Literature for peptidase C01.070: dipeptidyl-peptidase I

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Kazmierczak,M., Bilska-Markowska,M., Wisniewska,K., Pawelczak,M., Nowak,D. and Hoffmann,M. Design, Synthesis, and Biological Activity of (E)-alpha-Fluorovinylphosphonate-Based Reversible Cathepsin C Inhibitors J Org Chem (2026) 91, 3218-3231. PubMed Europe PubMed DOI
Shi,D., Liu,X., Huang,J., Li,C., Chen,Q., Zhou,F. and Chen,X. Design and anti-inflammatory activity evaluation of tryptophan analogs as novel dipeptidyl peptidase I inhibitors Eur J Med Chem (2026) 306, 118570-118570. PubMed Europe PubMed DOI

2025

Aljabali,A.A.A., Obeid,M.A., Gammoh,O., Alshaer,W., Qnais,E., Alqudah,A., Mishra,V., Mishra,Y. and El-Tanani,M. Cathepsin C: a critical mediator between immune response and cardiovascular disease - therapeutic implications of enzyme inhibition Drug Dev Ind Pharm (2025) , 1-26. PubMed Europe PubMed DOI
Elias,R.D., O'Neill,R.T., Demiralp,I.I., Allen,S., Serwas,D., Siems,H., Montabana,E.A., Ash,C., Yacoubian,D.A., Lederberg,O.L., Cravatt,B.F., Agard,D.A. and Kelly,J.W. Cathepsin C-Catalyzed Ligation Generates Intralysosomal Amyloid Fibrils from Dipeptide Esters bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Lu,F., Lei,H., Xiao,X. and Yu,L. Unraveling the gut microbiota-SCFAs-cathepsin C pathway in preeclampsia: a novel therapeutic target Front Immunol (2025) 16, 1700781-1700781. PubMed Europe PubMed DOI PMC EPMC
Pytelkova,J., Orsaghova,K., Benova,M., Horn,M., Schabussova,I. and Mares,M. Allergenic mites excrete cathepsins B and C as active cysteine proteases distinct from group 1 allergens Int J Biol Macromol (2025) 331, 148383-148383. PubMed Europe PubMed DOI
Zhang,D., Zhang,W., Hu,P. and Zhang,W. Dipeptidyl peptidase 1 inhibitors for inflammatory respiratory diseases: mechanisms, clinical trials, and therapeutic prospects Front Pharmacol (2025) 16, 1656316-1656316. PubMed Europe PubMed DOI PMC EPMC I
Zhou,F.L., Zhang,Y., Chang,C., Shi,D.X., Chen,X., Liu,X.H. and Shen,X.B. Identification of Marrubiin as a Cathepsin C Inhibitor for Treating Rheumatoid Arthritis Molecules (2025) 30 PubMed Europe PubMed DOI PMC EPMC I

2024

Aghdassi,A.A., Pham,C., Zierke,L., Mariaule,V., Korkmaz,B. and Rhimi,M. Cathepsin C role in inflammatory gastroenterological, renal, rheumatic, and pulmonary disorders Biochimie (2024) 216, 175-180. PubMed Europe PubMed DOI V
Chitsamankhun,C., Siritongtaworn,N., Fournier,B.P.J., Sriwattanapong,K., Theerapanon,T., Samaranayake,L. and Porntaveetus,T. Cathepsin C in health and disease: from structural insights to therapeutic prospects J Transl Med (2024) 22, 777-777. PubMed Europe PubMed DOI PMC EPMC V
Domain,R., Seren,S., Jerke,U., Makridakis,M., Chen,K.J., Zoidakis,J., Rhimi,M., Zhang,X., Bonvent,T., Croix,C., Gonzalez,L., Li,D., Basso,J., Paget,C., Viaud-Massuard,M.C., Lalmanach,G., Shi,G.P., Aghdassi,A., Vlahou,A., McDonald,P.P., Couillin,I., Williams,R., Kettritz,R. and Korkmaz,B. Pharmacological inhibition of cathepsin S and of NSPs-AAP-1 (a novel, alternative protease driving the activation of neutrophil serine proteases) Biochem Pharmacol (2024) 229, 116114-116114. PubMed Europe PubMed DOI
Mandal,M., Pires,D., Calado,M., Azevedo-Pereira,J.M. and Anes,E. Cystatin F Depletion in Mycobacterium tuberculosis-Infected Macrophages Improves Cathepsin C/Granzyme B-Driven Cytotoxic Effects on HIV-Infected Cells during Coinfection Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC
Nishibata,Y., Arai,S., Taniguchi,M., Nakade,I., Ogawa,H., Kitano,S., Hosoi,Y., Shindo,A., Nishiyama,R., Masuda,S., Nakazawa,D., Tomaru,U., Shimizu,T., Sinko,W., Nagakura,T., Terada,Y. and Ishizu,A. Cathepsin C inhibition reduces neutrophil serine protease activity and improves activated neutrophil-mediated disorders Nat Commun (2024) 15, 6519-6519. PubMed Europe PubMed DOI PMC EPMC I
Wang,X., Jia,Y. and Wang,D. Cathepsin C Promotes Tumorigenesis in Bladder Cancer by Activating the Wnt/beta-catenin Signalling Pathway Front Biosci (Landmark Ed) (2024) 29, 327-327. PubMed Europe PubMed DOI K
Yan,S.W., Cheng,Y.K., Lu,Q.Q., Zhang,R., Dan Liu,R., Long,S.R., Wang,Z.Q. and Cui,J. Characterization of a novel dipeptidyl peptidase 1 of Trichinella spiralis and its participation in larval invasion Acta Trop (2024) 249, 107076-107076. PubMed Europe PubMed DOI
Yu,J., Fu,Y., Gao,J., Zhang,Q., Zhang,N., Zhang,Z., Jiang,X., Chen,C. and Wen,Z. Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury Redox Biol (2024) 74, 103231-103231. PubMed Europe PubMed DOI

2023

Chalmers,J.D., Gupta,A., Chotirmall,S.H., Armstrong,A., Eickholz,P., Hasegawa,N., McShane,P.J., O'Donnell,A.E., Shteinberg,M., Watz,H., Eleftheraki,A., Diefenbach,C. and Sauter,W. A Phase 2 randomised study to establish efficacy, safety and dosing of a novel oral cathepsin C inhibitor, BI 1291583, in adults with bronchiectasis: Airleaf ERJ Open Res (2023) 9 PubMed Europe PubMed DOI PMC EPMC I
Cipolla,D., Zhang,J., Korkmaz,B., Chalmers,J.D., Basso,J., Lasala,D., Fernandez,C., Teper,A., Mange,K.C., Perkins,W.R. and Sullivan,E.J. Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial Respir Res (2023) 24, 133-133. PubMed Europe PubMed DOI PMC EPMC V
Kreideweiss,S., Schänzle,G., Schnapp,G., Vintonyak,V. and Grundl,M.A. BI 1291583: a novel selective inhibitor of cathepsin C with superior in vivo profile for the treatment of bronchiectasis Inflamm Res (2023) 72, 1709-1717. PubMed Europe PubMed I
Stoka,V., Vasiljeva,O., Nakanishi,H. and Turk,V. The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Tromsdorf,N., Ullrich,F.T.H., Rethmeier,M., Sommerhoff,C.P. and Schaschke,N. E-64c-Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1'-S2' Area ChemMedChem (2023) 18, e202300218-e202300218. PubMed Europe PubMed DOI

2022

Chen,X., Yan,Y., Du,J., Shen,X., He,C., Pan,H., Zhu,J. and Liu,X. Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo Eur J Med Chem (2022) 236, 114368-114368. PubMed Europe PubMed DOI I

