Literature for peptidase C01.040: cathepsin H

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Mou,H., She,H., Zhang,C.J., Li,M., Wang,W., Sun,S.N., Zhang,X. and Jin,Z.B. Cathepsin H deficiency leads to myopic phenotype in mice Exp Eye Res (2025) 258, 110447-110447. PubMed Europe PubMed DOI

2024

Deng,T., Lu,X., Jia,X., Du,J., Wang,L., Cao,B., Yang,M., Yin,Y. and Liu,F. Cathepsins and cancer risk: a Mendelian randomization study Front Endocrinol (Lausanne) (2024) 15, 1428433-1428433. PubMed Europe PubMed DOI PMC EPMC
Jangra,S., Raghav,N., Wadhwa,D., Kumar,A., Bhattacharyya,S., Kumar,V. and Sheokand,J. Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents J Biomater Sci Polym Ed (2024) , 1-19. PubMed Europe PubMed DOI I

2023

Chen,Q., Qu,S., Liang,Z., Liu,Y., Chen,H., Ma,S. and Liu,X. Cathepsin H Knockdown Reverses Radioresistance of Hepatocellular Carcinoma via Metabolic Switch Followed by Apoptosis Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC K
Stoka,V., Vasiljeva,O., Nakanishi,H. and Turk,V. The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Wang,Y., Zhao,J., Gu,Y., Wang,H., Jiang,M., Zhao,S., Qing,H. and Ni,J. Cathepsin H: Molecular characteristics and clues to function and mechanism Biochem Pharmacol (2023) 212, 115585-115585. PubMed Europe PubMed DOI V

2020

Prunk,M., Perisic Nanut,M., Jakos,T., Sabotic,J., Svajger,U. and Kos,J. Extracellular Cystatin F Is Internalised by Cytotoxic T Lymphocytes and Decreases Their Cytotoxicity Cancers (Basel) (2020) 12 PubMed Europe PubMed DOI PMC EPMC
Singh,S., Sharma,S. and Agarwal,S.K. A simple purification procedure of buffalo lung cathepsin H, its properties and influence of buffer constituents on the enzyme activity Biochem Biophys Rep (2020) 22, 100739-100739. PubMed Europe PubMed DOI PMC EPMC

2018

Hao,Y., Purtha,W., Cortesio,C., Rui,H., Gu,Y., Chen,H., Sickmier,E.A., Manzanillo,P. and Huang,X. Crystal structures of human procathepsin H PLoS ONE (2018) 13, e0200374-e0200374. PubMed Europe PubMed DOI PMC EPMC S
Okada,R., Zhang,X., Harada,Y., Wu,Z. and Nakanishi,H. Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade Inflamm Res (2018) 67, 371-374. PubMed Europe PubMed DOI K

2017

Naeem,A.S., Tommasi,C., Cole,C., Brown,S.J., Zhu,Y., Way,B., Willis Owen,S.A., Moffatt,M., Cookson,W.O., Harper,J.I., Di,W.L., Brown,S.J., Reinheckel,T. and O'Shaughnessy,R.F. A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin a novel mechanism for skin barrier disruption in patients with atopic dermatitis J Allergy Clin Immunol (2017) 139, 1228-1241. PubMed Europe PubMed DOI K
Qi,Z., Huang,B., Zhang,Q., Wang,Z., Wang,P. and Gao,Q. Molecular characterization, expression and evolutionary analysis of 3 cathepsin genes (CTSH, CTSL and CTSS) from Chinese giant salamander (Andrias davidianus) Gene Rep (2017) 7, 25-31. DOI

2016

Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J. Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones RSC Adv (2016) 6, 34588-34599. DOI I

2015

Singh,M. and Raghav,N. 2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H Bioorg Chem (2015) 59C, 12-22. PubMed Europe PubMed DOI I

2014

Che,R., Wang,R. and Xu,T. Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker Fish Shellfish Immunol (2014) 41, 163-171. PubMed Europe PubMed DOI
Raghav,N. and Singh,M. Design, synthesis and docking studies of bischalcones based quinazoline-2(1H)-ones and quinazoline-2(1H)-thiones derivatives as novel inhibitors of cathepsin B and cathepsin H Eur J Pharm Sci (2014) 54, 28-39. PubMed Europe PubMed DOI I
Raghav,N. and Singh,M. Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H Eur J Med Chem (2014) 77, 231-242. PubMed Europe PubMed DOI I
Raghav,N. and Garg,S. SAR studies of o-hydroxychalcones and their cyclized analogs and study them as novel inhibitors of cathepsin B and cathepsin H Eur J Pharm Sci (2014) 60, 55-63. PubMed Europe PubMed DOI I
Raghav,N. and Singh,M. SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H Bioorg Med Chem (2014) 22, 4233-4245. PubMed Europe PubMed DOI I
Ravish,I. and Raghav,N. Curcumin as inhibitor of mammalian cathepsin B, cathepsin H, acid phosphatase and alkaline phosphatase: a correlation with pharmacological activities Med Chem Res (2014) 23, 2847-2855. DOI I

