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Literature for peptidase C01.040: cathepsin H

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Mou,H., She,H., Zhang,C.J., Li,M., Wang,W., Sun,S.N., Zhang,X. and Jin,Z.B.
    Cathepsin H deficiency leads to myopic phenotype in mice
    Exp Eye Res258, 110447-110447. PubMed  Europe PubMed DOI
    2. 2024
  2. Deng,T., Lu,X., Jia,X., Du,J., Wang,L., Cao,B., Yang,M., Yin,Y. and Liu,F.
    Cathepsins and cancer risk: a Mendelian randomization study
    Front Endocrinol (Lausanne)15, 1428433-1428433. PubMed  Europe PubMed DOI
  3. Jangra,S., Raghav,N., Wadhwa,D., Kumar,A., Bhattacharyya,S., Kumar,V. and Sheokand,J.
    Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents
    J Biomater Sci Polym Ed1-19. PubMed  Europe PubMed DOI  I
    4. 2023
  4. Chen,Q., Qu,S., Liang,Z., Liu,Y., Chen,H., Ma,S. and Liu,X.
    Cathepsin H Knockdown Reverses Radioresistance of Hepatocellular Carcinoma via Metabolic Switch Followed by Apoptosis
    Int J Mol Sci24, PubMed  Europe PubMed DOI  K
  5. Stoka,V., Vasiljeva,O., Nakanishi,H. and Turk,V.
    The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  6. Wang,Y., Zhao,J., Gu,Y., Wang,H., Jiang,M., Zhao,S., Qing,H. and Ni,J.
    Cathepsin H: Molecular characteristics and clues to function and mechanism
    Biochem Pharmacol212, 115585-115585. PubMed  Europe PubMed DOI  V
    7. 2020
  7. Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J.
    Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity
    Cancers (Basel)12, PubMed  Europe PubMed DOI
  8. Singh,S., Sharma,S. and Agarwal,S.K.
    A simple purification procedure of buffalo lung cathepsin H, its properties and influence of buffer constituents on the enzyme activity
    Biochem Biophys Rep22, 100739-100739. PubMed  Europe PubMed DOI
    9. 2018
  9. Hao,Y., Purtha,W., Cortesio,C., Rui,H., Gu,Y., Chen,H., Sickmier,E.A., Manzanillo,P. and Huang,X.
    Crystal structures of human procathepsin H
    PLoS ONE13, e0200374-e0200374. PubMed  Europe PubMed DOI  S
  10. Okada,R., Zhang,X., Harada,Y., Wu,Z. and Nakanishi,H.
    Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade
    Inflamm Res67, 371-374. PubMed  Europe PubMed DOI  K
    11. 2017
  11. Naeem,A.S., Tommasi,C., Cole,C., Brown,S.J., Zhu,Y., Way,B., Willis Owen,S.A., Moffatt,M., Cookson,W.O., Harper,J.I., Di,W.L., Brown,S.J., Reinheckel,T. and O'Shaughnessy,R.F.
    A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin a novel mechanism for skin barrier disruption in patients with atopic dermatitis
    J Allergy Clin Immunol139, 1228-1241. PubMed  Europe PubMed DOI  K
  12. Qi,Z., Huang,B., Zhang,Q., Wang,Z., Wang,P. and Gao,Q.
    Molecular characterization, expression and evolutionary analysis of 3 cathepsin genes (CTSH, CTSL and CTSS) from Chinese giant salamander (Andrias davidianus)
    Gene Rep7, 25-31. DOI
    13. 2016
  13. Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J.
    Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones
    RSC Adv6, 34588-34599. DOI  I
    14. 2015
  14. Singh,M. and Raghav,N.
    2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H
    Bioorg Chem59C, 12-22. PubMed  Europe PubMed DOI  I
    15. 2014
  15. Che,R., Wang,R. and Xu,T.
    Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker
    Fish Shellfish Immunol41, 163-171. PubMed  Europe PubMed DOI
  16. Raghav,N. and Garg,S.
    SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H
    Eur J Pharm Sci60, 55-63. PubMed  Europe PubMed DOI  I
  17. Raghav,N. and Singh,M.
    SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H
    Bioorg Med Chem22, 4233-4245. PubMed  Europe PubMed DOI  I
  18. Raghav,N. and Singh,M.
    Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H
    Eur J Med Chem77, 231-242. PubMed  Europe PubMed DOI  I
  19. Raghav,N. and Singh,M.
    Design, synthesis and docking studies of bischalcones based quinazoline-2(1H)-ones and quinazoline-2(1H)-thiones derivatives as novel inhibitors of cathepsin B and cathepsin H
    Eur J Pharm Sci54, 28-39. PubMed  Europe PubMed DOI  I
  20. Ravish,I. and Raghav,N.
    Curcumin as inhibitor of mammalian cathepsin B, cathepsin H, acid phosphatase and alkaline phosphatase: a correlation with pharmacological activities
    Med Chem Res23, 2847-2855. DOI  I
    21. 2013
  21. Aldahmesh,M.A., Khan,A.O., Alkuraya,H., Adly,N., Anazi,S., Al-Saleh,A.A., Mohamed,J.Y., Hijazi,H., Prabakaran,S., Tacke,M., Al-Khrashi,A., Hashem,M., Reinheckel,T., Assiri,A. and Alkuraya,F.S.