2021

Banerjee,A., Velagaleti,R., Patil,S., Pawar,M., Yadav,P., Kadam,P., Qadri,M.M., Chakraborti,S., Saini,J.S., Behera,D.B., Karanjai,K., Iyer,P.S., Gharat,L.A. and Das,S. Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy Bioorg Med Chem Lett (2021) 47, 128202-128202. PubMed Europe PubMed DOI I
Chen,X., Yan,Y., Zhang,Z., Zhang,F., Liu,M., Du,L., Zhang,H., Shen,X., Zhao,D., Shi,J.B. and Liu,X. Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor J Med Chem (2021) 64, 11857-11885. PubMed Europe PubMed DOI I
Ghanei,M., Abbaszadegan,M.R., Forghanifard,M.M., Aarabi,A. and Arab,H. A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome Clin Exp Dent Res (2021) PubMed Europe PubMed DOI
Korkmaz,B., Lamort,A.S., Domain,R., Beauvillain,C., Gieldon,A., Yildirim,A.O., Stathopoulos,G.T., Rhimi,M., Jenne,D.E. and Kettritz,R. Cathepsin C inhibition as a potential treatment strategy in cancer Biochem Pharmacol (2021) , 114803-114803. PubMed Europe PubMed DOI V
Sanchez Klose,F.P., Bjornsdottir,H., Dahlstrand Rudin,A., Persson,T., Khamzeh,A., Sundqvist,M., Thorbert-Mros,S., Dieckmann,R., Christenson,K. and Bylund,J. A rare CTSC mutation in Papillon-Lefevre Syndrome results in abolished serine protease activity and reduced NET formation but otherwise normal neutrophil function PLoS ONE (2021) 16, e0261724-e0261724. PubMed Europe PubMed DOI PMC EPMC
Shen,X.B., Chen,X., Zhang,Z.Y., Wu,F.F. and Liu,X.H. Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities Eur J Med Chem (2021) 225, 113818-113818. PubMed Europe PubMed DOI I
Xiao,Y., Cong,M., Li,J., He,D., Wu,Q., Tian,P., Wang,Y., Yang,S., Liang,C., Liang,Y., Wen,J., Liu,Y., Luo,W., Lv,X., He,Y., Cheng,D.D., Zhou,T., Zhao,W., Zhang,P., Zhang,X., Xiao,Y., Qian,Y., Wang,H., Gao,Q., Yang,Q.C., Yang,Q. and Hu,G. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation Cancer Cell (2021) 39, 423-437. PubMed Europe PubMed DOI
Yu,H., He,X., Liu,X., Zhang,H., Shen,Z., Shi,Y. and Liu,X. A novel missense variant in cathepsin C gene leads to PLS in a Chinese patient: A case report and literature review Mol Genet Genomic Med (2021) , e1686-e1686. PubMed Europe PubMed DOI

2020

Chalmers,J.D., Haworth,C.S., Metersky,M.L., Loebinger,M.R., Blasi,F., Sibila,O., O'Donnell,A.E., Sullivan,E.J., Mange,K.C., Fernandez,C., Zou,J. and Daley,C.L. Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis N Engl J Med (2020) PubMed Europe PubMed DOI I
Khaket,T.P., Singh,M.P., Khan,I. and Kang,S.C. In vitro and in vivo studies on potentiation of curcumin-induced lysosomal-dependent apoptosis upon silencing of cathepsin C in colorectal cancer cells Pharmacol Res (2020) 161, 105156-105156. PubMed Europe PubMed DOI I
Korkmaz,B., Lesner,A., Marchand-Adam,S., Moss,C. and Jenne,D.E. Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS? J Med Chem (2020) PubMed Europe PubMed DOI PMC EPMC
Liu,Q.N., Kausar,S., Gul,I., Zhou,H.L., Abbas,M.N. and Dai,L.S. The red swamp crayfish, Procambarus clarkii cathepsin C, participates in the innate immune response to the viral and bacterial pathogens Fish Shellfish Immunol (2020) 100, 436-444. PubMed Europe PubMed DOI
Meenu,S., Pradeep,B., Ramalingam,S., Sairam,T., Rai,R. and Sankaran,R. Papillon-Lefevre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and Peptidase C1A domains of Cathepsin C gene Mol Biol Rep (2020) PubMed Europe PubMed DOI
Moura,A.L., Regateiro,F.S., Peres Resende,E., Coimbra Silva,H., Goncalo,M., Todo Bom,A. and Faria,E. A new terminal nonsense mutation of the cathepsin C gene in a patient with atypical Papillon-Lefevre Syndrome J Investig Allergol Clin Immunol (2020) 30, 151-153. PubMed Europe PubMed DOI M
Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J. Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity Cancers (Basel) (2020) 12 PubMed Europe PubMed DOI PMC EPMC
Shawli,A., Almaghrabi,Y., AlQuhaibi,A.S., Alghamdi,Y. and Aboud,A.M. A mutation in cathepsin C gene causing Papillon-Lefevre syndrome in a Saudi patient: a case report Cureus (2020) 12, e6546-e6546. PubMed Europe PubMed DOI PMC EPMC M

2019

Alam,S., Liu,Q., Liu,S., Liu,Y., Zhang,Y., Yang,X., Liu,G., Fan,K. and Ma,J. Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-kappaB pathway Exp Cell Res (2019) 382, 111472-111472. PubMed Europe PubMed DOI
Durose,W.W., Shimizu,T., Li,J., Abe,M., Sakimura,K., Chetsawang,B., Tanaka,K.F., Suzumura,A., Tohyama,K. and Ikenaka,K. Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis J Neurochem (2019) 148, 413-425. PubMed Europe PubMed DOI
Hou,W., Sun,H., Ma,Y., Liu,C. and Zhang,Z. Identification and optimization of novel cathepsin C inhibitors derived from EGFR inhibitors J Med Chem (2019) 62, 5901-5919. PubMed Europe PubMed DOI I
John,D.S., Aschenbach,J., Kruger,B., Sendler,M., Weiss,F.U., Mayerle,J., Lerch,M.M. and Aghdassi,A.A. Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin J Biol Chem (2019) 294, 697-707. PubMed Europe PubMed DOI K
Lamort,A.S., Hamon,Y., Czaplewski,C., Gieldon,A., Seren,S., Coquet,L., Lecaille,F., Lesner,A., Lalmanach,G., Gauthier,F., Jenne,D. and Korkmaz,B. Processing and maturation of cathepsin C zymogen: a biochemical and molecular modeling analysis Int J Mol Sci (2019) 20 PubMed Europe PubMed DOI M
Liu,Q., Zhang,Y., Liu,S., Liu,Y., Yang,X., Liu,G., Shimizu,T., Ikenaka,K., Fan,K. and Ma,J. Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca(2+)-dependent PKC/p38MAPK/NF-kappaB pathway J Neuroinflammation (2019) 16, 10-10. PubMed Europe PubMed DOI PMC EPMC
Liu,Y.G., Teng,Y.S., Cheng,P., Kong,H., Lv,Y.P., Mao,F.Y., Wu,X.L., Hao,C.J., Chen,W., Yang,S.M., Zhang,J.Y., Peng,L.S., Wang,T.T., Han,B., Ma,Q., Zou,Q.M. and Zhuang,Y. Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection FASEB J (2019) 33, 5018-5033. PubMed Europe PubMed DOI
Machado,R.A., Cuadra-Zelaya,F.J.M., Martelli-Junior,H., Miranda,R.T., Casarin,R.C.V., Correa,M.G., Nociti,F. and Coletta,R.D. Clinical and molecular analysis in Papillon-Lefevre syndrome Am J Med Genet A (2019) 179, 2124-2131. PubMed Europe PubMed DOI M
Molitor,A., Prud'homme,T., Miao,Z., Conrad,S., Bloch-Zupan,A., Pichot,A., Hanauer,A., Isidor,B., Bahram,S. and Carapito,R. Exome sequencing identifies a novel missense variant in CTSC causing nonsyndromic aggressive periodontitis J Hum Genet (2019) 64, 689-694. PubMed Europe PubMed DOI M
Rebernik,M., Lenarcic,B. and Novinec,M. The catalytic domain of cathepsin C (dipeptidyl-peptidase I) alone is a fully functional endoprotease Protein Expr Purif (2019) 157, 21-27. PubMed Europe PubMed DOI
Rebernik,M., Snoj,T., Klemencic,M. and Novinec,M. Interplay between tetrameric structure, enzymatic activity and allosteric regulation of human dipeptidyl-peptidase I Arch Biochem Biophys (2019) 675, 108121-108121. PubMed Europe PubMed DOI
Rehm,S.R.T., Smirnova,N.F., Morrone,C., Gotzfried,J., Feuchtinger,A., Pedersen,J., Korkmaz,B., Yildirim,A.O. and Jenne,D.E. Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation Sci Rep (2019) 9, 9925-9925. PubMed Europe PubMed DOI PMC EPMC I
Wei,S., Wang,S., Yang,M., Huang,Y., Wei,J., Huang,X. and Qin,Q. Characterization of cathepsin C from orange-spotted grouper, Epinephelus coioides involved in SGIV infection Fish Shellfish Immunol (2019) 84, 423-433. PubMed Europe PubMed DOI