2013

Aldahmesh,M.A., Khan,A.O., Alkuraya,H., Adly,N., Anazi,S., Al-Saleh,A.A., Mohamed,J.Y., Hijazi,H., Prabakaran,S., Tacke,M., Al-Khrashi,A., Hashem,M., Reinheckel,T., Assiri,A. and Alkuraya,F.S. Mutations in LRPAP1 are associated with severe myopia in humans Am J Hum Genet (2013) 93, 313-320. PubMed Europe PubMed DOI M
Jevnikar,Z., Rojnik,M., Jamnik,P., Doljak,B., Fonovic,U.P. and Kos,J. Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells J Biol Chem (2013) 288, 2201-2209. PubMed Europe PubMed DOI P
Kim,J.W., Park,C.I., Hwang,S.D., Jeong,J.M., Kim,K.H., Kim,D.H. and Shim,S.H. Molecular characterisation and expression analysis of the cathepsin H gene from rock bream (Oplegnathus fasciatus) Fish Shellfish Immunol (2013) 35, 188-194. PubMed Europe PubMed DOI

2012

Douglas Lu,W., Funkelstein,L., Toneff,T., Reinheckel,T., Peters,C. and Hook,V. Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters J Neurochem (2012) 122, 512-522. PubMed Europe PubMed DOI
Kirschke,H. Cathepsin H [ISSN:978-0-12-407743-0] (2012) 3, 1795-1800. DOI
Rojnik,M., Jevnikar,Z.R., Doljak,B., Turk,S., Zidar,N. and Kos,J. The influence of differential processing of procathepsin H on its aminopeptidase activity, secretion and subcellular localization in human cell lines Eur J Cell Biol (2012) 91, 757-764. PubMed Europe PubMed DOI

2011

Buhling,F., Kouadio,M., Chwieralski,C.E., Kern,U., Hohlfeld,J.M., Klemm,N., Friedrichs,N., Roth,W., Deussing,J.M., Peters,C. and Reinheckel,T. Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice PLoS ONE (2011) 6, e26247-e26247. PubMed Europe PubMed DOI PMC EPMC K
Rojnik,M., Jevnikar,Z., Mirkovic,B., Janes,D., Zidar,N., Kikelj,D. and Kos,J. Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines Radiol Oncol (2011) 45, 259-266. PubMed Europe PubMed DOI

2010

D'Angelo,M.E., Bird,P.I., Peters,C., Reinheckel,T., Trapani,J.A. and Sutton,V.R. Cathepsin H is an additional convertase of pro-granzyme B J Biol Chem (2010) 285, 20514-20519. PubMed Europe PubMed DOI
Gocheva,V., Chen,X., Peters,C., Reinheckel,T. and Joyce,J.A. Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer Biol Chem (2010) 391, 937-945. PubMed Europe PubMed DOI T

2008

Woischnik,M., Bauer,A., Aboutaam,R., Pamir,A., Stanzel,F., de Blic,J. and Griese,M. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis Eur Respir J (2008) 31, 1197-1204. PubMed Europe PubMed DOI

2007

Lu,J., Qian,J., Keppler,D. and Cardoso,W.V. Cathepsin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis J Biol Chem (2007) 282, 22176-22184. PubMed Europe PubMed DOI
Ruettger,A. and Wiederanders,B. Microplate assay for cathepsin detection in viable cells using derivatives of 4-methoxy-beta-naphthylamide Curr Protoc Protein Sci (2007) Unit 21.21, Unit 21.21- PubMed Europe PubMed DOI A

2006

Ruttger,A., Mollenhauer,J., Loser,R., Gutschow,M. and Wiederanders,B. Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide Biotechniques (2006) 41, 469-473. PubMed Europe PubMed DOI A

2005

Horn,M., Doleckova-Maresova,L., Rulisek,L., Masa,M., Vasiljeva,O., Turk,B., Gan-Erdene,T., Baudys,M. and Mares,M. Activation processing of cathepsin H impairs recognition by its propeptide Biol Chem (2005) 386, 941-947. PubMed Europe PubMed DOI

