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Literature for peptidase C01.070: dipeptidyl-peptidase I

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Kazmierczak,M., Bilska-Markowska,M., Wisniewska,K., Pawelczak,M., Nowak,D. and Hoffmann,M.
    Design, Synthesis, and Biological Activity of (E)-alpha-Fluorovinylphosphonate-Based Reversible Cathepsin C Inhibitors
    J Org Chem (2026) 91, 3218-3231. PubMed  Europe PubMed DOI
  2. Shi,D., Liu,X., Huang,J., Li,C., Chen,Q., Zhou,F. and Chen,X.
    Design and anti-inflammatory activity evaluation of tryptophan analogs as novel dipeptidyl peptidase I inhibitors
    Eur J Med Chem (2026) 306, 118570-118570. PubMed  Europe PubMed DOI
    3. 2025
  3. Aljabali,A.A.A., Obeid,M.A., Gammoh,O., Alshaer,W., Qnais,E., Alqudah,A., Mishra,V., Mishra,Y. and El-Tanani,M.
    Cathepsin C: a critical mediator between immune response and cardiovascular disease - therapeutic implications of enzyme inhibition
    Drug Dev Ind Pharm (2025) , 1-26. PubMed  Europe PubMed DOI
  4. Elias,R.D., O'Neill,R.T., Demiralp,I.I., Allen,S., Serwas,D., Siems,H., Montabana,E.A., Ash,C., Yacoubian,D.A., Lederberg,O.L., Cravatt,B.F., Agard,D.A. and Kelly,J.W.
    Cathepsin C-Catalyzed Ligation Generates Intralysosomal Amyloid Fibrils from Dipeptide Esters
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  5. Lu,F., Lei,H., Xiao,X. and Yu,L.
    Unraveling the gut microbiota-SCFAs-cathepsin C pathway in preeclampsia: a novel therapeutic target
    Front Immunol (2025) 16, 1700781-1700781. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Pytelkova,J., Orsaghova,K., Benova,M., Horn,M., Schabussova,I. and Mares,M.
    Allergenic mites excrete cathepsins B and C as active cysteine proteases distinct from group 1 allergens
    Int J Biol Macromol (2025) 331, 148383-148383. PubMed  Europe PubMed DOI
  7. Zhang,D., Zhang,W., Hu,P. and Zhang,W.
    Dipeptidyl peptidase 1 inhibitors for inflammatory respiratory diseases: mechanisms, clinical trials, and therapeutic prospects
    Front Pharmacol (2025) 16, 1656316-1656316. PubMed  Europe PubMed DOI  PMC  EPMC  I
  8. Zhou,F.L., Zhang,Y., Chang,C., Shi,D.X., Chen,X., Liu,X.H. and Shen,X.B.
    Identification of Marrubiin as a Cathepsin C Inhibitor for Treating Rheumatoid Arthritis
    Molecules (2025) 30 PubMed  Europe PubMed DOI  PMC  EPMC  I
    9. 2024
  9. Aghdassi,A.A., Pham,C., Zierke,L., Mariaule,V., Korkmaz,B. and Rhimi,M.
    Cathepsin C role in inflammatory gastroenterological, renal, rheumatic, and pulmonary disorders
    Biochimie (2024) 216, 175-180. PubMed  Europe PubMed DOI  V
  10. Chitsamankhun,C., Siritongtaworn,N., Fournier,B.P.J., Sriwattanapong,K., Theerapanon,T., Samaranayake,L. and Porntaveetus,T.
    Cathepsin C in health and disease: from structural insights to therapeutic prospects
    J Transl Med (2024) 22, 777-777. PubMed  Europe PubMed DOI  PMC  EPMC  V
  11. Domain,R., Seren,S., Jerke,U., Makridakis,M., Chen,K.J., Zoidakis,J., Rhimi,M., Zhang,X., Bonvent,T., Croix,C., Gonzalez,L., Li,D., Basso,J., Paget,C., Viaud-Massuard,M.C., Lalmanach,G., Shi,G.P., Aghdassi,A., Vlahou,A., McDonald,P.P., Couillin,I., Williams,R., Kettritz,R. and Korkmaz,B.