2018

Bozic,J., Stoka,V. and Dolenc,I. Glucosamine prevents polarization of cytotoxic granules in NK-92 cells by disturbing FOXO1/ERK/paxillin phosphorylation PLoS ONE (2018) 13, e0200757-e0200757. PubMed Europe PubMed DOI PMC EPMC
Khaket,T.P., Singh,M.P., Khan,I., Bhardwaj,M. and Kang,S.C. Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells Cell Signal (2018) 46, 92-102. PubMed Europe PubMed DOI
Korkmaz,B., Caughey,G.H., Chapple,I., Gauthier,F., Hirschfeld,J., Jenne,D.E., Kettritz,R., Lalmanach,G., Lamort,A.S., Lauritzen,C., Legowska,M., Lesner,A., Marchand-Adam,S., McKaig,S.J., Moss,C., Pedersen,J., Roberts,H., Schreiber,A., Seren,S. and Thakker,N.S. Therapeutic targeting of cathepsin C: from pathophysiology to treatment Pharmacol Ther (2018) 190, 202-236. PubMed Europe PubMed DOI T
Palmer,R., Maenpaa,J., Jauhiainen,A., Larsson,B., Mo,J., Russell,M., Root,J., Prothon,S., Chialda,L., Forte,P., Egelrud,T., Stenvall,K. and Gardiner,P. Dipeptidyl peptidase 1 inhibitor AZD7986 induces a sustained, exposure-dependent reduction in neutrophil elastase activity in healthy subjects Clin Pharmacol Ther (2018) 104, 1155-1164. PubMed Europe PubMed DOI I
Seren,S., Rashed Abouzaid,M., Eulenberg-Gustavus,C., Hirschfeld,J., Nasr Soliman,H., Jerke,U., N'Guessan,K., Dallet-Choisy,S., Lesner,A., Lauritzen,C., Schacher,B., Eickholz,P., Nagy,N., Szell,M., Croix,C., Viaud-Massuard,M.C., Al Farraj Aldosari,A., Ragunatha,S., Ibrahim Mostafa,M., Giampieri,F., Battino,M., Cornillier,H., Lorette,G., Stephan,J.L., Goizet,C., Pedersen,J., Gauthier,F., Jenne,D.E., Marchand-Adam,S., Chapple,I.L., Kettritz,R. and Korkmaz,B. Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis J Biol Chem (2018) 293, 12415-12428. PubMed Europe PubMed DOI

2017

Chu,Y., Guo,Y., Walls,A.F. and Zhou,X. The regulatory role of dipeptidyl peptidase I on the activation of immune granulocytes Cell Biol Int (2017) 41, 1093-1102. PubMed Europe PubMed DOI I
Gu,Y., Lewis,D.F., Alexander,J.S. and Wang,Y. Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia Hypertens Res (2017) 40, 976-981. PubMed Europe PubMed DOI
Guarino,C., Hamon,Y., Croix,C., Lamort,A.S., Dallet-Choisy,S., Marchand-Adam,S., Lesner,A., Baranek,T., Viaud-Massuard,M.C., Lauritzen,C., Pedersen,J., Heuze-Vourc'h,N., Si-Tahar,M., Firatli,E., Jenne,D.E., Gauthier,F., Horwitz,M.S., Borregaard,N. and Korkmaz,B. Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases Biochem Pharmacol (2017) 131, 52-67. PubMed Europe PubMed DOI I
Lenartowicz,P., Makowski,M., Oszywa,B., Haremza,K., Latajka,R., Pawelczak,M. and Kafarski,P. Addition of thiols to the double bond of dipeptide C-terminal dehydroalanine as a source of new inhibitors of cathepsin C Biochimie (2017) 139, 46-55. PubMed Europe PubMed DOI I
Liu,X., Wang,J., Chu,Y. and Zhou,X. Serum based fluorescent assay for evaluating dipeptidyl peptidase I activity in collagen induced arthritis rat model Mol Cell Probes (2017) 32, 5-12. PubMed Europe PubMed DOI A
Shimizu,T., Wisessmith,W., Li,J., Abe,M., Sakimura,K., Chetsawang,B., Sahara,Y., Tohyama,K., Tanaka,K.F. and Ikenaka,K. The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model Glia (2017) 65, 917-930. PubMed Europe PubMed DOI

2016

Doyle,K., Lönn,H., Käck,H., Van,d., Swallow,S., Gardiner,P., Connolly,S., Root,J., Wikell,C., Dahl,G., Stenvall,K. and Johannesson,P. Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986) J Med Chem (2016) 59, 9457-9472. PubMed Europe PubMed DOI I
Legowska,M., Hamon,Y., Wojtysiak,A., Grzywa,R., Sienczyk,M., Burster,T., Korkmaz,B. and Lesner,A. Development of the first internally-quenched fluorescent substrates of human cathepsin C: the application in the enzyme detection in biological samples Arch Biochem Biophys (2016) 612, 91-102. PubMed Europe PubMed DOI A P
Li,X., Jia,L.-F., Zheng,Y., Huang,Y., Qin,M. and Yang,Y. Loss of cathepsin C enhances keratinocyte proliferation and inhibits apoptosis Sci Bull (Beijing) (2016) 61, 1107-1114. DOI K M
Liang,J., Li,N., Zhang,Y., Hou,C., Yang,X., Shimizu,T., Wang,X., Ikenaka,K., Fan,K. and Ma,J. Disinhibition of cathepsin C caused by cystatin F deficiency aggravates the demyelination in a cuprizone model Front Mol Neurosci (2016) 9, 152-152. PubMed Europe PubMed DOI PMC EPMC
Szczesniak,P., Pieczykolan,M. and Stecko,S. The synthesis of alpha,alpha-disubstituted alpha-amino acids via Ichikawa rearrangement J Org Chem (2016) 81, 1057-1074. PubMed Europe PubMed DOI I

2015

Alkhiary,Y.M., Jelani,M., Almramhi,M.M., Mohamoud,H.S.A., Al-Rehaili,R., Al-Zahrani,H.S., Serafi,R., Yang,H. and Al-Aama,J.Y. Whole-exome sequencing reveals a recurrent mutation in the cathepsin C gene that causes Papillon-Lefevre syndrome in a Saudi family Saudi J Biol Sci (2015) 23, 571-576. PubMed Europe PubMed DOI M
Bragg,R.A., Brocklehurst,S., Gustafsson,F., Goodman,J., Hickling,K., Macfaul,P.A., Swallow,S. and Tugwood,J. Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation Chem Res Toxicol (2015) 28, 1991-1999. PubMed Europe PubMed DOI I
Herias,V., Biessen,E.A., Beckers,C., Delsing,D., Liao,M., Daemen,M.J., Pham,C.C. and Heeneman,S. Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses Arterioscler Thromb Vasc Biol (2015) 35, 79-86. PubMed Europe PubMed DOI K
Kumar,S., Briguglio,J.S. and Turkewitz,A.P. Secretion of polypeptide crystals from Tetrahymena thermophila secretory organelles (mucocysts) depends on processing by a cysteine cathepsin, Cth4p Eukaryot Cell (2015) 14, 817-833. PubMed Europe PubMed DOI
Makowski,M., Lenartowicz,P., Oszywa,B., Jewginski,M., Pawelczak,M. and Kafarski,P. Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C Med Chem Res (2015) 24, 3157-3165. PubMed Europe PubMed DOI I
Ragunatha,S., Ramesh,M., Anupama,P., Kapoor,M. and Bhat,M. Papillon-Lefevre syndrome with homozygous nonsense mutation of cathepsin C gene presenting with late-onset periodontitis Pediatr Dermatol (2015) 32, 292-294. PubMed Europe PubMed DOI M
Soliman,H., Eldeen,H.G. and Mustafa,M.I. A novel nonsense mutation in cathepsin C gene in an Egyptian patient presenting with Papillon-Lefevre syndrome Egypt J Med Hum Genet (2015) 16, 387-392. DOI M

2014

Aswath,N., Swamikannu,B., Ramakrishnan,S.N., Shanmugam,R., Thomas,J. and Ramanathan,A. Heterozygous Ile453Val codon mutation in exon 7, homozygous single nucleotide polymorphisms in intron 2 and 5 of cathepsin C are associated with Haim-Munk syndrome Eur J Dent (2014) 8, 79-84. PubMed Europe PubMed DOI M
Furber,M., Tiden,A.K., Gardiner,P., Mete,A., Ford,R., Millichip,I., Stein,L., Mather,A., Kinchin,E., Luckhurst,C., Barber,S., Cage,P., Sanganee,H., Austin,R., Chohan,K., Beri,R., Thong,B., Wallace,A., Oreffo,V., Hutchinson,R., Harper,S., Debreczeni,J., Breed,J., Wissler,L. and Edman,K. Cathepsin C inhibitors: property optimization and identification of a clinical candidate J Med Chem (2014) 57, 2357-2367. PubMed Europe PubMed DOI I
Liang,P., He,L., Xu,Y., Chen,X., Huang,Y., Ren,M., Liang,C., Li,X., Xu,J., Lu,G. and Yu,X. Identification, immunolocalization, and characterization analyses of an exopeptidase of papain superfamily, (cathepsin C) from Clonorchis sinensis Parasitol Res (2014) 113, 3621-3629. PubMed Europe PubMed DOI
Moghaddasian,M., Arab,H., Dadkhah,E., Boostani,H., Babak,A.R. and Abbaszadegan,M.R. Protein modeling of cathepsin C mutations found in Papillon-Lefevre syndrome Gene (2014) 538, 182-187. PubMed Europe PubMed DOI M
Poreba,M., Mihelic,M., Krai,P., Rajkovic,J., Krezel,A., Pawelczak,M., Klemba,M., Turk,D., Turk,B., Latajka,R. and Drag,M. Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C Amino Acids (2014) 46, 931-943. PubMed Europe PubMed DOI A P
Sorensen,O.E., Clemmensen,S.N., Dahl,S.L., Ostergaard,O., Heegaard,N.H., Glenthoj,A., Nielsen,F.C. and Borregaard,N. Papillon-Lefevre syndrome patient reveals species-dependent requirements for neutrophil defenses J Clin Invest (2014) 124, 4539-4548. PubMed Europe PubMed DOI M
Sutherland,R.E., Barry,S.S., Olsen,J.S., Salantes,D.B., Caughey,G.H. and Wolters,P.J. Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D Biochem Biophys Res Commun (2014) 450, 818-823. PubMed Europe PubMed DOI K