2004

Kirschke,H. Cathepsin H [ISSN:0-12-079610-4] (2004) 2, 1089-1092. V
[YEAR:16-4-2004]Ueno,T., Linder,S., Na,C.L., Rice,W.R., Johansson,J. and Weaver,T.E. Processing of pulmonary surfactant protein B by napsin and cathepsin H J Biol Chem (16-4-2004) 279, 16178-16184. PubMed Europe PubMed DOI P

2003

Brguljan,P.M., Turk,V., Nina,C., Brzin,J., Krizaj,I. and Popovic,T. Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme Peptides (2003) 24, 1977-1984. PubMed Europe PubMed DOI
Dodt,J. and Reichwein,J. Human cathepsin H: deletion of the mini-chain switches substrate specificity from aminopeptidase to endopeptidase Biol Chem (2003) 384, 1327-1332. PubMed Europe PubMed DOI
Guttentag,S., Robinson,L., Zhang,P., Brasch,F., Buhling,F. and Beers,M. Cysteine protease activity is required for surfactant protein B processing and lamellar body genesis Am J Respir Cell Mol Biol (2003) 28, 69-79. PubMed Europe PubMed DOI
Han,S.R., Momeni,A., Strach,K., Suriyaphol,P., Fenske,D., Paprotka,K., Hashimoto,S.I., Torzewski,M., Bhakdi,S. and Husmann,M. Enzymatically modified LDL induces cathepsin H in human monocytes: potential relevance in early atherogenesis Arterioscler Thromb Vasc Biol (2003) 23, 661-667. PubMed Europe PubMed DOI
[YEAR:21-2-2003]Jenko,S., Dolenc,I., Guncar,G., Dobersek,A., Podobnik,M. and Turk,D. Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases J Mol Biol (21-2-2003) 326, 875-885. PubMed Europe PubMed DOI S
Matsuishi,M., Saito,G., Okitani,A. and Kato,H. Purification and some properties of cathepsin H from rabbit skeletal muscle Int J Biochem Cell Biol (2003) 35, 474-485. PubMed Europe PubMed DOI
[YEAR:25-11-2003]Vasiljeva,O., Dolinar,M., Turk,V. and Turk,B. Recombinant human cathepsin H lacking the mini chain is an endopeptidase Biochemistry (25-11-2003) 42, 13522-13528. PubMed Europe PubMed DOI

2002

Brasch,F., ten Brinke,A., Johnen,G., Ochs,M., Kapp,N., Muller,K.M., Beers,M.F., Fehrenbach,H., Richter,J., Batenburg,J.J. and Buhling,F. Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes Am J Respir Cell Mol Biol (2002) 26, 659-670. PubMed Europe PubMed DOI
[YEAR:29-3-2002]Waghray,A., Keppler,D., Sloane,B.F., Schuger,L. and Chen,Y.Q. Analysis of a truncated form of cathepsin H in human prostate tumor cells J Biol Chem (29-3-2002) 277, 11533-11538. PubMed Europe PubMed DOI

2000

Castren,J.P., Kamel,D.E., Nurmi,M.J. and Collan,Y.U. Cathepsin H expression distinguishes oncocytomas from renal cell carcinomas Anticancer Res (2000) 20, 537-540. PubMed Europe PubMed
Tanaka,Y., Tanaka,R. and Himeno,M. Lysosomal cysteine protease, cathepsin H, is targeted to lysosomes by the mannose 6-phosphate-independent system in rat hepatocytes Biol Pharm Bull (2000) 23, 805-809. PubMed Europe PubMed

1998

[YEAR:15-1-1998]Guncar,G., Podobnik,M., Pungercar,J., Strukelj,B., Turk,V. and Turk,D. Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function Structure (15-1-1998) 6, 51-61. PubMed Europe PubMed S

1996

Bano,B., Kunapuli,S.P., Bradford,H.N. and Colman,R.W. Structural requirements for cathepsin B and cathepsin H inhibition by kininogens J Protein Chem (1996) 15, 519-525. PubMed Europe PubMed

1994

Kirschke,H. and Wiederanders,B. Cathepsin S and related lysosomal endopeptidases Methods Enzymol (1994) 244, 500-511. PubMed Europe PubMed DOI V

1993

Popovic,T., Brzin,J., Ritonja,A., Svetic,B. and Turk,V. Rapid affinity chromatographic method for the isolation of human cathepsin H J Chromatogr (1993) 615, 243-249. PubMed Europe PubMed DOI

1992

Koga,H., Mori,N., Yamada,H., Nishimura,Y., Tokuda,K., Kato,K. and Imoto,T. Endo- and aminopeptidase activities of rat cathepsin H Chem Pharm Bull (Tokyo) (1992) 40, 965-970. PubMed Europe PubMed
[YEAR:15-12-1992]Rothe,M. and Dodt,J. Studies on the aminopeptidase activity of rat cathepsin H Eur J Biochem (15-12-1992) 210, 759-764. PubMed Europe PubMed DOI

