Structure for peptidase C01.070: dipeptidyl-peptidase I

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1K3B_A	Homo sapiens	2.15 Å	exclusion domain
Catalytic residues are shown in ball-and-stick representation: Cys258 in yellow, His405 in purple and Asn427 in pink. The molecule is rotated 90 degrees in the Y direction with respect to papain.

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Brugia pahangi
theoretical model	0.00 Å	1BMU	1BMU	1BMU	1BMU	1BMU	1BMU
Homo sapiens
exclusion domain	2.15 Å	1K3B	1K3B	1K3B	1K3B	1K3B	1K3B	Turk et al., 2001
complex with the inhibitor Gly-Phe-CHN2	2.00 Å	2DJF	2DJF	2DJF	2DJF	2DJF	2DJF	Molgaard et al., 2007
re-refinement of the native structure of human dipeptidyl peptidase i (cathepsin c)	2.05 Å	2DJG	2DJG	2DJG	2DJG	2DJG	2DJG	Molgaard et al., 2007
discovery of novel cyanamide-based inhibitors of cathepsin c	1.85 Å	3PDF	3PDF	3PDF	3PDF	3PDF	3PDF
human dpp1 in complex with (2s)-2-amino-n-((1s)-1-cyano-2-(4- phenylphenyl)ethyl)butanamide	2.40 Å	4CDC	4CDC	4CDC	4CDC	4CDC	4CDC
human dpp1 in complex with (2s)-n-((1s)-1-cyano-2-(4-(4-cyanophenyl) phenyl)ethyl)piperidine-2-carboxamide	2.35 Å	4CDD	4CDD	4CDD	4CDD	4CDD	4CDD
human dpp1 in complex with 4-amino-n-((1s)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)tetrahydropyran-4-carboxamide	2.40 Å	4CDE	4CDE	4CDE	4CDE	4CDE	4CDE
human dpp1 in complex with (2s,4s)-n-((1s)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)-4-hydroxy-piperidine-2-carboxamide	2.20 Å	4CDF	4CDF	4CDF	4CDF	4CDF	4CDF
complex with dipeptide substrates	1.40 Å	4OEL	4OEL	4OEL	4OEL	4OEL	4OEL
complex with dipeptide substrates	1.52 Å	4OEM	4OEM	4OEM	4OEM	4OEM	4OEM
complex with dipeptidyl cyclopropyl nitrile inhibitor 2	2.00 Å	6IC5	6IC5	6IC5	6IC5	6IC5	6IC5
complex with cyclopropyl peptidyl nitrile inhibitor 1	1.90 Å	6IC6	6IC6	6IC6	6IC6	6IC6	6IC6
complex with dipeptidyl cyclopropyl nitrile inhibitor 3	2.00 Å	6IC7	6IC7	6IC7	6IC7	6IC7	6IC7
Rattus norvegicus
mature peptidase	2.40 Å	1JQP	1JQP	1JQP	1JQP	1JQP	1JQP	Olsen et al., 2001