2013

Drag,M., Wieczerzak,E., Pawelczak,M., Berlicki,L., Grzonka,Z. and Kafarski,P. Toward very potent, non-covalent organophosphonate inhibitors of cathepsin C and related enzymes by 2-amino-1-hydroxy-alkanephosphonates dipeptides Biochimie (2013) 95, 1640-1649. PubMed Europe PubMed DOI I
Radzey,H., Rethmeier,M., Klimpel,D., Grundhuber,M., Sommerhoff,C.P. and Schaschke,N. E-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors ChemMedChem (2013) 8, 1314-1321. PubMed Europe PubMed DOI I
Romero-Quintana,J.G., Frias-Castro,L.O., Arambula-Meraz,E., Aguilar-Medina,M., Duenas-Arias,J.E., Melchor-Soto,J.D., Romero-Navarro,J.G. and Ramos-Payan,R. Identification of novel mutation in cathepsin C gene causing Papillon-Lefevre Syndrome in Mexican patients BMC Med Genet (2013) 14, 7-7. PubMed Europe PubMed DOI M

2012

Kono,H., Orlowski,G.M., Patel,Z. and Rock,K.L. The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C J Immunol (2012) 189, 3734-3740. PubMed Europe PubMed DOI K
Kosem,R., Debeljak,M., Repic Lampret,B., Kansky,A., Battelino,T. and Trebusak Podkrajsek,K. Cathepsin C gene 5'-untranslated region mutation in Papillon-Lefevre syndrome Dermatology (2012) 225, 193-203. PubMed Europe PubMed DOI M
Rubach,J.K., Cui,G., Schneck,J.L., Taylor,A.N., Zhao,B., Smallwood,A., Nevins,N., Wisnoski,D., Thrall,S.H. and Meek,T.D. The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis Biochemistry (2012) 51, 7551-7568. PubMed Europe PubMed DOI P
Suban,D., Zajc,T., Renko,M., Turk,B., Turk,V. and Dolenc,I. Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin Biochimie (2012) 94, 719-726. PubMed Europe PubMed DOI
Turk,B., Turk,D., Dolenc,I. and Turk,V. Dipeptidyl-peptidase I [ISSN:978-0-12-407743-0] (2012) 3, 1968-1974. DOI
Wang,S., Shi,L.J., Liu,N., Chen,A.J., Zhao,X.F. and Wang,J.X. Involvement of Fenneropenaeus chinensis cathepsin C in antiviral immunity Fish Shellfish Immunol (2012) 33, 821-828. PubMed Europe PubMed DOI
Wen,X., Wang,X. and Duan,X. High immunoglobulin E in a Chinese Papillon-Lefevre syndrome patient with novel compound mutations of cathepsin C J Dermatol (2012) 39, 664-665. PubMed Europe PubMed DOI M

2011

Andoniou,C.E., Fleming,P., Sutton,V.R., Trapani,J.A. and Degli-Esposti,M.A. Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function Immunol Cell Biol (2011) 89, 540-548. PubMed Europe PubMed DOI K
Laine,D., Palovich,M., McCleland,B., Petitjean,E., Delhom,I., Xie,H., Deng,J., Lin,G., Davis,R., Jolit,A., Nevins,N., Zhao,B., Villa,J., Schneck,J., McDevitt,P., Midgett,R., Kmett,C., Umbrecht,S., Peck,B., Davis,A.B. and Bettoun,D. Discovery of novel cyanamide-based inhibitors of cathepsin C ACS Med Chem Lett (2011) 2, 142-147. PubMed Europe PubMed DOI I
Le,Q.T., Min,H.K., Xia,H.Z., Fukuoka,Y., Katunuma,N. and Schwartz,L.B. Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C J Immunol (2011) 186, 7136-7143. PubMed Europe PubMed DOI
Rosenthal,P.J. Falcipains and other cysteine proteases of malaria parasites Adv Exp Med Biol (2011) 712, 30-48. PubMed Europe PubMed DOI
Thong,B., Pilling,J., Ainscow,E., Beri,R. and Unitt,J. Development and validation of a simple cell-based fluorescence assay for dipeptidyl peptidase 1 (DPP1) activity J Biomol Screen (2011) 16, 36-43. PubMed Europe PubMed DOI A
Yishan,L., Shitian,L., Zaohe,W. and Jichang,J. Molecular cloning and mRNA expression of cathepsin C in white shrimp, Litopenaeus vannamei Aquac Res (2011) 42, 1569-1576. DOI

2010

D'Angelo,M.E., Bird,P.I., Peters,C., Reinheckel,T., Trapani,J.A. and Sutton,V.R. Cathepsin H is an additional convertase of pro-granzyme B J Biol Chem (2010) 285, 20514-20519. PubMed Europe PubMed DOI
Frizler,M., Stirnberg,M., Sisay,M.T. and Gutschow,M. Development of nitrile-based peptidic inhibitors of cysteine cathepsins Curr Top Med Chem (2010) 10, 294-322. PubMed Europe PubMed DOI T I
Guay,D., Beaulieu,C. and Percival,M.D. Therapeutic utility and medicinal chemistry of cathepsin C inhibitors Curr Top Med Chem (2010) 10, 708-716. PubMed Europe PubMed DOI V I
Kuo,W.H. and Chase,H.A. Adsorptive detagging of poly-histidine tagged protein using hexa-histidine tagged exopeptidase J Chromatogr A (2010) 1217, 7749-7758. PubMed Europe PubMed DOI
Kurban,M., Cheng,T., Wajid,M., Kiuru,M., Shimomura,Y. and Christiano,A.M. A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome J Eur Acad Dermatol Venereol (2010) 24, 967-969. PubMed Europe PubMed DOI M
Laine,D.I. and Busch-Petersen,J. Inhibitors of cathepsin C (dipeptidyl peptidase I) Expert Opin Ther Pat (2010) 20, 497-506. PubMed Europe PubMed DOI V I
Li,W.W., Jin,X.K., He,L., Jiang,H., Xie,Y.N. and Wang,Q. Molecular cloning, characterization and expression analysis of cathepsin C gene involved in the antibacterial response in Chinese mitten crab, Eriocheir sinensis Dev Comp Immunol (2010) 34, 1170-1174. PubMed Europe PubMed DOI
Pahwa,P., Lamba,A.K., Faraz,F. and Tandon,S. Haim-Munk syndrome J Indian Soc Periodontol (2010) 14, 201-203. PubMed Europe PubMed DOI PMC EPMC M
Pallos,D., Acevedo,A.C., Mestrinho,H.D., Cordeiro,I. and Hart,T.C. Novel cathepsin C mutation in a Brazilian family with Papillon-Lefevre syndrome: case report and mutation update J Dent Child (Chic) (2010) 77, 36-41. PubMed Europe PubMed M
Rai,R., Thiagarajan,S., Mohandas,S., Natarajan,K., Shanmuga Sekar,C. and Ramalingam,S. Haim Munk syndrome and Papillon Lefevre syndrome - allelic mutations in cathepsin C with variation in phenotype Int J Dermatol (2010) 49, 541-543. PubMed Europe PubMed DOI M

2009

Guay,D., Beaulieu,C., Jagadeeswar Reddy,T., Zamboni,R., Methot,N., Rubin,J., Ethier,D. and Percival,M.D. Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C Bioorg Med Chem Lett (2009) 19, 5392-5396. PubMed Europe PubMed DOI I
Kurban,M., Wajid,M., Shimomura,Y., Bahhady,R., Kibbi,A.G. and Christiano,A.M. Evidence for a founder mutation in the cathepsin C gene in three families with Papillon-Lefevre syndrome Dermatology (2009) 219, 289-294. PubMed Europe PubMed DOI M
Li,J., Petrassi,H.M., Tumanut,C., Masick,B.T., Trussell,C. and Harris,J.L. Substrate optimization for monitoring cathepsin C activity in live cells Bioorg Med Chem (2009) 17, 1064-1070. PubMed Europe PubMed DOI L
Ochiai,T., Nakano,H., Rokunohe,D., Akasaka,E., Toyomaki,Y., Mitsuhashi,Y. and Sawamura,D. Novel p.M1T and recurrent p.G301S mutations in cathepsin C in a Japanese patient with Papillon-Lefevre syndrome: implications for understanding the genotype/phenotype relationship J Dermatol Sci (2009) 53, 73-75. PubMed Europe PubMed DOI M
Qiu,G.F., Feng,H.Y. and Yamano,K. Expression and purification of active recombinant cathepsin C (dipeptidyl aminopeptidase I) of kuruma prawn Marsupenaeus japonicus in insect cells J Biomed Biotechnol (2009) 2009, 746289-746289. PubMed Europe PubMed DOI PMC EPMC E