1991

Koga,H., Mori,N., Yamada,H., Nishimura,Y., Tokuda,K., Kato,K. and Imoto,T. Rat cathepsin H-catalyzed transacylation: Comparisons of the mechanism and the specificity with papain-superfamily proteases J Biochem (1991) 110, 939-944. PubMed Europe PubMed
Tchoupe,J.R., Moreau,T., Gauthier,F. and Bieth,J.G. Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group Biochim Biophys Acta (1991) 1076, 149-151. PubMed Europe PubMed DOI A

1990

Qian,F., Frankfater,A., Miller,R.V., Chan,S.J. and Steiner,D.F. Molecular cloning of rat precursor cathepsin H and the expression of five lysosomal cathepsins in normal tissues and in a rat carcinosarcoma Int J Biochem (1990) 22, 1457-1464. PubMed Europe PubMed DOI

1989

[YEAR:15-8-1989]Angliker,H., Wikstrom,P., Kirschke,H. and Shaw,E. The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagents Biochem J (15-8-1989) 262, 63-68. PubMed Europe PubMed PMC EPMC I
Fuchs,R. and Gassen,H.G. Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase Nucleic Acids Res (1989) 17, 9471-9471. PubMed Europe PubMed PMC EPMC
Ishidoh,K., Kominami,E., Katunuma,N. and Suzuki,K. Gene structure of rat cathepsin H FEBS Lett (1989) 253, 103-107. PubMed Europe PubMed DOI
Mason,R.W. Interaction of lysosomal cysteine proteinases with alpha2-macroglobulin: conclusive evidence for the endopeptidase activities of cathepsins B and H Arch Biochem Biophys (1989) 273, 367-374. PubMed Europe PubMed

1988

Fuchs,R., Machleidt,W. and Gassen,H.G. Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H Biol Chem Hoppe Seyler (1988) 369, 469-475. PubMed Europe PubMed
Ritonja,A., Popovic,T., Kotnik,M., Machleidt,W. and Turk,V. Amino acid sequences of the human kidney cathepsins H and L FEBS Lett (1988) 228, 341-345. PubMed Europe PubMed
Takahashi,T., Dehdarani,A.H. and Tang,J. Porcine spleen cathepsin H hydrolyzes oligopeptides solely by aminopeptidase activity J Biol Chem (1988) 263, 10952-10957. PubMed Europe PubMed

1987

Wang,X., Chan,S.J., Eddy,R.L., Byers,M.G., Fukushima,Y., Henry,W.M., Haley,L.L., Steiner,D.F. and Shows,T.B. Chromosome assignment of cathepsin B (CTSB) to 8p22 and cathepsin H (CTSH) to 15q24-q25 Cytogenet Cell Genet (1987) 46, 710-711.

1982

Barrett,A.J., Kembhavi,A.A., Brown,M.A., Kirschke,H., Knight,C.G., Tamai,M. and Hanada,K. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L Biochem J (1982) 201, 189-198. PubMed Europe PubMed PMC EPMC I

1981

Barrett,A.J. and Kirschke,H. Cathepsin B, cathepsin H and cathepsin L Methods Enzymol (1981) 80, 535-561. PubMed Europe PubMed DOI V

1980

Barrett,A.J. Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates Biochem J (1980) 187, 909-912. PubMed Europe PubMed PMC EPMC A
Schwartz,W.N. and Barrett,A.J. Human cathepsin H Biochem J (1980) 191, 487-497. PubMed Europe PubMed PMC EPMC

1977

Kirschke,H., Langner,J., Wiederanders,B., Ansorge,S., Bohley,P. and Hanson,H. Cathepsin H: an endoaminopeptidase from rat liver lysosomes Acta Biol Med Ger (1977) 36, 185-199. PubMed Europe PubMed
Kirschke,H. Cathepsin H: an endoaminopeptidase Acta Biol Med Ger (1977) 36, 1547-1548. PubMed Europe PubMed

1976

Kirschke,H., Langner,J., Wiederanders,B., Ansorge,S., Bohley,P. and Broghammer,U. [Intracellular protein breakdown. VII. Cathepsin L and H; two new proteinases from rat liver lysosomes] Acta Biol Med Ger (1976) 35, 285-299. PubMed Europe PubMed

1941

Fruton,J.S., Irving,G.W., Jr. and Bergmann,M. On the proteolytic enzymes of animal tissues. II. The composite nature of beef spleen cathepsin J Biol Chem (1941) 138, 249-262.