<br>Biochimie (2019) 166, 161-172. PubMed  Europe PubMed DOI
    8. 2017
  8. Skottrup,P.D.<br>Structural insights into a high affinity nanobody:antigen complex by homology modelling<br>J Mol Graph Model (2017) 76, 305-312. PubMed  Europe PubMed DOI
  9. Wichert,R., Ermund,A., Schmidt,S., Schweinlin,M., Ksiazek,M., Arnold,P., Knittler,K., Wilkens,F., Potempa,B., Rabe,B., Stirnberg,M., Lucius,R., Bartsch,J.W., Nikolaus,S., Falk-Paulsen,M., Rosenstiel,P., Metzger,M., Rose-John,S., Potempa,J., Hansson,G.C., Dempsey,P.J. and Becker-Pauly,C.<br>Mucus detachment by host metalloprotease meprin beta requires shedding of its inactive pro-form, which is abrogated by the pathogenic protease RgpB<br>Cell Rep (2017) 21, 2090-2103. PubMed  Europe PubMed DOI
    10. 2015
  10. Dou,Y., Robles,A., Roy,F., Aruni,A.W., Sandberg,L., Nothnagel,E. and Fletcher,H.M.<br>The roles of RgpB and Kgp in late onset gingipain activity in the vimA-defective mutant of Porphyromonas gingivalis W83<br>Mol Oral Microbiol (2015) 30, 347-360. PubMed  Europe PubMed DOI
  11. Jung,Y.J., Jun,H.K. and Choi,B.K.<br>Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation<br>Cell Microbiol (2015) 17, 1304-1319. PubMed  Europe PubMed DOI
  12. Veillard,F., Potempa,B., Guo,Y., Ksiazek,M., Sztukowska,M.N., Houston,J.A., Koneru,L., Nguyen,K.A. and Potempa,J.<br>Purification and characterisation of recombinant His-tagged RgpB gingipain from Porphymonas gingivalis<br>Biol Chem (2015) 396, 377-384. PubMed  Europe PubMed DOI  E
    13. 2013
  13. Chen,Y.Y., Seers,C.A., Slakeski,N., Moore,C., Zhang,L. and Reynolds,E.C.<br>Reversible redox regulation of specificity of Arg-gingipain B in Porphyromonas gingivalis<br>FEBS Lett (2013) 587, 1275-1280. PubMed  Europe PubMed DOI  P
  14. de Diego,I., Veillard,F.T., Guevara,T., Potempa,B., Sztukowska,M., Potempa,J. and Gomis-Ruth,F.X.<br>Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases<br>J Biol Chem (2013) 288, 14287-14296. PubMed  Europe PubMed DOI
    15. 2012
  15. Nguyen,K.A. and Potempa,J.<br>Gingipain R<br>[ISSN:978-0-12-407743-0] (2012) 3, 2328-2336. DOI
    16. 2010
  16. Guo,Y., Nguyen,K.A. and Potempa,J.<br>Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins<br>Periodontol 2000 (2010) 54, 15-44. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2009
  17. Fitzpatrick,R.E., Wijeyewickrema,L.C. and Pike,R.N.<br>The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis<br>Future Microbiol (2009) 4, 471-487. PubMed  Europe PubMed DOI
    18. 2005
  18. Sato,K., Sakai,E., Veith,P.D., Shoji,M., Kikuchi,Y., Yukitake,H., Ohara,N., Naito,M., Okamoto,K., Reynolds,E.C. and Nakayama,K.<br>Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis<br>J Biol Chem (2005) 280, 8668-8677. PubMed  Europe PubMed DOI
    19. 2004
  19. Imamura,T., Potempa,J. and Travis,J.<br>Gingipain R<br>[ISSN:0-12-079610-4] (2004) 2, 1319-1328.  V
    20. 2003
  20. Kamaguchi,A., Ohyama,T., Sakai,E., Nakamura,R., Watanabe,T., Baba,H. and Nakayama,K.<br>Adhesins encoded by the gingipain genes of Porphyromonas gingivalis are responsible for co-aggregation with Prevotella intermedia<br>Microbiology (Reading) (2003) 149, 1257-1264. PubMed  Europe PubMed DOI
    21. 2001
  21. Imamura,T., Matsushita,K., Travis,J. and Potempa,J.<br>Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues<br>Antimicrobial Agents Chemother (2001) 45, 2871-2876. PubMed  Europe PubMed DOI  PMC  EPMC  I
    22. 1999
  22. [YEAR:15-10-1999]Eichinger,A., Beisel,H.G., Jacob,U., Huber,R., Medrano,F.J., Banbula,A., Potempa,J., Travis,J. and Bode,W.<br>Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold<br>EMBO J (15-10-1999) 18, 5453-5462. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  23. Simpson,W., Wang,C.Y., Mikolajczyk-Pawlinska,J., Potempa,J., Travis,J., Bond,V.C. and Genco,C.A.<br>Transposition of the endogenous insertion sequence element IS1126 modulates gingipain expression in Porphyromonas gingivalis<br>Infect Immun (1999) 67, 5012-5020. PubMed  Europe PubMed  PMC  EPMC
    24. 1998
  24. [YEAR:21-8-1998]Potempa,J., Mikolajczyk-Pawlinska,J., Brassell,D., Nelson,D., Thogersen,I.B., Enghild,J.J. and Travis,J.<br>Comparative properties of two cysteine proteinases (gingipains R), the products of two related but individual genes of Porphyromonas gingivalis<br>J Biol Chem (21-8-1998) 273, 21648-21657. PubMed  Europe PubMed DOI

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