2008

Akk,A.M., Simmons,P.M., Chan,H.W., Agapov,E., Holtzman,M.J., Grayson,M.H. and Pham,C.T. Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to sendai virus infection J Immunol (2008) 180, 3535-3542. PubMed Europe PubMed PMC EPMC
Hamilton,G., Colbert,J.D., Schuettelkopf,A.W. and Watts,C. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis EMBO J (2008) 27, 499-508. PubMed Europe PubMed DOI PMC EPMC
Janjua,S.A., Iftikhar,N., Hussain,I. and Khachemoune,A. Dermatologic, periodontal, and skeletal manifestations of Haim-Munk syndrome in two siblings J Am Acad Dermatol (2008) 58, 339-344. PubMed Europe PubMed DOI M V
Kim,K.H., Pham,C.T., Sleat,D.E. and Lobel,P. Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis Biochem J (2008) 415, 225-232. PubMed Europe PubMed DOI K
Latajka,R., Jewginski,M., Makowski,M., Pawelczak,M., Huber,T., Sewald,N. and Kafarski,P. Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C J Pept Sci (2008) 14, 1084-1095. PubMed Europe PubMed DOI I
Methot,N., Guay,D., Rubin,J., Ethier,D., Ortega,K., Wong,S., Normandin,D., Beaulieu,C., Reddy,T.J., Riendeau,D. and Percival,M.D. In vivo inhibition of serine protease processing requires a high fractional inhibition of cathepsin C Mol Pharmacol (2008) 73, 1857-1865. PubMed Europe PubMed DOI T I
Noack,B., Gorgens,H., Schacher,B., Puklo,M., Eickholz,P., Hoffmann,T. and Schackert,H.K. Functional cathepsin C mutations cause different Papillon-Lefevre syndrome phenotypes J Clin Periodontol (2008) 35, 311-316. PubMed Europe PubMed DOI M
Noack,B., Gorgens,H., Hempel,U., Fanghanel,J., Hoffmann,T., Ziegler,A. and Schackert,H.K. Cathepsin C gene variants in aggressive periodontitis J Dent Res (2008) 87, 958-963. PubMed Europe PubMed DOI M
Qiu,L., Jiang,S., Huang,J., Wang,W., Zhang,D., Wu,Q. and Yang,K. Molecular cloning and mRNA expression of cathepsin C gene in black tiger shrimp (Penaeus monodon) Comp Biochem Physiol A Mol Integr Physiol (2008) 150, 320-325. PubMed Europe PubMed DOI
Schneck,J.L., Villa,J.P., McDevitt,P., McQueney,M.S., Thrall,S.H. and Meek,T.D. Chemical mechanism of a cysteine protease, cathepsin C, as revealed by integration of both steady-state and pre-steady-state solvent kinetic isotope effects Biochemistry (2008) 47, 8697-8710. PubMed Europe PubMed DOI

2007

Methot,N., Rubin,J., Guay,D., Beaulieu,C., Ethier,D., Reddy,T.J., Riendeau,D. and Percival,M.D. Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing J Biol Chem (2007) 282, 20836-20846. PubMed Europe PubMed DOI I
Molgaard,A., Arnau,J., Lauritzen,C., Larsen,S., Petersen,G. and Pedersen,J. The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2 Biochem J (2007) 401, 645-650. PubMed Europe PubMed DOI PMC EPMC S I
Pagano,M.B., Bartoli,M.A., Ennis,T.L., Mao,D., Simmons,P.M., Thompson,R.W. and Pham,C.T. Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms Proc Natl Acad Sci U S A (2007) 104, 2855-2860. PubMed Europe PubMed DOI PMC EPMC K
Yang,Y., Bai,X., Liu,H., Li,L., Cao,C. and Ge,L. Novel mutations of cathepsin C gene in two Chinese patients with Papillon-Lefevre syndrome J Dent Res (2007) 86, 735-738. PubMed Europe PubMed DOI M

2006

[YEAR:26-4-2006]Bondebjerg,J., Fuglsang,H., Valeur,K.R., Pedersen,J. and Naerum,L. Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors Bioorg Med Chem Lett (26-4-2006) 16, 3614-3617. PubMed Europe PubMed DOI I
Mallen-St Clair,J., Shi,G.P., Sutherland,R.E., Chapman,H.A., Caughey,G.H. and Wolters,P.J. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice Biol Chem (2006) 387, 1143-1146. PubMed Europe PubMed DOI PMC EPMC
[YEAR:12-1-2006]Meade,J.L., de Wynter,E.A., Brett,P., Sharif,S.M., Woods,C.G., Markham,A.F. and Cook,G.P. A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity Blood (12-1-2006) 107, 3665-3668. PubMed Europe PubMed DOI M
Wani,A.A., Devkar,N., Patole,M.S. and Shouche,Y.S. Description of two new cathepsin C gene mutations in patients with Papillon-Lefevre syndrome J Periodontol (2006) 77, 233-237. PubMed Europe PubMed DOI M
Yang,Y., Bai,X.W., Liu,H.S., Cao,C.F. and Ge,L.H. [Novel mutations of cathepsin C gene in two Chinese patients with Papillon-Lefevre syndrome] Zhonghua Kou Qiang Yi Xue Za Zhi (2006) 41, 602-605. PubMed Europe PubMed M
[YEAR:3-5-2006]Yuan,F., Verhelst,S.H., Blum,G., Coussens,L.M. and Bogyo,M. A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C J Am Chem Soc (3-5-2006) 128, 5616-5617. PubMed Europe PubMed DOI I

2005

[YEAR:11-5-2005]Bondebjerg,J., Fuglsang,H., Valeur,K.R., Kaznelson,D.W., Hansen,J.A., Pedersen,R.O., Krogh,B.O., Jensen,B.S., Lauritzen,C., Petersen,G., Pedersen,J. and Naerum,L. Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI) Bioorg Med Chem (11-5-2005) 13, 4408-4424. PubMed Europe PubMed DOI I
Cury,V.F., Gomez,R.S., Costa,J.E., Friedman,E., Boson,W. and De Marco,L. A homozygous cathepsin C mutation associated with Haim-Munk syndrome Br J Dermatol (2005) 152, 353-356. PubMed Europe PubMed DOI M
[YEAR:25-6-2005]Hsiung,H.M., Smiley,D.L., Zhang,X.Y., Zhang,L., Yan,L.Z., Craft,L., Heiman,M.L. and Smith,D.P. Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human beta-MSH(5-22) by dipeptidyl peptidase I and dipeptidyl peptidase IV Peptides (25-6-2005) 26, 1988-1996. PubMed Europe PubMed DOI
Hu,Y. and Pham,C.T. Dipeptidyl peptidase I regulates the development of collagen-induced arthritis Arthritis Rheum (2005) 52, 2553-2558. PubMed Europe PubMed DOI
Nitta,H., Wara-Aswapati,N., Lertsirivorakul,J., Nakamura,T., Yamamoto,M., Izumi,Y., Nakamura,T. and Ishikawa,I. A novel mutation of the cathepsin C gene in a Thai family with Papillon-Lefevre syndrome J Periodontol (2005) 76, 492-496. PubMed Europe PubMed DOI
Qiu,G.F., Yamano,K. and Unuma,T. Cathepsin C transcripts are differentially expressed in the final stages of oocyte maturation in kuruma prawn Marsupenaeus japonicus Comp Biochem Physiol B Biochem Mol Biol (2005) 140, 171-181. PubMed Europe PubMed DOI