    Mutations in LRPAP1 are associated with severe myopia in humans
    Am J Hum Genet93, 313-320. PubMed  Europe PubMed DOI  M
  22. Jevnikar,Z., Rojnik,M., Jamnik,P., Doljak,B., Fonovic,U.P. and Kos,J.
    Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells
    J Biol Chem288, 2201-2209. PubMed  Europe PubMed DOI  P
  23. Kim,J.W., Park,C.I., Hwang,S.D., Jeong,J.M., Kim,K.H., Kim,D.H. and Shim,S.H.
    Molecular characterisation and expression analysis of the cathepsin H gene from rock bream (Oplegnathus fasciatus)
    Fish Shellfish Immunol35, 188-194. PubMed  Europe PubMed DOI
    24. 2012
  24. Douglas Lu,W., Funkelstein,L., Toneff,T., Reinheckel,T., Peters,C. and Hook,V.
    Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters
    J Neurochem122, 512-522. PubMed  Europe PubMed DOI
  25. Kirschke,H.
    Cathepsin H
    [ISSN:978-0-12-407743-0]3, 1795-1800. DOI
  26. Rojnik,M., Jevnikar,Z.R., Doljak,B., Turk,S., Zidar,N. and Kos,J.
    The influence of differential processing of procathepsin H on its aminopeptidase activity, secretion and subcellular localization in human cell lines
    Eur J Cell Biol91, 757-764. PubMed  Europe PubMed DOI
    27. 2011
  27. Buhling,F., Kouadio,M., Chwieralski,C.E., Kern,U., Hohlfeld,J.M., Klemm,N., Friedrichs,N., Roth,W., Deussing,J.M., Peters,C. and Reinheckel,T.
    Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice
    PLoS ONE6, e26247-e26247. PubMed  Europe PubMed DOI  K
  28. Rojnik,M., Jevnikar,Z., Mirkovic,B., Janes,D., Zidar,N., Kikelj,D. and Kos,J.
    Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines
    Radiol Oncol45, 259-266. PubMed  Europe PubMed DOI
    29. 2010
  29. D'Angelo,M.E., Bird,P.I., Peters,C., Reinheckel,T., Trapani,J.A. and Sutton,V.R.
    Cathepsin H is an additional convertase of pro-granzyme B
    J Biol Chem285, 20514-20519. PubMed  Europe PubMed DOI
  30. Gocheva,V., Chen,X., Peters,C., Reinheckel,T. and Joyce,J.A.
    Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer
    Biol Chem391, 937-945. PubMed  Europe PubMed DOI  T
    31. 2008
  31. Woischnik,M., Bauer,A., Aboutaam,R., Pamir,A., Stanzel,F., de Blic,J. and Griese,M.
    Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis
    Eur Respir J31, 1197-1204. PubMed  Europe PubMed DOI
    32. 2007
  32. Lu,J., Qian,J., Keppler,D. and Cardoso,W.V.
    Cathepsin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis
    J Biol Chem282, 22176-22184. PubMed  Europe PubMed DOI
  33. Ruettger,A. and Wiederanders,B.
    Microplate assay for cathepsin detection in viable cells using derivatives of 4-methoxy-beta-naphthylamide
    Curr Protoc Protein SciUnit 21.21, Unit 21.21- PubMed  Europe PubMed DOI  A
    34. 2006
  34. Ruttger,A., Mollenhauer,J., Loser,R., Gutschow,M. and Wiederanders,B.
    Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide
    Biotechniques41, 469-473. PubMed  Europe PubMed DOI  A
    35. 2005
  35. Horn,M., Doleckova-Maresova,L., Rulisek,L., Masa,M., Vasiljeva,O., Turk,B., Gan-Erdene,T., Baudys,M. and Mares,M.
    Activation processing of cathepsin H impairs recognition by its propeptide
    Biol Chem386, 941-947. PubMed  Europe PubMed DOI
    36. 2004
  36. Kirschke,H.
    Cathepsin H
    [ISSN:0-12-079610-4]2, 1089-1092.  V
  37. [YEAR:16-4-2004]Ueno,T., Linder,S., Na,C.L., Rice,W.R., Johansson,J. and Weaver,T.E.
