$VAR1 = undef;
Summary for peptidase C15.010: pyroglutamyl-peptidase I (chordate)
| Names | |
|---|---|
| MEROPS Name | pyroglutamyl-peptidase I (chordate) |
| Other names | 5-oxoprolyl-peptidase, pyroglutamyl aminopeptidase, pyrrolidone-carboxylate peptidase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan CF >> Subclan (none) >> Family C15 >> Subfamily (none) >> C15.010 |
| Holotype | pyroglutamyl-peptidase I (chordate) (Homo sapiens), Uniprot accession Q9NXJ5 (peptidase unit: 4-209), MERNUM MER0011032 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Cysteine | ||
| Peplist | Included in the Peplist with identifier PL00106 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase 3.4.19.3 | ||
| Enzymology | BRENDA database | ||
| Activity status | human: active (Dando, 2004) mouse: active (by similarity) | ||
| Physiology | Inactivates TRH and LHRH by removal of pyroglutamyl groups. | ||
| Other databases | TREEFAM | http://www.treefam.org/family/TF313278 | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| PGPEP1 | 19p13.11 | ENSG00000130517 | 54858 | PGPEP1 | 610694 | |
| Mouse genetics | ||||||
| Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
| Pgpep1 | 8:C1 | ENSMUSG00000003989 | 66522 | MGI:1913772 | ||