2004

de Haar,S.F., Jansen,D.C., Schoenmaker,T., De Vree,H., Everts,V. and Beertsen,W. Loss-of-function mutations in cathepsin C in two families with Papillon-Lefevre syndrome are associated with deficiency of serine proteinases in PMNs Hum Mutat (2004) 23, 524-524. PubMed Europe PubMed DOI
Hewitt,C., McCormick,D., Linden,G., Turk,D., Stern,I., Wallace,I., Southern,L., Zhang,L., Howard,R., Bullon,P., Wong,M., Widmer,R., Gaffar,K.A., Awawdeh,L., Briggs,J., Yaghmai,R., Jabs,E.W., Hoeger,P., Bleck,O., Rudiger,S.G., Petersilka,G., Battino,M., Brett,P., Hattab,F., Al-Hamed,M., Sloan,P., Toomes,C., Dixon,M., James,J., Read,A.P. and Thakker,N. The role of cathepsin C in Papillon-Lefevre syndrome, prepubertal periodontitis, and aggressive periodontitis Hum Mutat (2004) 23, 222-228. PubMed Europe PubMed DOI
Kam,C.M., Gotz,M.G., Koot,G., McGuire,M., Thiele,D., Hudig,D. and Powers,J.C. Design and evaluation of inhibitors for dipeptidyl peptidase I (cathepsin C) Arch Biochem Biophys (2004) 427, 123-134. PubMed Europe PubMed DOI I
Lidar,M., Zlotogorski,A., Langevitz,P., Tweezer-Zaks,N. and Zandman-Goddard,G. Destructive arthritis in a patient with Haim-Munk syndrome J Rheumatol (2004) 31, 814-817. PubMed Europe PubMed
Mallen-St Clair,J., Pham,C.T., Villalta,S.A., Caughey,G.H. and Wolters,P.J. Mast cell dipeptidyl peptidase I mediates survival from sepsis J Clin Invest (2004) 113, 628-634. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:21-6-2004]Mucha,A., Pawel,M., Hurek,J. and Kafarski,P. Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin C Bioorg Med Chem Lett (21-6-2004) 14, 3113-3116. PubMed Europe PubMed DOI I
Noack,B., Gorgens,H., Hoffmann,T., Fanghanel,J., Kocher,T., Eickholz,P. and Schackert,H.K. Novel mutations in the cathepsin C gene in patients with pre-pubertal aggressive periodontitis and Papillon-Lefevre syndrome J Dent Res (2004) 83, 368-370. PubMed Europe PubMed
[YEAR:15-12-2004]Pham,C.T., Ivanovich,J.L., Raptis,S.Z., Zehnbauer,B. and Ley,T.J. Papillon-Lefevre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans J Immunol (15-12-2004) 173, 7277-7281. PubMed Europe PubMed M
Turk,B., Turk,D., Dolenc,I. and Turk,V. Dipeptidyl-peptidase I [ISSN:0-12-079610-4] (2004) 2, 1192-1196. V

2003

Henningsson,F., Wolters,P., Chapman,H.A., Caughey,G.H. and Pejler,G. Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5 Biol Chem (2003) 384, 1527-1531. PubMed Europe PubMed DOI
[YEAR:1-12-2003]Sheth,P.D., Pedersen,J., Walls,A.F. and McEuen,A.R. Inhibition of dipeptidyl peptidase I in the human mast cell line HMC-1: blocked activation of tryptase, but not of the predominant chymotryptic activity Biochem Pharmacol (1-12-2003) 66, 2251-2262. PubMed Europe PubMed DOI I

2002

Adkison,A.M., Raptis,S.Z., Kelley,D.G. and Pham,C.T. Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis J Clin Invest (2002) 109, 363-371. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:30-8-2002]Bidere,N., Briet,M., Durrbach,A., Dumont,C., Feldmann,J., Charpentier,B., de Saint-Basile,G. and Senik,A. Selective inhibition of dipeptidyl peptidase I, not caspases, prevents the partial processing of procaspase-3 in CD3-activated human CD8(+) T lymphocytes J Biol Chem (30-8-2002) 277, 32339-32347. PubMed Europe PubMed DOI
Cury,V.F., Costa,J.E., Gomez,R.S., Boson,W.L., Loures,C.G. and De,M.L. A novel mutation of the cathepsin C gene in Papillon-Lefevre syndrome J Periodontol (2002) 73, 307-312. PubMed Europe PubMed DOI
Horn,M., Baudys,M., Voburka,Z., Kluh,I., Vondrasek,J. and Mares,M. Free-thiol Cys331 exposed during activation process is critical for native tetramer structure of cathepsin C (dipeptidyl peptidase I) Protein Sci (2002) 11, 933-943. PubMed Europe PubMed DOI PMC EPMC
Komeda,T., Tazumi,K., Shimada,H., Kano,K., Hayashi,T., Saito,H., Tsumura,H., Kato,N., Sakai,Y. and Kondo,K. Production of active bovine cathepsin C (dipeptidyl aminopeptidase I) in the methylotrophic yeast Candida boidinii Appl Microbiol Biotechnol (2002) 59, 252-258. PubMed Europe PubMed DOI E
[YEAR:26-6-2002]Matsui,K., Yuyama,N., Akaiwa,M., Yoshida,N.L., Maeda,M., Sugita,Y. and Izuhara,K. Identification of an alternative splicing variant of cathepsin C/dipeptidyl-peptidase I Gene (26-6-2002) 293, 1-7. PubMed Europe PubMed DOI R
[YEAR:15-7-2002]Tran,T.V., Ellis,K.A., Kam,C.M., Hudig,D. and Powers,J.C. Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity Arch Biochem Biophys (15-7-2002) 403, 160-170. PubMed Europe PubMed DOI

2001

Allende,L.M., Garcia-Perez,M.A., Moreno,A., Corell,A., Carasol,M., Martinez-Canut,P. and Arnaiz-Villena,A. Cathepsin C gene: first compound heterozygous patient with Papillon-Lefevre syndrome and a novel symptomless mutation Hum Mutat (2001) 17, 152-153. PubMed Europe PubMed DOI M
[YEAR:13-2-2001]Dahl,S.W., Halkier,T., Lauritzen,C., Dolenc,I., Pedersen,J., Turk,V. and Turk,B. Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing Biochemistry (13-2-2001) 40, 1671-1678. PubMed Europe PubMed DOI E
Korver,G.E., Kam,C.M., Powers,J.C. and Hudig,D. Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I Int Immunopharmacol (2001) 1, 21-32. PubMed Europe PubMed DOI I
Nakano,A., Nomura,K., Nakano,H., Ono,Y., LaForgia,S., Pulkkinen,L., Hashimoto,I. and Uitto,J. Papillon-Lefevre syndrome: mutations and polymorphisms in the cathepsin C gene J Invest Dermatol (2001) 116, 339-343. PubMed Europe PubMed DOI M
[YEAR:12-10-2001]Olsen,J.G., Kadziola,A., Lauritzen,C., Pedersen,J., Larsen,S. and Dahl,S.W. Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain FEBS Lett (12-10-2001) 506, 201-206. PubMed Europe PubMed DOI S
[YEAR:3-12-2001]Turk,D., Janjic,V., Stern,I., Podobnik,M., Lamba,D., Dahl,S.W., Lauritzen,C., Pedersen,J., Turk,V. and Turk,B. Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases EMBO J (3-12-2001) 20, 6570-6582. PubMed Europe PubMed DOI PMC EPMC S
[YEAR:25-5-2001]Wolters,P.J., Pham,C.T., Muilenburg,D.J., Ley,T.J. and Caughey,G.H. Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice J Biol Chem (25-5-2001) 276, 18551-18556. PubMed Europe PubMed DOI
Zhang,Y., Lundgren,T., Renvert,S., Tatakis,D.N., Firatli,E., Uygur,C., Hart,P.S., Gorry,M.C., Marks,J.J. and Hart,T.C. Evidence of a founder effect for four cathepsin C gene mutations in Papillon-Lefevre syndrome patients J Med Genet (2001) 38, 96-101. PubMed Europe PubMed PMC EPMC M

2000

[YEAR:10-10-2000]Cigic,B., Dahl,S.W. and Pain,R.H. The residual pro-part of cathepsin C fulfills the criteria required for an intramolecular chaperone in folding and stabilizing the human proenzyme Biochemistry (10-10-2000) 39, 12382-12390. PubMed Europe PubMed DOI
Hart,P.S., Zhang,Y., Firatli,E., Uygur,C., Lotfazar,M., Michalec,M.D., Marks,J.J., Lu,X., Coates,B.J., Seow,W.K., MarshaIl,R., Williams,D., Reed,J.B., Wright,J.T. and Hart,T.C. Identification of cathepsin C mutations in ethnically diverse Papillon-Lefevre syndrome patients J Med Genet (2000) 37, 927-932. PubMed Europe PubMed PMC EPMC K
Hart,T.C., Hart,P.S., Michalec,M.D., Zhang,Y., Marazita,M.L., Cooper,M., Yassin,O.M., Nusier,M. and Walker,S. Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation J Med Genet (2000) 37, 95-101. PubMed Europe PubMed PMC EPMC
Hola-Jamriska,L., King,L.T., Dalton,J.P., Mann,V.H., Aaskov,J.G. and Brindley,P.J. Functional expression of dipeptidyl peptidase I (cathepsin C) of the oriental blood fluke Schistosoma japonicum in Trichoplusia ni insect cells Protein Expr Purif (2000) 19, 384-392. PubMed Europe PubMed DOI E
Horn,M., Pavlik,M., Doleckova,L., Baudys,M. and Mares,M. Arginine-based structures are specific inhibitors of cathepsin C. Application of peptide combinatorial libraries Eur J Biochem (2000) 267, 3330-3336. PubMed Europe PubMed DOI I
Sentandreu,M.A. and Toldra,F. Purification and biochemical properties of dipeptidyl peptidase I from porcine skeletal muscle J Agric Food Chem (2000) 48, 5014-5022. PubMed Europe PubMed DOI
[YEAR:1-8-2000]Tseng,C.C., Tseng,C.P., Levine,M.J. and Bobek,L.A. Differential effect toward inhibition of papain and cathepsin C by recombinant human salivary cystatin SN and its variants produced by a baculovirus system Arch Biochem Biophys (1-8-2000) 380, 133-140. PubMed Europe PubMed DOI
Wolters,P.J., Laig-Webster,M. and Caughey,G.H. Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways Am J Respir Cell Mol Biol (2000) 22, 183-190. PubMed Europe PubMed DOI