    Processing of pulmonary surfactant protein B by napsin and cathepsin H
    J Biol Chem279, 16178-16184. PubMed  Europe PubMed DOI  P
    38. 2003
  38. Brguljan,P.M., Turk,V., Nina,C., Brzin,J., Krizaj,I. and Popovic,T.
    Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme
    Peptides24, 1977-1984. PubMed  Europe PubMed DOI
  39. Dodt,J. and Reichwein,J.
    Human cathepsin H: deletion of the mini-chain switches substrate specificity from aminopeptidase to endopeptidase
    Biol Chem384, 1327-1332. PubMed  Europe PubMed DOI
  40. Guttentag,S., Robinson,L., Zhang,P., Brasch,F., Buhling,F. and Beers,M.
    Cysteine protease activity is required for surfactant protein B processing and lamellar body genesis
    Am J Respir Cell Mol Biol28, 69-79. PubMed  Europe PubMed DOI
  41. Han,S.R., Momeni,A., Strach,K., Suriyaphol,P., Fenske,D., Paprotka,K., Hashimoto,S.I., Torzewski,M., Bhakdi,S. and Husmann,M.
    Enzymatically modified LDL induces cathepsin H in human monocytes: potential relevance in early atherogenesis
    Arterioscler Thromb Vasc Biol23, 661-667. PubMed  Europe PubMed DOI
  42. [YEAR:21-2-2003]Jenko,S., Dolenc,I., Guncar,G., Dobersek,A., Podobnik,M. and Turk,D.
    Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases
    J Mol Biol326, 875-885. PubMed  Europe PubMed DOI  S
  43. Matsuishi,M., Saito,G., Okitani,A. and Kato,H.
    Purification and some properties of cathepsin H from rabbit skeletal muscle
    Int J Biochem Cell Biol35, 474-485. PubMed  Europe PubMed DOI
  44. [YEAR:25-11-2003]Vasiljeva,O., Dolinar,M., Turk,V. and Turk,B.
    Recombinant human cathepsin H lacking the mini chain is an endopeptidase
    Biochemistry42, 13522-13528. PubMed  Europe PubMed DOI
    45. 2002
  45. Brasch,F., ten Brinke,A., Johnen,G., Ochs,M., Kapp,N., Muller,K.M., Beers,M.F., Fehrenbach,H., Richter,J., Batenburg,J.J. and Buhling,F.
    Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes
    Am J Respir Cell Mol Biol26, 659-670. PubMed  Europe PubMed DOI
  46. [YEAR:29-3-2002]Waghray,A., Keppler,D., Sloane,B.F., Schuger,L. and Chen,Y.Q.
    Analysis of a truncated form of cathepsin H in human prostate tumor cells
    J Biol Chem277, 11533-11538. PubMed  Europe PubMed DOI
    47. 2000
  47. Castren,J.P., Kamel,D.E., Nurmi,M.J. and Collan,Y.U.
    Cathepsin H expression distinguishes oncocytomas from renal cell carcinomas
    Anticancer Res20, 537-540. PubMed  Europe PubMed
  48. Tanaka,Y., Tanaka,R. and Himeno,M.
    Lysosomal cysteine protease, cathepsin H, is targeted to lysosomes by the mannose 6-phosphate-independent system in rat hepatocytes
    Biol Pharm Bull23, 805-809. PubMed  Europe PubMed
    49. 1998
  49. [YEAR:15-1-1998]Guncar,G., Podobnik,M., Pungercar,J., Strukelj,B., Turk,V. and Turk,D.
    Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function
    Structure6, 51-61. PubMed  Europe PubMed  S
    50. 1996
  50. Bano,B., Kunapuli,S.P., Bradford,H.N. and Colman,R.W.
    Structural requirements for cathepsin B and cathepsin H inhibition by kininogens
    J Protein Chem15, 519-525. PubMed  Europe PubMed
    51. 1994
  51. Kirschke,H. and Wiederanders,B.
    Cathepsin S and related lysosomal endopeptidases
    Methods Enzymol244, 500-511. PubMed  Europe PubMed DOI  V
    52. 1993
  52. Popovic,T., Brzin,J., Ritonja,A., Svetic,B. and Turk,V.
    Rapid affinity chromatographic method for the isolation of human cathepsin H
    J Chromatogr615, 243-249. PubMed  Europe PubMed DOI
    53. 1992
  53. Koga,H., Mori,N., Yamada,H., Nishimura,Y., Tokuda,K., Kato,K. and Imoto,T.
    Endo- and aminopeptidase activities of rat cathepsin H
    Chem Pharm Bull (Tokyo)40, 965-970. PubMed  Europe PubMed
  54. [YEAR:15-12-1992]Rothe,M. and Dodt,J.
