Literature for peptidase C25.003: gingipain RgpB

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, I Inhibitor, P Specificity, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Amer,L., Retout,M. and Jokerst,J.V.
    Activatable prodrug for controlled release of an antimicrobial peptide via the proteases overexpressed in Candida albicans and Porphyromonas gingivalis
    Theranostics14, 1781-1793. PubMed  Europe PubMed DOI
  2. 2023
  3. Retout,M., Amer,L., Yim,W., Creyer,M.N., Lam,B., Trujillo,D.F., Potempa,J., O'Donoghue,A.J., Chen,C. and Jokerst,J.V.
    A Protease-Responsive Polymer/Peptide Conjugate and Reversible Assembly of Silver Clusters for the Detection of Porphyromonas gingivalis Enzymatic Activity
    ACS Nano17, 17308-17319. PubMed  Europe PubMed DOI
  4. 2022
  5. Dorgan,B., Liu,Y., Wang,S., Aduse-Opoku,J., Whittaker,S.B., Roberts,M.A.J., Lorenz,C.D., Curtis,M.A. and Garnett,J.A.
    Structural Model of a Porphyromonas gingivalis type IX Secretion System Shuttle Complex
    J Mol Biol434, 167871-167871. PubMed  Europe PubMed DOI
  6. 2020
  7. Mo,W., Luo,H., Wu,J., Xu,N., Zhang,F., Qiu,Q., Zhu,W. and Liang,M.
    Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin beta3 in RAW264.7 cells
    J Mol Histol51, 147-159. PubMed  Europe PubMed DOI
  8. Seers,C.A., Mahmud,A.S.M., Huq,N.L., Cross,K.J. and Reynolds,E.C.
    Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains
    J Oral Microbiol13, 1858001-1858001. PubMed  Europe PubMed DOI
  9. Shibata,S., Shoji,M., Okada,K., Matsunami,H., Matthews,M.M., Imada,K., Nakayama,K. and Wolf,M.
    Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange
    Nat Microbiol5, 830-837. PubMed  Europe PubMed DOI
  10. 2019
  11. Veillard,F., Sztukowska,M., Nowakowska,Z., Mizgalska,D., Thogersen,I.B., Enghild,J.J., Bogyo,M., Potempa,B., Nguyen,K.A. and Potempa,J.
    Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis
    Biochimie166, 161-172. PubMed  Europe PubMed DOI
  12. 2017
  13. Skottrup,P.D.
    Structural insights into a high affinity nanobody:antigen complex by homology modelling
    J Mol Graph Model76, 305-312. PubMed  Europe PubMed DOI
  14. Wichert,R., Ermund,A., Schmidt,S., Schweinlin,M., Ksiazek,M., Arnold,P., Knittler,K., Wilkens,F., Potempa,B., Rabe,B., Stirnberg,M., Lucius,R., Bartsch,J.W., Nikolaus,S., Falk-Paulsen,M., Rosenstiel,P., Metzger,M., Rose-John,S., Potempa,J., Hansson,G.C., Dempsey,P.J. and Becker-Pauly,C.
    Mucus detachment by host metalloprotease meprin beta requires shedding of its inactive pro-form, which is abrogated by the pathogenic protease RgpB
    Cell Rep21, 2090-2103. PubMed  Europe PubMed DOI
  15. 2015
  16. Dou,Y., Robles,A., Roy,F., Aruni,A.W., Sandberg,L., Nothnagel,E. and Fletcher,H.M.
    The roles of RgpB and Kgp in late onset gingipain activity in the vimA-defective mutant of Porphyromonas gingivalis W83
    Mol Oral Microbiol30, 347-360. PubMed  Europe PubMed DOI
  17. Jung,Y.J., Jun,H.K. and Choi,B.K.
    Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation
    Cell Microbiol17, 1304-1319. PubMed  Europe PubMed DOI
  18. Veillard,F., Potempa,B., Guo,Y., Ksiazek,M., Sztukowska,M.N., Houston,J.A., Koneru,L., Nguyen,K.A. and Potempa,J.
    Purification and characterisation of recombinant His-tagged RgpB gingipain from Porphymonas gingivalis
    Biol Chem396, 377-384. PubMed  Europe PubMed DOI  E
  19. 2013
  20. Chen,Y.Y., Seers,C.A., Slakeski,N., Moore,C., Zhang,L. and Reynolds,E.C.
    Reversible redox regulation of specificity of Arg-gingipain B in Porphyromonas gingivalis
    FEBS Lett587, 1275-1280. PubMed  Europe PubMed DOI  P
  21. de Diego,I., Veillard,F.T., Guevara,T., Potempa,B., Sztukowska,M., Potempa,J. and Gomis-Ruth,F.X.
    Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases
    J Biol Chem288, 14287-14296. PubMed  Europe PubMed DOI
  22. 2012
  23. Nguyen,K.A. and Potempa,J.
    Gingipain R
    [ISSN:978-0-12-407743-0]3, 2328-2336. DOI
  24. 2010
  25. Guo,Y., Nguyen,K.A. and Potempa,J.
    Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins
    Periodontol 200054, 15-44. PubMed  Europe PubMed DOI
  26. 2009
  27. Fitzpatrick,R.E., Wijeyewickrema,L.C. and Pike,R.N.
    The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis
    Future Microbiol4, 471-487. PubMed  Europe PubMed DOI
  28. 2005
  29. Sato,K., Sakai,E., Veith,P.D., Shoji,M., Kikuchi,Y., Yukitake,H., Ohara,N., Naito,M., Okamoto,K., Reynolds,E.C. and Nakayama,K.
    Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis
    J Biol Chem280, 8668-8677. PubMed  Europe PubMed DOI
  30. 2004
  31. Imamura,T., Potempa,J. and Travis,J.
    Gingipain R
    [ISSN:0-12-079610-4]2, 1319-1328.  V
  32. 2003
  33. Kamaguchi,A., Ohyama,T., Sakai,E., Nakamura,R., Watanabe,T., Baba,H. and Nakayama,K.
    Adhesins encoded by the gingipain genes of Porphyromonas gingivalis are responsible for co-aggregation with Prevotella intermedia
    Microbiology (Reading)149, 1257-1264. PubMed  Europe PubMed DOI
  34. 2001
  35. Imamura,T., Matsushita,K., Travis,J. and Potempa,J.
    Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues
    Antimicrobial Agents Chemother45, 2871-2876. PubMed  Europe PubMed DOI  I
  36. 1999
  37. [YEAR:15-10-1999]Eichinger,A., Beisel,H.G., Jacob,U., Huber,R., Medrano,F.J., Banbula,A., Potempa,J., Travis,J. and Bode,W.
    Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold
    EMBO J18, 5453-5462. PubMed  Europe PubMed DOI  S  I
  38. Simpson,W., Wang,C.Y., Mikolajczyk-Pawlinska,J., Potempa,J., Travis,J., Bond,V.C. and Genco,C.A.
    Transposition of the endogenous insertion sequence element IS1126 modulates gingipain expression in Porphyromonas gingivalis
    Infect Immun67, 5012-5020. PubMed  Europe PubMed
  39. 1998
  40. [YEAR:21-8-1998]Potempa,J., Mikolajczyk-Pawlinska,J., Brassell,D., Nelson,D., Thogersen,I.B., Enghild,J.J. and Travis,J.
    Comparative properties of two cysteine proteinases (gingipains R), the products of two related but individual genes of Porphyromonas gingivalis
    J Biol Chem273, 21648-21657. PubMed  Europe PubMed DOI