1999

Hart,T.C., Hart,P.S., Bowden,D.W., Michalec,M.D., Callison,S.A., Walker,S.J., Zhang,Y. and Firatli,E. Mutations of the cathepsin C gene are responsible for Papillon-Lefevre syndrome J Med Genet (1999) 36, 881-887. PubMed Europe PubMed PMC EPMC K
Hola-Jamriska,L., Dalton,J.P., Aaskov,J. and Brindley,P.J. Dipeptidyl peptidase I and III activities of adult schistosomes Parasitology (1999) 118, 275-282. PubMed Europe PubMed DOI
[YEAR:13-4-1999]Nagler,D.K., Tam,W., Storer,A.C., Krupa,J.C., Mort,J.S. and Menard,R. Interdependency of sequence and positional specificities for cysteine proteases of the papain family Biochemistry (13-4-1999) 38, 4868-4874. PubMed Europe PubMed DOI
[YEAR:20-7-1999]Pham,C.T. and Ley,T.J. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo Proc Natl Acad Sci U S A (20-7-1999) 96, 8627-8632. PubMed Europe PubMed DOI PMC EPMC
Toomes,C., James,J., Wood,A.J., Wu,C.L., McCormick,D., Lench,N., Hewitt,C., Moynihan,L., Roberts,E., Woods,C.G., Markham,A., Wong,M., Widmer,R., Ghaffar,K.A., Pemberton,M., Hussein,I.R., Temtamy,S.A., Davies,R., Read,A.P., Sloan,P., Dixon,M.J. and Thakker,N.S. Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis Nat Genet (1999) 23, 421-424. PubMed Europe PubMed DOI K

1998

[YEAR:1-8-1998]Hola-Jamriska,L., Tort,J.F., Dalton,J.P., Day,S.R., Fan,J., Aaskov,J. and Brindley,P.J. Cathepsin C from Schistosoma japonicum - cDNA encoding the preproenzyme and its phylogenetic relationships Eur J Biochem (1-8-1998) 255, 527-534. PubMed Europe PubMed DOI
Lauritzen,C., Pedersen,J., Madsen,M.T., Justesen,J., Martensen,P.M. and Dahl,S.W. Active recombinant rat dipeptidyl aminopeptidase I (cathepsin C) produced using the baculovirus expression system Protein Expr Purif (1998) 14, 434-442. PubMed Europe PubMed DOI E
[YEAR:15-6-1998]Mabee,C.L., McGuire,M.J. and Thiele,D.L. Dipeptidyl peptidase I and granzyme A are coordinately expressed during CD8+ T cell development and differentiation J Immunol (15-6-1998) 160, 5880-5885. PubMed Europe PubMed
[YEAR:16-1-1998]Pham,C.T., Thomas,D.A., Mercer,J.D. and Ley,T.J. Production of fully active recombinant murine granzyme B in yeast J Biol Chem (16-1-1998) 273, 1629-1633. PubMed Europe PubMed DOI E I
[YEAR:19-6-1998]Wolters,P.J., Raymond,W.W., Blount,J.L. and Caughey,G.H. Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I J Biol Chem (19-6-1998) 273, 15514-15520. PubMed Europe PubMed DOI

1997

McGuire,M.J., Lipsky,P.E. and Thiele,D.L. Cloning and characterization of the cDNA encoding mouse dipeptidyl peptidase I (cathepsin C) Biochim Biophys Acta (1997) 1351, 267-273. PubMed Europe PubMed DOI
Pham,C.T., Armstrong,R.J., Zimonjic,D.B., Popescu,N.C., Payan,D.G. and Ley,T.J. Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase I J Biol Chem (1997) 272, 10695-10703. PubMed Europe PubMed DOI
Rao,N.V., Rao,G.V. and Hoidal,J.R. Human dipeptidyl-peptidase I. Gene characterization, localization, and expression J Biol Chem (1997) 272, 10260-10265. PubMed Europe PubMed DOI
Thiele,D.L., McGuire,M.J. and Lipsky,P.E. A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8+ T cell cytotoxic effector function J Immunol (1997) 158, 5200-5210. PubMed Europe PubMed I

1996

Dolenc,I., Turk,B., Kos,J. and Turk,V. Interaction of human cathepsin C with chicken cystatin FEBS Lett (1996) 392, 277-280. PubMed Europe PubMed DOI
Kummer,J.A., Kamp,A.M., Citarella,F., Horrevoets,A.J. and Hack,C.E. Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C J Biol Chem (1996) 271, 9281-9286. PubMed Europe PubMed DOI

1995

Paris,A., Strukelj,B., Pungercar,J., Renko,M., Dolenc,I. and Turk,V. Molecular cloning and sequence analysis of human preprocathepsin C FEBS Lett (1995) 369, 326-330. PubMed Europe PubMed DOI

1994

[YEAR:15-7-1994]Nauland,U. and Rijken,D.C. Activation of thrombin-inactivated single-chain urokinase-type plasminogen activator by dipeptidyl peptidase I (cathepsin C) Eur J Biochem (15-7-1994) 223, 497-501. PubMed Europe PubMed DOI

1993

McGuire,M.J., Lipsky,P.E. and Thiele,D.L. Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I J Biol Chem (1993) 268, 2458-2467. PubMed Europe PubMed
Muno,D., Ishidoh,K., Ueno,T. and Kominami,E. Processing and transport of the precursor of cathepsin C during its transfer into lysosomes Arch Biochem Biophys (1993) 306, 103-110. PubMed Europe PubMed DOI
Pal,S., Raghav,N., Kamboj,R.C. and Singh,H. Dipeptidyl peptidase I from goat brain: purification, characterization and its action on Leu-enkephalin Neurochem Int (1993) 22, 59-68. PubMed Europe PubMed DOI

1992

McGuire,M.J., Lipsky,P.E. and Thiele,D.L. Purification and characterization of dipeptidyl peptidase I from human spleen Arch Biochem Biophys (1992) 295, 280-288. PubMed Europe PubMed DOI
Nikawa,T., Towatari,T. and Katunuma,N. Purification and characterization of cathepsin J from rat liver Eur J Biochem (1992) 204, 381-393. PubMed Europe PubMed I

1990

Thiele,D.L. and Lipsky,P.E. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells Proc Natl Acad Sci U S A (1990) 87, 83-87. PubMed Europe PubMed DOI PMC EPMC

1989

[YEAR:15-8-1989]Angliker,H., Wikstrom,P., Kirschke,H. and Shaw,E. The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagents Biochem J (15-8-1989) 262, 63-68. PubMed Europe PubMed PMC EPMC I

1988

[YEAR:15-12-1988]D'Agrosa,R.M. and Callahan,J.W. In vitro activation of neuraminidase in the beta-galactosidase-neuraminidase-protective protein complex by cathepsin C Biochem Biophys Res Commun (15-12-1988) 157, 770-775. PubMed Europe PubMed
[YEAR:16-6-1988]Lynch,G.W. and Pfueller,S.L. Thrombin-independent activation of platelet factor XIII by endogenous platelet acid protease Thromb Haemost (16-6-1988) 59, 372-377. PubMed Europe PubMed

1986

Thompson,S.A., Andrews,P.R. and Hanzlik,R.P. Carboxyl-modified amino acids and peptides as protease inhibitors J Med Chem (1986) 29, 104-111. PubMed Europe PubMed I

1984

Nicklin,M.J. and Barrett,A.J. Inhibition of cysteine proteinases and dipeptidyl peptidase I by egg-white cystatin Biochem J (1984) 223, 245-253. PubMed Europe PubMed PMC EPMC

1983

Paszkowski,A., Singh,H. and Kalnitsky,G. Properties of dipeptidyl peptidase I from rabbit (Oryctolagus cuniculus) lungs Acta Biochim Pol (1983) 30, 363-380. PubMed Europe PubMed

1978

[YEAR:12-10-1978]Metrione,R.M. Chromatography of dipeptidyl aminopeptidase I on inhibitor-Sepharose columns Biochim Biophys Acta (12-10-1978) 526, 531-536. PubMed Europe PubMed

1977

McDonald,J.K. and Schwabe,C. Intracellular exopeptidases (1977) , 311-391.