    Pharmacological inhibition of cathepsin S and of NSPs-AAP-1 (a novel, alternative protease driving the activation of neutrophil serine proteases)
    Biochem Pharmacol (2024) 229, 116114-116114. PubMed  Europe PubMed DOI
  12. Mandal,M., Pires,D., Calado,M., Azevedo-Pereira,J.M. and Anes,E.
    Cystatin F Depletion in Mycobacterium tuberculosis-Infected Macrophages Improves Cathepsin C/Granzyme B-Driven Cytotoxic Effects on HIV-Infected Cells during Coinfection
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  13. Nishibata,Y., Arai,S., Taniguchi,M., Nakade,I., Ogawa,H., Kitano,S., Hosoi,Y., Shindo,A., Nishiyama,R., Masuda,S., Nakazawa,D., Tomaru,U., Shimizu,T., Sinko,W., Nagakura,T., Terada,Y. and Ishizu,A.
    Cathepsin C inhibition reduces neutrophil serine protease activity and improves activated neutrophil-mediated disorders
    Nat Commun (2024) 15, 6519-6519. PubMed  Europe PubMed DOI  PMC  EPMC  I
  14. Wang,X., Jia,Y. and Wang,D.
    Cathepsin C Promotes Tumorigenesis in Bladder Cancer by Activating the Wnt/beta-catenin Signalling Pathway
    Front Biosci (Landmark Ed) (2024) 29, 327-327. PubMed  Europe PubMed DOI  K
  15. Yan,S.W., Cheng,Y.K., Lu,Q.Q., Zhang,R., Dan Liu,R., Long,S.R., Wang,Z.Q. and Cui,J.
    Characterization of a novel dipeptidyl peptidase 1 of Trichinella spiralis and its participation in larval invasion
    Acta Trop (2024) 249, 107076-107076. PubMed  Europe PubMed DOI
  16. Yu,J., Fu,Y., Gao,J., Zhang,Q., Zhang,N., Zhang,Z., Jiang,X., Chen,C. and Wen,Z.
    Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury
    Redox Biol (2024) 74, 103231-103231. PubMed  Europe PubMed DOI
    17. 2023
  17. Chalmers,J.D., Gupta,A., Chotirmall,S.H., Armstrong,A., Eickholz,P., Hasegawa,N., McShane,P.J., O'Donnell,A.E., Shteinberg,M., Watz,H., Eleftheraki,A., Diefenbach,C. and Sauter,W.
    A Phase 2 randomised study to establish efficacy, safety and dosing of a novel oral cathepsin C inhibitor, BI 1291583, in adults with bronchiectasis: Airleaf
    ERJ Open Res (2023) 9 PubMed  Europe PubMed DOI  PMC  EPMC  I
  18. Cipolla,D., Zhang,J., Korkmaz,B., Chalmers,J.D., Basso,J., Lasala,D., Fernandez,C., Teper,A., Mange,K.C., Perkins,W.R. and Sullivan,E.J.
    Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial
    Respir Res (2023) 24, 133-133. PubMed  Europe PubMed DOI  PMC  EPMC  V
  19. Kreideweiss,S., Schänzle,G., Schnapp,G., Vintonyak,V. and Grundl,M.A.
    BI 1291583: a novel selective inhibitor of cathepsin C with superior in vivo profile for the treatment of bronchiectasis
    Inflamm Res (2023) 72, 1709-1717. PubMed  Europe PubMed  I
  20. Stoka,V., Vasiljeva,O., Nakanishi,H. and Turk,V.
    The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  21. Tromsdorf,N., Ullrich,F.T.H., Rethmeier,M., Sommerhoff,C.P. and Schaschke,N.
    E-64c-Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1'-S2' Area
    ChemMedChem (2023) 18, e202300218-e202300218. PubMed  Europe PubMed DOI
    22. 2022
  22. Chen,X., Yan,Y., Du,J., Shen,X., He,C., Pan,H., Zhu,J. and Liu,X.
    Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo
    Eur J Med Chem (2022) 236, 114368-114368. PubMed  Europe PubMed DOI  I
    23. 2021
  23. Banerjee,A., Velagaleti,R., Patil,S., Pawar,M., Yadav,P., Kadam,P., Qadri,M.M., Chakraborti,S., Saini,J.S., Behera,D.B., Karanjai,K., Iyer,P.S., Gharat,L.A. and Das,S.
    Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy
    Bioorg Med Chem Lett (2021) 47, 128202-128202. PubMed  Europe PubMed DOI  I
  24. Chen,X., Yan,Y., Zhang,Z., Zhang,F., Liu,M., Du,L., Zhang,H., Shen,X., Zhao,D., Shi,J.B. and Liu,X.
    Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor
    J Med Chem (2021) 64, 11857-11885. PubMed  Europe PubMed DOI  I
  25. Ghanei,M., Abbaszadegan,M.R., Forghanifard,M.M., Aarabi,A. and Arab,H.
    A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome
    Clin Exp Dent Res (2021) PubMed  Europe PubMed DOI
  26. Korkmaz,B., Lamort,A.S., Domain,R., Beauvillain,C., Gieldon,A., Yildirim,A.O., Stathopoulos,G.T., Rhimi,M., Jenne,D.E. and Kettritz,R.
    Cathepsin C inhibition as a potential treatment strategy in cancer
    Biochem Pharmacol (2021) , 114803-114803. PubMed  Europe PubMed DOI  V
  27. Sanchez Klose,F.P., Bjornsdottir,H., Dahlstrand Rudin,A., Persson,T., Khamzeh,A., Sundqvist,M., Thorbert-Mros,S., Dieckmann,R., Christenson,K. and Bylund,J.
    A rare CTSC mutation in Papillon-Lefevre Syndrome results in abolished serine protease activity and reduced NET formation but otherwise normal neutrophil function
    PLoS ONE (2021) 16, e0261724-e0261724. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Shen,X.B., Chen,X., Zhang,Z.Y., Wu,F.F. and Liu,X.H.
    Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities
    Eur J Med Chem (2021) 225, 113818-113818. PubMed  Europe PubMed DOI  I
  29. Xiao,Y., Cong,M., Li,J., He,D., Wu,Q., Tian,P., Wang,Y., Yang,S., Liang,C., Liang,Y., Wen,J., Liu,Y., Luo,W., Lv,X., He,Y., Cheng,D.D., Zhou,T., Zhao,W., Zhang,P., Zhang,X., Xiao,Y., Qian,Y., Wang,H., Gao,Q., Yang,Q.C., Yang,Q. and Hu,G.
    Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation
    Cancer Cell (2021) 39, 423-437. PubMed  Europe PubMed DOI
  30. Yu,H., He,X., Liu,X., Zhang,H., Shen,Z., Shi,Y. and Liu,X.
    A novel missense variant in cathepsin C gene leads to PLS in a Chinese patient: A case report and literature review
    Mol Genet Genomic Med (2021) , e1686-e1686. PubMed  Europe PubMed DOI
    31. 2020
  31. Chalmers,J.D., Haworth,C.S., Metersky,M.L., Loebinger,M.R., Blasi,F., Sibila,O., O'Donnell,A.E., Sullivan,E.J., Mange,K.C., Fernandez,C., Zou,J. and Daley,C.L.
    Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis
    N Engl J Med (2020) PubMed  Europe PubMed DOI  I
  32. Khaket,T.P., Singh,M.P., Khan,I. and Kang,S.C.
    In vitro and in vivo studies on potentiation of curcumin-induced lysosomal-dependent apoptosis upon silencing of cathepsin C in colorectal cancer cells
    Pharmacol Res (2020) 161, 105156-105156. PubMed  Europe PubMed DOI  I
  33. Korkmaz,B., Lesner,A., Marchand-Adam,S., Moss,C. and Jenne,D.E.
    Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?
    J Med Chem (2020) PubMed  Europe PubMed DOI  PMC  EPMC
  34. Liu,Q.N., Kausar,S., Gul,I., Zhou,H.L., Abbas,M.N. and Dai,L.S.
    The red swamp crayfish, Procambarus clarkii cathepsin C, participates in the innate immune response to the viral and bacterial pathogens
    Fish Shellfish Immunol (2020) 100, 436-444. PubMed  Europe PubMed DOI
  35. Meenu,S., Pradeep,B., Ramalingam,S., Sairam,T., Rai,R. and Sankaran,R.
    Papillon-Lefevre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and Peptidase C1A domains of Cathepsin C gene
    Mol Biol Rep (2020) PubMed  Europe PubMed DOI
  36. Moura,A.L., Regateiro,F.S., Peres Resende,E., Coimbra Silva,H., Goncalo,M., Todo Bom,A. and Faria,E.
    A new terminal nonsense mutation of the cathepsin C gene in a patient with atypical Papillon-Lefevre Syndrome
    J Investig Allergol Clin Immunol (2020) 30, 151-153. PubMed  Europe PubMed DOI  M
  37. Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J.
    Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  38. Shawli,A., Almaghrabi,Y., AlQuhaibi,A.S., Alghamdi,Y. and Aboud,A.M.
    A mutation in cathepsin C gene causing Papillon-Lefevre syndrome in a Saudi patient: a case report
    Cureus (2020) 12, e6546-e6546. PubMed  Europe PubMed DOI  PMC  EPMC  M
    39. 2019
  39. Alam,S., Liu,Q., Liu,S., Liu,Y., Zhang,Y., Yang,X., Liu,G., Fan,K. and Ma,J.
    Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-kappaB pathway
    Exp Cell Res (2019) 382, 111472-111472. PubMed  Europe PubMed DOI
  40. Durose,W.W., Shimizu,T., Li,J., Abe,M., Sakimura,K., Chetsawang,B., Tanaka,K.F., Suzumura,A., Tohyama,K. and Ikenaka,K.
    Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
    J Neurochem (2019) 148, 413-425. PubMed  Europe PubMed DOI
  41. Hou,W., Sun,H., Ma,Y., Liu,C. and Zhang,Z.
    Identification and optimization of novel cathepsin C inhibitors derived from EGFR inhibitors
    J Med Chem (2019) 62, 5901-5919. PubMed  Europe PubMed DOI  I
  42. John,D.S., Aschenbach,J., Kruger,B., Sendler,M., Weiss,F.U., Mayerle,J., Lerch,M.M. and Aghdassi,A.A.
    Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin
    J Biol Chem (2019) 294, 697-707. PubMed  Europe PubMed DOI  K
  43. Lamort,A.S., Hamon,Y., Czaplewski,C., Gieldon,A., Seren,S., Coquet,L., Lecaille,F., Lesner,A., Lalmanach,G., Gauthier,F., Jenne,D. and Korkmaz,B.
    Processing and maturation of cathepsin C zymogen: a biochemical and molecular modeling analysis
    Int J Mol Sci (2019) 20 PubMed  Europe PubMed DOI  M
  44. Liu,Q., Zhang,Y., Liu,S., Liu,Y., Yang,X., Liu,G., Shimizu,T., Ikenaka,K., Fan,K. and Ma,J.
    Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca(2+)-dependent PKC/p38MAPK/NF-kappaB pathway
    J Neuroinflammation (2019) 16, 10-10. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Liu,Y.G., Teng,Y.S., Cheng,P., Kong,H., Lv,Y.P., Mao,F.Y., Wu,X.L., Hao,C.J., Chen,W., Yang,S.M., Zhang,J.Y., Peng,L.S., Wang,T.T., Han,B., Ma,Q., Zou,Q.M. and Zhuang,Y.
    Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection
    FASEB J (2019) 33, 5018-5033. PubMed  Europe PubMed DOI
  46. Machado,R.A., Cuadra-Zelaya,F.J.M., Martelli-Junior,H., Miranda,R.T., Casarin,R.C.V., Correa,M.G., Nociti,F. and Coletta,R.D.
    Clinical and molecular analysis in Papillon-Lefevre syndrome
    Am J Med Genet A (2019) 179, 2124-2131. PubMed  Europe PubMed DOI  M
  47. Molitor,A., Prud'homme,T., Miao,Z., Conrad,S., Bloch-Zupan,A., Pichot,A., Hanauer,A., Isidor,B., Bahram,S. and Carapito,R.