    Studies on the aminopeptidase activity of rat cathepsin H
    Eur J Biochem210, 759-764. PubMed  Europe PubMed DOI
    55. 1991
  55. Koga,H., Mori,N., Yamada,H., Nishimura,Y., Tokuda,K., Kato,K. and Imoto,T.
    Rat cathepsin H-catalyzed transacylation: Comparisons of the mechanism and the specificity with papain-superfamily proteases
    J Biochem110, 939-944. PubMed  Europe PubMed
  56. Tchoupe,J.R., Moreau,T., Gauthier,F. and Bieth,J.G.
    Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group
    Biochim Biophys Acta1076, 149-151. PubMed  Europe PubMed DOI  A
    57. 1990
  57. Qian,F., Frankfater,A., Miller,R.V., Chan,S.J. and Steiner,D.F.
    Molecular cloning of rat precursor cathepsin H and the expression of five lysosomal cathepsins in normal tissues and in a rat carcinosarcoma
    Int J Biochem22, 1457-1464. PubMed  Europe PubMed DOI
    58. 1989
  58. [YEAR:15-8-1989]Angliker,H., Wikstrom,P., Kirschke,H. and Shaw,E.
    The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagents
    Biochem J262, 63-68. PubMed  Europe PubMed  I
  59. Fuchs,R. and Gassen,H.G.
    Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase
    Nucleic Acids Res17, 9471-9471. PubMed  Europe PubMed
  60. Ishidoh,K., Kominami,E., Katunuma,N. and Suzuki,K.
    Gene structure of rat cathepsin H
    FEBS Lett253, 103-107. PubMed  Europe PubMed DOI
  61. Mason,R.W.
    Interaction of lysosomal cysteine proteinases with alpha2-macroglobulin: conclusive evidence for the endopeptidase activities of cathepsins B and H
    Arch Biochem Biophys273, 367-374. PubMed  Europe PubMed
    62. 1988
  62. Fuchs,R., Machleidt,W. and Gassen,H.G.
    Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H
    Biol Chem Hoppe Seyler369, 469-475. PubMed  Europe PubMed
  63. Ritonja,A., Popovic,T., Kotnik,M., Machleidt,W. and Turk,V.
    Amino acid sequences of the human kidney cathepsins H and L
    FEBS Lett228, 341-345. PubMed  Europe PubMed
  64. Takahashi,T., Dehdarani,A.H. and Tang,J.
    Porcine spleen cathepsin H hydrolyzes oligopeptides solely by aminopeptidase activity
    J Biol Chem263, 10952-10957. PubMed  Europe PubMed
    65. 1987
  65. Wang,X., Chan,S.J., Eddy,R.L., Byers,M.G., Fukushima,Y., Henry,W.M., Haley,L.L., Steiner,D.F. and Shows,T.B.
    Chromosome assignment of cathepsin B (CTSB) to 8p22 and cathepsin H (CTSH) to 15q24-q25
    Cytogenet Cell Genet46, 710-711.
    66. 1982
  66. Barrett,A.J., Kembhavi,A.A., Brown,M.A., Kirschke,H., Knight,C.G., Tamai,M. and Hanada,K.
    L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L
    Biochem J201, 189-198. PubMed  Europe PubMed  I
    67. 1981
  67. Barrett,A.J. and Kirschke,H.
    Cathepsin B, cathepsin H and cathepsin L
    Methods Enzymol80, 535-561. PubMed  Europe PubMed DOI  V
    68. 1980
  68. Barrett,A.J.
    Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates
    Biochem J187, 909-912. PubMed  Europe PubMed  A
  69. Schwartz,W.N. and Barrett,A.J.
    Human cathepsin H
    Biochem J191, 487-497. PubMed  Europe PubMed
    70. 1977
  70. Kirschke,H.
    Cathepsin H: an endoaminopeptidase
    Acta Biol Med Ger36, 1547-1548. PubMed  Europe PubMed
  71. Kirschke,H., Langner,J., Wiederanders,B., Ansorge,S., Bohley,P. and Hanson,H.
    Cathepsin H: an endoaminopeptidase from rat liver lysosomes
    Acta Biol Med Ger36, 185-199. PubMed  Europe PubMed
    72. 1976
  72. Kirschke,H., Langner,J., Wiederanders,B., Ansorge,S., Bohley,P. and Broghammer,U.
    [Intracellular protein breakdown. VII. Cathepsin L and H; two new proteinases from rat liver lysosomes]
    Acta Biol Med Ger35, 285-299. PubMed  Europe PubMed
    73. 1941
  73. Fruton,J.S., Irving,G.W., Jr. and Bergmann,M.
    On the proteolytic enzymes of animal tissues. II. The composite nature of beef spleen cathepsin
    J Biol Chem138, 249-262.

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