1975

Keilova,H. and Tomasek,V. Inhibition of cathepsin C by papain inhibitor from chicken egg white and by complex of this inhibitor with cathepsin B1 Collect Czech Chem Commun (1975) 40, 218-224.
[YEAR:2-12-1975]Metrione,R.M. and MacGeorge,N.L. The mechanism of action of dipeptidyl aminopeptidase. Inhibition by amino acid derivatives and amines; activation by aromatic compounds Biochemistry (2-12-1975) 14, 5249-5252. PubMed Europe PubMed I

1974

[YEAR:10-1-1974]McDonald,J.K., Zeitman,B.B., Callahan,P.X. and Ellis,S. Angiotensinase activity of dipeptidyl aminopeptidase I (cathepsin C) of rat liver J Biol Chem (10-1-1974) 249, 234-240. PubMed Europe PubMed

1973

[YEAR:1-11-1973]Caprioli,R.M., Seifert,W.E., Jr. and Sutherland,D.E. Polypeptide sequencing: use of dipeptidylaminopeptidase I and gas chromatography-mass spectrometry Biochem Biophys Res Commun (1-11-1973) 55, 67-75. PubMed Europe PubMed

1972

[YEAR:13-7-1972]Calam,D.H. and Thomas,H.J. Water-insoluble enzymes for peptide sequencing: dipeptidyl aminopeptidase I (cathepsin C), an enzyme with subunit structure Biochim Biophys Acta (13-7-1972) 276, 328-332. PubMed Europe PubMed
[YEAR:12-5-1972]Huang,F.L. and Tappel,A.L. Properties of cathepsin C from rat liver Biochim Biophys Acta (12-5-1972) 268, 527-538. PubMed Europe PubMed
Iodice,A.A., Chin,J., Perker,S. and Weinstock,I.M. Cathepsins A, B, C, D and autolysis during development of breast muscle of normal and dystrophic chickens Arch Biochem Biophys (1972) 152, 166-174. PubMed Europe PubMed
Lindley,H. The specificity of dipeptidyl aminopeptidase I (cathepsin C) and its use in peptide sequence studies Biochem J (1972) 126, 683-685. PubMed Europe PubMed PMC EPMC
McDonald,J.K., Callahan,P.X. and Ellis,S. Preparation and specificity of dipeptidyl aminopeptidase I Methods Enzymol (1972) 25, 272-281.
[YEAR:1-4-1972]Ovchinnikov,Y.A. and Kiryushkin,A.A. Determination of the amino acid sequence of peptides using dipeptidyl aminopeptidases FEBS Lett (1-4-1972) 21, 300-302. PubMed Europe PubMed

1970

[YEAR:18-3-1970]Gorter,J. and Gruber,M. Cathepsin C: an allosteric enzyme Biochim Biophys Acta (18-3-1970) 198, 546-555. PubMed Europe PubMed

1969

McDonald,J.K., Callahan,P.X., Zeitman,B.B. and Ellis,S. Inactivation and degradation of glucagon by dipeptidyl aminopeptidase I (cathepsin C) of rat liver J Biol Chem (1969) 244, 6199-6208. PubMed Europe PubMed
McDonald,J.K., Zeitman,B.B., Reilly,T.J. and Ellis,S. New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones J Biol Chem (1969) 244, 2693-2709. PubMed Europe PubMed

1968

Heinrich,C.P. and Fruton,J.S. The action of dipeptidyl transferase as a polymerase Biochemistry (1968) 7, 3556-3565. PubMed Europe PubMed
Hopsu-Havu,V.K. and Rintola,P. A sulphydryl-dependent and chloride-activated peptidase (cathepsin C) that hydrolyses alanyl-alanine naphthylamide Histochem J (1968) 1, 1-17. DOI
Voynick,I.M. and Fruton,J.S. The specificity of dipeptidyl transferase Biochemistry (1968) 7, 40-44. PubMed Europe PubMed

1966

McDonald,J.K., Reilly,T.J., Zeitman,B.B. and Ellis,S. Cathepsin C: a chloride-requiring enzyme Biochem Biophys Res Commun (1966) 22, 771-775. PubMed Europe PubMed
McDonald,J.K., Ellis,S. and Reilly,T.J. Properties of dipeptidyl arylamidase I of the pituitary. Chloride and sulfhydryl activation of seryltyrosyl-beta-naphthylamide hydrolysis J Biol Chem (1966) 241, 1494-1501. PubMed Europe PubMed
Metroione,R.M., Neves,A.G. and Fruton,J.S. Purification and properties of dipeptidyl transferase (cathepsin C) Biochemistry (1966) 5, 1597-1604. PubMed Europe PubMed

1965

McDonald,J.K., Reilly,T.J. and Ellis,S. A chloride-activated dipeptidyl-beta-naphthylamidase of the pituitary gland Life Sci (1965) 4, 1665-1668. PubMed Europe PubMed

1964

Nilsson,K.K. and Fruton,J.S. Polymerization reactions catalyzed by intracellular proteinases. IV. Factors influencing the polymerization of dipeptide amides by cathepsin C Biochemistry (1964) 3, 1220-1224. PubMed Europe PubMed
Planta,R.J., Gorter,J. and Gruber,M. The catalytic properties of cathepsin C Biochim Biophys Acta (1964) 89, 511-519. PubMed Europe PubMed
[YEAR:18-9-1964]Planta,R.J. and Gruber,M. CHROMATOGRAPHIC PURIFICATION OF THE THIOL ENZYME CATHEPSIN C Biochim Biophys Acta (18-9-1964) 89, 503-510. PubMed Europe PubMed

1963

Planta,R.J. and Gruber,M. A simple estimation of cathepsin C using a new chromogenic substrate Anal Biochem (1963) 5, 360-362. PubMed Europe PubMed A
[YEAR:13-12-1963]Purcell,G.M. and Barnhart,M.I. Prothrombin activation with cathepsin C Biochim Biophys Acta (13-12-1963) 78, 800-802. PubMed Europe PubMed

1962

Fruton,J.S. and Knappenberger,M.H. Polymerization reactions catalyzed by intracellular proteinases. III. Action of cathepsin C on a tetrapeptide amide Biochemistry (1962) 1, 674-676. PubMed Europe PubMed
Wurz,H., Tanaka,A. and Fruton,J.S. Polymerization of dipeptide amides by cathepsin C Biochemistry (1962) 1, 19-29. PubMed Europe PubMed

1961

[YEAR:28-10-1961]Planta,R.J. and Gruber,M. Specificity of cathepsin C Biochim Biophys Acta (28-10-1961) 53, 443-444. PubMed Europe PubMed P

1959

De la Haba,G., Cammarata,P.S. and Timasheff,S.N. The partial purification and some physical properties of cathepsin C from beef spleen J Biol Chem (1959) 234, 316-319. PubMed Europe PubMed

1958

Fujii,S. and Fruton,J.S. Transamidation reactions catalyzed by cathepsins J Biol Chem (1958) 230, 1-11. PubMed Europe PubMed

1956

Fruton,J.S. and Mycek,M.J. Studies on beef spleen cathepsin C Arch Biochem Biophys (1956) 65, 11-20. PubMed Europe PubMed
Izumiya,N. and Fruton,J.S. Specificity of cathepsin C J Biol Chem (1956) 218, 59-76. PubMed Europe PubMed

1955

De la Haba,G., Cammarata,P.S. and Fruton,J.S. [6] Cathepsin C from beef spleen Methods Enzymol (1955) 2, 64-68. DOI

1954

Wiggans,D.S., Winitz,M. and Fruton,J.S. Action of cathepsin C on dipeptide esters Yale J Biol Med (1954) 27, 11-19. PubMed Europe PubMed PMC EPMC

1953

Fruton,J.S., Hearn,W.R., Ingram,V.M., Wiggans,D.S. and Winitz,M. Synthesis of polymeric peptides in proteinase-catalyzed transamidation reactions J Biol Chem (1953) 204, 891-902. PubMed Europe PubMed

1952

Jones,M.E., Hearn,W.R., Fried,M. and Fruton,J.S. Transamidation reactions catalyzed by cathepsin C J Biol Chem (1952) 195, 645-656. PubMed Europe PubMed
Tallan,H.H., Jones,M.E. and Fruton,J.S. On the proteolytic enzymes of animal tissues. X. Beef spleen cathepsin C J Biol Chem (1952) 194, 793-805. PubMed Europe PubMed

1948

Gutmann,H.R. and Fruton,J.S. On the proteolytic enzymes of animal tissues. VII. An intracellular enzyme related to chymotrypsin J Biol Chem (1948) 174, 851-858. PubMed Europe PubMed

1941

Fruton,J.S., Irving,G.W., Jr. and Bergmann,M. On the proteolytic enzymes of animal tissues. III. The proteolytic enzymes of beef spleen, beef kidney and swine kidney. Classification of the cathepsins J Biol Chem (1941) 141, 763-774.