    Exome sequencing identifies a novel missense variant in CTSC causing nonsyndromic aggressive periodontitis
    J Hum Genet (2019) 64, 689-694. PubMed  Europe PubMed DOI  M
  48. Rebernik,M., Lenarcic,B. and Novinec,M.
    The catalytic domain of cathepsin C (dipeptidyl-peptidase I) alone is a fully functional endoprotease
    Protein Expr Purif (2019) 157, 21-27. PubMed  Europe PubMed DOI
  49. Rebernik,M., Snoj,T., Klemencic,M. and Novinec,M.
    Interplay between tetrameric structure, enzymatic activity and allosteric regulation of human dipeptidyl-peptidase I
    Arch Biochem Biophys (2019) 675, 108121-108121. PubMed  Europe PubMed DOI
  50. Rehm,S.R.T., Smirnova,N.F., Morrone,C., Gotzfried,J., Feuchtinger,A., Pedersen,J., Korkmaz,B., Yildirim,A.O. and Jenne,D.E.
    Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation
    Sci Rep (2019) 9, 9925-9925. PubMed  Europe PubMed DOI  PMC  EPMC  I
  51. Wei,S., Wang,S., Yang,M., Huang,Y., Wei,J., Huang,X. and Qin,Q.
    Characterization of cathepsin C from orange-spotted grouper, Epinephelus coioides involved in SGIV infection
    Fish Shellfish Immunol (2019) 84, 423-433. PubMed  Europe PubMed DOI
    52. 2018
  52. Bozic,J., Stoka,V. and Dolenc,I.
    Glucosamine prevents polarization of cytotoxic granules in NK-92 cells by disturbing FOXO1/ERK/paxillin phosphorylation
    PLoS ONE (2018) 13, e0200757-e0200757. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Khaket,T.P., Singh,M.P., Khan,I., Bhardwaj,M. and Kang,S.C.
    Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells
    Cell Signal (2018) 46, 92-102. PubMed  Europe PubMed DOI
  54. Korkmaz,B., Caughey,G.H., Chapple,I., Gauthier,F., Hirschfeld,J., Jenne,D.E., Kettritz,R., Lalmanach,G., Lamort,A.S., Lauritzen,C., Legowska,M., Lesner,A., Marchand-Adam,S., McKaig,S.J., Moss,C., Pedersen,J., Roberts,H., Schreiber,A., Seren,S. and Thakker,N.S.
    Therapeutic targeting of cathepsin C: from pathophysiology to treatment
    Pharmacol Ther (2018) 190, 202-236. PubMed  Europe PubMed DOI  T
  55. Palmer,R., Maenpaa,J., Jauhiainen,A., Larsson,B., Mo,J., Russell,M., Root,J., Prothon,S., Chialda,L., Forte,P., Egelrud,T., Stenvall,K. and Gardiner,P.
    Dipeptidyl peptidase 1 inhibitor AZD7986 induces a sustained, exposure-dependent reduction in neutrophil elastase activity in healthy subjects
    Clin Pharmacol Ther (2018) 104, 1155-1164. PubMed  Europe PubMed DOI  I
  56. Seren,S., Rashed Abouzaid,M., Eulenberg-Gustavus,C., Hirschfeld,J., Nasr Soliman,H., Jerke,U., N'Guessan,K., Dallet-Choisy,S., Lesner,A., Lauritzen,C., Schacher,B., Eickholz,P., Nagy,N., Szell,M., Croix,C., Viaud-Massuard,M.C., Al Farraj Aldosari,A., Ragunatha,S., Ibrahim Mostafa,M., Giampieri,F., Battino,M., Cornillier,H., Lorette,G., Stephan,J.L., Goizet,C., Pedersen,J., Gauthier,F., Jenne,D.E., Marchand-Adam,S., Chapple,I.L., Kettritz,R. and Korkmaz,B.
    Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
    J Biol Chem (2018) 293, 12415-12428. PubMed  Europe PubMed DOI
    57. 2017
  57. Chu,Y., Guo,Y., Walls,A.F. and Zhou,X.
    The regulatory role of dipeptidyl peptidase I on the activation of immune granulocytes
    Cell Biol Int (2017) 41, 1093-1102. PubMed  Europe PubMed DOI  I
  58. Gu,Y., Lewis,D.F., Alexander,J.S. and Wang,Y.
    Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia
    Hypertens Res (2017) 40, 976-981. PubMed  Europe PubMed DOI
  59. Guarino,C., Hamon,Y., Croix,C., Lamort,A.S., Dallet-Choisy,S., Marchand-Adam,S., Lesner,A., Baranek,T., Viaud-Massuard,M.C., Lauritzen,C., Pedersen,J., Heuze-Vourc'h,N., Si-Tahar,M., Firatli,E., Jenne,D.E., Gauthier,F., Horwitz,M.S., Borregaard,N. and Korkmaz,B.
    Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
    Biochem Pharmacol (2017) 131, 52-67. PubMed  Europe PubMed DOI  I
  60. Lenartowicz,P., Makowski,M., Oszywa,B., Haremza,K., Latajka,R., Pawelczak,M. and Kafarski,P.
    Addition of thiols to the double bond of dipeptide C-terminal dehydroalanine as a source of new inhibitors of cathepsin C
    Biochimie (2017) 139, 46-55. PubMed  Europe PubMed DOI  I
  61. Liu,X., Wang,J., Chu,Y. and Zhou,X.
    Serum based fluorescent assay for evaluating dipeptidyl peptidase I activity in collagen induced arthritis rat model
    Mol Cell Probes (2017) 32, 5-12. PubMed  Europe PubMed DOI  A
  62. Shimizu,T., Wisessmith,W., Li,J., Abe,M., Sakimura,K., Chetsawang,B., Sahara,Y., Tohyama,K., Tanaka,K.F. and Ikenaka,K.
    The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model
    Glia (2017) 65, 917-930. PubMed  Europe PubMed DOI
    63. 2016
  63. Doyle,K., Lönn,H., Käck,H., Van,d., Swallow,S., Gardiner,P., Connolly,S., Root,J., Wikell,C., Dahl,G., Stenvall,K. and Johannesson,P.
    Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)
    J Med Chem (2016) 59, 9457-9472. PubMed  Europe PubMed DOI  I
  64. Legowska,M., Hamon,Y., Wojtysiak,A., Grzywa,R., Sienczyk,M., Burster,T., Korkmaz,B. and Lesner,A.
    Development of the first internally-quenched fluorescent substrates of human cathepsin C: the application in the enzyme detection in biological samples
    Arch Biochem Biophys (2016) 612, 91-102. PubMed  Europe PubMed DOI  A  P
  65. Li,X., Jia,L.-F., Zheng,Y., Huang,Y., Qin,M. and Yang,Y.
    Loss of cathepsin C enhances keratinocyte proliferation and inhibits apoptosis
    Sci Bull (Beijing) (2016) 61, 1107-1114. DOI  K  M
  66. Liang,J., Li,N., Zhang,Y., Hou,C., Yang,X., Shimizu,T., Wang,X., Ikenaka,K., Fan,K. and Ma,J.
    Disinhibition of cathepsin C caused by cystatin F deficiency aggravates the demyelination in a cuprizone model
    Front Mol Neurosci (2016) 9, 152-152. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Szczesniak,P., Pieczykolan,M. and Stecko,S.
    The synthesis of alpha,alpha-disubstituted alpha-amino acids via Ichikawa rearrangement
    J Org Chem (2016) 81, 1057-1074. PubMed  Europe PubMed DOI  I
    68. 2015
  68. Alkhiary,Y.M., Jelani,M., Almramhi,M.M., Mohamoud,H.S.A., Al-Rehaili,R., Al-Zahrani,H.S., Serafi,R., Yang,H. and Al-Aama,J.Y.
    Whole-exome sequencing reveals a recurrent mutation in the cathepsin C gene that causes Papillon-Lefevre syndrome in a Saudi family
    Saudi J Biol Sci (2015) 23, 571-576. PubMed  Europe PubMed DOI  M
  69. Bragg,R.A., Brocklehurst,S., Gustafsson,F., Goodman,J., Hickling,K., Macfaul,P.A., Swallow,S. and Tugwood,J.
    Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation
    Chem Res Toxicol (2015) 28, 1991-1999. PubMed  Europe PubMed DOI  I
  70. Herias,V., Biessen,E.A., Beckers,C., Delsing,D., Liao,M., Daemen,M.J., Pham,C.C. and Heeneman,S.
    Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses
    Arterioscler Thromb Vasc Biol (2015) 35, 79-86. PubMed  Europe PubMed DOI  K
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